Heritability of macular pigment: A twin study

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 12, 2005, Pages 4430-4436

  Liew, Shiao Hui Melissa ^a   Gilbert, Clare E ^b   Spector, Tim D ^a   Mellerio, John ^c   Marshall, John ^a   Van Kuijk, Fredericus J ^d   Beatty, Stephen ^e   Fitzke, Fred ^f   Hammond, Christopher J ^a,g  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c UNIVERSITY OF WESTMINSTER   (United Kingdom)

^d University of Texas Medical Branch School of Medicine   (United States)

^e Ireland   (Ireland)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

^g Bromley Hospitals NHS Trust   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; AUTOFLUORESCENCE; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; EYE FUNDUS; FEMALE; GENETIC MODEL; GENETIC PREDISPOSITION; HERITABILITY; HETEROCHROMATIC FLICKER PHOTOMETRY; HUMAN; MONOZYGOTIC TWINS; NORMAL HUMAN; OPTICAL DENSITY; PHOTOMETRY; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; RETINA MACULA LUTEA; ADOLESCENT; FLUORESCENCE; GENETICS; INFANT; INHERITANCE; METHODOLOGY; MIDDLE AGED; OPHTHALMOSCOPY; TWINS;

BETA CAROTENE; DRUG DERIVATIVE; VISUAL PIGMENT; XANTHOPHYLL; ZEAXANTHIN;

ADOLESCENT; ADULT; BETA CAROTENE; FEMALE; FLUORESCENCE; HUMANS; INFANT; INHERITANCE PATTERNS; LUTEIN; MIDDLE AGED; OPHTHALMOSCOPY; PHOTOMETRY; RETINAL PIGMENTS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; XANTHOPHYLLS;

EID: 31644438239     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.05-0519     Document Type: Article

References (60)

