Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a newcancer/testis-like antigen NW-BR-3 by serological screening of a testicularlibrary with breast cancer serum

Cancer Immunity

Volumn 5, Issue , 2002, Pages 1-12

  Jäger, Dirk ^a   Unkelbach, Marc ^a   Frei, Claudia ^a   Bert, Florian ^a   Scanlan, Matthew J ^b   Jäger, Elke ^a   Old, Lloyd J ^b   Chen, Yao Tseng ^b   Knuth, Alexander ^a  

^a KRANKENHAUS NORDWEST   (Germany)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Breast cancer; Human; mRNA; RNA sequence analysis; SEREX; Tissue distribution; Tumor antigens

Indexed keywords

CANCER TESTIS ANTIGEN; MESSENGER RNA; NW BR 1 ANTIGEN; NW BR 10 ANTIGEN; NW BR 11 ANTIGEN; NW BR 12 ANTIGEN; NW BR 13 ANTIGEN; NW BR 2 ANTIGEN; NW BR 3 ANTIGEN; NW BR 4 ANTIGEN; NW BR 5 ANTIGEN; NW BR 6 ANTIGEN; NW BR 7 ANTIGEN; NW BR 8 ANTIGEN; NW BR 9 ANTIGEN; NY BR 1 ANTIGEN; SCP 1 ANTIGEN; TUMOR ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ANTIGEN DETECTION; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE ISOLATION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NORTHERN BLOTTING; ORGAN DISTRIBUTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; SEROLOGICAL ANALYSIS OF RECOMBINANT CDNA EXPRESSION LIBRARIES; SEROLOGY; SERUM;

