CD46: A complement regulator and pathogen receptor that mediates links between innate and acquired immune function

Tissue Antigens

Volumn 64, Issue 2, 2004, Pages 111-118

  Russell, S ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

CD46; Cell polarity; Complement; HHV6; Measles; Membrane cofactor protein; Neisseria; Signal transduction

Indexed keywords

ANTIGEN; COMPLEMENT; MEMBRANE ANTIGEN; MEMBRANE COFACTOR PROTEIN; RECEPTOR;

ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTATION; ANTIGEN STRUCTURE; BINDING AFFINITY; CELL ACTIVITY; CELL ORGANELLE; CELL PROTECTION; CELLULAR IMMUNITY; COMPLEMENT ACTIVATION; COMPLEMENT FIXATION; HUMAN; HUMAN HERPESVIRUS 6; IMMUNE RESPONSE; IMMUNITY; IMMUNOCOMPETENT CELL; INFECTION; MEASLES; MOLECULAR MECHANICS; NEISSERIA; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIGEN PRESENTATION; ANTIGENS, CD; ANTIGENS, CD46; HERPESVIRUS 6, HUMAN; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, NATURAL; INFECTION; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NEISSERIA; RECEPTORS, COMPLEMENT; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 6; NEISSERIA;

EID: 3242800341     PISSN: 00012815     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2004.00277.x     Document Type: Review

References (64)

