A Strategy for the Synthesis of Aryl α-Ketoamides Based upon the Acylation of Anions Derived from Cyanomethylamines Followed by Oxidative Cleavage

Organic Letters

Volumn 4, Issue 7, 2002, Pages 1103-1105

  Yang, Zhong ^a   Zhang, Zhongxing ^a   Meanwell, Nicholas A ^a   Kadow, John F ^a   Wang, Tao ^a  

^a BRISTOL MYERS SQUIBB   (United States)

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ARTICLE;

EID: 0041374164     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol010297l     Document Type: Article

References (22)

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21. 4. Concentration in vacuo afforded a residue that was purified by silica gel chromatography to provide N,N-diethyl 2-oxo-(4-pyridyl)-acetamide (1.07 g, 71%).
22. The library was achieved in 100 mg scale for each reaction.