COX-2 status in relation to tumor microvessel density and VEGF expression: Analysis in ovarian carcinoma patients with low versus high survival rates

Oncology Reports

Volumn 11, Issue 2, 2004, Pages 309-313

  Raspollini, Maria Rosaria ^a   Amunni, Gianni ^a   Villanucci, Alessandro ^a   Boddi, Vieri ^a   Baroni, Gianna ^a   Taddei, Antonio ^a   Taddei, Gian Luigi ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

COX 2; Microvessel density; Ovarian carcinoma; Prognosis; Vascular endothelial growth factor

Indexed keywords

CYCLOOXYGENASE 2; ISOENZYME; MEMBRANE PROTEIN; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN; TUMOR MARKER; VASCULOTROPIN A;

ANALYSIS OF VARIANCE; ARTICLE; COMPARATIVE STUDY; ENZYMOLOGY; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MORTALITY; NEOVASCULARIZATION (PATHOLOGY); OVARY TUMOR; PATHOLOGY; PROGNOSIS; REGRESSION ANALYSIS; RETROSPECTIVE STUDY; SURVIVAL RATE;

ANALYSIS OF VARIANCE; CYCLOOXYGENASE 2; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; MEMBRANE PROTEINS; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; PROGNOSIS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 3242749985     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.11.2.309     Document Type: Article

References (25)

1. Tsujii M and Dubois RN: Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 83: 493-501, 1995.
2. Tsujii M, Kawano S and Dubois RN: Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 94: 3336-3340, 1997. (Pubitemid 27157312)
3. Tsujii M, Kawano S, Tsujii S, et al: Cyclooxygenase-2 regulates angiogenesis induced by colon cancer cells. Cell 93: 705-716, 1998. (Pubitemid 28257578)
4. Ferrandina G, Lauriola L, Zannoni GF, Fagotti A, Fanfani F, Legge F, Maggiano N, Gessi M, Mancuso S, Ranelletti FO and Scambia G: Increased cyclooxygenase-2 (COX-2) expression is associated with chemotherapy resistance and outcome in ovarian cancer patients. Ann Oncol 13: 1205-1211, 2002. (Pubitemid 34960128)
5. Denkert C, Kobel M, Pest S, Koch I, Berger S, Schwabe M, Siegert A, Reles A, Klosterhalfen B and Hauptmann S: Expression of cyclooxygenase-2 is an independent prognostic factor in human ovarian carcinoma. Am J Pathol 160: 893-903, 2002. (Pubitemid 34224579)
6. Craft PS and Harris AL: Clinical prognostic significance of tumour angiogenesis. Ann Oncol 5: 305-311, 1994. (Pubitemid 24142366)
7. Hollingsworth HC, Kohn EC, Steinberg SM, Rothenberg ML and Merino MJ: Tumor angiogenesis in advanced stage ovarian carcinoma. Am J Pathol 147: 33-41, 1995.
8. Lutgendorf SK, Johnsen EL, Cooper B, et al: Vascular endothelial growth factor and social support in patiens with ovarian carcinoma. Cancer 95: 808-815, 2002. (Pubitemid 34839673)
9. Brower V: Tumor angiogenesis - new drugs on the block. Nat Biotechnol 17: 963-968, 1999.
10. Giavazzi R and Taraboletti G: Angiogenesis and angiogenesis inhibitors in cancer. Forum 9: 261-272, 1999. (Pubitemid 29495721)
11. Taraboletti G and Margosio B: Antiangiogenic and antivascular therapy for cancer. Curr Opin Pharmacol 1: 378-384, 2001. (Pubitemid 33585987)
12. Miller KD, Sweeney CJ and Sledge GW: Redefining the target: chemotherapeutics as antiangiogenics. J Clin Oncol 19: 1195-1206, 2001. (Pubitemid 32176298)
13. Schirner M: Antiangiogenic chemotherapeutic agents. Cancer Metastasis Rev 19: 67-73, 2000.
14. Weidner N, Semple JP, Welch WR and Folkman J: Tumor angiogenesis and metastasis - Correlation in invasive breast carcinoma. N Engl J Med 324: 1-8, 1991.
15. Bosari S, Lee AK, De Lellis RA, Wiley B, Heatley GJ and Silverman ML: Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 23: 755-761, 1992.
16. Aoki T, Nagakama Y, Tsuchida A, et al: Expression of cyclooxygenase-2 and vascular endothelial growth factor in pancreatic tumors. Oncol Rep 9: 761-765, 2002.
17. Hosmer DW and Lemeshow S: Applied Logistic Regression. 2nd edition. A. Wiley Interscience Publication, 2000.
18. Fisher LD and van Belle G: Biostatistics: A Methodology for the Health Sciences. 2nd edition, 3rd series. A. Wiley Interscience Publication, 1993.
19. Stata Press: Statistics-Stata 7. Reference Q-ST. College Station, TX, 2000.
20. Sano H, Kawahito Y, Wilder RL, et al: Expression of cyclooxygenase-1 and -2 in human colorectal cancer. Cancer Res 55: 3785-3789, 1995.
21. Fujita T, Matsui M, Takaku K, et al: Size- and invasion-dependent increase in cyclooxygenase-2 levels in human colorectal carcinomas. Cancer Res 58: 4823-4826, 1998. (Pubitemid 28503676)
22. Seed MP, Brown JR, Freemantle CN, et al: The inhibition of colon-26 adenocarcinoma development and angiogenesis by topical diclofenac in 2.5% hyaluronam. Cancer Res 57: 1625-1629, 1997. (Pubitemid 27199647)
23. Ferrandina G, Legge F, Ranelletti FO, et al: Cyclooxygenase-2 expression in endometrial carcinoma. Correlation with clinicopathologic parameters and clinical outcome. Cancer 95: 801-807, 2002. (Pubitemid 34839672)
24. Munkarah AR, Genhai Z, Morris R, et al: Inhibition of paclitaxel-induced apoptosis by the specific COX-2 inhibitor, NS398, in epithelial ovarian cancer cells. Gynecol Oncol 88: 429-433, 2003. (Pubitemid 36332001)
25. Faviana P, Boldrini L, Spisni R, et al: Neoangiogenesis in colon cancer: correlation between vascular density, vascular endothelial growth factor (VEGF) and p53 protein expression. Oncol Rep 9: 617-620, 2002.