Formulation and characterization of bupivacaine lipospheres

International Journal of Pharmaceutics

Volumn 280, Issue 1-2, 2004, Pages 57-65

  Toongsuwan, Siriporn ^a   Li, Luk Chiu ^a   Erickson, Bryan K ^a   Chang, Hung Chih ^b  

^a ABBOTT LABORATORIES   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Bupivacaine; Injectable; Liposphere; Phospholipids; Sustained release

Indexed keywords

BUPIVACAINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLCHOLINE; DISTEAROYLPHOSPHATIDYLCHOLINE; PHOSPHOLIPID; POLYMER;

ARTICLE; DISPERSION; DRUG FORMULATION; DRUG STORAGE; GELATION; PARTICLE SIZE; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE;

BUPIVACAINE; CHEMISTRY, PHARMACEUTICAL; LIPOSOMES; MICROSPHERES; PARTICLE SIZE;

EID: 3242724894     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.04.020     Document Type: Article

References (12)

1. Domb, A.J., 1993a. Liposphere Delivery Systems for Local Anesthetics. US Patent 5,227,165, 13 Jul.
2. Domb, A.J., 1993b. Lipospheres for Controlled Delivery of Substances. US Patent 5,188,837, 23 Feb.
3. Kopacz D.J., Bernards C.M., Allen H.W., Landau C., Nandy P., Wu D., Lacouture P.G. A method to evaluate the pharmacokinetic and pharmacodynamic variables of extended-release products using in vivo tissue microdialysis in humans: bupivacaine-loaded microcapsules. Anesth. Analg. 97:2003;124-131
4. Lasic, D.D., 1993. Liposomes: a Practical Approach. Elsevier Science Publishers, Amsterdam.
5. Malinovsky J.M., Bernard J.M., Le Corre P., Dumand J.B., Lepage J.Y., Le Verge R., Souron R. Motor and blood pressure effects of epidural sustained-release bupivacaine from polymer microspheres: a dose-response study in rabbits. Anesth. Analg. 81:1995;519-524
6. Malinovsky J.M., Benhamou D., Alafandy M., Mussini J.M., Coussaert C., Couarraze G., Pinaud M., Legros F.J. Neurotoxicological assessment after intracistern al injection of liposomal bupivacaine in rabbits. Anesth. Analg. 85:1997;1331-1336
7. Malinovsky J.M., Le Corre P., Meunier J.F., Chevanne F., Pinaud M., Leverge R., Legros F. A dose-response study of epidural liposomal bupivacaine in rabbits. J. Control. Release. 60:1999;111-119
8. Masters D.B., Berde C.B., Dutta S.K., Griggs C.T., Hu D., Kupsky W., Langer R. Prolonged regional nerve blockade by controlled release of local anesthetic from a biodegradable polymer matrix. Anesthesiology. 79:1993;340-346
9. Moustafa M.A., Ebian A.R., Khalil S.A., Motawi M.M. Succinylsulfathiazole crystal forms. III. Crystal growth studies. J. Pharm. Sci. 64:1975;1485-1489
10. Physician Desk's Reference, 2003. Medical Economics. Montvale, NJ, pp. 642-644.
11. Usui F., Maeda K., Kusai A., Nashimura K., Yamamoto K. Inhibitory effects of water-soluble polymers on precipitation of RS-8359. Int. J. Pharm. 154:1997;59-66
12. Ziller K.H., Rupprecht H. Control of crystal growth in drug suspensions. Drug Dev. Ind. Pharm. 14:1988;2341-2370