1. Liszewski MK, Post TW, Atkinson JP. Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu Rev Immunol 1991: 9: 431.
2. Post TW, Liszewski MK, Adams EM, Tedja I, Miller EA, Atkinson JP. Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype. J Exp Med 1991: 174: 93.
3. Russell SM, Sparrow RL, McKenzie IF, Purcell DF. Tissue-specific and allelic expression of the complement regulator CD46 is controlled by alternative splicing. Eur J Immunol 1992: 22: 1513.
4. Manchester M, Valsamakis A, Kaufman R et al. Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). Proc Natl Acad Sci USA 1995: 92: 2303.
5. Johnstone RW, Russell SM, Loveland BE, McKenzie IF. Polymorphic expression of CD46 protein isoforms due to tissue-specific RNA splicing. Mol Immunol 1993: 30: 1231.
6. Miwa T, Nonaka M, Okada N, Wakana S, Shiroishi T, Okada H. Molecular cloning of rat and mouse membrane cofactor protein (MCP, CD46): preferential expression in testis and close linkage between the mouse Mcp and Cr2 genes on distal chromosome 1. Immunogenetics 1998: 48: 363.
7. Barilla-LaBarca ML, Liszewski MK, Lambris JD, Hourcade D, Atkinson JP. Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. J Immunol 2002: 168: 6298.
8. Naniche D, Varior-Krishnan G, Cervoni F et al. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J Virol 1993: 67: 6025.
9. Dorig RE, Mardi A, Chopra A, Richardson CD. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 1993: 75: 295.
10. Santoro F, Kennedy PE, Locatelli G, Malnati MS, Berger EA, Lusso P. CD46 is a cellular receptor for human herpesvirus 6. Cell 1999: 99: 817.
11. Giannakis E, Jokiranta TS, Ormsby RJ et al. Identification of the streptococcal M protein binding site on membrane cofactor protein (CD46). J Immunol 2002: 168: 4585.
12. Gaggar A, Shayakhmetov DM, Lieber A. CD46 is a cellular receptor for group B adenoviruses. Nat Med 2003: 9: 1408.
13. Johansson L, Rytkonen A, Bergman P et al. CD46 in meningococcal disease. Science 2003: 301: 373.
14. Segerman A, Atkinson JP, Marttila M, Dennerquist V, Wadell G, Arnberg N. Adenovirus type 11 uses CD46 as a cellular receptor. J Virol 2003: 77: 9183.
15. Gerlier D, Trescol-Biemont MC, Varior-Krishnan G, Naniche D, Fugier-Vivier I, Rabourdin-Combe C. Efficient major histocompatibility complex class II-restricted presentation of measles virus relies on hemagglutinin- mediated targeting to its cellular receptor human CD46 expressed by murine B cells. J Exp Med 1994: 179: 353.
16. Cardoso AI, Beauverger P, Gerlier D, Wild TF, Rabourdin-Combe C. Formaldehyde inactivation of measles virus abolishes CD46-dependent presentation of nucleoprotein to murine class I-restricted CTLs but not to class II-restricted helper T cells. Virology 1995: 212: 255.
17. Rivailler P, Trescol-Biemont MC, Gimenez C, Rabourdin-Combe C, Horvat B. Enhanced MHC class II-restricted presentation of measles virus (MV) hemagglutinin in transgenic mice expressing human MV receptor CD46. Eur J Immunol 1998: 28: 1301.
18. Krantic S, Gimenez C, Rabourdin-Combe C. Cell-to-cell contact via measles virus haemagglutinin-CD46 interaction triggers CD46 downregulation. J Gen Virol 1995: 76: 2793.
19. Karp CL, Wysocka M, Wahl LM et al. Mechanism of suppression of cell-mediated immunity by measles virus. Science 1996: 273: 228.
20. Kemper C, Chan AC, Green JM, Brett KA, Murphy KM, Atkinson JP. Activation of human CD4(+) cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 2003: 421: 388.
21. Gill DB, Koomey M, Cannon JG, Atkinson JP. Down-regulation of CD46 by piliated Neisseria gonorrhoeae. J Exp Med 2003: 198: 1313.
22. WHO-UMCEF joint statement on strategies to reduce measles mortality worldwide. Wkly Epidemiol Rec 2002: 77: 224.
23. Marie JC, Kehren J, Trescol-Biemont MC et al. Mechanism of measles virus-induced suppression of inflammatory immune responses. Immunity 2001: 14: 69.
24. Slifka MK, Homann D, Tishon A, Pagarigan R, Oldstone MB. Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection. J Clin Invest 2003: 111: 805.
25. Smith A, Santoro F, Di Lullo G, Dagna L, Verani A, Lusso P. Selective suppression of IL-12 production by human herpesvirus 6. Blood 2003: 102: 2877.
26. Hirano A, Yang Z, Katayama Y, Korte-Sarfaty J, Wong TC. Human CD46 enhances nitric oxide production in mouse macrophages in response to measles virus infection in the presence of gamma interferon: dependence on the CD46 cytoplasmic domains. J Virol 1999: 73: 4776.
27. Katayama Y, Hirano A, Wong TC. Human receptor for measles virus (CD46) enhances nitric oxide production and restricts virus replication in mouse macrophages by modulating production of alpha/beta interferon. J Virol 2000: 74: 1252.
28. Thorley BR, Milland J, Christiansen D et al. Transgenic expression of a CD46 (membrane cofactor protein) minigene: studies of xenotransplantation and measles virus infection. Eur J Immunol 1997: 27: 726.
29. Mrkic B, Pavlovic J, Rulicke T et al. Measles virus spread and pathogenesis in genetically modified mice. J Virol 1998: 72: 7420.
30. Oldstone MB, Lewicki H, Thomas D et al. Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease. Cell 1999: 98: 629.
31. Marie JC, Astier AL, Rivailler P, Rabourdin-Combe C, Wild TF, Horvat B. Linking innate and acquired immunity: divergent role of CD46 cytoplasmic domains in T cell induced inflammation. Nat Immunol 2002: 3: 659.
32. Tatsuo H, Ono N, Tanaka K, Yanagi Y. SLAM (CDw150) is a cellular receptor for measles virus. Nature 2000: 406: 893.
