Clonogenic survival and cytokinesis-blocked binucleation of skin fibroblasts and normal tissue complications in soft tissue sarcoma patients treated with preoperative radiotherapy

Radiotherapy and Oncology

Volumn 72, Issue 1, 2004, Pages 103-112

  Akudugu, John M ^a   Bell, Robert S ^a,b   Catton, Charles ^c,d   Davis, Aileen M ^a   O'Sullivan, Brian ^c,d   Waldron, John ^d   Wunder, Jay S ^a,b   Hill, Richard P ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

Binucleation; Clonogenic survival; Prediction; Tissue complications

Indexed keywords

COBALT;

ADULT; AGED; ARTICLE; CANCER RADIOTHERAPY; CANCER SURVIVAL; CELL CULTURE; CELL PROLIFERATION; CLONOGENESIS; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; FEMALE; GAMMA RADIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MICRONUCLEUS; PREOPERATIVE CARE; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIOSENSITIVITY; SKIN FIBROBLAST; SKIN FIBROSIS; SOFT TISSUE SARCOMA; WOUND HEALING;

ADULT; AGED; BIOPSY; CELL DIVISION; CELL NUCLEUS; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; FEMALE; FIBROBLASTS; HUMANS; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; PREDICTIVE VALUE OF TESTS; RADIATION PNEUMONITIS; SARCOMA; SKIN; SKIN DISEASES; SOFT TISSUE NEOPLASMS; WOUND HEALING;

EID: 3242715948     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2004.03.010     Document Type: Article

References (63)

