Impaired migration of NOD mouse thymocytes: A fibronectin receptor-related defect

European Journal of Immunology

Volumn 34, Issue 6, 2004, Pages 1578-1587

  Cotta de Almeida, Vinícius ^a   Serra Villa Verde, Déa Maria ^a   Lepault, Françoise ^b   Pléau, Jean Marie ^b   Dardenne, Mireille ^b   Savino, Wilson ^a,b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b CNRS   (France)

Author keywords

Fibronectin; Integrins; NOD mice; Thymocyte migration; VLA

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; FIBRONECTIN; FIBRONECTIN RECEPTOR; LAMININ; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 5; VERY LATE ACTIVATION ANTIGEN 6; LAMININ RECEPTOR; RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; DIABETES MELLITUS; DIABETOGENESIS; EPITHELIUM CELL; EXPERIMENTAL DIABETES MELLITUS; FEMALE; IMMUNOPATHOGENESIS; LYMPHATIC SYSTEM; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MOTION; CHEMISTRY; CROSS BREEDING; CYTOLOGY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETICS; GERMFREE ANIMAL; IMMUNOLOGY; METABOLISM; NONOBESE DIABETIC MOUSE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THYMUS;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL MOVEMENT; CROSSES, GENETIC; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED NOD; RECEPTORS, FIBRONECTIN; RECEPTORS, LAMININ; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SPECIFIC PATHOGEN-FREE ORGANISMS; THYMUS GLAND;

EID: 3242722496     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324765     Document Type: Article

References (47)

