Early prediction of severity in acute pancreatitis. Is this possible?

Journal of the Pancreas

Volumn 3, Issue 5, 2002, Pages 116-125

  Sandberg, Åke Andrén ^a,b   Borgström, Anders ^a,b,c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c MALMÖ UNIVERSITY   (Sweden)

Author keywords

Acute necrotizing; Biological markers; C reactive protein; Cytokines; Diagnostic techniques; Diagnostic techniques endocrine; Digestive system; Health status indicators; Pancreatitis; Peptides (diagnostic use); Severity of illness index; Trypsin (diagnostic use)

Indexed keywords

AMYLASE; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; BIOCHEMICAL MARKER; C REACTIVE PROTEIN; CARBOXYPEPTIDASE B; CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 8; PANCREAS ENZYME; TRIACYLGLYCEROL LIPASE; TRYPSIN; TRYPSINOGEN; TRYPSINOGEN ACTIVATION PEPTIDE; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL PAIN; ACUTE PANCREATITIS; CYTOKINE PRODUCTION; DIAGNOSTIC ACCURACY; DIGESTIVE TRACT PARAMETERS; DISEASE SEVERITY; ENDOSCOPIC SPHINCTEROTOMY; HOSPITAL ADMISSION; HUMAN; INFLAMMATION; MEDIATOR RELEASE; MORTALITY; PATHOPHYSIOLOGY; PREDICTION; PROGNOSIS; REVIEW; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; ACUTE DISEASE; BLOOD; COMPARATIVE STUDY; EDITORIAL; ENZYMOLOGY; HOSPITALIZATION; PANCREATITIS; PREDICTION AND FORECASTING;

ACUTE DISEASE; HUMANS; PANCREATITIS; PREDICTIVE VALUE OF TESTS; PROGNOSIS; SEVERITY OF ILLNESS INDEX;