1. Akudugu J.M., Böhm L. Micronuclei and apoptosis in glioma and neuroblastoma cell lines and role of other lesions in the reconstruction of cellular radiosensitivity. Radiat Environ Biophys. 40:2001;295-300
2. Akudugu J.M., Slabbert J.P., Serafin A., Böhm L. Frequency of radiation-induced micronuclei in neuronal cells does not correlate with clonogenic survival. Radiat Res. 57:2000;62-67
3. Alsbeih G., Malone S., Lochrin C., Girard A., Fertil B., Raaphorst P. Correlation between normal tissue complications and in vitro radiosensitivity of skin fibroblasts derived from radiotherapy patients treated for variety of tumors. Int J Radiat Oncol Biol Phys. 46:2000;143-152
4. Barcellos-Hoff M.H. Radiation-induced transforming growth factor beta and subsequent extracellular matrix reorganization in murine mammary gland. Cancer Res. 53:1993;3880-3886
5. Bayreuther K., Francz P.I., Rodemann H.P. Fibroblasts in normal and pathological terminal differentiation, aging, apoptosis and transformation. Arch Gerontol Geriatr. Suppl 3:1992;47-74
6. Bayreuther K., Rodemann H.P., Hommel R., Dittmann K., Albiez M., Francz P.I. Human skin fibroblasts in vitro differentiate along a terminal cell lineage. Proc Natl Acad Sci USA. 85:1988;5112
7. Borgmann K., Röper B., El-Awady R.A., et al. Indicators of late tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol. 64:2002;141-152
8. Brock W.A., Tucker S.L., Geara F.B., et al. Fibroblast radiosensitivity versus acute and late normal skin responses in patients treated for breast cancer. Int J Radiat Oncol Biol Phys. 32:1995;1371-1379
9. Brock W.A., Tucker S.L. In vitro radiosensitivity and normal tissue damage. Radiother Oncol. 55:2000;93-94
10. Bujko K., Suit H.D., Springfield D.S., Convey K. Wound healing after pre-operative radiation for sarcoma of soft tissue. Surg Gynecol Obstet. 176:1993;124-134
11. Burger A., Löffler H., Bamberg M., Rodemann H.P. Molecular and cellular basis of radiation fibrosis. Int J Radiat Biol. 73:1998;401-408
12. Cox J.D., Stetz J., Pajak T.F. Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC). Int J Radiat Oncol Biol Phys. 31:1995;1341-1346
13. Dantzer D., Ferguson P., Hill R.P., et al. Effect of radiation and cell implantation on wound healing in a rat model. J Surg Oncol. 83:2003;185-190
14. Denham J.W., Hauer-Jensen M. The radiotherapy injury - a complex 'wound'. Radiother Oncol. 63:2002;129-145
15. Dickson J., Magee B., Stewart A., West C.M.L. Relationship between residual radiation-induced double-strand breaks in cultured fibroblasts and late radiation reactions: a comparison of training and validation cohorts of breast cancer patients. Radiother Oncol. 62:2002;321-326
16. Dikomey E., Brammer I., Johansen J., Bentzen S., Overgaard J. Relationship between DNA double-strand breaks, cell killing, and fibrosis studied in confluent skin fibroblasts derived from breast cancer patients. Int J Radiat Oncol Biol Phys. 46:2000;481-490
17. Dimitrijevic-Bussod M., Balzaretti-Maggi V.S., Gadbois D.M. Extracellular matrix and radiation G1 cell cycle arrest in human fibroblasts. Cancer Res. 59:1999;4843-4847
18. Drake D.B., Oishi S.N. Wound healing considerations in chemotherapy and radiation therapy. Clin Plast Surg. 22:1995;31-37
19. Ferguson P.C., Boynton E.L., Wunder J.S., et al. Intradermal injection of autologous dermal fibroblasts improves wound healing in irradiated skin. J Surg Res. 85:1999;331-338
20. Fournier C., Scholz M., Kraft-Weyrather W., Kraft G., Rodemann H.P. Changes in fibrosis-related parameters after high and low LET irradiation of fibroblasts. Int J Radiat Biol. 77:2001;713-722
21. Geara F.B., Peters L.J., Ang K.K., Wike J.L., Brock W.A. Prospective comparison of in vitro normal cell radiosensitivity and normal tissue reactions in radiotherapy patients. Int J Radiat Oncol Biol Phys. 27:1993;1173-1179
22. Gorodetsky R., McBride W.H., Withers H.R. Assay of radiation effects in mouse skin as expressed in wound healing. Radiat Res. 116:1988;135-144
23. Gorodetsky R., McBride W.H., Withers H.R., et al. Effect of fibroblast implants on wound healing of irradiated skin: assay of wound strength and quantitative immunohistology of collagen. Radiat Res. 125:1991;181-186
24. Gorodetsky R., Mou X., Fisher D.R., et al. Radiation effect in mouse skin: dose fractionation and wound healing. Int J Radiat Oncol Biol Phys. 18:1990;1077-1081
25. Greenhalgh D.G. The role of apoptosis in wound healing. Int J Biochem Cell Biol. 30:1998;1019-1030
26. Grunkemeier G.L., Jin R. Receiver operating characteristic curve analysis of clinical risk models. Ann Thorac Surg. 72:2001;323-326
27. Hakenjos L., Bamberg M., Rodemann H.P. TGF-β1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced phenotype. Int J Radiat Biol. 76:2000;503-509
28. Herskind C., Bentzen S.M., Overgaard J., Overgaard M., Bamberg M., Rodemann H.P. Differentiation state of skin fibroblast cultures versus risk of subcutaneous fibrosis after radiotherapy. Radiother Oncol. 47:1998;263-269
29. Herskind C., Johansen J., Bentzen S.M., et al. Fibroblast differentiation in subcutaneous fibrosis after postmastectomy radiotherapy. Acta Oncol. 39:2000;383-388
30. Illsley M.C., Peacock J.H., McAnulty R.J., Yarnold J.R. Increased collagen production in fibroblasts cultured from irradiated skin and effect of TGF β1 - clinical study. Br J Cancer. 83:2000;650-654
31. Johansen J., Bentzen S.M., Overgaard J., Overgaard M. Evidence of a positive correlation between in vitro radiosensitivity of normal human skin fibroblasts and the occurrence of subcutaneous fibrosis after radiotherapy. Int J Radiat Biol. 66:1994;407-412
32. Karasek K., Constine L.S., Rosier R. Sarcoma therapy: functional outcome and relationship to treatment parameters. Int J Radiat Oncol Biol Phys. 24:1992;651-656
