Evaluation of the binding characteristics of [5-11C-methoxyl]donepezil in the rat brain for in vivo visualization of acetylcholinesterase

Journal Pharmacological Sciences

Volumn 91, Issue 2, 2003, Pages 105-112

  Funaki, Yoshihito ^b   Kato, Motohisa ^a   Iwata, Ren ^b   Sakurai, Eiko ^a   Sakurai, Eiichi ^c   Tashiro, Manabu ^a   Ido, Tatsuo ^b   Yanai, Kazuhiko ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Acetylcholinesterase; Binding; Donepezil; Positron emission tomography; Tacrine

Indexed keywords

ACETYLCHOLINESTERASE; CARBON 11; DONEPEZIL; DRUG METABOLITE; TRIFLUOROMETHANESULFONIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING KINETICS; BRAIN HOMOGENATE; BRAIN REGION; BRAIN STEM; CELL HETEROGENEITY; CEREBELLUM; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DISTRIBUTION; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HIPPOCAMPUS; IC 50; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MESENCEPHALON; METHYLATION; NON INVASIVE MEASUREMENT; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT;

EID: 0037687964     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.91.105     Document Type: Article

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