Synthesis of potential purinoceptor antagonists: Application of P1-tBU phosphazene base for alkylation of adenine in solution and on solid phase

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 2, 2006, Pages 141-157

  Enkvist, Erki ^a   Raidaru, Gerda ^a   Uri, Asko ^a   Patel, Roshni ^b   Redick, Catherine ^b   Boyer, José L ^b   Subbi, Julian ^c   Tammiste, Indrek ^c  

^a UNIVERSITY OF TARTU   (Estonia)

^b Inspire Pharmaceuticals   (United States)

^c NATIONAL INSTITUTE OF CHEMICAL PHYSICS AND BIOPHYSICS   (Estonia)

Author keywords

Adenine alkylation; Nucleotide analog; Phosphazene base; Solid phase synthesis

Indexed keywords

ADENINE NUCLEOTIDE DERIVATIVE; ADENOSINE DIPHOSPHATE; BASE; MINERAL; N (ADENIN 9 YL ACETYL)IMINODIACETIC ACID; N (ADENIN 9 YL ACETYL)IMINODIACETIC ACID DIBENZYLESTER; N (BROMOACETYL)IMINODIACETIC ACID DIBENZYLESTER; N (N6 METHYLADENIN 9 YL ACETYL)IMINODIACETIC ACID; N (N6 METHYLADENIN 9 YL ACETYL)IMINODIACETIC ACID DIBENZYLESTER; PHOSPHORANE DERIVATIVE; POLYSTYRENE; PURINERGIC RECEPTOR BLOCKING AGENT; TERT BUTYLIMINO TRIS(DIMETHYLAMINO)PHOSPHORANE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CELL ASSAY; CHEMICAL BINDING; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SYNTHESIS; GENE INDUCTION; HUMAN; HUMAN CELL; ISOMER; NORMAL HUMAN; QUANTUM YIELD; SOLID; THROMBOCYTE AGGREGATION;

ADENINE; ALKYLATION; AZIRIDINES; HUMANS; PHOSPHORANES; PLATELET AGGREGATION INHIBITORS; POLYSTYRENES; RECEPTORS, PURINERGIC; SOLUTIONS; STEREOISOMERISM; TIME FACTORS;

EID: 31644437965     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770500446857     Document Type: Article

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