Radiation-induced micronucleus formation in human skin fibroblasts of patients showing severe and normal tissue damage after radiotherapy

International Journal of Radiation Biology

Volumn 73, Issue 3, 1998, Pages 279-287

  Nachtrab, U ^a   Oppitz, U ^a   Flentje, M ^a   Stopper, H ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DOSE RESPONSE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MICRONUCLEUS TEST; PRIORITY JOURNAL; RADIATION DOSE; RADIATION INJURY; RADIOSENSITIVITY; SKIN BIOPSY; SKIN FIBROBLAST;

ADULT; AGED; ATAXIA TELANGIECTASIA; HUMANS; MICRONUCLEUS TESTS; MIDDLE AGED; RADIATION INJURIES; RADIOTHERAPY; SKIN;

EID: 0031925106     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530098142374     Document Type: Article

References (21)

1. ARLETT, C. F. and PRIESTLY, A., 1985, An assessment of the radiosensitivity of ataxia-telangiectasia heterozygotes. In Ataxia Telangiectasia: Genetics, Neuropathology, and Immunology of a Degenerative Disease of Childhood, edited by R. A .G. a. M. Swift (New York: Alan R. Liss).
2. BENTZEN, S. M., 1997, Potential clinical impact of normal-tissue intrinsic radiosensitivity testing. Radiotherapy and Oncology, 43, 121-131.
3. CHAMPION, A. R., HANSON, J. A., VENABLES, S. E., MCGREGOR, A. D. and GAFFNEY, C. C., 1997. Determination of radiosensitivity in established and primary squamous cell carcinoma cultures using the micronucleus assay. European Journal of Cancer, 33(3), 453-462.
4. FENECH, M., 1993, The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research, 285, 35-44.
5. GEARD, C. R. and CHEN, C. Y., 1990, Micronuclei and clonogenicity following low-and high-dose-rale gamma irradiation of normal human fibroblasts. Radiation Research, 124 (Suppl. 1), S56-S61.
6. JONES, L. A., SCOTT, D., COWAN, R. and ROBERTS, S. A., 1995, Abnormal radiosensitivity of lymphocytes from breast cancer patients with excessive normal tissue damage after radiotherapy: chromosome aberrations alter low dose-rate irradiation. International Journal of Radiation Biology, 67, 519-528.
7. JORGENSEN, T. J. and SHILOH, Y., 1996, The ATM gene and the radiobiology of ataxia-telangiectasia. International Journal of Radiation Biology, 69, 527-537.
8. MILLER, B., LOCHER, F., SEELBACH, A., STOPPER, H., UTESCH, D. and MADLE, S., 1997, Evaluation of the in vitro micronucleus test (MNT) as an alternative to the in vitro chromosomal aberration assay (CA): position of the GUM working group on the in vitro micronucleus test. Mutation Research, in press.
9. MORGAN, J. L., HOLCOMB, T. M. and MORRISSFY, R. W., 1968, Radiation reactions in ataxia telangiectasia. American Journal of Diseases of Childhood, 116, 557-558.
10. MÜLLER, W. U., STREFFER, C. and WUTTKE, K., 1995, Micronucleus determination as a means to assess radiation exposure. Stem Cells, 13, 199-206.
11. MÜLLER, W. U., NÜSSE, M., MILLER, B. M., SLAVOTINEK, A., VIAGGI, S. and STREFFER, C., 1996, Micronuclei: a biological indicator of radiation damage. Mutation Research, 366, 163-169.
12. OSANTO, S., THJISSEN, J. C., WOLDERING, V. M., VAN RIJN, J. L., NATARAJAN, A. T. and TATES, A. D., 1991, Increased frequency of chromosomal damage in peripheral blood lymphocytes up to nine years following curative chemotherapy of patients with testicular carcinoma. Environmental and Molecular Mutagenesis, 17, 71-78.
13. RIGAUD, O., GUEDENEY, G., DURANTON, I., LEROY, A., DOLOY, M. T. and MAGDELENAT, H., 1990a, Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. I. Chromosome aberrations induced in vivo. Mutation Research, 242, 17-23.
14. RIGAUD, O., GUEDENEY, G., DURANTON, I., LEROY, A., DOLOY, M. T. and MAGDELENAT, H., 1990b, Genotoxic effects of radiotherapy and chemotherapy on the circulating lymphocytes of breast cancer patients. II. Alteration of DNA repair and chromosome radiosensitivity. Mutation Research, 242, 25-35.
15. RUDAT, V., DIETZ, A., CONRADT, C., WEBER, K.-J. and FLENTJE, M., 1997, In vitro radiosensitivity of primary human fibroblasts. Lack of correlation with acute radiation toxicity in patients with head and neck cancer. Radiotherapy and Oncology, 43, 181-188.
16. SCOTT, D., HU, Q. and ROBERTS, S. A., 1996, Dose-rate sparing for micronucleus induction in lymphocytes of controls and ataxia-telangiectasia heterozygotes exposed to 60Co gamma-irradiation in vitro. International Journal of Radiation Biology, 70, 521-527.
17. SHIBAMOTO, Y., STREFFER, C., FUHRMANN, C. and BUDACH, V., 1991, Tumor radiosensitivity prediction by the cytokinesis-block micronucleus assay. Radiation Research, 128, 293-300.
18. STOPPER, H. and MüLLER, S. O., 1997, A mini review: micronuclei as biological endpoints for genotoxicity, Toxicology in Vitro, in press.
19. TAYLOR, A. M., BYRD, P. J., MCCONVILLE, C. M. and THACKER, S., 1994, Genetic and cellular features of ataxia telangiectasia. International Journal of Radiation Biology, 65, 65-70.
20. TUCKER, S. L., GEARA, F. B., PETERS, L. J. and BROCK, W. A., 1996, How much could the radiotherapy dose be altered for individual patients based on a predictive assay of normal-tissue radiosensitivity? Radiotherapy and Oncology, 38, 103-113.
21. WENNERBERG, J., 1996, Predicting response to therapy of squamous cell carcinoma of the head and neck (Review). Anticancer Research, 16, 2389-2396.