Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxia

Neuroscience Letters

Volumn 366, Issue 1, 2004, Pages 24-28

  Spandou, Evangelia ^a   Soubasi, Vassiliki ^a   Papoutsopoulou, Stamatia ^a   Karkavelas, George ^a   Simeonidou, Constantina ^a   Kaiki Astara, A ^a   Guiba Tziampiri, Olympia ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Apoptosis; Erythropoietin; Hypoxia ischemia; Neuroprotection; Newborn rat; Sensorimotor reflexes

Indexed keywords

BIOTIN; DEOXYURIDINE TRIPHOSPHATE DERIVATIVE; DNA FRAGMENT; DNA NUCLEOTIDYLEXOTRANSFERASE; ERYTHROPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN PROTECTION; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROPHORESIS; FEMALE; MALE; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PERINATAL ASPHYXIA; PRIORITY JOURNAL; RAT;

ANIMALS; ANIMALS, NEWBORN; ASPHYXIA NEONATORUM; BRAIN; DISEASE MODELS, ANIMAL; DNA FRAGMENTATION; ERYTHROPOIETIN; FEMALE; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; REFLEX;

EID: 3242696200     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.05.032     Document Type: Article

References (23)

1. Agnelllo D., Bigini P., Villa P., Mennini T., Cerami A., Brines M.L., Ghezzi P. Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis. Brain Res. 1:2002;128-134
2. Aydin A., Genc K., Akhisaroglu M., Yorukoglu K., Gokmen N., Gonullu E. Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic-ischemic brain injury. Brain Dev. 25:2003;494-498
3. Bernaudin M., Bellail A., Marti H.H., Yvon A., Vivien D., Duchatelle I., Mackenzie E.T., Petit E. Neurons and astrocytes express EPO mRNA: oxygen-sensing mechanisms that involve the redox-state of the brain. Glia. 30:2000;271-278
4. Bernaudin M., Marti H.H., Roussel S., Divoux D., Andre N., Mackenzie E.T., Petit E. A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 19:1999;643-651
5. Brines M.L., Ghezzi P., Keenan S., Agnello D., de Lanerolle N.C., Cerami C., Itri L.M., Cerami A. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc. Natl. Acad. Sci. U.S.A. 97:2000;10526-10531
6. Cataltepe O., Vannucci R.C., Hietgan D.F., Towfighi J. Effect of status epilepticus on hypoxic-ischemic brain damage in the immature rat. Pediatr. Res. 38:1995;251-257
7. Delivoria-Papadopoulos M., Mishra O.P. Mechanisms of perinatal cerebral injury in fetus and newborn. Ann. N.Y. Acad. Sci. 900:2000;159-168
8. Digicaylioglu M.S., Lipton S.A. Erythropoietin-mediated neuroprotection involves cross-talk between JAK2 and NF-kB signaling cascades. Nature. 412:2001;641-647
9. Hill I.E., MacManus J.P., Rasquinha I., Tuor U.I. DNA fragmentation indicative of apoptosis following unilateral cerebral hypoxia-ischemia in the neonatal rat. Brain Res. 676:1995;398-403
10. Jelkmann W. Erythropoietin: structure, control of production and function. Physiol. Rev. 72:1992;449-489
11. Juul S.L., Anderson D.K., Li Y., Christensen R.D. Erythropoietin and erythropoeitin receptor in the developing human central nervous system. Pediatr. Res. 43:1998;40-49
12. Kumral A., Ozer E., Yilmaz O., Akhisaroglu M., Gokman N., Duman N., Uluku C., Gen S. Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats. Biol. Neonate. 83:2003;224-226
13. Lamprecht, Creatine phosphate, in: H.U. Bergmeyer (Ed.), Methods of Enzymatic Analysis, vol. 4, Academic Press, New York.
14. Marti H.H., Bernaudin M., Petit E., Bauer C. Neuroprotection and angiogenesis: dual role of erythropoietin in brain ischemia. News Physiol. Sci. 15:2000;225-229
15. Matushita H., Johnston M.V., Lange M.S., Wilson M.A. Protective effect of erythropoietin in neonatal hypoxic ischemia in mice. Dev. Neurosci. 14:2003;1757-1761
16. Pletnikov M.V., Rubin S.A., Carbone K.M., Moran T.H., Schwartz G.J. Neonatal Borna disease virus infection (BDF)-induced damage to the cerebellum is associated with sensorimotor deficits in developing Lewis rats. Dev. Brain Res. 126:2001;1-12
17. Rice J.E., Vannucci R.C., Brierley J.B. The influence of immaturity on hypoxic-ischemic brain damage in the rat. Ann. Neurol. 9:1981;131-141
18. Sakanaka M., Wen T.C., Masuda S., Morishita E., Nagao M., Sasaki R. In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc. Natl. Acad. Sci. U.S.A. 98:1998;4635-4640
19. Siren A.L., Fratelli M., Brines M., Goemans C., Casagrande S., Lewczuk P., Keenan S., Gleiter C., Pasquali C., et al. Erythropoetin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl. Acad. Sci. U.S.A. 98:2001;4044-4049
20. Solaroglu I., Solaroglu A., Kaptanoglu E., Dede S., Haberal A., Beskonakli E., Kilinc K. Erythropoietin prevents ischemia-reperfusion from inducing oxidative damage in fetal rat brain. Child Nerv. Syst. 19:2003;19-22
21. Spandou E., Karkavelas G., Soubasi V., Augoustides-Savvopoulou P., Loizidis T., Guiba-Tziampiri O. Effect of ketamine on hypoxic-ischemic brain damage in newborn rats. Brain Res. 819:1999;1-7
22. Ten V.S., Bradley-Moore M., Gingrich J.A., Stark R.I., Pinsky D.J. Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy. Behav. Brain Res. 145:2003;209-219
23. Wen T.C., Sadamoto Y., Tanaka J., Zhu P.X., Nakata K., Ma Y.J., Hata R., Sakanaka M. Erythropoietin protects neurons against chemical hypoxia and cerebral ischemic injury by up-regulating Bcl-xL expression. J. Neurosci. Res. 67:2002;795-803