The effect of the interleukin-6-174G > C promoter gene polymorphism on endothelial function in healthy volunteers

European Journal of Clinical Investigation

Volumn 32, Issue 3, 2002, Pages 153-157

  Brull, David J ^a   Lesson, C P M ^b   Montgomery, H E ^a   Mullen, M ^b   DeDivitiis, M ^b   Humphries, S E ^a   Deanfield, J E ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

Endothelial function; Genetics; Inflammation; Interleukin 6 polymorphism

Indexed keywords

INTERLEUKIN 6;

ADULT; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; BRACHIAL ARTERY; CARDIOVASCULAR RISK; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; FOREARM; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; MULTIVARIATE ANALYSIS; NORMAL HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SEX DIFFERENCE; SMOKING; VASCULAR ENDOTHELIUM;

ADULT; ARTERIOSCLEROSIS; BRACHIAL ARTERY; ENDOTHELIUM, VASCULAR; FEMALE; GENOTYPE; HUMANS; INTERLEUKIN-6; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); RISK FACTORS; SEX DISTRIBUTION; SMOKING;

EID: 0036997522     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2002.00966.x     Document Type: Article

References (30)

1. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-26.
2. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990;265:621-36.
3. Seino Y, Ikeda U, Ikeda M, Yamamoto K, Misawa Y, Hasegawa T et al. Interleukin 6 gene transcripts are expressed in human atherosclerotic lesions. Cytokine 1994;6:87-91.
4. Rus HG, Vlaicu R, Niculescu F. Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall. Atherosclerosis 1996;127:263-71.
5. Huber SA, Sakkinen P, Conze D, Hardin N, Tracy R. Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Thromb Vasc Biol 1999;19:2364-7.
6. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000;101:1767-72.
7. Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 2000;342:836-43.
8. Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999;19:972-8.
9. Cleland SJ, Sattar N, Petrie JR, Forouhi NG, Elliott HL, Connell JM. Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease. Clin Sci (Colch) 2000;98:531-5.
10. Sinisalo J, Paronen J, Mattila KJ, Syrjala M, Alfthan G, Palosuo T et al. Relation of inflammation to vascular function in patients with coronary heart disease. Atherosclerosis 2000;149:403-11.
11. Hingorani AD, Cross J, Kharbanda RK, Mullen MJ, Bhagat K, Taylor M et al. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation 2000;102:994-9.
12. Celermajer DS. Testing endothelial function using ultrasound. J Cardiovasc Pharmacol 1998;32 (Suppl. 3):S29-32.
13. Anderson TJ, Gerhard MD, Meredith IT, Charbonneau F, Delagrange D, Creager MA et al. Systemic nature of endothelial dysfunction in atherosclerosis. Am J Cardiol 1995;75:71B-74B.
14. Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998;102:1369-76.
15. Jones KG, Brull DJ, Brown LC, Sian M, Greenhalgh RM, Humphries SE et al. Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation 2001;103:2260-5.
16. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nuc Acid Res 1988;16:1215-6.
17. Leeson P, Thorne S, Donald A, Mullen M, Clarkson P, Deanfield. J. Non-invasive measurement of endothelial function: effect on brachial artery dilatation of graded endothelial dependent and independent stimuli. Heart 1997;78:22-7.
18. Hoeks AP, Brands PJ, Smeets FA, Reneman RS. Assessment of the distensibility of superficial arteries. Ultrasound Med Biol 1990;16:121-8.
19. Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A et al. Passive smoking and impaired endothelium-dependent arterial dilatation in healthy young adults [see comments]. N Engl J Med 1996;334:150-4.
20. Tappia PS, Troughton KL, Langley-Evans SC, Grimble RF. Cigarette smoking influences cytokine production and antioxidant defences. Clin Sci (Colch) 1995;88:485-9.
21. de Maat MP, Pietersma A, Kofflard M, Sluiter W, Kluft C. Association of plasma fibrinogen levels with coronary artery disease, smoking and inflammatory markers. Atherosclerosis 1996;121:185-91.
22. Woodward M, Rumley A, Tunstall-Pedoe H, Lowe GD. Associations of blood rheology and interleukin-6 with cardiovascular risk factors and prevalent cardiovascular disease. Br J Haematol 1999;104:246-57.
23. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE. Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 1994;24:1468-74.
24. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-5.
25. Fernandez-Real JM, Broch M, Vendrell J, Richart C, Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 2000;85:1334-9.
26. Steinberg HO, Tarshoby M, Monestel R, Hook G, Cronin J, Johnson A et al. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 1997;100:1230-9.
27. Chowienczyk PJ, Watts GF, Cockcroft JR, Brett SE, Ritter JM. Sex differences in endothelial function in normal and hypercholesterolaemic subjects. Lancet 1994;344:305-6.
28. Pottratz ST, Bellido T, Mocharla H, Crabb D, Manolagas SC. 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest 1994;93:944-50.
29. Sukovich DA, Kauser K, Shirley FD, DelVecchio V, Halks-Miller M, Rubanyi GM. Expression of interleukin-6 in atherosclerotic lesions of male ApoE- knockout mice: inhibition by 17beta-estradiol. Arterioscler Thromb Vasc Biol 1998;18:1498-505.
30. Galien R, Garcia T. Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-kappaB site. Nucl Acids Res 1997;25:2424-9.