Protein transport in packed-bed ultrafiltration hollow-fibre bioreactors

Chemical Engineering Science

Volumn 52, Issue 14, 1997, Pages 2251-2263

  Koska, Jürgen ^a   Bowen, Bruce D ^a   Piret, James M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Hollow fibre bioreactor; Packed bed; Protein transport; Ultrafiltration membrane

Indexed keywords

CELLS; DIFFUSION IN SOLIDS; FIBROUS MEMBRANES; HYDRODYNAMICS; MASS TRANSFER; MATHEMATICAL MODELS; NUMERICAL METHODS; PACKED BEDS; POROUS MATERIALS; PROTEINS; REYNOLDS NUMBER; ULTRAFILTRATION;

AGAROSE; DARCY'S LAW; EXTRACAPILLARY SPACE (ECS); HOLLOW FIBER BIOREACTORS (HFBR);

BIOREACTORS;

HYDRODYNAMICS; MODELLING-MATHEMATICAL; PACKED BEDS; PROTEINS; ULTRAFILTRATION;

EID: 0031193950     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2509(97)00002-X     Document Type: Article

References (25)

1. Apelblat, A., Katzir-Katchalsky, A. and Silberberg, A. (1974) A mathematical analysis of capillary-tissue fluid exchange, Biorheology 11, 1-49.
2. Atkinson, B. and Mavituna, F. (1991) Biochemical Engineering and Biotechnology Handbook, 2nd Edn. Nature Press, New York.
3. Bassi, A. S., Rohani, S. and Macdonald, D. G. (1987) Measurement of effective diffusivities of lactose and lactic acid in 3% agarose gel membrane. Biotechnol. Bioengng 30, 794-797.
4. Bear, J. (1972) Dynamics of Fluids in Porous Media. Dover, New York.
5. Belfort, G. (1989) Membranes and bioreactors: a technical challenge in biotechnology. Biotechnol. Bioengng 33, 1047-1065.
6. Carman, P. C. (1937) Fluid flow through a granular bed. Trans. Inst. Chem. Engng London 15, 150-156.
7. Heath, C., Belfort, G., Hammer, B. E., Mirer, S. D. and Pimbley, J. M. (1990) Magnetic resonance imaging and modeling of flow in hollow-fiber bioreactors. A.I.Ch.E. J. 4, 547-558.
8. Hjerten, S. (1962) Molecular sieve chromatography on polyacrylamide gels, prepared according to a simplified method. Arch. Biochem. Biophys. 1, 147-151.
9. Kelsey, L. J., Pillarella, M. R. and Zydney, A. L. (1990) Theoretical analysis of convective flow profiles in a hollow-fiber membrane bioreactor. Chem. Engng Sci. 45, 3211-3220.
10. Labecki, M., Piret, J. M. and Bowen, B. D. (1995) Two-dimensional analysis of fluid flow in hollow-fiber bioreactor modules. Chem. Engng Sci. 50, 3369-3384.
11. Li, R. H., Altreuer, D. H. and Gentile, F. T. (1990) Transport characterization of hydrogel matrices for cell encapsulation. Biotechnol. Bioengng 50, 365-373.
12. Patankar, S. V. (1980) Numerical Heat Transfer and Fluid Flow. Hemisphere, New York.
13. Patkar, A. Y., Koska, J., Taylor, D. G., Bowen, B. D. and Piret, J. M. (1995) Experimental and modeling study of hollow-fiber bioreactor protein distribution. A.I.Ch.E. J. 41, 415-425.
14. Peaceman, D. W. and Rachford, H. H. (1955) The numerical solution of parabolic and elliptic differential equations. J. Soc. Ind. Appl. Math. 3, 28-41.
15. Piret, J. M. and Cooney, C. L. (1990) Mammalian cell and protein distributions in ultrafiltration hollow-fiber bioreactors. Biotechnol. Bioengng 36, 902-910.
16. Salmon, P. M., Libicki, S. B. and Robertson, C. R. (1988) A theoretical investigation of convective transport in the hollow-fiber reactor. Chem. Engng Commun 66, 221-248.
17. Starling, E. H. (1896) On the absorption of fluids from the convective tissue space. J. Physiol. 19, 312-326.
18. Swabb, E., Wei, J. and Gullion, P. M. (1974) Diffusion and convection in normal neoplastic tissues. Cancer Res. 34, 2814-2822.
19. Tanford, C. (1961) Physical Chemistry of Macromolecules. Wiley, New York.
20. Taylor, D. G., Bowen, B. D. and Piret, J. M. (1994) Protein polarization in isotropic membrane hollow-fiber bioreactors. A.I.Ch.E. J. 40, 321-333.
21. Tharakan, J. P. and Chau, P. C. (1986) Operation and pressure distribution of immobilized cell hollow fiber bioreactors. Biotechnol. Bioengng 28, 1064-1071.
22. van den Berg, G. B. and Smolders, C. A. (1989) The boundary-layer resistance for unstirred ultrafiltration. New approach. J. Membrane Sci. 40, 149-172.
23. Walker, J. M. and Gingold, E. B. (1988) Molecular Biotechnology & Biotechnology, 2nd edn. Royal Society of Chemistry, London.
24. Wei, J. and Russ, M. B. (1981) Convection and diffusion in tissue and tissue cultures. J. Theor. Biol. 66, 775-787.
25. Zydney, A. L., Saltzman, W. M. and Colton, C. K. (1986) Hydraulic resistance of red cell beds in an unstirred filtration cell. Chem. Engng Sci. 44, 147-159.