1. Bone RA, Landrum JT, Tarsis SL. Preliminary identification of the human macular pigment. Vision Res. 1985;25:1531-1535.
2. Malinow MR, Feeney-Burns L, Peterson LH, Klein ML, Neuringer M. Diet-related macular anomalies in monkeys. Invest Ophthalmol Vis Sci. 1980;19:857-863.
3. Snodderly DM, Brown PK, Delori FC, Auran JD. The macular pigment. I. Absorbance spectra, localization, and discrimination from other yellow pigments in primate retinas. Invest Ophthalmol Vis Sci. 1984;25:660-673.
4. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Carotenoids in the human macula and whole retina. Invest Ophthalmol Vis Sci. 1988;29:850-855.
5. Schalch W, Weber P. Vitamins and carotenoids - a promising approach to reducing the risk of coronary heart disease, cancer and eye diseases. Adv Exp Med Biol. 1994;366:335-3350.
6. Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr. 2003;23:171-201.
7. Snodderly DM, Auran JD, Delori FC. The macular pigment. II. Spatial distribution in primate retinas. Invest Ophthalmol Vis Sci. 1984;25:674-685.
8. Pease PL, Adams AJ, Nuccio E. Optical density of human macular pigment. Vision Res. 1987;27:705-10.
9. Khachik F, Bernstein PS, Garland DL. Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci. 1997;38:1802-1811.
10. Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy. The Beaver Dam Eye Study. Ophthalmology. 1992;99:933-943.
11. Beatty S, Koh H, Phil M, Henson D, Boulton M. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol. 2000;45:115-134.
12. Margrain TH, Boulton M, Marshall J, Sliney DH. Do blue light filters confer protection against age-related macular degeneration? Prog Retin Eye Res. 2004;23:523-531.
13. Cho E, Seddon JM, Rosner B, Willett WC, Hankinson SE. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. Arch Ophthalmol. 2004;122:883-892.
14. Gale CR, Hall NF, Phillips DI, Martyn CN. Lutein and zeaxanthin status and risk of age-related macular degeneration. Invest Ophthalmol Vis Sci. 2003;44:2461-2465.
15. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group. JAMA. 1994;272:1413-1420.
16. Snodderly DM. Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins. Am J Clin Nutr. 1995;62:1448S-1461S.
17. Beatty S, Boulton M, Henson D, Koh HH, Murray IJ. Macular pigment and age related macular degeneration. Br J Ophthalmol. 1999;83:867-877.
18. Beatty S, Murray IJ, Henson DB, Carden D, Koh H, Boulton ME. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Invest Ophthalmol Vis Sci. 2001;42:439-446.
19. Hammond BR Jr, Woolen BR, Snodderly DM. Individual variations in the spatial profile of human macular pigment. J opt Soc Am A Opt Image Sci Vis. 1997;14:1187-1196.
20. Hammond BR Jr, Wooten BR, Snodderly DM. Cigarette smoking and retinal carotenoids: implications for age-related macular degeneration. Vision Res. 1996;36:3003-3009.
21. Hammond BR Jr, Fuld K, Snodderly DM. Iris color and macular pigment optical density. Exp Eye Res. 1996;62:293-297.
22. Hammond BR Jr, Johnson EJ, Russell RM, et al. Dietary modification of human macular pigment density. Invest Ophthalmol Vis Sci. 1997;38:1795-1801.
23. Hammond BR Jr, Ciulla TA, Snodderly DM. Macular pigment density is reduced in obese subjects. Invest Ophthalmol Vis Sci. 2002;43:47-50.
24. Nolan J, O'Donovan O, Kavanagh H, et al. Macular pigment and percentage of body fat. Invest Ophthalmol Vis Sci. 2004;45:3940-3950.
25. Curran-Celentano J, Hammond BR Jr, Ciulla TA, Cooper DA, Pratt LM, Danis RB. Relation between dietary intake, serum concentrations, and retinal concentrations of lutein and zeaxanthin in adults in a Midwest population. Am J Clin Nutr. 2001;74:796-802.
26. Sommerburg O, Keunen JE, Bird AC, van Kuijk FJ. Fruits and vegetables that are sources for lutein and zeaxanthin: the macular pigment in human eyes. Br J Ophthalmol. 1998;82:907-910.
27. Hammond CJ, Webster AR, Snieder H, Bird AC, Gilbert CE, Spector TD. Genetic influence on early age-related maculopathy: a twin study. Ophthalmology. 2002;109:730-736.
28. Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science. 2005;308:385-389.
29. Seddon JM, Santangelo SL, Book K, Chong S, Cote J. A genome-wide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet. 2003;73:780-790.
30. Seddon JM, Cote J, Page WF, Aggen SH, Neale MC. The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences. Arch Ophthalmol. 2005;123:321-327.
31. Martin NG, Martin PG. The inheritance of scholastic abilities in a sample of twins. I. Ascertainments of the sample and diagnosis of zygosity. Ann Hum Genet. 1975;39:213-218.
32. Bone RA, Landrum JT, Fernandez L, Tarsis SL. Analysis of the macular pigment by HPLC: retinal distribution and age study. Invest Ophthalmol Vis Sci. 1988;29:843-849.