EID: 3242679665     PISSN: 15908577     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. Ranson JH, Rifkind KM, Roses DF, Fink SD, Eng K, Spencer FC. Prognostic signs and the role of operative management in acute pancreatitis. Surg Gynecol Obstet 1974; 139:69-81. [AN 74263630]
2. Imrie CW, Benjamin IS, Ferguson JC, McKay AJ, Mackenzie I, O'Neill J, Blumgart LH. A single-center double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg 1978; 65:337-41. [AN 78166422]
3. Larvin M, McMahon MJ. APACHE-II score for assessment and monitoring of acute pancreatitis. Lancet 1989; 2:201-5. [AN 89313013]
4. Banks PA. Predictors of severity in acute pancreatitis. Pancreas 1991; 6(Suppl 1):S7-12. [AN 92158985]
5. Pederzoli P, Bassi C, Vesentini S, Campedelli A. A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 1993; 176:480-3. [AN 93242503]
6. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, et al. Early antibiotic treatment in acute necrotising pancreatitis. Lancet 1995; 346:663-7. [AN 95387770]
7. Neoptolemos JP, Carr-Locke DL, London NJ, Bailey IA, James D, Fossard DP. Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988; 2:979-83. [AN 89013632]
8. Messori A, Rampazzo R, Scroccaro G, Olivato R, Bassi C, Falconi M, et al. Effectiveness of gabexate mesilate in acute pancreatitis. A metaanalysis. Dig Dis Sci 1995; 40:734-8. [AN 95236882]
9. Cavallini G, Tittobello A, Frulloni L, Masci E, Mariani A, Di Francesco V. Gabexate for the prevention of pancreatic damage related to endoscopic retrograde cholangiopancreatography. N Eng J Med 1996; 335:961-3. [AN 96365276]
10. Rinderknecht H. Activation of pancreatic zymogens. Normal activation, premature intrapancreatic activation, protective mechanisms against inappropriate activation. Dig Dis Sci 1986; 31:314-21. [AN 86135215]
11. Glasbrenner B, Adler G. Pathophysiology of acute pancreatitis. Hepatogastroenterology 1993; 40:517-21. [AN 94164589]
12. Ohlsson K, Balldin G, Bohe M, Borgström A, Genell S, Lasson Å. Pancreatic proteases and antiproteases in pancreatic disease; biochemical, pathophysiological and clinical aspects. Int J Pancreatol 1988; 3(Suppl 1): S67-78. [AN 89094006]
13. Lasson Å, Laurell AB, Ohlsson K. Correlation among complement activation, protease inhibitors, and clinical course in acute pancreatitis in man. Scand J Gastroenterol 1985; 20:335-45. [AN 85218451]
14. Lasson Å, Ohlsson K. Changes in the kallikrein kinin system during acute pancreatitis in man. Thromb Res 1984; 35:27-41. [AN 84300885]
15. Lasson Å, Ohlsson K. Systemic involvement in pancreatic damage: coagulation and fibrinolysis. Int J Pancreatol 1988; 3(Suppl 1): S79-86. [AN 89094007]
16. Nevalainen TJ. Phospholipase A2 in acute pancreatitis. Scand J Gastroenterol 1988; 23:897-904. [AN 89072496]
17. Appelros S, Thim L, Borgström A. The activation peptide of carboxypeptidase B in serum and urine in acute pancreatitis. Gut 1998; 42:97-102. [AN 98166792]
18. Büchler M, Malfertheiner P, Uhl W, Beger HB. Diagnostic and prognostic value of serum elastase 1 in acute pancreatitis. Klin Wochenschr 1986; 64:1186-91. [AN 87113796]
19. Nagai H, Henrich H, Wunsch PH, Fischbach W, Mössner J. Role of pancreatic enzymes and their substrates in autodigestion of the pancreas. In vitro studies with isolated rat pancreatic acini. Gastroenterology 1989; 96:838-47. [AN 89121403]
20. Dominguez-Munoz JE, Carballo F, Garcia MJ, de Diego JM, Rábago L, Simón MA, de la Morena J. Clinical usefulness off polymorphonuclear elastase in predicting the severity of acute pancreatitis: results of a multicentre study. Br J Surg 1991; 78:1230-4. [AN 92069552]
21. Gross V, Schölmerich J, Leser HG, Salm R, Lausen M, Ruckauer K, et al. Granulocyte elastase in assessment of acute pancreatitis. Dig Dis Sci 1990; 35:97-105. [AN 90107663]
22. Kusske AM, Rongione AJ, Reber HA. Cytokines and acute pancreatitis. Gastroenterology 1996; 110:639-42. [AN 96156071]
