Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[f]-fluorobenzyl)-4-piperidinyl]ethyl]-6h-pyrrolo[3,2-f]-1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase*

Nuclear Medicine Communications

Volumn 25, Issue 6, 2004, Pages 591-596

  Lee, Sang Yoon ^a   Choe, Yearn Seong ^a   Kim, Yu Ri ^a   Paik, Jin Young ^a   Choi, Byoung Wook ^a   Kim, Sang Eun ^a   Lee, Kyung Han ^a   Choi, Yong ^a   Kim, Byung Tae ^a  

^a Samsung Medical Center   (South Korea)

Author keywords

4 F fluoro CP 118,954; Acetylcholinesterase; Acetylcholinesterase inhibitor; Alzheimer's disease; PET

Indexed keywords

4 FLUOROBENZALDEHYDE; 4 METHYL 3 NITROANISOLE; 5,7 DIHYDRO 3 [2 [1 (2 FLUOROBENZYL) 4 PIPERIDINYL]ETHYL] 6H PYRROLO[3,2 F] 1,2 BENZISOXAZOL 6 ONE; 5,7 DIHYDRO 3 [2 [1 (4 FLUOROBENZYL) 4 PIPERIDINYL]ETHYL] 6H PYRROLO[3,2 F] 1,2 BENZISOXAZOL 6 ONE; 5,7 DIHYDRO 3 [2 [1 (PHENYLMETHYL) 4 PIPERIDINYL]ETHYL] 6H PYRROLO[3,2 F] 1,2 BENZISOXAZOL 6 ONE; ANISOLE DERIVATIVE; BENZALDEHYDE DERIVATIVE; CHOLINESTERASE INHIBITOR; CP 118954; FLUORINE 18; PIPERIDINE; RADIOLIGAND; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN SLICE; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; DRUG SCREENING; DRUG SYNTHESIS; GENE MAPPING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VIVO STUDY; INCUBATION TIME; MALE; MOUSE; NONHUMAN; RAT;

ACETYLCHOLINESTERASE; ANIMALS; BIOLOGICAL MARKERS; BRAIN; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; ISOXAZOLES; MALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED ICR; ORGAN SPECIFICITY; PIPERIDINES; RADIOPHARMACEUTICALS; RATS; TISSUE DISTRIBUTION;

EID: 2542570144     PISSN: 01433636     EISSN: 14735628     Source Type: Journal    
DOI: 10.1097/01.mnm.0000126629.09543.1d     Document Type: Article

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