1. Bach, J. F., Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr. Rev. 1994. 15: 516-542.
2. Tisch, R. and McDevitt, H., Insulin-dependent diabetes mellitus. Cell 1996. 85: 291-297.
3. Delovitch, T. L. and Singh, B., The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1997. 7: 727-738.
4. André, I., Gonzalez, A., Wang, B., Katz, J., Benoist, C. and Mathis, D., Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc. Natl. Acad. Sci. USA 1996. 93: 2260-2263.
5. Bach, J. F., Chatenoud, L., Herbelin, A., Gombert, J. M. and Carnaud, C., Autoimmune diabetes: how many steps for one disease? Res. Immunol. 1997. 148: 332-338.
6. Gombert, J. M., Herbelin, A., Tracrede-Bohin, E., Dy, M., Carnaud, C. and Bach, J. F., Early quantitative and functional deficiency of NK1+-like thymocytes in the NOD mouse. Eur. J. Immunol. 1996. 26: 2989-2998.
7. Godfrey, D. I., Kinder, S. J., Silveira, P. and Baxter, A. G., Flow cytometric study of T cell development in NOD mice reveals a deficiency in α/βTCR+CD4-CD8- thymocytes. J. Autoimmun. 1997. 10: 279-285.
8. Rapoport, M. J., Jaramillo, A., Zipris, D., Lazarus, A. H., Serreze, D. V., Leiter, E. H., Cyopick, P., Danska, J. S. and Delovitch, T. L., Interleukin-4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 1993. 178: 87-99
9. Dosch, H., Cheung, R. K., Karges, W., Pietropaulo, M. and Becker, D. J., Persistent T cell anergy in human type 1 diabetes. J. Immunol. 1999. 163: 6933-6940.
10. Garchon, H. J., Luan, J. J., Eloy, E., Bedossa, P. and Bach, J. F., Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: mapping of a susceptibility locus close to the Bcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction. Eur. J. Immunol. 1994. 24: 380-384.
11. Arreaza, G., Salojin, K., Yang, W., Zhang, J., Gill, B., Mi, Q. S., Gao, J. X., Meagher, C., Cameron, M. and Delovitch, T. L., Deficient activation and resistance to activation-induced apoptosis of CD8+ T cells is associated with defective peripheral tolerance in nonobese diabetic mice. Clin. Immunol. 2003. 107: 103-115.
12. Wicker, L. S., Miller, B. J., Chai, A., Terada, M. and Mullen, Y., Expression of genetically determined diabetes and insulitis in the nonobese diabetic (NOD) mouse at the level of bone marrow-derived cells. Transfer of diabetes and insulitis to nondiabetic (NOD × B10) F1 mice with bone marrow cells from NOD mice. J. Exp. Med. 1988. 167: 1801-1810.
13. Serreze, D. V. and Leiter, E. H., Development of diabetogenic T cells from NOD/Lt marrow is blocked when an allo-H-2 haplotype is expressed on cells of hemopoietic origin, but not on thymic epithelium. J. Immunol. 1991. 147: 1222-1229.
14. Posselt, A. M., Barker, C. F., Tomaszewski, J. E., Markmann, J. F., Choti, M. A. and Naji, A., Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science 1990. 249: 1293-1295.
15. Dardenne, M., Lepault, F., Bendelac, A. and Bach, J. F., Acceleration of the onset of diabetes in NOD mice by thymectomy at weaning. Eur. J. Immunol. 1989. 19: 889-895.
16. Boitard, C., Yasunami, R., Dardenne, M. and Bach, J. F.5 T cell- mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J. Exp. Med. 1989.169:1669-1680.
17. Herbelin, A., Gombert, J. M., Lepault, F., Bach, J. F. and Chatenoud, L., Mature mainstream TCRαβ+CD4+ thymocytes expressing L-selectin mediate "active tolerance" in the nonobese diabetic mouse. J. Immunol. 1998. 161: 2620-2628.
18. Stephens, L. A. and Mason, D., CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are in both CD25+ and CD25- subpopulations. J. Immunol. 2000. 165: 3105-3110.
19. Hammond, K. J. L., Poulton, L. D., Palmisano, L. J., Silveira, P. A., Godfrey, D. I. and Baxter, A. G., Alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 1998. 187: 1047-1056.
20. Atlan-Gepner, C., Naspetti, M., Valero, R., Barad, M., Lepault, F., Vialettes, B. and Naquet, P., Disorganization of thymic medulla precedes evolution towards diabetes in female NOD mice. Autoimmunity 1999. 31: 249-260.
21. Savino, W., Boitard, C., Bach, J. F. and Dardenne, M., Studies on the thymus in nonobese diabetic (NOD) mice. I. Changes in the microenvironmental compartments. Lab. Invest. 1991. 64: 405-417.
22. Savino, W., Carnaud, C., Luan, J. J., Bach, J. F. and Dardenne, M., Characterization of the extracellular matrix-containing giant perivascular spaces in the thymus of the nonobese diabetic mouse. Diabetes 1993. 42: 134-140.
23. Anderson, G., Moore, N. C., Owen, J. J. T. and Jenkinson, E. J., Cellular interactions in thymocyte development. Annu. Rev. Immunol. 1996. 14: 1473-1499.
24. Robey, E. A. and Fowlkes, B. J., Selective events in T cell development. Annu. Rev. Immunol. 1994. 12: 675-705.
25. Savino, W., Villa-Verde, D. M. S. and Lannes-Vieira, J., Extracellular matrix proteins in intrathymic T cell migration and differentiation? Immunol. Today 1993. 14: 158-161.
