Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors

Seminars in Diagnostic Pathology

Volumn 22, Issue 1, 2005, Pages 3-32

  McCluggage, W Glenn ^a   Young, Robert H ^b  

^a ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Differential diagnosis; Immunohistochemistry; Ovarian neoplasm; Ovary

Indexed keywords

ALPHA FETOPROTEIN; BETA CATENIN; CALRETININ; EPITHELIAL MEMBRANE ANTIGEN; INHIBIN; PROTEIN P16; PROTEIN S 100; RACEMASE; THYROGLOBULIN; TRANSCRIPTION FACTOR CDX2; VILLIN;

CANCER CLASSIFICATION; CANCER STAGING; CARCINOID; DIFFERENTIAL DIAGNOSIS; ENDOMETRIOID CARCINOMA; EPENDYMOMA; GRANULOSA CELL TUMOR; IMMUNOHISTOCHEMISTRY; INTESTINE CARCINOMA; INVASIVE CARCINOMA; MELANOMA; OVARY FOLLICLE DEVELOPMENT; OVARY TUMOR; PRIORITY JOURNAL; REVIEW; SEX CORD TUMOR; TROPHOBLAST; UTERINE CERVIX CARCINOMA; YOLK SAC TUMOR;

EID: 31544469755     PISSN: 07402570     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.semdp.2005.11.002     Document Type: Article

References (115)

