Imidazo[1,2-b][1,2,4]triazines as α2/α3 subtype selective GABAA agonists for the treatment of anxiety

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1477-1480

  Jennings, Andrew S R ^a   Lewis, Richard T ^a   Russell, Michael G N ^a   Hallett, David J ^a   Street, Leslie J ^a   Castro, José L ^a   Atack, John R ^a   Cook, Susan M ^a   Lincoln, Rachael ^a   Stanley, Joanna ^a   Smith, Alison J ^a   Reynolds, David S ^a   Sohal, Bindi ^a   Pike, Andrew ^a   Marshall, George R ^a   Wafford, Keith A ^a   Sheppard, Wayne F A ^a   Tye, Spencer J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

2 3 subtype selective; Anxiolytic; GABAA receptors; Imidazo 1,2 a pyrimidines; Imidazo 1,2 b 1,2,4 triazines

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; ANXIOLYTIC AGENT; IMIDAZO[1,2 A]PYRIMIDINE DERIVATIVE; IMIDAZO[1,2 B][1,2,4]TRIAZINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOG; DRUG BINDING SITE; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; FEMALE; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ADMINISTRATION, ORAL; ANIMALS; ANXIETY DISORDERS; ATAXIA; BINDING SITES; BIOLOGICAL AVAILABILITY; DISEASE MODELS, ANIMAL; DOGS; FEMALE; GABA AGONISTS; IMIDAZOLES; MALE; MAZE LEARNING; MOLECULAR STRUCTURE; PROTEIN SUBUNITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SAIMIRI; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

ANIMALIA; CANIS FAMILIARIS;

EID: 32044474168     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.044     Document Type: Article

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