Mechanisms of perinatal cerebral injury in fetus and newborn

Annals of the New York Academy of Sciences

Volumn 900, Issue , 2000, Pages 159-168

  Delivoria Papadopoulos, Maria ^a,b   Mishra, Om Prakash ^a  

^a ST CHRISTOPHER'S HOSPITAL FOR CHILDREN   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; ARACHIDONIC ACID; CALCIUM ION; FREE RADICAL; INDOMETACIN; LIPOXYGENASE; MAGNESIUM SULFATE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; NITRIC OXIDE SYNTHASE; NORDIHYDROGUAIARETIC ACID; PHOSPHOLIPASE A2; PROSTAGLANDIN SYNTHASE; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE;

ARACHIDONIC ACID METABOLISM; BIRTH INJURY; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN INJURY; CALCIUM CELL LEVEL; CEREBRAL PALSY; CONFERENCE PAPER; ELECTRON SPIN RESONANCE; FETUS; GUINEA PIG; HYPOXEMIA; LIPID PEROXIDATION; MENTAL DEFICIENCY; NEWBORN; NEWBORN MORBIDITY; NEWBORN MORTALITY; NONHUMAN; SEIZURE; SWINE;

CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0034056440     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06226.x     Document Type: Conference Paper

References (45)

1. 1. ANDERSEN, C.B., P.J. MARRO, T. OHNISHI, A. ZHU & M. DELIVORIA-PAPADOPOULOS. 1996. Effect of allipurinol on free radical formation during cerebral hypoxia in newborn piglets. Pediatr. Res. 39: 43A.
2. 2. ANDERSEN, C.B., T. OHNISHI, J.E. MCGOWAN, O.P. MISHRA & M. DELIVORIA-PAPADOPOULOS. 1995. Effect of indomethacin (INDO) on free radical formation during hypoxia. Pediatr. Res. 37: 42A.
3. 3. BAUM, R.M. 1984. Superoxide theory of oxygen toxicity is center of heated debate. Chem. Eng. News 9: 20-28.
4. 4. BECKMAN, J.S. 1991. The double-edged role of nitric oxide in brain function and superoxide-mediated injury. J. Dev. Physiol. 15: 53-59.
5. 5. BECKMAN, J.S., T.W. BECKMAN, J. CHEN, P.A. MARSHALL & B.A. FREEMAN. 1990. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87: 1620-1624.
6. 6. BENVENISTE, H., J. DREJER, A. SCHOUSBOE & N.H. DIEMER. 1984. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippcampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43: 1369-1374.
7. 7. BREDT, D.S. & S.H. SNYDER. 1989. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc. Natl. Acad. Sci. USA 86: 9030-9033.
8. 8. BUISSON, A., M. PLOTKINE & R.G. BOULU. 1992. The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia. Br. J. Pharmacol. 106: 766-767.
9. 9. CAZEVIELLE, C., A. MULLER, F. MEYNIER & C. BONNE. 1993. Superoxide and nitricoxide cooperation in hypoxia/reoxygenation-induced neuron injury. Free Radic. Biol. Med. 14: 389-395.
10. 10. DAWSON, D.A. 1994. Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome. Cerebrovasc. Brain Metab. 64: 299-324.
11. 11. DAWSON, T.M. & S.H, SNYDER. 1994. Gases as biological messengers: nitrix oxide and carbon monoxide in the brain. J. Neurosci. 14: 5147-5159.
12. 12. DAWSON, V.L., T.M. DAWSON, E.D. LONDON, D.S. BREDT & S.H. SNYDER. 1991. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc. Natl. Acad. Sci. USA 88: 6368-6371.
13. 13. DELIVORIA-PAPADOPOULOS, M. & O.P. MISHRA. 1998. Mechanisms of cerebral injury in perinatal asphyxia and strategies for prevention. J. Pediatr. 132: S30-S34.
14. 14. DIGIACOMO, J.E., C.R. PANE, S. GWIAZDOWSKI, O.P. MISHRA & M. DELIVORIA-PAPADOPOULOS. 1992. Effect of graded hypoxia on brain cell membrane injury in newborn piglets. Biol. Neonate. 61: 25-32.
15. 15. FARACI, F.M. 1991. Role of endothelium-derived relaxing factor in cerebral circulation: large arteries vs. microcirculation. Am J. Physiol. 261: H1038-1042.
16. 16. FERRER, I. 1996. Cell death in the normal developing brain, and following ionizing radiation, methylazoxy methanol acetate, and hypoxic-ischemia in the rat. Neuropathol. Appl. Neurobiol. 22: 489-492.
17. 17. FRANDSEN, A. & A. SCHOUSBOE. 1993. Excitatory amino acid-mediated cytotoxicity and calcium homeostasis in cultured neurons. J. Neurochem. 60: 1202-1211.
18. 18. FRITZ, K.I., F. GROENEDAAL, J.E. MCGOWAN, O.P. MISHRA & M. DELIVORIA-PAPADOPOULOS. 1996. Effect of cerebral hypoxia on NMDA receptor binding characteristics after treatment with 3-(2-carboxypiperizin-4-yl)propyl-1-phosphonic acid (CPP) in newborn piglets. Brain Res. 729: 16-74.
19. 19. GARTHWAITE, J. G. GARTHWAITE, R.M. PALMER & S. MONCADE. 1989. NMDA receptor activation induces nitric oxide syntesis from arginine in rat brain slices. Eur. J. Pharmacol. 172: 413-416.