33. Kiltie A.E., Ryan A.J., Swindell R., et al. A correlation between residual radiation-induced double-strand breaks in cultured fibroblasts and late radiotherapy reactions in breast cancer patients. Radiother Oncol. 51:1999;55-65
34. Kunisada T., Ngan S.Y., Powell G., Choong P.F.M. Wound complications following pre-operative radiotherapy for soft tissue sarcoma. Eur J Surg Oncol. 28:2002;75-79
35. Lara P.C., Russell N.S., Smolders I.J.H., Bartelink H., Begg A.C., Coco-Martin J.M. Radiation-induced differentiation of human skin fibroblasts: relationship with cell survival and collagen production. Int J Radiat Biol. 70:1996;683-692
36. Martin M., Lefaix J.-L., Delanian S. TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys. 47:2000;277-290
37. Martin M., Lefaix J.-L., Pinto P., Crechet F., Daburon F. Temporal modulation of TGFβ1 and β actin gene expression in pig skin and muscular fibrosis after ionizing radiation. Radiat Res. 134:1993;63-70
38. Martin M., Remy J., Daburon F. Abnormal proliferation and aging of cultured fibroblasts from pigs with subcutaneous fibrosis induced by gamma irradiation. J Invest Dermatol. 93:1989;497-500
39. Nachtrap U., Oppitz U., Flentje M., Stopper H. Radiation-induced micronucleus formation in human skin fibroblasts of patients showing severe and normal tissue damage after radiotherapy. Int J Radiat Biol. 73:1998;279-287
40. Ono K., Masunaga S., Akaboshi M., Akuta K. Estimation of the initial slope of the cell survival curve after irradiation from micronucleus frequency in cytokinesis-blocked cells. Radiat Res. 138:1994;S101-S104
41. Oppitz U., Denzinger S., Nauchtrab U., Flentje M., Stopper H. Radiation-induced comet-formation in human skin fibroblasts from radiotherapy patients with different normal tissue reactions. Strahlenther Onkol. 175:1999;341-346
42. O'Sullivan B., Davis A.M., Turcotte R., et al. Preoperative versus postoperative radiotherapy in soft tissue sarcoma of the limbs: a randomised trial. Lancet. 359:2002;2235-2241
43. Peacock J., Ashton A., Bliss J., et al. Cellular radiosensitivity and complication risk after curative radiotherapy. Radiother Oncol. 55:2000;173-178
44. Peters L., McKay M. Predictive assays: will they ever have a role in the clinic? Int J Radiat Oncol Biol Phys. 49:2001;501-504
45. Raaphorst G.P., Malone S., Alsbeih G., Souhani L., Szumacher E., Girard A. Skin fibroblasts in vitro radiosensitivity can predict for late complications following AVM radiosurgery. Radiother Oncol. 64:2002;153-156
46. Robinson M.H., Spruce L., Eeles R., et al. Limb function following conservation treatment of adult soft tissue sarcoma. Eur J Cancer. 27:1991;1567-1574
47. Rodemann H., Bamberg M. Cellular basis of radiation induced fibrosis. Radiother Oncol. 35:1995;83-90
48. Rodemann H.P., Binder A., Burger A., Güven N., Löffler H., Bamberg M. The underlying cellular mechanism of fibrosis. Kidney Int. 49:1996;32-36
49. Rodemann H., Peterson H., Schwenke K., von Wangenheim K. Terminal differentiation of human fibroblasts is induced by irradiation. Scanning Microsc. 5:1991;1135-1143
50. Rudolph R., Arganese T., Woodward M. The ultrastructure and etiology of chronic radiotherapy damage in human skin. Ann Plast Surg. 9:1982;282-292
51. Rudolph R., Van de Berg J., Schneider J.A., et al. Slowed growth of cultured fibroblasts from human radiation wounds. Plast Reconstr Surg. 82:1988;669-675
52. Russell N.S., Begg A.C. Editorial radiotherapy and oncology : predictive assays for normal tissue damage. Radiother Oncol. 64:2002;125-129
53. Russell N.S., Grummels A., Hart A.A.M., et al. Low predictive value of intrinsic fibroblast radiosensitivity for fibrosis development following radiotherapy for breast cancer. Int J Radiat Biol. 73:1998;661-670
54. Russell N.S., Lara P.C., Grummels A., et al. In vitro differentiation characteristics of human skin fibroblasts: correlation with radiotherapy-induced breast fibrosis in patients. Int J Radiat Biol. 76:2000;231-240
55. Smith K.C., Hahn G.M., Hoppe R.T., Earle D.J. Radiosensitivity in vitro of human fibroblasts derived from patients with severe skin reactions to radiation therapy. J Radiat Oncol. 6:1980;1573
56. Springfield D.S. Surgical wound healing. Verweij J., Pinedo H.M., Suit H.D. Multidisciplinary treatment of soft tissue sarcomas. Cancer Treatment and Research. vol. 67:1993;81-98. chapter 5
57. Stausbøl-Grøn B., Overgaard J. Relationship between tumour cell in vitro radiosensitivity and clinical outcome after curative radiotherapy for squamous cell carcinoma of the head and neck. Radiother Oncol. 50:1999;47-55
58. Stinson S.F., DeLaney T.F., Greenberg J., et al. Acute and long-term effects on limb function of combined modality limb sparing therapy for extremity soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 21:1991;1493-1499
59. Suit H.D., Spiro I.J. Role of radiation in the management of adult patients with sarcoma of soft tissue. Semin Surg Oncol. 10:1994;347-356
60. Tibbs M.K. Wound healing following radiation therapy: a review. Radiother Oncol. 42:1997;99-106
61. van Erkel A.R., Pattynama P.M.T. Receiver operating characteristic (ROC) analysis: Basic principles and applications in radiology. Eur J Radiol. 27:1998;88-94
62. van Kampen M., Eble M.J., Lehnert T., et al. Correlation of intraoperatively irradiated volume and fibrosis in patients with soft-tissue sarcoma of the extremities. Int J Radiat Biol. 51:2001;94-99
63. von Pfeil A., Hakenjos L., Herskind C., Dittmann K., Weller M., Rodemann H.P. Irradiated homozygous TGF-β1 knockout fibroblasts show enhanced clonogenic survival as compared with TGF-β1 wild-type fibroblasts. Int J Radiat Biol. 78:2002;331-339