23. Formela LJ, Galloway SW, Kingsnorth AN. Inflammatory mediators in acute pancreatitis. Br J Surg 1995; 82:6-13. [AN 95187762]
24. Pezzilli R, Billi P, Miniero R, Fiocchi M, Cappelletti O, Morselli-Labate AM, et al. Serum interleukin-6, interleukin-8, and beta 2-microglobulin in early assessment of severity of acute pancreatitis. Comparison with serum C-reactive protein. Dig Dis Sci 1995; 40:2341-8. [AN 96083453]
25. Gross V, Andreesen R, Leser HG, Ceska M, Liehl E, Lausen M, et al. Interleukin-8 and neutrophil activation in acute pancreatitis. Eur J Clin Invest 1992; 22:200-3. [AN 92258463]
26. Mayer J Rau B, Gansauge F, Beger HG. Inflammatory mediators in human acute pancreatitis: clinical and pathophysiological implications. Gut 2000; 47:546-52. [AN 20444133]
27. Wilson C, Heads A, Shenkin A, Imrie CW. Creactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis. Br J Surg 1989; 76:177-81. [AN 89194750]
28. Kylänpää-Bäck ML, Takala A, Puolakkainen P, Kautiainen H, Jansson SE, Haapiainen R, Repo H. Cellular markers of systemic inflammation and immune suppression in patients with organ failure due to severe acute pancreatitis. Scand J Gastroenterol 2001; 36:1100-7. [AN 21473074]
29. Borgström A, Lasson Å. Trypsin-alpha1-protease inhibitor complexes in serum and clinical course in acute pancreatitis. Scand J Gastroenterol 1984; 19:1119-22. [AN 85192340]
30. Hedström J, Sainio V, Kemppainen E, Haapiainen R, Kivilaakso E, Schröder T, et al. Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: clinical study in consecutive patients. Br Med J 1996; 313:333-7. [AN 96343745]
31. Gudgeon AM, Heath DI, Hurley P, Jehanli A, Patel G, Wilson C, et al. Trypsinogen activation peptides assay in the early prediction of severity of acute pancreatitis. Lancet 1990; 335:4-8. [AN 90113538]
32. Neoptolemos JP, Kemppainen EA, Mayer JM, Fitzpatrick JM, Raraty MG, Slavin J, et al. Early prediction of severity in acute pancreatitis by urinary trypsinogen activation peptide: a multicentre study. Lancet 2000; 355:1955-60. [AN 20315573]
33. Appelros S, Petersson U, Toh S, Johnson C, Borgström A Activation peptide of carboxypeptidase B and anionic trypsinogen as early predictors of severity of acute pancreatitis. Br J Surg 2001; 88:216-21. [AN 21095476]
34. Müller CA, Appelros S, Uhl W, Büchler MW, Borgström A. Serum levels of procarboxypeptidase B and its activation peptide in patients with acute pancreatitis and non-pancreatic diseases. Gut 2002; 51:229-35. [AN 22112739]
35. Sainio V, Puolakkainen P, Kemppainen E, Hedström J, Haapiainen R, Kivisaari L, et al. Serum trypsinogen-2 in the prediction of outcome in acute necrotizing pancreatitis. Scand J Gastroenterol 1996; 31:818-24. [AN 97011762]
36. Hedström J, Kemppainen E, Andersen J, Jokela H, Puolakkainen P, Stenman UH. A comparison of serum trypsinogen-2 and trypsin-2-alpha1-antitrypsin complex with lipase and amylase in the diagnosis and assessment of severity in the early phase of acute pancreatitis. Am J Gastroenterol 2001; 96:424-30. [AN 21122346]
37. Lempinen M, Kylanpaa-Bäck ML, Stenman UH, Puolakkainen P, Haapiainen R, Finne P, et al. Predicting the severity of acute pancreatitis by rapid measurement of trypsinogen-2 in urine. Clin Chem 2001; 47:2103-7. [AN 21575880]
38. Kemppainen E, Hedström J, Puolakkainen P, Halttunen J, Sainio V, Haapiainen R, et al. Increased serum trypsinogen 2 and trypsin 2-alpha-1-antitrypsin complex values identify endoscopic retrograde cholangiopancreatography induced pancreatitis with high accuracy. Gut 1997; 41:690-5. [AN 98076681]
39. Hedström J, Korvuo A, Kenkimäki P, Tikanoja S, Haapiainen R, Kivilaakso E, Stenman UH. Urinary trypsinogen-2 test strip for acute pancreatitis. Lancet 1996; 347:729-30. [AN 96181133]
40. Petersson U, Appelros S, Borgström A. Different patterns in immunoreactive anionic and cationic trypsinogen in urine and serum in acute pancreatitis. Int J Pancreatol 1999; 25:165-170. [AN 99382790]
