Interleukin 6 -174 G/C promoter gene polymorphism in centenarians: No evidence of association with human longevity or interaction with apolipoprotein e alleles

Experimental Gerontology

Volumn 39, Issue 7, 2004, Pages 1109-1114

  Capurso, Cristiano ^a,b   Solfrizzi, Vincenzo ^b   D'Introno, Alessia ^b   Colacicco, Anna M ^b   Capurso, Sabrina A ^b   Semeraro, Cosimo ^b   Capurso, Antonio ^b   Panza, Francesco ^b  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

Apolipoprotein E; Centenarians; Interleukin 6; Longevity

Indexed keywords

APOLIPOPROTEIN E; INTERLEUKIN 6;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENETIC DIFFERENCE; GENOTYPE; HUMAN; ITALY; LONGEVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION;

ADULT; AGED; AGED, 80 AND OVER; AGING; APOLIPOPROTEINS E; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INTERLEUKIN-6; LONGEVITY; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 3242699699     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2004.03.037     Document Type: Article

References (34)

1. Baggio G., Donazzan S., Monti D., Mari D., Martini S., Gabelli C., Dalla Vestra M., Previato L., Guido M., Pigozzo S., Cortella I., Crepaldi G., Franceschi C. Lipoprotein(a) and lipoprotein profile in healthy centenarians: a reappraisal of vascular risk factors. FASEB J. 12:1998;433-437
2. Basso F., Lowe G.D., Rumley A., McMahon A.D., Humphries S.E. Interleukin-6 -174G>C polymorphism and risk of coronary heart disease in West of Scotland coronary prevention study (WOSCOPS). Arterioscler. Thromb. Vasc. Biol. 22:2002;599-604
3. Bonafè M., Olivieri F., Cavallone L., Giovagnetti S., Mayegiani F., Cardelli M., Pieri C., Marra M., Antonicelli R., Lisa R., Rizzo M.R., Paolisso G., Monti D., Franceschi C. A gender-dependent genetic predisposition to produce high levels of IL-6 is detrimental for longevity. Eur. J. Immunol. 31:2001;2357-2361
4. Brull D.J., Montgomery H.E., Sanders J., Dhamrait S., Luong L., Rumley A., Lowe G.D., Humphries S.E. Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler. Thromb. Vasc. Biol. 21:2001;1458-1463
5. Brull D.J., Leeson C.P., Montgomery H.E., Mullen M., deDivitiis M., Humphries S.E., Deanfield J.E., Lesson C.P. The effect of the Interleukin-6-174G >C promoter gene polymorphism on endothelial function in healthy volunteers. Eur. J. Clin. Invest. 32:2002;153-157
6. Burzotta F., Iacoviello L., Di Castelnuovo A., Glieca F., Luciani N., Zamparelli R., Schiavello R., Donati M.B., Maseri A., Possati G., Andreotti F. Relation of the -174 G/C polymorphism of interleukin-6 to interleukin-6 plasma levels and to length of hospitalization after surgical coronary revascularization. Am. J. Cardiol. 88:2001;1125-1128
7. Capurso A., Resta F., D'Amelio A., Gaddi A., Daddato S., Galletti C., Trabucchi M., Boffelli S., Rozzini R., Motta L., Rapisarda R., Receputo G., Mattace R., Motta M., Pansini L., Masotti G., Marchionni N., Petruzzi E., Bertolini S., Agretti M., Costelli P., Mari D., Duca F., Ferrazzi P., Bosi E., Manzoni M., Tomasello F.B., Salvioli G., Baldelli M.V., Neri M., Franceschi C., Cossarizza A., Monti D., Varricchio M., Gambardella A., Paolisso G., Baggio G., DallaVestra M., Donazzan S., Sangiorgi G.B., Barbagallo M., Frada G., Passeri M., Fagnoni F., Sansoni P., Senin U., Cherubini A., Polidori M.C., Marigliano V., Bauco C., Cacciafesta M., Forconi S., Guerrini M., Boschi S., Fabris F., Cappa G., Ferrario E., Giarelli L., Cavalieri F., Stanta G. Epidemiological and socioeconomic aspects of Italian centenarians. Arch. Gerontol. Geriatr. 25:1997;149-157
8. Davignon J., Gregg R.E., Sing C.F. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 8:1988;1-21
9. Ershler W.B., Keller E.T. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu. Rev. Med. 51:2000;245-270
10. Fagiolo U., Cossarizza A., Scala E., Fanales-Belasio E., Ortolani C., Cozzi E., Monti D., Franceschi C., Paganelli R. Increased cytokine production in mononuclear cells of healthy elderly people. Eur. J. Immunol. 23:1993;2375-2378
11. Ferrucci L., Harris T.B., Guralnik J.M., Tracy R.P., Corti M.C., Cohen H.J., Penninx B., Pahor M., Wallace R., Havlik R.J. Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47:1999;639-646
12. Flex A., Gaetani E., Pola R., Santoliquido A., Aloi F., Papaleo P., Dal Lago A., Pola E., Serricchio M., Tondi P., Pola P. The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with peripheral artery occlusive disease. Eur. J. Vasc. Endovasc. Surg. 24:2002;264-268
13. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J. Clin. Invest. 102:1998;1369-1376
