Mechanism of HBV genome variability and replication of HBV mutants

Journal of Clinical Virology

Volumn 34, Issue SUPPL. 1, 2005, Pages

  Tong, Shuping ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

Core promoter mutants; Encapsidation signal; Hepatitis B virus; Replication; Transfection; Translation initiation; Virion secretion

Indexed keywords

HEPATITIS B(E) ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; GENE MAPPING; GENE REPLICATION; GENETIC VARIABILITY; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HEPATOMA CELL; HUMAN; MISSENSE MUTATION; MOLECULAR CLONING; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN GLYCOSYLATION; RACE DIFFERENCE; SITE DIRECTED MUTAGENESIS; VIREMIA; VIRION; VIRUS MUTANT; VIRUS MUTATION; VIRUS REPLICATION;

GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; HEPATITIS B; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HUMANS; MUTATION; PROMOTER REGIONS (GENETICS); VIRUS REPLICATION;

EID: 32044468107     PISSN: 13866532     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6532(05)80023-X     Document Type: Article

References (25)

1. Ahn S., Kramvis A., Kawai S., Spangenberg H., Li J., and Kimbi G. Sequence variation upstream of precore translation initiation codon reduces hepatitis B virus e antigen production Gastroenterology 125 2003 1370 1378
2. Bang G., Kim K., Guarnied M., Zoulim F., Kawai S., and Li J. Effect of mutating the two cysteines required for HBe antigenicity on hepatitis B virus DNA replication and virion secretion Virology 332 2005 216 224
3. Baptista M., Kramvis A., and Kew M. High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from Black Africans with hepatocellular carcinoma compared with asymptomatic carriers Hepatology 29 1999 946 953
4. Baumert T., Rogers S., Hasegawa K., and Liang T. Two core promoter mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication J Clin Invest 98 1996 2268 2276
5. Buckwold V., Xu Z., Chen M., Yen T., and Ou J. Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication J Virol 70 1996 5845 5851
6. Chu C., and Lok A. Clinical significance of hepatitis B virus genotypes Hepatology 35 2002 1274 1276
7. in press Guamierm M., Kim K., Bang G., Li J., Zhou Y., and Tang X. Point mutations upstream of hepatitis B virus core gene affect DNA replication at the step of core protein expression J Virol 80 2 2006
8. Kalinina T., Iwanski A., Will H., and Sterneck M. Deficiency in virion secretion and decreased stability of the hepatitis B virus immune escape mutant G145R Hepatology 38 2003 1274 1281
9. Kao J., Chen P., Lai M., and Chen D. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers Gastroenterology 124 2003 327 334
10. Khan N., Guarnied M., Ahn S., Li J., Zhou Y., and Bang G. Modulation of hepatitis B virus secretion by naturally occurring mutations in the S gene J Virol 78 2004 3262 3270
11. Kozak M. At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells J Mol Biol 196 1987 947 950
12. Kuang S., Jackson P., Wang J., Lu P., Munoz A., and Qian G. Specific mutations of hepatitis B virus in plasma predict liver cancer development Proc Natl Acad Sci USA 101 2004 3575 3580
13. Le Pogam S., Yuan T., Sahu G., Chatterjee S., and Shih C. Low-level secretion of human hepatitis B virus virions caused by two independent, naturally occurring mutations (P5T and L60V) in the capsid protein J Virol 74 2000 9099 9105
14. Liang T., Hasegawa K., Rimon N., Wands J., and Ben-Porath E. A hepatitis B virus mutant associated with an epidemic of fulminant hepatitis B N Engl J Med 324 1991 1705 1709
15. Nielsen H., Engelbrecht J., Brunak S., and von Heijne G. Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites Protein Eng 10 1997 1 6
16. Okamoto H., Tsuda F., Akahane Y., Sugai Y., Yoshiba M., and Moriyama K. Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen J Virol 68 1994 8102 8110
17. Orito E., Mizokamm M., Sakugawa H., and Michitaka K. A case-control study for clinical and molecular biological differences between hepatitis B viruses of genotypes B and C Hepatology 33 2001 218 233
18. Paetzel M., Karla A., Strynadka N., and Dalbey R. Signal peptidases Chem Rev 102 2002 4549 4579
19. Parekh S., Zoulim F., Ahn S., Tsai A., Li J., and Kawai S. Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants J Virol 77 2003 6601 6612
20. Sugauchi F., Kumada H., Acharya S., Shrestha S., Gamutan M., and Khan M. Epidemiological and sequence difference between two subtypes (Ae and Aa) of hepatitis B virus genotype A J Gen Virol 85 2004 811 820
21. Summ H., Yokosuka O., Seki N., and Arai M. Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease Hepatology 37 2003 19 26
22. Tanaka Y., Hasegawa I., Kato T., Orito E., Hirashima N., and Acharya S. A case-control study for differences among hepatitis B virus infections of genotypes A (subtypes Aa and Ae) and D Hepatology 40 2004 747 755
23. Tang H., Raney A., and McLachlan A. Replication of the wild type and a natural hepatitis B virus nucleocapsid promoter variant is differentially regulated by nuclear hormone receptors in cell culture J Virol 75 2001 8937 8948
24. Yu X., and Mertz J. Distinct modes of regulation of transcription of hepatitis B virus by the nuclear receptors HNF4α and COUP-TF1 J Virol 77 2003 2489 2499
25. Yuen M., Tanaka Y., Mizokamm M., Yuen C., and Wong D. Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations of hepatocellular carcinoma: a case control study Carcinogenesis 25 2004 1593 1598