1. R.J. Kurman, P. Ganjei, M. Nadji Contributions of immunocytochemistry to the diagnosis and study of ovarian neoplasms Int J Gynecol Pathol 3 1984 3 26
2. R.E. Scully Immunohistochemistry of ovarian tumors J. Russo I. Russo Immunocytochemistry in Tumor Diagnosis 1985 Martinus Nijhoff Boston, MA 293 320
3. W.G. McCluggage Recent advances in immunohistochemistry in gynaecological pathology Histopathology 40 2002 309 326
4. P.M. Baker, E. Oliva Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors an update Int J Gynecol Pathol 24 2004 39 55
5. R.H. Young, R.E. Scully Differential diagnosis of ovarian tumors based primarily on their patterns and cell types Semin Diagn Pathol 18 2001 161 235
6. H.P. Cathro, M.H. Stoler The utility of calretinin, inhibin, and WT1 immunohistochemical staining in the differential diagnosis of ovarian tumors Hum Pathol 36 2005 195 201
7. W.G. McCluggage, P. Maxwell Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord-stromal tumours Histopathology 38 2001 403 408
8. Q.J. Cao, J.G. Jones, M. Li Expression of calretinin in human ovary, testis, and ovarian sex cord-stromal tumors Int J Gynecol Pathol 20 2001 346 352
9. C.J. Stewart, C.L. Nandini, J.A. Richmond Value of A103 (melan-A) immunostaining in the differential diagnosis of ovarian sex cord stromal tumours J Clin Pathol 53 2000 206 211
10. K.T. Loo, A.K. Leung, J.K. Chan Immunohistochemical staining of ovarian granulosa cell tumours with MIC2 antibody Histopathology 27 1995 388 390
11. A.M. Bamberger, R. Ivell, M. Balvers Relaxin-like factor (RLF) a new specific marker for Leydig cells in the ovary Int J Gynecol Pathol 18 1999 163 168
12. W.G. McCluggage, P. Maxwell Adenocarcinomas of various sites may exhibit immunoreactivity with anti-inhibin antibodies Histopathology 35 1999 216 220
13. W.G. McCluggage, P. Maxwell, J.M. Sloan Immunohistochemical staining of ovarian granulosa cell tumors with monoclonal antibody against inhibin Hum Pathol 28 1997 1034 1038
14. C.J. Stewart, M.D. Jeffers, A. Kennedy Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics Histopathology 31 1997 67 74
15. M.J. Costa, P.F. Ames, J. Walls Inhibin immunohistochemistry applied to ovarian neoplasms a novel, effective, diagnostic tool Hum Pathol 28 1997 1247 1254
16. F. Kommoss, E. Oliva, A.K. Bhan Inhibin expression in ovarian tumors and tumor-like lesions an immunohistochemical study Mod Pathol 11 1998 656 664
17. X. Matias-Guiu, C. Pons, J. Prat Mullerian inhibiting substance, alpha-inhibin, and CD99 expression in sex cord-stromal tumors and endometrioid ovarian carcinomas resembling sex cord-stromal tumors Hum Pathol 29 1998 840 845
18. M.A. Riopel, E.J. Perlman, J.D. Seidman Inhibin and epithelial membrane antigen immunohistochemistry assist in the diagnosis of sex cord-stromal tumors and provide clues to the histogenesis of hypercalcemic small cell carcinomas Int J Gynecol Pathol 17 1998 46 53
19. M. Rishi, L.N. Howard, G.L. Bratthauer Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary Am J Surg Pathol 21 1997 583 589
20. T.J. Pelkey, H.F. Frierson Jr, S.E. Mills The diagnostic utility of inhibin staining in ovarian neoplasms Int J Gynecol Pathol 17 1998 97 105
21. C. Guerrieri, B. Franlund, H. Malmstrom Ovarian endometrioid carcinomas simulating sex cord-stromal tumors a study using inhibin and cytokeratin 7 Int J Gynecol Pathol 17 1998 266 271
22. D.X. Yao, R.A. Soslow, C.V. Hedvat Melan-A (A103) and inhibin expression in ovarian neoplasms Appl Immunohistochem Mol Morphol 11 2003 244 249
23. M.T. Deavers, A. Malpica, J. Liu Ovarian sex cord-stromal tumors an immunohistochemical study including a comparison of calretinin and inhibin Mod Pathol 16 2003 584 590
24. S. Movahedi-Lankarani, R.J. Kurman Calretinin, a more sensitive but less specific marker than alpha-inhibin for ovarian sex cord-stromal neoplasms an immunohistochemical study of 215 cases Am J Surg Pathol 26 2002 1477 1483
25. V.I. Shah, O.N. Freites, P. Maxwell Inhibin is more specific than calretinin as an immunohistochemical marker for differentiating sarcomatoid granulosa cell tumour of the ovary from other spindle cell neoplasms J Clin Pathol 56 2003 221 224
26. P. Flemming, A. Wellmann, H. Maschek Monoclonal antibodies against inhibin represent key markers of adult granulosa cell tumors of the ovary even in their metastases. A report of three cases with late metastasis, being previously misinterpreted as hemangiopericytoma Am J Surg Pathol 19 1995 927 933