14. Frisoni G.B., Louhija J., Geroldi C., Trabucchi M. Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. J. Gerontol. A Biol. Sci. Med. Sci. 56:2001;M75-M78
15. Harris T.B., Ferrucci L., Tracy R.P., Corti M.C., Wacholder S., Ettinger W.H. Jr., Heimovitz H., Cohen H.J., Wallace R. Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106:1999;506-512
16. Jones K.G., Brull D.J., Brown L.C., Sian M., Greenhalgh R.M., Humphries S.E., Powell J.T. Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation. 103:2001;2260-2265
17. Louhija J., Miettinen H.E., Kontula K., Tikkanen M.J., Miettinen T.A., Tilvis R.S. Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscl. Thromb. 14:1994;1084-1089
18. Kilpinen S., Hulkkonen J., Wang X.Y., Hurme M. The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults. Eur. Cytokine Netw. 12:2001;62-68
19. Moos V., Rudwaleit M., Herzog V., Hohlig K., Sieper J., Muller B. Association of genotypes affecting the expression of interleukin-1beta or interleukin-1 receptor antagonist with osteoarthritis. Arthritis Rheum. 43:2000;2417-2422
20. Olivieri F., Bonafe M., Cavallone L., Giovagnetti S., Marchegiani F., Cardelli M., Mugianesi E., Giampieri C., Moresi R., Stecconi R., Lisa R., Franceschi C. The -174 C/G locus affects in vitro/in vivo IL-6 production during aging. Exp. Gerontol. 37:2002;309-314
21. Olivieri F., Bonafe M., Giovagnetti S., Stecconi R., Cardelli M., Cavallone L., Spazzafumo L., Marchegiani F., Carrieri G., Mugianesi E., Giampieri C., Centurelli M., Moresi R., Tesei S., Lisa R., Viticchi C., Falsetti L., Salvioli S., Franceschi C. In vitro IL-6 production by EBV-immortalized B lymphocytes from young and elderly people genotyped for -174 C/G polymorphism in IL-6 gene: a model to study the genetic basis of inflamm-aging. Mech. Ageing Dev. 124:2003;549-553
22. Panza F., Solfrizzi V., Torres F., Mastroianni F., Del Parigi A., Colacicco A.M., Basile A.M., Capurso C., Noya R., Capurso A. Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians. Neurosci. Lett. 277:1999;53-56
23. Panza F., Solfrizzi V., D'Introno A., Colacicco A.M., Capurso C., Kehoe P.G., Capurso A. Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe. Exp. Gerontol. 38:2003;1015-1020
24. Panza F., D'Introno A., Colacicco A.M., Capurso C., Capurso S., Kehoe P.G., Capurso A., Solfrizzi V. Vascular genetic factors and human longevity. Mech. Ageing Dev. 125:2004;169-178
25. Pola R., Flex A., Gaetani E., Lago A.D., Gerardino L., Pola P., Bernabei R. The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with Alzheimer's disease in an Italian population. Neuroreport. 13:2002;1645-1647
26. Pola R., Gaetani E., Flex A., Aloi F., Papaleo P., Gerardino L., De Martini D., Flore R., Pola P., Bernabei R. -174 G/C interleukin-6 gene polymorphism and increased risk of multi-infarct dementia: a case-control study. Exp. Gerontol. 37:2002;949-955
27. Rauramaa R., Vaisanen S.B., Luong L.A., Schmidt-Trucksass A., Penttila I.M., Bouchard C., Toyry J., Humphries S.E. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 20:2000;2657-2662
28. Rea I.M., Ross O.A., Armstrong M., McNerlan S., Alexander D.H., Curran M.D., Middleton D. Interleukin-6-gene C/G 174 polymorphism in nonagenarian and octogenarian subjects in the BELFAST study. Reciprocal effects on IL-6, soluble IL-6 receptor and for IL-10 in serum and monocyte supernatants. Mech. Ageing Dev. 124:2003;555-561
29. Ross O.A., Curran M.D., Meenagh A., Williams F., Barnett Y.A., Middleton D., Rea I.M. Study of age-association with cytokine gene polymorphisms in an aged Irish population. Mech. Ageing Dev. 124:2003;199-206
30. Saunders A.M., Strittmatter W.J., Schmechel D., St. George-Hyslop P.H., Pericak-Vance M.A., Joo S.H., Rosi B.L., Gusella J.F., Crapper-MacLachlan D.R., Alberts M.J., Hulette C., Crain B., Goldgaber D., Roses A.D. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 43:1993;1467-1472
31. Schachter F., Faure-Delanef L., Guenot F., Rouger H., Froguel P., Lesueur-Ginot L., Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6:1994;29-32
32. Solfrizzi V., Panza F., Torres F., Mastroianni F., Del Parigi A., Venezia A., Capurso A. High monounsaturated fatty acids intake protects against age-related cognitive decline. Neurology. 52:1999;1563-1569
33. Terry C.F., Loukaci V., Green F.R. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J. Biol. Chem. 275:2000;18138-18144
34. Wang X.Y., Hurme M., Jylha M., Hervonen A. Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians. Mech. Ageing Dev. 123:2001;29-38