33. Hahm B, Arbour N, Naniche D, Homann D, Manchester M, Oldstone MB. Measles virus infects and suppresses proliferation of T lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule. J Virol 2003: 77: 3505.
34. Bartz R, Firsching R, Rima B, ter Meulen V, Schneider-Schaulies J. Differential receptor usage by measles virus strains. J Gen Virol 1998: 79: 1015.
35. Manchester M, Eto DS, Valsamakis A et al. Clinical isolates of measles virus use CD46 as a cellular receptor. J Virol 2000: 74: 3967.
36. Ono N, Tatsuo H, Hidaka Y, Aoki T, Minagawa H, Yanagi Y. Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor. J Virol 2001: 75: 4399.
37. Hsu EC, Iorio C, Sarangi F, Khine AA, Richardson CD. CDw150 (SLAM) is a receptor for a lymphotropic strain of measles virus and may account for the immunosuppressive properties of this virus. Virology 2001: 279: 9.
38. Hashimoto K, Ono N, Tatsuo H et al. SLAM (CD150)-independent measles virus entry as revealed by recombinant virus expressing green fluorescent protein. J Virol 2002: 76: 6743.
39. Rall GF. Measles virus 1998-2002: progress and controversy. Annu Rev Microbiol 2003: 57: 343.
40. Astier A, Trescol-Biemont MC, Azocar O, Lamouille B, Rabourdin-Combe C. Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation. J Immunol 2000: 164: 6091.
41. Ghali M, Schneider-Schaulies J. Receptor (CD46)- and replication-mediated interleukin-6 induction by measles virus in human astrocytoma cells. J Neurovirol 1998: 4: 521.
42. Noe KH, Cenciarelli C, Moyer SA, Rota PA, Shin ML. Requirements for measles virus induction of RANTES chemokine in human astrocytoma-derived U373 cells. J Virol 1999: 73: 3117.
43. Imani F, Proud D, Griffin DE. Measles virus infection synergizes with IL-4 in IgE class switching. J Immunol 1999: 162: 1597.
44. Perrin-Cocon LA, Villiers CL, Salamero J, Gabert F, Marche PN. B cell receptors and complement receptors target the antigen to distinct intracellular compartments. J Immunol 2004: 172: 3564.
45. Gerlier D, Trescol-Biemont MC, Varior- Krishnan G, Naniche D, Fugier-Vivier I, Rabourdin-Combe C. Efficient MHC class II-restricted presentation of measles virus to T cells relies on its targeting to its cellular receptor human CD46 and involves an endosomal pathway. Cell Biol Int 1994: 18: 315.
46. Wang G, Liszewski MK, Chan AC, Atkinson JP. Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J Immunol 2000: 164: 1839.
47. Lee SW, Bonnah RA, Higashi DL, Atkinson JP, Milgram SL, So M. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. J Cell Biol 2002: 158: 951.
48. Ludford-Menting MJ, Thomas SJ, Crimeen B et al. A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. J Biol Chem 2002: 277: 4477.
49. Kallstrom H, Islam MS, Berggren PO, Jonsson AB. Cell signaling by the type IV pili of pathogenic Neisseria. J Biol Chem 1998: 273: 21777.
50. Zaffran Y, Destaing O, Roux A et al. CD46/ CD3 costimulation induces morphological changes of human T cells and activation of Vav, Rac, and extracellular signal-regulated kinase mitogen-activated protein kinase. J Immunol 2001: 167: 6780.
51. Kurita-Taniguchi M, Fukui A, Hazeki K et al. Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46. J Immunol 2000: 165: 5143.
52. Kurita-Taniguchi M, Hazeki K, Murabayashi N et al. Molecular assembly of CD46 with CD9, alpha3-beta1 integrin and protein tyrosine phosphatase SHP-1 in human macrophages through differentiation by GM-CSF. Mol Immunol 2002: 38: 689.
53. Husi H, Grant SG. Isolation of 2000-kDa complexes of N-methyl-D-aspartate receptor and postsynaptic density 95 from mouse brain. J Neurochem 2001: 77: 281.
54. Humbert P, Russell S, Richardson H. Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays 2003: 25: 542.
55. Liszewski MK, Tedja I, Atkinson JP. Membrane cofactor protein (CD46) of complement. Processing differences related to alternatively spliced cytoplasmic domains. J Biol Chem 1994: 269: 10776.
56. Crimeen-Irwin B, Ellis S, Christiansen D et al. Ligand binding determines whether CD46 is internalized by clathrin coated pits or niacropinocytosis. J Biol Chem 2003: 278: 46927.
57. Kleijmeer M, Ramm G, Schuurhuis D et al. Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells. J Cell Biol 2001: 155: 53.
58. Kleijmeer MJ, Escola JM, UytdeHaag FG et al. Antigen loading of MHC class I molecules in the endocytic tract. Traffic 2001: 2: 124.
59. Bansal P, Mukherjee P, Basu SK, George A, Bal V, Rath S. MHC class I-restricted presentation of maleylated protein binding to scavenger receptors. J Immunol 1999: 162: 4430.
60. Peppelenbosch MP, DeSmedt M, Pynaert G, van Deventer SJ, Grooten J. Macrophages present pinocytosed exogenous antigen via MHC class I whereas antigen ingested by receptor-mediated endocytosis is presented via MHC class II. J Immunol 2000: 165: 1984.
61. Singh M, Cattaneo R, Billeter MA. A recombinant measles virus expressing hepatitis B virus surface antigen induces humoral immune responses in genetically modified mice. J Virol 1999: 73: 4823.
62. Grote D, Russell SJ, Cornu TI et al. Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice. Blood 2001: 97: 3746.
63. Putz MM, Bouche FB, de Swart RL, Muller CP. Experimental vaccines against measles in a world of changing epidemiology. Int J Parasitol 2003: 33: 525.
64. Shann F. A little bit of measles does you good. Even if measles is eradicated, immunisation may still be desirable in developing countries. BMJ 1999: 319: 4.