Leukocytes utilize both α4 and α5 tegrins for intraislet infiltration in non-obese diabetic mice

Journal of Autoimmunity

Volumn 12, Issue 3, 1999, Pages 167-176

  Uniyal, Shashi ^a   Boeters, Linda ^a   Chakrabarti, Subrata ^a   Singh, Bhagirath ^a   Chan, Bosco M C ^a  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

Diabetes; Insulitis; Integrins

Indexed keywords

INTEGRIN; ALPHA4 INTEGRIN; ALPHA5 INTEGRIN; LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; CELL INFILTRATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; LEUKOCYTE MIGRATION; MOUSE; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; CELL ADHESION; DRUG EFFECT; IMMUNOLOGY; LEUKOCYTE; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; SPLEEN; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CELL ADHESION; DIABETES MELLITUS, TYPE 1; INTEGRIN ALPHA4; INTEGRIN ALPHA5; ISLETS OF LANGERHANS; LEUKOCYTES; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; SPLEEN; T-LYMPHOCYTES;

EID: 0032587159     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1998.0268     Document Type: Article

References (41)

1. Makino S., Kunimoto K., Muraoka Y., Katagiri K. Effects of castration on the appearance of diabetes in NOD mice. Exp. Anim. 3:1981;137-140.
2. Fujita T., Yui R., Kusumoto Y., Serizawa Y., Makino S., Tochino Y. Lymphocyte insulitis in a 'non-obese diabetic (NOD)' strain of mice: an immunohistochemical and electron microscope investigation. Biochem. Res. 3:1982;429-443.
3. O'Reilly L., Hutchings P.R., Crocker P.R., Simpson E., Lund T., Kioussis D., Takei F., Baird J., Cooke A. Characterization of pancreatic islet cell infiltrates in NOD mice: effect of cell transfer and transgene expression. Eur. J. Immunol. 21:1991;1171-1180.
4. Lo D., Reilly C.R., Scott B., Liblau R., McDevitt H.O., Burkly L.C. Antigen-presenting cells in adoptively transferred and spontaneous autoimmune diabetes. Eur. J. Immunol. 23:1993;1693-1698.
5. +T cells. J. Exp. Med. 166:1987;823-832.
6. Wicker L.S., Miller B.J., Mullen Y. Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice. Diabetes. 35:1986;855-860.
7. +T cell subsets are required for the transfer of diabetes in nonobese diabetic mice. J. Immunol. 140:1988;52-58.
8. +T-cells in autoimmune diabetes in NOD mice using transfer to NOD athymic nude mice. Eur. J. Immunol. 22:1992;2387-2393.
9. Springer T.A. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell. 76:1994;301-314.
10. Berlin C., Berg E.L., Briskin M.J., Andrew D.P., Holzmann B., Weissmann I.L., Hamann A., Butcher E.C. α4/β7 integrin mediates lymphocyte binding to the mucossal vascular addressin MadCAM-1. Cell. 74:1993;1.
11. Alon R., Kassner P.D., Carr M.W., Finger E.B., Hemler M.E., Springer T.A. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J. Cell. Biol. 128:1995;1243-1253.
12. Baron J.L., Reich E.P., Visintin I., Janeway C.A. The pathogenesis of adoptive murine autoimmune diabetes requires an interaction between alpha 4-integrins and vascular cell adhesion molecule-1. J. Clin. Invest. 93:1994;1700-1708.
13. Yang X.-D., Karin N., Tisch R., Steinman L., McDevitt H.O. Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors. Proc. Natl. Acad. Sci. USA. 90:1993;10494-10498.
14. Burkly L.C., Jakubowski A., Hattori M. Protection against adoptive transfer of autoimmune diabetes mediated through very late antigen-4 integrin. Diabetes. 43:1994;529-534.
15. Hasegawa Y., Yokono K., Taki T., Amano K., Tominaga Y., Yoneda R., Yagi N., Maeda S., Yagita H., Okumura K., Kasuga M. Prevention of autoimmune insulin-dependent diabetes in non-obese diabetic mice by anti-LFA-1 and anti-ICAM-1 mAb. Int. Immunol. 6:1994;831-838.
16. Fabien N., Bergerot I., Orgiazzi J., Thivolet C. Lymphocyte function associated antigen-1, integrin α4, and L-selectin mediate T-cell homing to the pancreas in the model of adoptive transfer of diabetes in NOD mice. Diabetes. 45:1996;1181-1186.
17. Yang X.-D., Michie S.A., Mebius R.E., Tisch R., Weissman I., McDevitt H.O. The role of cell adhesion molecules in the development of IDDM. Diabetes. 45:1996;705-710.
18. Strauch U.G., Lifka A., Gosslar U., Kilshaw P.J., Clements P.J., Holzmann B. Distinct binding specificities of integrins α4β7 (LPAM-1), α4β1 (VLA-4), and αIELβ7. Int. Immunol. 6:1994;263-275.
19. Ruegg C., Postigo A.A., Sikorski E.E., Butcher E.C., Pytela R., Erle D.J. Role of integrin α4β7/α4βp in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. J. Cell Biol. 117:1992;179.
