The progesterone derivative dydrogesterone down-regulates neurokinin 1 receptor expression on lymphocytes, induces a Th2 skew and exerts hypoalgesic effects in mice

Journal of Molecular Medicine

Volumn 84, Issue 2, 2006, Pages 159-167

  Orsal, Arif Suphi ^a   Blois, Sandra ^a   Labuz, Dominika ^a   Peters, Eva M J ^a   Schaefer, Martin ^a   Arck, Petra C ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Biomedizinisches Forschungszentrum   (Germany)

Author keywords

Cytokines; Dydrogesterone; Neurogenic inflammation; Neurokinin 1 receptor; Nociception; Progesterone

Indexed keywords

CYTOKINE; DYDROGESTERONE; NEUROKININ 1 RECEPTOR; PROGESTERONE; SESAME SEED OIL; SUBSTANCE P;

ARTICLE; CELL CULTURE; CELL ISOLATION; CELL SURFACE; CONCENTRATION RESPONSE; DRUG MECHANISM; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HELPER CELL; HORMONE ACTION; HYPOALGESIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LATENT PERIOD; LYMPHOCYTE; MOLECULAR INTERACTION; MOUSE; MOUSE STRAIN; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SPLEEN CELL; TAIL FLICK TEST; TH1 CELL; TH2 CELL; TISSUE DISTRIBUTION; UTERUS;

ANIMALS; CELLS, CULTURED; CYTOKINES; DOWN-REGULATION; DYDROGESTERONE; FEMALE; INFLAMMATION; LYMPHOCYTES; MAST CELLS; MICE; MICE, INBRED CBA; NEUROTRANSMITTER AGENTS; PAIN THRESHOLD; RECEPTORS, NEUROKININ-1; SUBSTANCE P; TH2 CELLS; UTERUS;

EID: 32044461523     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-005-0005-5     Document Type: Article

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