Molecular analysis of the interaction of the pyrazine derivatives RPR119990 and RPR117824 with human AMPA-type glutamate receptor channels

Neuropharmacology

Volumn 50, Issue 4, 2006, Pages 479-490

  Krampfl, Klaus ^a   Schlesinger, Friedrich ^a   Cordes, Anna Lena ^a   Bufler, Johannes ^a  

^a CENTER FOR SYSTEMS NEUROSCIENCE   (Germany)

Author keywords

Competitive inhibition; Computer calculation; Kinetic analysis; Patch clamp; Pyrazine derivatives; Recombinant AMPA type receptors

Indexed keywords

9 CARBOXYMETHYL 4 OXO 5H,10H IMIDAZOL[1,2 A] INDENO[1,2 E]PYRAZIN 2 PHOSPHONIC ACID; 9 CARBOXYMETHYL 5H,100H IMIDAZOL[1,2 A] INDENO[1,2 E]PYRAZIN 4 ONE 2 CARBOCYCLIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR 1; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 6; ION CHANNEL; LIGAND; OLIGOMER; PYRAZINE DERIVATIVE; RECOMBINANT RECEPTOR; RPR 117824; RPR 119990; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; COMPETITIVE INHIBITION; COMPUTER SIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BINDING SITE; DRUG MECHANISM; DRUG MEGADOSE; EMBRYO; EQUILIBRIUM CONSTANT; HUMAN; HUMAN CELL; IC 50; ION CURRENT; OBSERVATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RECEPTOR DOWN REGULATION;

CELL LINE; HUMANS; IMIDAZOLES; KIDNEY; KINETICS; PYRAZINES; RECEPTORS, AMPA; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 32144433527     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2005.10.010     Document Type: Article

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