DNA arms do the legwork to ensure the directionality of λ site-specific recombination

Current Opinion in Structural Biology

Volumn 16, Issue 1, 2006, Pages 42-50

  Radman Livaja, Marta ^a   Biswas, Tapan ^b   Ellenberger, Tom ^b   Landy, Arthur ^a   Aihara, Hideki ^b  

^a BROWN UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TETRAMER;

BACTERIOPHAGE LAMBDA; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; DNA BINDING; DNA CLEAVAGE; ESCHERICHIA COLI; GENOME; HOLLIDAY JUNCTION; NONHUMAN; PRIORITY JOURNAL; REVIEW;

BACTERIOPHAGE LAMBDA; DNA, VIRAL; INTEGRASES; RECOMBINATION, GENETIC; VIRUS INTEGRATION;

ENTEROBACTERIA PHAGE LAMBDA; ESCHERICHIA COLI;

EID: 32344451042     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sbi.2005.12.003     Document Type: Review

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40. ••] is important for DNA cleavage by an Int tetramer, in addition to the previously documented intramolecular role of β9 in positioning the Y342 nucleophile.
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50. ••].
51. •• ]. These peptides specifically recognize structural features of four-way DNA junctions, and have proven to be great tools for trapping unstable HJ intermediates of the λ and Cre systems, thus facilitating their biochemical and structural characterization.