Effects of free convection on three-dimensional protein transport in hollow-fiber bioreactors

AIChE Journal

Volumn 50, Issue 8, 2004, Pages 1974-1990

  Łabȩcki, Marek ^a   Piret, James M ^a   Bowen, Bruce D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Free convection; Hollow fiber bioreactors; Hollow fiber membranes; Mammalian cell culture; Porous medium model

Indexed keywords

BIOLOGICAL MEMBRANES; GRAVITATION; OSMOSIS; PROTEINS; ULTRAFILTRATION; VISCOSITY OF LIQUIDS;

EXTRACAPILLARY SPACE (ECS); FLUID DENSITY; THREE-DIMENSIONAL ANALYSIS;

BIOREACTORS;

BIOREACTOR; CONVECTION; MATHEMATICAL ANALYSIS; PROTEIN; REACTOR; THREE-DIMENSIONAL FLOW;

ARTICLE; CELL CULTURE; DENSITY; HOLLOW FIBER REACTOR; MEMBRANE MODEL; OSMOTIC PRESSURE; POROSITY; PROTEIN TRANSPORT; THERMODYNAMICS; VISCOSITY;

MAMMALIA;

EID: 3242755049     PISSN: 00011541     EISSN: None     Source Type: Journal    
DOI: 10.1002/aic.10159     Document Type: Article

References (37)

