Synthesis of Tic-D-Phe Ψ[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1721-1725

  Tian, Xinrong ^a   Chen, Xuemei ^a,b   Gan, Lixian ^a   Hayes, Jeffery C ^a   Switzer, Adrian G ^a   Solinsky, Mark G ^a   Ebetino, Frank H ^a   Wos, John A ^a   Pinney, Beth B ^a   Farmer, Julie A ^a   Crossdoersen, Doreen ^a   Sheldon, Russell J ^a  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Melanocortin agonists; Tic D Phe CH2 CH2 isostere

Indexed keywords

HORMONE RECEPTOR STIMULATING AGENT; LACTAM; MELANOCORTIN RECEPTOR; OLIGOPEPTIDE; TIC D PHE PSI(CH2 CH2) ISOSTERE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION; COMPLEX FORMATION; DIASTEREOISOMER; SYNTHESIS;

ALKYLATION; DIPEPTIDES; HUMANS; LACTAMS; LIGANDS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PHENYLALANINE; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 32044467410     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.005     Document Type: Article

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20. Details of this research will be reported elsewhere.