EID: 3242724158     PISSN: 14249634     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Black MM, Zachrau RE, Shore B, Moore DH, Leis HP Jr. Prognostically favorable immunogens of human breast cancer tissue: antigenic similarity to murine mammary tumor virus. Cancer 1975; 35: 121-8. (PMID: 162850)
2. Springer GF. Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy. J Mol Med 1997; 75: 594-602. (PMID: 9297627)
3. Gnjatic S, Cai Z, Viguier M, Chouaib S, Guillet JG, Choppin J. Accumulation of the p53 protein allows recognition by human CTL of a wild-type p53 epitope presented by breast carcinomas and melanomas. J Immunol 1998; 160: 328-33. (PMID: 9551988)
4. Disis ML, Calenoff E, McLaughlin G, Murphy AE, Chen W, Groner B, Jeschke M, Lydon N, McGlynn E, Livingston RB, Moe R, Cheever MA. Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res 1994; 54: 16-20. (PMID: 7505195)
5. Disis ML, Cheever MA. HER-2/neu protein: a target for antigen-specific immunotherapy of human cancer. Adv Cancer Res 1997; 71: 343-71. (PMID: 9111870)
6. Sahin U, Tureci O, Schmitt H, Cochlovius B, Johannes T, Schmits R, Stenner F, Luo G, Schobert I, Pfreundschuh M. Human neoplasms elicit multiple specific immune responses in the autologous host. Proc Natl Acad Sci U S A 1995; 92: 11810-3. (PMID: 8524854)
7. Tureci O, Sahin U, Zwick C, Koslowski M, Seitz G, Pfreundschuh M. Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens. Proc Natl Acad Sci U S A 1998; 95: 5211-6. (PMID: 9560255)
8. Jäger D, Stockert E, Gure AO, Scanlan MJ, Karbach J, Jäger E, Knuth A, Old LJ, Chen YT. Identification of a tissue-specific putative transcription factor in breast tissue by serological screening of a breast cancer library. Cancer Res 2001; 61: 2055-61. (PMID: 11280766)
9. Chen YT, Scanlan MJ, Sahin U, Tureci O, Gure AO, Tsang S, Williamson B, Stockert E, Pfreundschuh M, Old LJ. A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening. Proc Natl Acad Sci U S A 1997; 94: 1914-8. (PMID: 9050879)
10. Chen YT, Gure AO, Tsang S, Stockert E, Jäger E, Knuth A, Old LJ. Identification of multiple cancer/testis antigens by allogeneic antibody screening of a melanoma cell line library. Proc Natl Acad Sci U S A 1998; 95: 6919-23. (PMID: 9618514)
11. Gure AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. Cancer Res 1998; 58: 1034-41. (PMID: 9500467)
12. Gure AO, Stockert E, Scanlan MJ, Keresztes RS, Jäger D, Altorki NK, Old LJ, Chen YT. Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer. Proc Natl Acad Sci U S A 2000; 97: 4198-203. (PMID: 10760287)
13. Jäger D, Stockert E, Scanlan MJ, Gure AO, Jäger E, Knuth A, Old LJ, Chen YT. Cancer-testis antigens and ING1 tumor suppressor gene product are breast cancer antigens: characterization of tissue-specific ING1 transcripts and a homologue gene. Cancer Res 1999; 59: 6197-204. (PMID: 10626813)
14. Jäger D, Stockert E, Jäger E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT. Serological cloning of a melanocyte rab guanosine 5′-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. Cancer Res 2000; 60: 3584-91. (PMID: 10910072)
15. Obata Y, T TA, Tamaki H, Tominaga S, Murai H, Iwase T, Iwata H, Mizutani M, Chen YT, Old LJ, Miura S. Identification of Cancer Antigens in Breast Cancer by the SEREX Expression Cloning Method. Breast Cancer 1999; 6: 305-311. (PMID: 11091735)
16. Obata Y, Takahashi T, Sakamoto J, Tamaki H, Tominaga S, Hamajima N, Chen YT, Old LJ. SEREX analysis of gastric cancer antigens. Cancer Chemother Pharmacol 2000; 46 Suppl: S37-42. (PMID: 10950146)
17. Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ. Characterization of human colon cancer antigens recognized by autologous antibodies. Int J Cancer 1998; 76: 652-8. (PMID: 9610721)
18. Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Int J Cancer 1999; 83: 456-64. (PMID: 10508479)
19. Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. Cancer Immunity 2001; 1: 4.
20. Gure AO, Tureci O, Sahin U, Tsang S, Scanlan MJ, Jäger E, Knuth A, Pfreundschuh M, Old LJ, Chen YT. SSX: a multigene family with several members transcribed in normal testis and human cancer. Int J Cancer 1997; 72: 965-71. (PMID: 9378559)
21. Old LJ, Chen YT. New paths in human cancer serology. J Exp Med 1998; 187: 1163-7. (PMID: 9547328)
22. von Wettstein D, Rasmussen SW, Holm PB. The synaptonemal complex in genetic segregation. Annu Rev Genet 1984; 18: 331-413. (PMID: 6241453)
23. Heyting C, Dietrich AJ, Moens PB, Dettmers RJ, Offenberg HH, Redeker EJ, Vink AC. Synaptonemal complex proteins. Genome 1989; 31: 81-7. (PMID: 2687109)
24. Mashino K, Sadanaga N, Tanaka F, Yamaguchi H, Nagashima H, Inoue H, Sugimachi K, Mori M. Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas. Br J Cancer 2001; 85: 713-20. (PMID: 11531257)
25. Jäger E, Nagata Y, Gnjatic S, Wada H, Stockert E, Karbach J, Dunbar PR, Lee SY, Jungbluth A, Jäger D, Arand M, Ritter G, Cerundolo V, Dupont B, Chen YT, Old LJ, Knuth A, Monitoring CD8 T cell responses to NY-ESO-1: correlation of humoral and cellular immune responses. Proc Natl Acad Sci U S A 2000; 97: 4760-5. (PMID: 10781081)
26. Jäger E, Chen YT, Drijfhout JW, Karbach J, Ringhoffer M, Jäger D, Arand M, Wada H, Noguchi Y, Stockert E, Old LJ, Knuth A. Simultaneous humoral and cellular immune response against cancer-testis antigen NY-ESO-1: definition of human histocompatibility leukocyte antigen (HLA)-A2-binding peptide epitopes. J Exp Med 1998; 187: 265-70. (PMID: 9432985)
27. Marchand M, van Baren N, Weynants P, Brichard V, Dreno B, Tessier MH, Rankin E, Parmiani G, Arienti F, Humblet Y, Bourlond A, Vanwijck R, Lienard D, Beauduin M, Dietrich PY, Russo V, Kerger J, Masucci G, Jäger E, De Greve J, Atzpodien J, Brasseur F, Coulie PG, van der Bruggen P, Boon T. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1. Int J Cancer 1999; 80: 219-30. (PMID: 9935203)
28. Jungbluth AA, Chen YT, Stockert E, Busam KJ, Kolb D, Iversen K, Coplan K, Williamson B, Altorki N, Old LJ. Immunohistochemical analysis of NY-ESO-1 antigen expression in normal and malignant human tissues. Int J Cancer 2001; 92: 856-60. (PMID: 11351307)
29. Jungbluth AA, Stockert E, Chen YT, Kolb D, Iversen K, Coplan K, Williamson B, Altorki N, Busam KJ, Old LJ. Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours. Br J Cancer 2000; 83: 493-7. (PMID: 10945497)