Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress

Annals of the New York Academy of Sciences

Volumn 1019, Issue , 2004, Pages 206-210

  Trougakos, Ioannis P ^a   Gonos, Efstathios S ^a  

^a INSTITUTE OF BIOLOGY   (Greece)

Author keywords

Apoptosis; Clusterin apolipoprotein J; Doxorubicin

Indexed keywords

CLUSTERIN; DOXORUBICIN; SMALL INTERFERING RNA;

CARCINOGENESIS; CELL DAMAGE; CELL DEATH; CONCENTRATION RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DATA ANALYSIS; DISEASE SEVERITY; DRUG SENSITIZATION; GENOTOXICITY; HOMEOSTASIS; HUMAN; HUMAN CELL; OSTEOSARCOMA; PROTEIN FUNCTION; PROTEIN SECRETION; STRESS; UPREGULATION;

EID: 3242682459     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1297.033     Document Type: Conference Paper

References (11)

1. WILSON, M.R. & S.B. EASTERBROOK-SMITH. 2000. Clusterin is a secreted mammalian chaperone. Trends Biochem. Sci. 25: 95-98.
2. CALERO, M., A. ROSTAGNO, E. MATSUBARA, et al. 2000. Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc. Res. Tech. 50: 305-315.
3. TROUGAKOS, I.P. & E.S. GONOS. 2002. Clusterin/apolipoprotein J in human aging and cancer. Int. J. Biochem. Cell. Biol. 34: 1430-1448.
4. GONOS, E.S., A. DERVENTZI, M. KVEIBORG, et al. 1998. Cloning and identification of genes that associate with mammalian senescence. Exp. Cell Res. 240: 66-74.
5. PETROPOULOU, C., I.P. TROUGAKOS, E. KOLETTAS, et al. 2001. Clusterin/apolipoprotein J is a novel biomarker of cellular senescence, that does not affect the proliferative capacity of human diploid fibroblasts. FEBS Lett. 509: 287-297.
6. TROUGAKOS, I.P., M. POULAKOU, M. STATHATOS, et al. 2002. Serum levels of the senescence biomarker clusterin/apolipoprotein J increase significantly in diabetes type II and during development of coronary heart disease or at myocardial infarction. Exp. Gerontol. 37: 1175-1187.
7. ELBASHIR, S.M., J. HARBORTH, W. LENDECKEL, et al. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.
8. GLEAVE, M.E., H. MIYAKE, T. ZELLWEGER, et al. 2001. Use of antisense oligonucleotides targeting the antiapoptotic gene, clusterin/testosterone- repressed prostate message 2, to enhance androgen sensitivity and chemosensitivity in prostate cancer. Urology 58: 39-49.
9. KALKA, K., N. AHMAD, T. CRISWELL, et al. 2000. Up-regulation of clusterin during phthalocyanine 4 photodynamic therapy-mediated apoptosis of tumor cells and ablation of mouse skin tumors. Cancer Res. 60: 5984-5987.
10. WALTON, M., D. YOUNG, E. SIRIMANNE, et al. 1996. Induction of clusterin in the immature brain following a hypoxic-ischemic injury. Brain Res. Mol. Brain Res. 39: 137-152.
11. DEBURE, L., J.L. VAYSSIERE, V. RINCHEVAL, et al. 2003. Intracellular clusterin causes juxtanuclear aggregate formation and mitochondrial alteration. J. Cell Sci. 116: 3109-3121.