Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: Different allele frequencies between the North and South of Europe

Experimental Gerontology

Volumn 38, Issue 9, 2003, Pages 1015-1020

  Panza, Francesco ^a   Solfrizzi, Vincenzo ^a   D'Introno, Alessia ^a   Colacicco, Anna Maria ^a   Capurso, Cristiano ^a   Kehoe, Patrick G ^b   Capurso, Antonio ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Angiotensin I converting enzyme 1; Apolipoprotein E; Centenarians; Longevity; Southern Italy

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; EUROPE; FEMALE; GENE DELETION; GENE FREQUENCY; GENE INSERTION; HUMAN; ITALY; LONGEVITY; MALE; NORMAL HUMAN; PHENOTYPE; POPULATION GENETICS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE;

INSERTION SEQUENCES;

EID: 0042885981     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(03)00154-2     Document Type: Article

References (24)

1. Agerholm-Larsen B., Nordestgaard B.G., Steffensen R., Sorensen T.I., Jensen G., Tybjaerg-Hansen A. ACE gene polymorphism: ischemic heart disease and longevity in 10,150 individuals. A case-referent and retrospective cohort study based on the Copenhagen City Heart Study. Circulation. 95:1997;2358-2367.
2. Bladbjerg E.M., Andersen-Ranberg K., de Maat M.P., Kristensen S.R., Jeune B., Gram J., Jespersen J. Longevity is independent of common variations in genes associated with cardiovascular risk. Thromb. Haemost. 82:1999;1100-1105.
3. Blanchè H., Cabanne L., Sahbatou M., Thomas G. A study of French centenarians: are ACE and APOE associated with longevity? C. R. Acad. Sci. III. 324:2001;129-135.
4. Cambien F., Poirier O., Lecerf L., Evans A.E., Cambou J.P., Arveiller D., Luc G., Bard J.M., Bara L., Ricard S., Tiret L., Amouyel P., Alhenc-Gelas F., Soubrier F. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 359:1992;641-644.
5. Capurso A., Resta F., D'Amelio A., Gaddi A., Daddato S., Galletti C., Trabucchi M., Boffelli S., Rozzini R., Motta L., Rapisarda R., Receputo G., Mattace R., Motta M., Pansini L., Masotti G., Marchionni N., Petruzzi E., Bertolini S., Agretti M., Costelli P., Mari D., Duca F., Ferrazzi P., Bosi E., Manzoni M., Tomasello F.B., Salvioli G., Baldelli M.V., Neri M., Franceschi C., Cossarizza A., Monti D., Varricchio M., Gambardella A., Paolisso G., Baggio G., DallaVestra M., Donazzan S., Sangiorgi G.B., Barbagallo M., Frada G., Passeri M., Fagnoni F., Sansoni P., Senin U., Cherubini A., Polidori M.C., Marigliano V., Bauco C., Cacciafesta M., Forconi S., Guerrini M., Boschi S., Fabris F., Cappa G., Ferrario E., Giarelli L., Cavalieri F., Stanta G. Epidemiological and socioeconomic aspects of Italian centenarians. Arch. Gerontol. Geriatr. 25:1997;149-157.
6. Costerousse O., Jaspard E., Wei L., Corvol P., Alhenc-Gelas F. The angiotensin I-converting enzyme (kininase II): molecular organization and regulation of its expression in humans. J. Cardiovasc. Pharmacol. 20:(Suppl. 9):1992;S10-S15.
7. Davignon J., Gregg R.E., Sing C.F. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis. 8:1988;1-21.
8. Eisenlohr L.C., Bacik I., Bennink J.R., Bernstein K., Yewdell J.W. Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes. Cell. 71:1992;963-972.
9. Evans A.E., Poirier O., Kee F., Lecerf L., McCrum E., Falconer T., Crane J., O'Rourke D.F., Cambien F. Polymorphisms of the angiotensin-converting-enzyme gene in subjects who die from coronary heart disease. Q. J. Med. 87:1994;211-214.