1. Allen, J. W., T. Hassanein, and S. N. Bhatia. "Advances in Bioartificial Liver Devices," Hepatology, 34, 447 (2001).
2. Anderson, J. L., F. Rauh, and A. Morales, "Particle Diffusion as a Function of Concentration and Ionic Strength," J. Phys. Chem., 82, 608 (1978).
3. Bear, J., Dynamics of Fluids in Porous Media, Dover Publications, New York (1972).
4. Douglas, J., "Alternating Direction Methods for Three Space Variables," Numer. Math., 4, 41 (1962).
5. Dowd, J. E., K. E. Kwok, and J. M. Piret, "Increased t-PA Yields Using Ultrafiltration of an Inhibitory Product from CHO Fed-Batch Culture," Biotechnol. Prog., 16, 786 (2000).
6. Gramer, M. J., D. M. Poeschl, M. J. Conroy, and B. E. Hammer, "Effect of Harvesting Protocol on Performance of a Hollow Fiber Bioreactor," Biotechnol. Bioeng., 65, 334 (1999).
7. Happel, J., "Viscous Flow Relative to Arrays of Cylinders," AIChE J., 5, 174 (1959).
8. Jackson, L. R., L. J. Trudel, J. G. Fox, and N. S. Lipman, "Evaluation of Hollow Fiber Bioreactors as an Alternative to Murine Ascites Production for Small Scale Monoclonal Antibody Production," J. Immunol. Methods, 189, 217 (1996).
9. Kim, S.-S., and D. O. Cooney, "An Improved Theoretical Model for Hollow-Fiber Enzyme Reactors," Chem. Eng. Sci., 31, 289 (1976).
10. Koska, J., B. D. Bowen, and J. M. Piret, "Protein Transport in Packed-Bed Ultrafiltration Hollow-Fibre Bioreactors," Chem. Eng. Sci., 52, 2251 (1997).
11. Krogh, A., "The Number and Distribution of Capillaries in Muscles with Calculations of the Oxygen Pressure Head Necessary for Supplying the Tissue," J. Physiol., 52, 409 (1919).
12. Łabȩcki, M., "Experimental and Theoretical Studies of Protein Transport in Hollow-Fibre Bioreactors for Mammalian Cell Culture," PhD Thesis, University of British Columbia, Canada (2001).
13. Łabȩcki, M., B. D. Bowen, and J. M. Piret, "Two-Dimensional Analysis of Protein Transport in the Extracapillary Space of Hollow-Fibre Bioreactors," Chem. Eng. Sci., 51, 4197 (1996).
14. Łabȩcki, M., B. D. Bowen, and J. M. Piret, "Protein Transport in Ultrafiltration Hollow-Fiber Bioreactors for Mammalian Cell Culture," Membrane Separations in Biotechnology, 2nd Edition, W. K. Wang, ed., Marcel Dekker, New York, pp. 1-62 (2001).
15. Łabȩcki, M., J. M. Piret, and B. D. Bowen, "Two-Dimensional Analysis of Fluid Flow in Hollow-Fibre Modules," Chem. Eng. Sci., 50, 3369 (1995).
16. Łabȩcki, M., I. Weber, Y. Dudal, J. Koska, J. M. Piret, and B. D. Bowen, "Hindered Transmembrane Protein Transport in Hollow-Fibre Devices," J. Membr. Sci., 146, 197 (1998).
17. Lee, Y.-T., O. Henry, H. A. L. Sczerba, B. D. Bowen, and J. M. Piret, "Factors Affecting Hybridoma Cell Growth during Start-Up of Hollow Fibre Bioreactor," Biotechnol. Bioeng., (Submitted 2003).
18. Malone, C. C., P. M. Schiltz, A. D. Mackintosh, L. D. Beutel, F. S. Heinemann, and R. O. Dillman, "Characterization of Human Tumor-Infiltrating Lymphocytes Expanded in Hollow-Fiber Bioreactors for Immunotherapy of Cancer," Cancer Biother. Radiopharm., 16, 381 (2001).
19. Patankar, S. V., Numerical Heat Transfer and Fluid Flow, Hemisphere, Washington, DC (1980).
20. Patkar, A. Y., J. Koska, D. G. Taylor, B. D. Bowen, and J. M. Piret, "Protein Transport in Ultrafiltration Hollow Fiber Bioreactors," AIChE J., 41, 415 (1995).
21. Perry, R. H., and D. Green, eds., Perry's Chemical Engineering Handbook, 6th Edition, McGraw-Hill, New York (1984).
22. Pillarella, M. R., and A. L. Zydney, "Theoretical Analysis of the Effect of Convective Flow on Solute Transport and Insulin Release in a Hollow Fiber Bioartificial Pancreas," J. Biomech. Eng. (Trans. ASME), 112, 220 (1990).
23. Piret, J. M., and C. L. Cooney, "Mammalian Cell and Protein Distributions in Ultrafiltration Hollow-Fiber Bioreactors," Biotechnol. Bioeng., 36, 902 (1990).
24. Piret, J. M., and C. L. Cooney, "Model of Oxygen Transport Limitations in Hollow Fiber Bioreactors," Biotechnol. Bioeng., 37, 80 (1991).
25. Rony, P. R., "Multiphase Catalysis. II. Hollow-Fiber Catalysts," Biotechnol. Bioeng., 13, 431 (1971).
26. Salmon, P. M., S. B. Libicki, and C. R. Robertson, "A Theoretical Investigation of Convective Transport in the Hollow-Fiber Reactor," Chem. Eng. Commun., 66, 221 (1988).
27. Starling, E. H., "On the Absorption of Fluids from the Connective Tissue Spaces," J. Physiol., 19, 312 (1896).
28. Tannehill, J. C., D. A. Anderson, and R. H. Pletcher, Computational Fluid Mechanics and Heat Transfer, 2nd Edition, Taylor & Francis, Philadelphia (1997).
29. Taylor, D. G., J. M. Piret, and B. D. Bowen, "Protein Polarisation in Isotropic Membrane Hollow-Fiber Bioreactors," AIChE J., 40, 321 (1994).
30. Tharakan, J. P., S. Gallagher, and P. C. Chau, "Hollow Fiber Bioreactors in Mammalian Cell Culture," Adv. Biotechnol. Process., 7, 153 (1988).
31. van den Berg, G. B., and C. A. Smolders, "The Boundary-Layer Resistance Model for Unstirred Ultrafiltration. A New Approach," J. Membr. Sci., 40, 149 (1989).
32. Vilker, V. L., C. K. Colton, and K. A. Smith, "The Osmotic Pressure of Concentrated Protein Solutions: Effect of Concentration and pH in Saline Solutions of Bovine Serum Albumin," J. Colloid Interface Sci., 79, 548 (1981).
33. Waterland, L. R., A. S. Michaels, and C. R. Robertson, "A Theoretical Model for Enzymatic Catalysis Using Asymmetric Hollow-Fiber Membranes," AIChE J., 20, 50 (1974).
34. Waterland, L. R., C. R. Robertson, and A. S. Michaels, "Enzymatic Catalysis Using Asymmetric Hollow Fiber Membranes," Chem. Eng. Commun., 2, 37 (1975).
35. Weast, R. C., ed., Handbook of Chemistry and Physics, 56th Edition, CRC Press, Boca Raton, FL (1975).
36. Webster, I. A., and M. L. Shuler, "Mathematical Models for Hollow-Fiber Enzyme Reactors," Biotechnol Bioeng., 20, 1541 (1978).
37. Youm, K. H., A. G. Fane, and D. E. Wiley, "Effects of Natural Convection Instability on Membrane Performance in Dead-End and Cross-Flow Ultrafiltration," J. Membr. Sci., 116, 229 (1996).