41. Gumaste V, Dave P, Sereny G. Serum lipase: a better test to diagnose acute alcoholic pancreatitis. Am J Med 1992; 92:239-42. [AN 92189026]
42. Håkansson HO, Borgström A, Ohlsson K. Human cationic pancreatic elastase in acute pancreatitis. Scand J Clin Lab Invest 1993; 53:17-24. [AN 93197822]
43. Beutler B, Cerami A. Cachectin: more than a tumor necrosis factor. N Eng J Med 1987; 316:379-85. [AN 87115667]
44. Exley AR, Leese T, Holliday MP, Swann RA, Cohen J. Endotoxaemia and serum tumour necrosis factor as prognostic markers in severe acute pancreatitis. Gut 1992; 33:1126-8. [AN 93013161]
45. De Beaux AC, Goldie AS, Ross JA, Carter DC, Fearon KCH. Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis. Br J Surg 1996; 83:349-53. [AN 96246258]
46. McKay CJ, Gallagher G, Brooks B, Imrie CW, Baxter JN. Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. Br J Surg 1996; 83:919-23. [AN 96408790]
47. Dominguez-Munoz JE, Carballo F, Garcia MJ, de Diego JM, Gea F, Yangüela J, de la Morena J. Monitoring of serum proteinase-antiproteinase balance and systemic inflammatory response in prognostic evaluation of acute pancreatitis. Results of a prospective multicenter study. Dig Dis Sci 1993; 38:507-13. [AN 93185467]
48. Borgström A, Lasson Å, Ohlsson K. Patterns of immunoreactive trypsin in serum from patients with acute abdominal disorders. Scand J Clin Lab Invest 1989; 49:757-62. [AN 90140422]
49. Winslet M, Hall C, London NJ, Neoptolemos JP. Relation of diagnostic serum amylase levels to aetiology and severity of acute pancreatitis. Gut 1992; 33:982-6. [AN 92354973]
50. Clavien PA, Burgan S, Moossa AR. Serum enzymes and other laboratory tests in acute pancreatitis. Br J Surg 1989; 76;1234-43. [AN 90106122]
51. Millat B, Fingerhut A, Gayral F, Zazzo JF, Brivet F. Predictability of clinicobiochemical scoring systems for early identification of severe gallstone-associated pancreatitis. Am J Surg 1992; 164:32-8. [AN 92328089]
52. Blamey SL, Imrie CW, O'Neill J, Gilmour WH, Carter DC. Prognostic factors in acute pancreatitis. Gut 1984; 25:1340-6. [AN 85077717]
53. Kemppainen E, Poulakkainen P, Leppaniemi A, Hietaranta A, Grönroos J, Happiainen R. Diagnosis of acute pancreatitis. Ann Chir Gynaecol 1998; 87:191-4. [AN 99042503]
54. Steer M. Pancreatitis severity: who calls the shots? Gastroenterology 2002; 122:1168-72. [AN 21906805]
55. Stimac D, Lenac T, Marusic Z. A scoring system for early differentiation of the etiology of acute pancreatitis. Scand J Gastroenterol 1998; 33:209-11. [AN 98176711]
56. Williams M, Simms HH. Prognostic usefulness of scoring systems in critically ill patients with severe acute pancreatitis. Crit Care Med 1999; 27:901-7. [AN 99289257]
57. Eachempati SR, Hydo LJ, Barie PS. Severity scoring for prognostication in patients with severe acute pancreatitis. Comparative analysis of the Ranson score and the APACHE III score. Arch Surg 2002; 137:730-6. [AN 22045017]
58. Imrie CW. Classification of acute pancreatitis and the role of prognostic factors in assessing severity of disease. Schweiz Med Wochenschr 1997; 127:798-804. [AN 97318258]
59. Fan ST, Lai EC, Mok FP, Lo CM, Zheng SS, Wong J. Prediction of the severity of acute pancreatitis. Am J Surg 1993; 166:262-8. [AN 93377960]
60. Wilson C, Heath DI, Imrie CW. Prediction of outcome in acute pancreatitis: a comparative study of APACHE II, clinical assessment and multiple factor scoring system. Br J Surg 1990; 77:1260-4. [AN 91070206]
61. Jaeschke R, Guyatt GH, Sackett DL. Users' Guides to the medical literature: How to use an article about a diagnostic test.B. What are the results and will they help me in caring for my patients? The Evidence-Based Medicine Working Group. JAMA 1994; 271:703-7. [AN 94142091]
62. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin Chem 1993; 39:561-77. [AN 93230672]
63. Bradley EL. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Arch Surg 1993; 128:586-90. [AN 93256758]