10. Frisoni G.B., Louhija J., Geroldi C., Trabucchi M. Longevity and the epsilon2 allele of apolipoprotein E: the Finnish Centenarians Study. J. Gerontol. A Biol. Sci. Med. Sci. 56:2001;M75-M78.
11. Galinsky D., Tysoe C., Brayne C.E., Easton D.F., Huppert F.A., Dening T.R., Paykel E.S., Rubinsztein D.C. Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. Atherosclerosis. 129:1997;177-183.
12. Lindpaintner K., Pfeffer M.A., Kreutz R., Stampfer M.J., Grodstein F., LaMotte F., Buring J., Hennekens C.H. A prospective evaluation of an angiotensin converting-enzyme gene polymorphism and the risk of ischemic heart disease. N. Eng. J. Med. 332:1995;706-711.
13. Louhija J., Miettinen H.E., Kontula K., Tikkanen M.J., Miettinen T.A., Tilvis R.S. Aging and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E4 phenotype in centenarians. Arterioscl. Thromb. 14:1994;1084-1089.
14. Kehoe P.G., Russ C., McIlory S., Williams H., Holmans P., Holmes C., Liolitsa D., Vahidassr D., Powell J., McGleenon B., Liddell M., Plomin R., Dynan K., Williams N., Neal J., Cairns N.J., Wilcock G., Passmore P., Lovestone S., Williams J., Owen M.J. Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease. Nat. Genet. 21:1999;71-72.
15. Panza F., Solfrizzi V., Torres F., Mastroianni F., Del Parigi A., Colacicco A.M., Basile A.M., Capurso C., Noya R., Capurso A. Decreased frequency of apolipoprotein E epsilon4 allele from Northern to Southern Europe in Alzheimer's disease patients and centenarians. Neurosci. Lett. 277:1999;53-56.
16. Panza F., Solfrizzi V., D'Introno A., Colacicco A.M., Capurso C., Kehoe P.G., Capurso A. Shifts in angiotensin I converting enzyme insertion allele frequency across Europe: implications for Alzheimer's disease risk. J. Neurol. Neurosurg. Psychiatry. 2003;. (in press).
17. Paolisso G., Manzella D., Ferrara N., Gambardella A., Abete P., Tagliamonte M.R., De Lucia D., Furgi G., Picone C., Gentile S., Rengo F., Varricchio M. ACE gene polymorphism and insulin action in older subjects and healthy centenarians. J. Am. Geriatr. Soc. 49:2001;610-614.
18. Proc-LogXact 5, Copyright 2001-2003 by CYTEL Software Corporation, Cambridge, MA 021139.
19. Rigat B., Hubert C., Alhenc-Gelas F., Cambien F., Corvol P., Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 86:1990;1343-1346.
20. Rigat B., Hubert C., Corvol P., Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res. 20:1992;1433.
21. Saunders A.M., Strittmatter W.J., Schmechel D., St George-Hyslop P.H., Pericak-Vance M.A., Joo S.H., Rosi B.L., Gusella J.F., Crapper-MacLachlan D.R., Alberts M.J., Hulette C., Crain B., Goldgaber D., Roses A.D. Association of apolipoprotein E allele e4 with late-onset familial and sporadic Alzheimer's disease. Neurology. 43:1993;1467-1472.
22. Schachter F., Faure-Delanef L., Guenot F., Rouger H., Froguel P., Lesueur-Ginot L., Cohen D. Genetic associations with human longevity at the APOE and ACE loci. Nat. Genet. 6:1994;29-32.
23. Solfrizzi V., Panza F., Torres F., Mastroianni F., Del Parigi A., Venezia A., Capurso A. High monounsaturated fatty acids intake protects against age-related cognitive decline. Neurology. 52:1999;1563-1569.
24. Ueda S., Heeley R.P., Lees K.R., Elliott H.L., Connell J.M. Mistyping of the human angiotensin-converting enzyme gene polymorphism: frequency, causes and possible methods to avoid errors in typing. J. Mol. Endocrinol. 17:1996;27-30.