Design, synthesis, and conformational analysis of eight-membered cyclic peptidomimetics prepared using ring closing metathesis

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 16, 2004, Pages 4375-4385

  Creighton, Christopher J ^a   Leo, Gregory C ^a   Du, Yanming ^a   Reitz, Allen B ^a  

^a Drug Discovery   (United States)

Author keywords

Conformational analysis; Peptidomimetics; Ring closing metathesis; Type VI turns

Indexed keywords

7 AMINO 8 OXO 1,2,3,4,6,7 PENTAHYDROAZOCINE 2 CARBOXYLIC ACID; 7 AMINO 8 OXOAZOCANE 2 CARBOXYLIC ACID; ALKENE; AMIDE; AMINO ACID DERIVATIVE; BENZYLIDENE DERIVATIVE; LACTAM DERIVATIVE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; CYCLOPEPTIDE; DIPEPTIDE; LACTAM;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CATALYST; CONFORMATIONAL TRANSITION; CORRELATION ANALYSIS; CYCLIZATION; DERIVATIZATION; ENERGY YIELD; EXPERIMENTAL DESIGN; GEOMETRY; ISOMERISM; MOLECULAR DYNAMICS; OLIGOMERIZATION; OXYGEN SATURATION; PROTEIN DEGRADATION; REACTION ANALYSIS; RING CLOSING METATHESIS; STEREOISOMERISM; SYNTHESIS; CHEMISTRY; CONFORMATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; LACTAMS; MOLECULAR CONFORMATION; PEPTIDES, CYCLIC;

EID: 3242792576     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.06.015     Document Type: Article

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