27. P. Aguirre, A.D. Thor, R.E. Scully Ovarian endometrioid carcinomas resembling sex cord-stromal tumors Int J Gynecol Pathol 8 1989 364 373
28. J.H. Lagendijk, H. Mullink, P.J. Van Diest Tracing the origin of adenocarcinomas with unknown primary using immunohistochemistry differential diagnosis between colonic and ovarian carcinomas as primary sites Hum Pathol 29 1998 491 497
29. K. Berezowski, J.F. Stastny, M.J. Kornstein Cytokeratins 7 and 20 and carcinoembryonic antigen in ovarian and colonic carcinoma Mod Pathol 9 1996 426 429
30. H. Ji, C. Isacson, J.D. Seidman Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors Dpc4 assists in identifying metastatic pancreatic carcinomas Int J Gynecol Pathol 21 2002 391 400
31. S.Y. Park, H.S. Kim, E.K. Hong Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary Hum Pathol 33 2002 1078 1085
32. W.G. McCluggage Immunoreactivity of ovarian juvenile granulosa cell tumours with epithelial membrane antigen Histopathology 46 2005 235 236
33. C.N. Otis, J.L. Powell, D. Barbuto Intermediate filamentous proteins in adult granulosa cell tumors. An immunohistochemical study of 25 cases Am J Surg Pathol 16 1992 962 968
34. B. Czernobilsky, R. Moll, R. Levy Co-expression of cytokeratin and vimentin filaments in mesothelial, granulosa and rete ovarii cells of human ovary Eur J Cell Biol 37 1985 175 190
35. M.J. Costa, P.B. De Rose, L.M. Roth Immunohistochemical phenotype of ovarian granulosa cell tumors absence of epithelial membrane antigen has diagnostic value Hum Pathol 25 1994 60 66
36. M.T. Deavers, A. Malpica, J. Liu Ovarian sex cord-stromal tumors an immunohistochemical study including a comparison of calretinin and inhibin Mod Pathol 16 2003 584 590
37. E. Oliva CD10 expression in the female genital tract does it have useful diagnostic applications? Adv Anat Pathol 11 2004 310 315
38. P. Chu, E. Wu, L.M. Weiss Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms a survey of 435 cases Mod Pathol 13 2000 962 972
39. M.A. Kim, H.S. Lee, H.K. Yang Cytokeratin profile in gastric carcinomas Hum Pathol 35 2004 576 581
40. C. Tornos, R. Soslow, S. Chen Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary Am J Surg Pathol 29 2005 1482 1489
41. C. Monteagudo, M.J. Merino, N. LaPorte Value of gross cystic disease fluid protein-15 in distinguishing metastatic breast carcinomas among poorly differentiated neoplasms involving the ovary Hum Pathol 22 1991 368 372
42. W.M. Szyfelbein, R.H. Young, R.E. Scully Struma ovarii simulating ovarian tumors of other types. A report of 30 cases Am J Surg Pathol 19 1995 21 29
43. P.E. Palmer, S. Bogojavlensky, A.K. Bhan Prolactinoma in wall of ovarian dermoid cyst with hyperprolactinemia Obstet Gynecol 75 1990 540 543
44. C.A. Axiotis, H.A. Lippes, M.J. Merino Corticotroph cell pituitary adenoma within an ovarian teratoma. A new cause of Cushing's syndrome Am J Surg Pathol 11 1987 218 224
45. D. Gupta, M.T. Deavers, E.G. Silva Malignant melanoma involving the ovary a clinicopathologic and immunohistochemical study of 23 cases Am J Surg Pathol 28 2004 771 780
46. W. Hart Diagnostic challenge of secondary (metastatic) ovarian simulating primary endometrioid and mucinous neoplasms Pathol Int 55 2005 231 243
47. W.G. McCluggage, N. Wilkinson Metastatic neoplasms involving the ovary a review with an emphasis on morphological and immunohistochemical features Histopathology 47 2005 247 321
48. R.W. Werling, H. Yaziji, C.E. Bacchi CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin an immunohistochemical survey of 476 primary and metastatic carcinomas Am J Surg Pathol 27 2003 303 310
49. Y.Y. Chou, Y.M. Jeng, H.L. Kao Differentiation of ovarian mucinous carcinoma and metastatic colorectal adenocarcinoma by immunostaining with beta-catenin Histopathology 43 2003 151 156
50. G.M. Groisman, A. Meir, E. Sabo The value of Cdx2 immunostaining in differentiating primary ovarian carcinomas from colonic carcinomas metastatic to the ovaries Int J Gynecol Pathol 23 2004 52 57
51. L. Tornillo, H. Moch, P.A. Diener CDX-2 immunostaining in primary and secondary ovarian carcinomas J Clin Pathol 57 2004 641 643