20. Osborn L., Hession C., Tizard R., Vassallo C., Luhowskyj S., Chi-Rosso G., Lobb R. Direct expression cloning of vascular cell adhesion molecules-1, a cytokine-induced endothelial protein that binds to lymphocytes. Cell. 59:1989;1203.
21. Jakubowski A., Ehrenfels B.N., Pepinsky R.B., Burkly L.C. Vascular cell adhesion molecule-Ig fusion protein selectively targets activated α4-integrin receptors in vivo. J. Immunol. 155:1995;938-946.
22. Tsukamoto K., Yokono K., Amano K., Nagata M., Yagi N., Tominaga Y., Moriyama H., Miki M., Okamoto N., Yoneda R., Inoue Y., Yagita H., Okumura K., Kasuga M. Administration of monoclonal antibodies against vascular cell adhesion molecule-1/very late antigen-4 abrogates predisposing autoimmune diabetes in NOD mice. Cell. Immunol. 165:1995;193-201.
23. Hanninen A., Jaakkola I., Jalkanen S. Mucosal addressin is required for the development of diabetes in nonobese diabetic mice. J. Immunol. 160:1998;6018-6025.
24. Palecek S.P., Loftus J.C., Ginsberg M.H., Lauffenburger D.A., Horwitz A.F. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature. 385:1997;537-540.
25. Huttenlocher A., Ginsberg M.H., Horwitz A.F. Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity. J. Cell Biol. 134:1996;1551-1562.
26. Ho W.-C., Heinemann C., Hangan D., Uniyal S., Morris V.L., Chan B.M.C. Modulation of in vivo migratory function of α2β1 integrin in mouse liver. Mol. Biol. Cell. 8:1997;1863-1875.
27. Hangan D., Uniyal S., Morris V.L., MacDonald I.C., von Ballestrem C.G., Chau T., Schmidt E.E., Chambers A.F., Groom A.V., Chan B.M.C. Integrin VLA-2 (α2β1) function in post-extravasation movement of human rhabdomyosarcoma RD cells in the liver. Cancer Res. 56:1996;3142-3149.
28. Qin H.-Y., Sadelain M.W.J., Hitchon C., Lauzon J., Singh B. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol. 150:1993;2072-2080.
29. Fehlner-Gardiner C., Uniyal S., von Ballestrem C., Dougherty G.J., Chan B.M.C. Differential usage of α4 and α5 integrins during mouse bone marrow-derived mast cell development. Differentiation. 60:1996;317-325.
30. von Ballestrem C.G., Uniyal S., McCormick J.I., Chau T., Singh B., Chan B.M.C. VLA-β1 integrin subunit specific monoclonal antibodies MB1.1 and MB1.2: Binding to epitopes not dependent on thymocyte development or regulated by phorbol ester and divalent cations. Hybridoma. 15:1996;125-132.
31. Hangan D., Morris V.L., Boeters L., von Ballestrem C.G., Uniyal S., Chan B.M.C. An epitope on VLA-6 (α6β1) integrin required for migration but not adhesion mediates extravasation of murine melanoma B16F1 cells in liver. Cancer Res. 57:1997;3812-3817.
32. Rabinowich H., Suarez-Pinzon W., Sorensen O., Bleackley R.C., Power R.F. IFN-γ gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes in nonobese diabetic mice. J. Immunol. 154:1995;4874-4882.
33. Shimizu Y., Van Seventer G.A., Horgan K.J., Shaw S. Regulated expression and binding of three VLA (β1) integrin receptors on T cells. Nature. 345:1990;250-253.
34. van Kooyk Y., van de Wiel-van Kemenade E., Weder P., Kuijpers T.W., Figdor C.G. Enhancement of LFA-1 mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes. Nature. 342:1989;811-813.
35. Savino W., Carnaud C., Luan J.-J., Bach J.-F., Dardenne M. Characterization of the extracellular matrix-containing giant perivascular spaces in the NOD mouse thymus. Diabetes. 42:1993;134-140.
36. Chan B.M.C., Wong J.G.P., Rao A., Hemler M.E. T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix. J. Immunol. 147:1991;398-404.
37. Boitard C., Yasunami R., Dardenne M., Bach J.F. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J. Exp. Med. 169:1989;1669-1680.
38. Faveeuw C., Gagnerault M.-C., Lepault F. Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice. J. Immunol. 152:1994;5969-5978.
39. Hanninen A., Taylor C., Streeter P.R., Stark L.S., Sarte J.M., Shizuru J.A., Simell O., Michie S.A. Vascular addressins are induced on islet vessels during insulitis to nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium. J. Clin. Invest. 92:1993;2509-2515.
40. highlymphocytes accumulate early in the pancreas of NOD mice and show aberrant recirculation behavior. Diabetes. 45:1996;1173-1180.
41. Yang X.-D., Michie S.A., Tisch R., Karin N., Steinman L., McDevitt H.O. A predominant role of integrin α4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice. Proc. Natl. Acad. Sci. USA. 91:1994;12604-12608.