Cardioprotective effect of calcium dobesilate during open-heart surgery

Acta Cardiologica

Volumn 61, Issue 1, 2006, Pages 69-74

  Iskesen, Ihsan ^a   Saribulbul, Osman ^a   Cerrahoglu, Mustafa ^a   Onur, Ece ^a   Tekin, Cetin ^a   Sirin, Hayrettin ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

Calcium dobesilate; Cardioplegic arrest; Myocardial protection

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CREATINE KINASE; CREATINE KINASE MB; DOBESILATE CALCIUM; LACTIC ACID; MYOGLOBIN; TROPONIN T;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY SINUS; DOUBLE BLIND PROCEDURE; ELECTIVE SURGERY; FEMALE; HEART MUSCLE INJURY; HEART PROTECTION; HUMAN; LACTATE BLOOD LEVEL; MALE; OPEN HEART SURGERY; PREOPERATIVE TREATMENT; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; CALCIUM DOBESILATE; CARDIAC SURGICAL PROCEDURES; CREATINE KINASE; CREATINE KINASE, MB FORM; DOUBLE-BLIND METHOD; FEMALE; HEMOSTATICS; HUMANS; MALE; MIDDLE AGED; MYOGLOBIN; PREOPERATIVE CARE; PROSPECTIVE STUDIES; TREATMENT OUTCOME; TROPONIN T;

EID: 32044443893     PISSN: 00015385     EISSN: None     Source Type: Journal    
DOI: 10.2143/AC.61.1.2005142     Document Type: Article

References (18)

1. Szlavy L, Kubik S, de Courten A, Hachen HJ, Solti F. CLS 2210, hyaluronidase and the cardiac lymphatic system. Angiology 1985; 36: 452-7.
2. Szlavy L, Repa I, Szabo Z, de Courten A, Hachen HJ. Salvage of ischemic myocardium by CLS 2210 in the dog: a preliminary double-blind study. Angiology 1987; 38: 85-91.
3. Repa I, Garnic JD, Hollenberg NK. Myocardial infarction treated with two lymphagogues, calcium dobesilate (CLS 2210) and hyaluronidase: a coded, placebo-controlled animal study. J Cardiovasc Pharmacol 1990; 16: 286-91.
4. Huttl K, Hollenberg NK. Effect of CLS 2210 (calcium dobesilate) on survival and myocardial infarction size in the rat: influence of dose and duration of treatment. Cardiology 1992; 80: 28-33.
5. Hannaert P, Brunet J, Farine JC, Garay RP. Antioxidant-angioprotective actions of calcium dobesilate in diabetic rats. Int J Angiol 1999; 8: 2-4.
6. Rota R, Chiavaroli C, Garay RP, Hannaert P. Reduction of retinal albumin leakage by the antioxidant calcium dobesilate in streptozotocin-diabetic rats. Eur J Pharmacol 2004; 495: 217-24.
7. Pares-Herbute N, Fliche E, Monnier L. Involvement of nitric oxide in the inhibition of aortic smooth muscle cell proliferation by calcium dobesilate. Int J Angiol 1999; 8: 5-10.
8. Benarroch IS, Brodsky M, Rubinstein A, Viggiano C, Salama EA. Treatment of blood hyperviscosity with calcium dobesilate in patients with diabetic retinopathy. Ophthalmic Res 1985; 17: 131-8.
9. Tejerina T, Ruiz E. Calcium dobesilate: pharmacology and future approaches. Gen Pharmacol 1998; 31: 357-60.
10. Szlavy L, Repa I, Lengyel I, Lamboy L. Calcium dobesilate (CLS 2210) protects the myocardium in early acute myocardial infarction: a preliminary randomized, double-blind, placebo-controlled study of its effects on biochemical markers. J Cardiovasc Pharmacol 1990; 15: 89-95.
11. Szlavy L, Koster K, de Courten A, Hollenberg NK. Early disappearance of lymphatics draining ischemic myocardium in the dog. Angiology 1987; 38: 73-84.
12. Gloviczki P, Solti F, Szlavy L, Jellinek H. Ultrastructural and electrophysiologic changes of experimental acute cardiac lymphostasis. Lymphology 1983; 16: 185-92.
13. Szlavy L, Repa I, De Courten A. Influence of a lymphagogue, CLS 2210, on regional cardiac lymphatics and the electrocardiogram after coronary artery occlusion in the dog. Lymphology 1986; 19: 15-20.
14. Penttila K, Koukkunen H, Halinen M, Rantanen T, Pyorala K, Punnonen K, Penttila I. Myoglobin, creatine kinase MB isoforms and creatine kinase MB mass in early diagnosis of myocardial infarction in patients with acute chest pain. Clin Biochem 2002; 35: 647-53.
15. Szlavy L, Repa I, Lengye I, Lamboy L. Effects of intravenous streptokinase and CLS 2210 (calcium dobesilate) on the biochemical markers of early acute myocardial infarction: a historic comparison with both studies. Angiology 1992; 43: 741-7.
16. Szlavy L, Repa I, Hachen HJ. The influence of CLS 2210 on the course of myocardial infarction: a pilot study in man. Angiology 1991; 42: 639-47.
17. Szabo ME, Haines D, Garay E, Chiavaroli C, Farine JC, Hannaert P, Berta A, Garay RP. Antioxidant properties of calcium dobesilate in ischemic/reperfused diabetic rat retina. Eur J Pharmacol 2001; 428: 277-86.
18. Bozkurt AK, Konukoglu D, Ustundag N, Yuceyar L, Mayda AS. Calcium dobesilate ameliorates lung injury following lower limb ischemia/reperfusion. Drugs Exp Clin Res 2002; 28: 127-32.