26. Magner, W. J., Chang, A. C., Owens, J., Hong, M. J., Brooks, A. and Coligan, J. E., Aberrant development of thymocytes in mice lacking laminin-2. Dev. Immunol. 2000. 7: 179-193.
27. Sawada, M., Nagamine, J., Takeda, K., Utsumi, K., Kosugi, A., Tatsumi, Y., Hamaoka, T., Miyake, K., Nakajima, K., Watanabe, T., Sakakibara, S. and Fujiwara, H., Expression of VLA-4 on thymocytes. Maturation stage-associated transition and its correlation with their capacity to adhere to thymic stromal cells. J. Immunol. 1992. 149: 3517-3524.
28. Salomon, D. R., Mojcik, C. F., Chang, A. C., Wadsworth, S., Adams, D. H., Coligan, J. E. and Shevach, E. M., Constitutive activation of integrin alpha 4 beta 1 defines a unique stage of human thymocyte development. J. Exp. Med. 1994. 179: 1573-1584.
29. Crisa, L., Cirulli, V., Ellisman, M. H., Ishii, J. K., Elices, M. J. and Salomón, D. R., Cell adhesion and migration are regulated at distinct stages of thymic T cell development: the roles of fibronectin, VLA-4 and VLA-5. J. Exp. Med. 1996. 184: 215-228.
30. Dalmau, S. R., Freitas, C. S. and Savino, W., High expression of fibronectin receptors and L-selectin as a hallmark of early steps of thymocyte differentiation: lessons from sublethally irradiated mice. Blood 1999. 93: 974-990.
31. Tchilian, E. Z., Owen, J. J. T. and Jenkinson, E. J., Anti-α4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells. Immunology 1997. 92: 321-327.
32. Takayama, E., Kina, T., Katsura, Y. and Tadakuma, T., Enhancement of activation-induced cell death by fibronectin in murine CD4+CD8+ thymocytes. Immunology 1998. 95: 553-558.
33. Zaitseva, M. B., Mojcik, C. F., Salomon, D. R., Shevach, E. M. and Golding, H., Co-ligation of α4β1 integrin and TCR rescues human thymocytes from steroid-induced apoptosis. Int. Immunol. 1998. 10: 1551-1561.
34. Villa-Verde, D. M. S., Mello-Coelho, V., Lagrota-Cândido, J. M. and Savino, W., The thymic nurse cell complex: an in vitro model for extracellular matrix-mediated intrathymic T cell migration. Braz. J. Med. Biol. Res. 1995. 28: 907-912.
35. Oliveira-dos-Santos, A. J., Penninger, J. M., Rieker-Geley, T., Matsumoto, G., Mak, T. M. and Wick, G., Thymic heterotypic cellular complexes in gene-targeted mice with defined blocks in T cell development and adhesion molecule expression. Eur. J. Immunol. 1998. 28: 2882-2892.
36. Guyden, J. C. and Pezzano, M., Thymic nurse cells: a microenvironment for thymocyte development and selection. Int. Rev. Cytol. 2003. 223: 1-37.
37. Villa-Verde, D. M. S., Chammas, R., Lagrota-Candido, J. M., Brentani, R. R. and Savino, W., Extracellular matrix components of the mouse thymus microenvironment. IV. Thymic nurse cells express extracellular matrix ligands and receptors. Eur. J. Immunol. 1994. 24: 659-664.
38. Mello-Coelho, V., Villa-Verde, D. M. S., Dardenne, M. and Savino, W., Pituitary hormones modulate by extracellular matrix-mediated interactions between thymocyte and thymic epithelial cell mediated ligands and receptors. J. Neuroimmunol. 1997. 76: 39-49.
39. Uniyal, S., Boeters, L., Chakrabarti, S., Singh, B. and Chan, B. M. C., Leukocytes utilize both α4 and α5 integrins for intraislet infiltration in nonobese diabetic mice. J. Autoimmunity 1999. 12: 167-176.
40. Gabor, M. J., Godfrey, D. I. and Scollay, R., Recent thymic emigrants are distinct from most medullary thymocytes. Eur. J. Immunol. 1997. 27: 2010-2015.
41. Lepault, F. and Gagnerault, M. C., Characterization of peripheral regulatory CD4+ T cells that prevent diabetes onset in nonobese diabetic mice. J. Immunol. 2000. 164: 240-247.
42. Sakaguchi, S., Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000. 101: 455-458.
43. Colomb, E., Savino, W., Wicker, L., Peterson, L., Dardenne, M. and Carnaud, C., Genetic control of giant perivascular space formation in the thymus of NOD mice. Diabetes 1996. 45: 1535-1540.
44. Wu, A. J., Hua, H., Munson, S. H. and McDevitt, H. O., Tumor necrosis factor-α regulation of CD4+CD25+ T cell levels in NOD mice. Proc. Natl. Acad. Sci. USA 2002. 99: 12287-12292.
45. Salaün, J., Simmenauer, N., Coutinho, A. and Le Douarin, N. M., Grafts of supplementary thymuses injected with allogeneic pancreatic islets protect nonobese diabetic mice against diabetes. Proc. Natl. Acad. Sci. USA 2002. 99: 874-877.
46. Throsby, M., Herbelin, A., Pleau, J. M. and Dardenne, M., CD11c+ eosinophils in the murine thymus: developmental regulation and recruitment upon MHC class I restricted thymocyte deletion. J. Immunol. 2000. 165: 1965-1975.
47. Amarante-Mendes, J. G., Chammas, R., Abrahamsohn, P., Patel, P. C., Potworowski, E. F. and Macedo, M. S., Cloning of a thymic stromal cell capable of protecting thymocytes from apoptosis. Cell. Immunol. 1995. 166: 173-179.