Synthesis and evaluation of an N-acylated photoactivatable analogue of glutathione as probe for glutathione-utilizing enzymes

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1601-1604

  Bernardi, Dan ^a   Battaglia, Eric ^a   Kirsch, Gilbert ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

Author keywords

Benzophenone; Glutathione; Glutathione S transferases; Inhibition; Photoaffinity labelling

Indexed keywords

GLUTATHIONE DERIVATIVE; GLUTATHIONE TRANSFERASE; N (4 BENZOYLBENZOYL)GLUTATHIONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; LIVER; NONHUMAN; PHOTOAFFINITY LABELING; RAT;

AFFINITY LABELS; ANIMALS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; LIVER; RATS;

ANIMALIA;

EID: 32044447156     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.047     Document Type: Article

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45. All reagents were purchased from Sigma. Purified rat liver GST (3.12 μg protein/mL) was assayed at 30°C in the presence of 1-chloro-2,4-dinitrobenzene (4 mM) and GSH (3 mM) for 4 min, together with (8) at the concentrations indicated in the figure. The residual activity was calculated, with the enzyme activity in the absence of (8) representing 100% residual activity.
46. 0 representing 100% residual activity. GST activity protection against photoinactivation by (8) (2 mM) was studied in the presence of GSH (5 mM).