20. 20. GLOBUS, M.Y.T., R. BUSTO, W.B. DIETRICH, E. MARTINEZ, I. VALDES & M.D. GINSBERG. 1988. Effect of ischemia on the in vivo release of striatal dopamine, glutamate, and y-aminobutryic acid studied by intracerebral microdialysis. J. Neurochem. 51: 1455-1464.
21. 21. HALLIWELL, B. 1992. Reactive oxygen species and the central nervous system. J. Neurochem. 59: 1609-1623.
22. 22. HAMADA, Y., T. HAYAKAWA, H. HATTORI & H. MIKAWA. 1994. Inhibitors of nitric oxide synthesis reduce hypoxic-ischemic brain damage in the neonatal rat. Pediatr. Res. 35: 10-14.
23. 23. HUANG, Z., P.L. HUANG, N. PANAHIAN, T. DALKARA, M.C. FISHMAN & M.A. MOSKOWITZ. 1994. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide. Science 265: 1883-1885.
24. 24. JOHNSTON, M.V. 1995. Neurotransmitters and vulnerability of the developing brain. Brain Dev. 17: 301-306.
25. 25. LAFON, C.M., S. PIETRI, M. CULCASI & J. BOCKAERT. 1993. NMDA-dependent superoxide production and neurotoxicity. Nature 364: 535-537.
26. 26. LIPTON, S.A. & P.A. ROSENBERG. 1994. Excitatory amino acids as a final common pathway for neurological disorders. N. Engl. J. Med. 330: 613-622.
27. 27. LONGO, L.D. & S. PACKINTHAN. 1997. Hypoxia-ischemia and the developing brain: hypotheses regarding the pathophysiology of fetal-neonatal brain damage. Br. J. Obstet. Gynaecol. 104: 653-662.
28. 28. MAULIK, D., Y. NUMAGAMI, T. OHNISHI, O.P. MISHRA & M. DELIVORIA PAPADOPOULOS. 1998. Direct detection of oxygen free radical generation during in-utero hypoxia in the fetal guinea pig. Brain Res. 798: 166-172.
29. 29. MAULIK, D., S.A. ZANELLI, Y. NUMAGAMI, T. OHNISHI, O.P. MISHRA & M. DELIVORIA-PAPADOPOULOS. 1999. Oxygen free radical generation during in-utero hypoxia in the fetal guinea pig brain: the effects of maturity and of magnesium sulfate administration. Brain Res. 817: 117-122.
30. 30. MISHRA, O.P. & M. DELIVORIA-PAPADOPOULOS. 1999. Cellular mechanisms of hypoxic brain injury in the developing brain. Brain Res. Bull. 48: 233-238.
31. +-ATPase in developing fetal guinea pig brain and the effect of maternal hypoxia. Neurochem. Res. 17: 1223-1228.
32. 32. MISHRA, O.P. & M. DELIVORIA-PAPADOPOULOS. 1989. Lipid peroxidation in developing fetal guinea pig brain during normoxia and hypoxia. Dev. Brain Res. 45: 129-135.
33. 33. NOWICKI, J.P., D. DUVAL, H. POIGNET & B. SCATTON. 1991. Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. Eur. J. Pharmacol. 204: 339-340.
34. 34. NUMAGAMI, Y., A.B. ZUBROW, O.P. MISHRA & M. DELIVORIA-PAPADOPOULOS. 1997. Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet. J. Neurochem. 69: 1542-1547.
35. 35. QUAST, M.J., J. WEI & N.C. HUANG. 1995. Nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester decreases ischemic damage in reversible focal cerebral ischemia in hyperglycemic rats. Brain Res. 677: 204-212.
36. 36. RADI, R., J.S. BECKMAN, L.M. BUSH & B.A. FREEMAN. 1991. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch. Biochem. Biophys. 288: 481-487.
37. 37. RAICHLE, M.E. 1983. The pathophysiology of brain ischemia. Ann. Neurol. 13: 2-10.
38. 38. RAZDAN, B., P.J. MARRO, O. TAMMELA, R. GOEL, O.P. MISHRA & M. DELIVORIA-PAPADOPOULOS. 1994. Selective sensitivity of synaptosomal membrane function to cerebral cortical hypoxia in newborn piglet. Brain Res. 600: 308-314.
39. +-ATPase activity following severe hypoxic injury in the newborn piglet. Brain Res. 730: 52-57.
40. 40. SAKAMOTO, A., S.T. OHNISHI, T. OHNISHI & R. OGAWA. 1991. Relationship between free radical production and lipid peroxidation during ischemia-reperfusion injury in the rat brain. Brain Res. 554: 186-192.
41. 41. SAWYER, D.T. & J.S. VALENTINE. 1981. How super is superoxide? Accounts Chem. Res. 14: 393-400.
42. 42. SHIN, S.M., B. RAZDAN, O.P. MISHRA, L. JOHNSON & M. DELIVORIA PAPADOPOULOS. 1994. Protective effect of a-tocopherol on brain cell membrane function during cerebral cortical hypoxia in newborn piglets. Brain Res. 553: 45-50.
43. 43. VANNUCCI, R.C. 1990. Experimental biology of cerebral hypoxia-ischemia: relation to perinatal brain damage. Pediatr. Res. 27: 317-326.
44. 44. VOLPE, J.J. 1995. Neurology of the Newborn, 3rd Ed. WB Saunders. Philadelphia.
45. 45. ZANELLI, S.A., Y. NUMAGAMI, J.E. MCGOWAN, O.P. MISHRA & M. DELIVORIA-PAPADOPOULOS. 1999. NMDA receptor-mediated calcium influx in cerebral cortical synaptosomes of the hypoxic guinea pig fetus. Neurochem. Res. 24: 437-446.