Malononitrile as a carbonyl synthon: A one-pot preparation of heteroaryl amide via a SNAr-oxidation-displacement strategy

Tetrahedron Letters

Volumn 45, Issue 30, 2004, Pages 5909-5911

  Zhu, Juliang ^a   Wong, Henry ^a   Zhang, Zhongxing ^a   Yin, Zhiwei ^a   Kadow, John F ^a   Meanwell, Nicholas A ^a   Wang, Tao ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Carboxamide synthon; Condensation oxidation; Heteroaryl amide; Malononitrile

Indexed keywords

AMIDE; AMINE; ANION; ARGON; BASE; CARBONYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CHLORIDE; HALIDE; MALONONITRILE; NITRILE; PERACETIC ACID; SODIUM;

ARTICLE; METHODOLOGY; OXIDATION; REACTION ANALYSIS; SYNTHESIS;

EID: 3242776108     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.05.154     Document Type: Article

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42. 4, concentrated and the residue purified by silica gel chromatography to afford 10b (250 mg, 65%) as a yellowish oil
43. The reaction and the subsequent work-up should be undertaken with care in a well ventilated hood due to the potential for HCN to be liberated