Does redox regulation of cell function explain why antioxidants perform so poorly as therapeutic agents?

Redox Report

Volumn 4, Issue 3, 1999, Pages 129-131

  Gutteridge, John M C ^a  

^a ROYAL BROMPTON AND HAREFIELD NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; IRON; REACTIVE OXYGEN METABOLITE;

CELL FUNCTION; HUMAN; NOTE; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; CELLS; HOMEOSTASIS; HUMANS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES;

EID: 0032777558     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100099101534819     Document Type: Note

References (27)

1. Gutteridge JMC, Halliwell B. Antioxidants in Nutrition, Health and Disease. Oxford: Oxford University Press, 1994.
2. Halliwell B, Gutteridge JMC. Free Radicals in Biology and Medicine. Oxford: Oxford University Press, 1999.
3. Halliwell B, Gutteridge JMC. Oxygen free radicals and iron in relation to biology and medicine: some problems and concepts. Arch Biochem Biophys 1986; 246: 501-514.
4. Saran M, Bors W. Oxygen radicals acting as chemical messengers: a hypothesis. Free Radic Res Commun 1989; 7: 213-220.
5. Chaudhri G, Hunt NH, Clark IA, Ceredig R. Antioxidants inhibit proliferation and cell surface expression of receptors for interleukin-2 and transferrin in T lymphocytes stimulated with phorbol myristate acetate and ionomycin. Cell Immunol 1988; 115: 204-213.
6. Thomas HV, Mueller PK, Lyman RL. Lipoperoxidation of lung lipids in rats exposed to nitrogen dioxide. Science 1968; 159: 532-534.
7. Moncada S, Higgs EA. Endogenous nitric oxide: physiology, pathology and clinical relevance. Eur J Clin Invest 1991; 21: 361-374.
8. . with superoxide. Free Radic Res Commun 1993; 18: 195-199.
9. Pryor WA, Squadrito GL. The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am J Physiol 1993; 268: L699-L722.
10. Kaur H, Whitemar M, Halliwell B. Peroxynitritc-dependent aromatic hydroxylation and nitration of salicylate and phenylalanine. Is hydroxyl radical involved? Free Radic Res 1997; 26: 71-82.
11. Babior BM. Oxygen-dependent microbial killing by phagocytes. N Engl J Med 1978; 298: 721-725.
12. Peng HB, Libby P, Liao JK. Induction and stabilization of I Kappa B alpha by NO mediates inhibition of NF-Kappa B. J Biol Chem 1995; 270: 14214-14219.
13. Laurindo FR, da Luz PL, Vint L, Rocha TF, Jaeger RG, Lopes EA. Evidence for superoxide radical-dependent coronary vasospasm after angioplasty in intact dogs. Circulation 1991; 83: 1705-1715.
14. Halliwell B. Superoxide, iron, vascular endothelium and reperfusion injury. Free Radic Res Commun 1989; 5: 315-318.
15. Castro L, Rodriguez M, Radi R. Aconitase is readily inactivated by peroxynitrite but not by its precursor nitric oxide. J Biol Chem 1994; 269: 29409-29415.
16. Rubbo H, Darley-Usmar V, Halliwell B. Nitric oxide regulation of tissue free radical activity. Chem Res Toxicol 1996; 9: 809-820.
17. Lamb NJ, Gutteridge JMC, Evans TW, Baker CS, Quinlan GJ. Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with ARDS. Evidence for neutrophil mediated hydroxylation, nitration and chlorination. Crit Care Med 1999; In press.
18. Cabantchik ZI, Glickstein H, Milgram P, Breuer W. A fluorescence assay for assessing chelation of intracellular iron in a membrane model system and in mammalian cells. Anal Biochem 1996; 233: 221-227.
19. Gutteridge JMC. The antioxidant activity of haptoglobins towards haemoglobin stimulated lipid peroxidation. Biochim Biophys Acta 1987; 917: 219-223.
20. Gutteridge JMC, Smith A. Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation. Biochem J 1988; 256: 261-265.
21. Gutteridge JMC, Stocks J. Caeruloplasmin: physiological and pathological perspectives. Crit Rev Clin Lab Sci 1981; 14: 257-329.
22. Schrek R, Albermann K, Bacuerle PA. Nuclear factor kappa B: an oxidative stress-responsible transcription factor of eukaryotic cells (a review). Free Radic Res Commun 1992; 17: 221-237.
23. Steinberg D, Pathasarathy S, Carew TE et al. Beyond cholesterol, modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989; 320: 915-924.
24. Gey KF, Pusak P, Jordan P, Moser VK. Inverse correlation between plasma vitamin E and mortality from ischaemic heart disease in cross-cultural epidemiology. Am J Clin Nutr 1991; 53: 3265-3345.
25. Greenwald RA. Therapeutic benefits of oxygen radical scavenger treatments remain unproven. J Free Radic Biol Med 1985; 1: 173-178.
26. Li P-F, Dietz R, von Harsdorf R. Superoxide induces apoptosis in cardiomyocytes but proliferation and expression of transforming growth factor-B-1 in cardiac fibroblasts. Fed Eur Biochem Soc Lett 1999; 448: 206-210.
27. 2 in relation to mammalian cell proliferation. Free Radic Biol Med 1994; 18: 775-794.