33. Mellerio J, Ahmadi-Lari S, van Kuijk F, Pauleikhoff D, Bird A, Marshall J. A portable instrument for measuring macular pigment with central fixation. Curr Eye Res. 2002;25:37-47.
34. Delori FC, Goger DG, Hammond BR, Snodderly DM, Burns SA. Macular pigment density measured by autofluorescence spectrometry: comparison with reflectometry and heterochromatic flicker photometry. J Opt Soc Am A Opt Image Sci Vis. 2001;18:1212-1230.
35. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG, Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol Vis Sci. 1995;36:718-729.
36. Delori FC. Autofluorescence method to measure macular pigment optical densities fluorometry and autofluorescence imaging. Arch Biochem Biophys. 2004;430:156-l62.
37. Robson AG, Moreland JD, Pauleikhoff D, et al. Macular pigment density and distribution: comparison of fundus autofluorescence with minimum motion photometry. Vision Res. 2003;43:1765-1775.
38. Delori FC, Goger DG, Dorey CK. Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects. Invest Ophthalmol Vis Sci. 2001;42:1855-1866.
39. Wustemeyer H, Moessner A, Jahn C, Wolf S. Macular pigment density in healthy subjects quantified with a modified confocal scanning laser ophthalmoscope. Graefes Arch Clin Exp Ophthalmol. 2003;241:647-651.
40. Neale MC. Mx: Statistical Modeling. Richmond, VA: Department of Psychiatry, Medical College of Virginia; 1997.
41. Neale MC, Cardon LA. Methodology for Genetic Studies of Twins and Families. Dordrecht, The Netherlands: Kluwer Academic Publishers; 1992.
42. Kyvic KO. Generalisability and assumptions of twin studies. In: Spector TD, Sneider H, MacGregor AJ, eds. Advances in Twin and Sib-Pair Analysis. London: Greenwich Medical Media; 2004:67-77.
43. Beatty S, Koh HH, Carden D, Murray IJ. Macular pigment optical density measurement: a novel compact instrument. Ophthalmic Physiol Opt. 2000;20:105-111.
44. Werner JS, Donnelly SK, Kliegl R. Aging and human macular pigment density: appended with translations from the work of Max Schultze and Ewald Hering. Vision Res. 1987;27:257-268.
45. Ciulla TA, Curran-Celantano J, Cooper DA, et al. Macular pigment optical density in a midwestern sample. Ophthalmology. 2001;108:730-737.
46. Hammond BR Jr, Caruso-Avery M. Macular pigment optical density in a Southwestern sample. Invest Ophthalmol Vis Sci. 2000;41:1492-1497.
47. Bone RA, Landrum JT, Gibert JC. Macular pigment and the edge hypothesis of flicker photometry. Vision Res. 2004;44:3045-3051.
48. Hammond BR Jr, Curran-Celentano J, Judd S, et al. Sex differences in macular pigment optical density: relation to plasma carotenoid concentrations and dietary patterns. Vision Res. 1996;36:2001-2012.
49. Bone RA, Sparrock JM. Comparison of macular pigment densities in human eyes. Vision Res. 1971;11:1057-1064.
50. Bone RA, Landrum JT, Dixon Z, Chen Y, Llerena CM. Lutein and zeaxanthin in the eyes, serum and diet of human subjects. Exp Eye Res. 2000;71:239-245.
51. Hammond BR Jr, Fuld K, Curran-Celentano J. Macular pigment density in monozygotic twins. Invest Ophthalmol Vis Sci. 1995;36:2531-2541.
52. Beatty S, Nolan J, Kavanagh H, O'Donovan O. Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin. Arch Biochem Biophys. 2004;430:70-76.
53. Lowe GM, Bilton RF, Davies IG, Ford TC, Billington D, Young AJ. Carotenoid composition and antioxidant potential in subtractions of human low-density lipoprotein. Ann Clin Biochem. 1999;36:323-332.
54. Middelberg RP, Spector TD, Swaminathan R, Snieder H. Genetic and environmental influences on lipids, lipoproteine, and apolipoproteins: effects of menopause. Arterioscler Thromb Vasc Biol. 2002;22:1142-1147.
55. Scholz M, Kraft HG, Lingenhel A, et al. Genetic control of lipoprotein(a) concentrations is different in Africans and Caucasians. Eur J Hum Genet. 1999;7:169-178.
56. Bhosale P, Larson AJ, Frederick JM, Southwick K, Thulin CD, Bernstein PS. Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye. J Biol Chem. 2004;279:49447-49454.
57. Yemelyanov AY, Katz NB, Bernstein PS. Ligand-binding characterization of xanthophyll carotenoids to solubilized membrane proteins derived from human retina. Exp Eye Res. 2001;72:381-392.
58. Edwards AO, Ritter R III, Abel KJ, Manning A, Panhuysen C, Farrer LA. Complement factor H polymorphism and age-related macular degeneration. Science. 2005;308:421-424.
59. Berendschot TT, Broekmans WM, Klopping-Ketelaars IA, Kardinaal AF, Van Poppel G, van Norren D. Lens aging in relation to nutritional determinants and possible risk factors for age-related cataract. Arch Ophthalmol. 2002;120:1732-1737.
60. Andrew T, Hart DJ, Snieder H, de Lange M, Spector TD, MacGregor AJ. Are twins and singletons comparable? - a study of disease-related and lifestyle characteristics in adult women. Twin Res. 2001;4:464-477.