52. M.R. Raspollini, G. Amunni, A. Villanucci Utility of CDX-2 in distinguishing between primary and secondary (intestinal)mucinous ovarian carcinoma an immunohistochemical comparison of 43 cases Appl Immunohistochem Mol Morphol 12 2004 127 131
53. S. Logani, E. Oliva, P.M. Arnell Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma Mod Pathol 18 2005 19 25
54. D. Cao, H. Ji, B.M. Ronnett Expression of mesothelin, fascin, and prostate stem cell antigen in primary ovarian mucinous tumors and their utility in differentiating primary ovarian mucinous tumors from metastatic pancreatic mucinous carcinomas in the ovary Int J Gynecol Pathol 24 2004 67 72
55. E. Elishaev, C.B. Gilks, D. Miller Synchronous and metachronous endocervical and ovarian neoplasms evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms Am J Surg Pathol 29 2005 281 294
56. J.A. Irving, R.H. Young Lung carcinoma metastatic to the ovary. A clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis Am J Surg Pathol 29 2005 997 1006
57. S. Gagnon, B. Tetu, E.G. Silva Frequency of alpha-fetoprotein production by Sertoli-Leydig cell tumors of the ovary an immunohistochemical study of eight cases Mod Pathol 2 1989 63 67
58. R. Vang, M.E. Herrmann, F.A. Tavassoli Comparative immunohistochemical analysis of granulosa and Sertoli components in ovarian sex cord-stromal tumors with mixed differentiation potential implications for derivation of Sertoli differentiation in ovarian tumors Int J Gynecol Pathol 23 2004 151 161
59. M.J. Costa, R.J. Morris, R. Wilson Utility of immunohistochemistry in distinguishing ovarian Sertoli-stromal cell tumors from carcinosarcomas Hum Pathol 23 1992 787 797
60. E. Oliva, T. Alvarez, R.H. Young Sertoli cell tumors of the ovary. A clinicopathological and immunohistochemical study of 54 cases Am J Surg Pathol 29 2005 143 156
61. M. Devouassoux-Shisheboran, S.A. Silver, F.A. Tavassoli Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO) immunohistochemical evidence in support of a Wolffian origin Hum Pathol 30 1999 856 863
62. A.J. Tiltman, U. Allard Female adnexal tumors of probable Wolffian origin an immunohistochemical study comparing tumours, mesonephric remnants and paramesonephric derivatives Histopathology 38 2001 327 342
63. I. Riedel, B. Czernobilsky, B. Lifschitz-Mercer Brenner tumors but not transitional cell carcinomas of the ovary show urothelial differentiation immunohistochemical staining of urothelial markers, including cytokeratins and uroplakins Virchows Arch 435 2001 181 191
64. K. Ogawa, S.L. Johansson, S.M. Cohen Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues and benign and neoplastic lesions of the female genital tract Am J Pathol 155 1999 1047 1050
65. N.G. Ordonez Transitional cell carcinomas of the ovary and bladder are phenotypically different Histopathology 36 2000 433 438
66. R.A. Soslow, R.V. Rouse, M.R. Hendrickson Transitional cell neoplasms of the ovary and urinary bladder a comparative immunohistochemical analysis Int J Gynecol Pathol 15 1996 257 265
67. S. Logani, E. Oliva, M.B. Amin Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers histogenetic and diagnostic implications Am J Surg Pathol 27 2003 1434 1441
68. R.H. Young, J.H. Eichhorn, G.R. Dickersin Ovarian involvement by the intra-abdominal desmoplastic small round cell tumor with divergent differentiation a report of three cases Hum Pathol 23 1992 454 464
69. N.G. Ordonez Desmoplastic small round cell tumor. II. An ultrastructural and immunohistochemical study with emphasis on new immunohistochemical markers Am J Surg Pathol 122 1998 1314 1327
70. W.G. McCluggage, V.P. Sumathi, P. Maxwell CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms Histopathology 39 2001 273 278
71. P.G. Chu, D.A. Arber, L.M. Weiss Utility of CD10 in distinguishing between endometrial stromal sarcoma and uterine smooth muscle tumors an immunohistochemical comparison of 34 cases Mod Pathol 14 2001 465 471
72. E. Oliva, R.H. Young, M.B. Amin An immunohistochemical analysis of endometrial stromal and smooth muscle tumors of the uterus a study of 54 cases emphasizing the importance of using a panel because of overlap in immunoreactivity for individual antibodies Am J Surg Pathol 26 2002 403 412
73. M.R. Nucci, J.T. O'Connell, P.C. Huettner h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors Am J Surg Pathol 25 2001 455 463
74. V.P. Sumathi, M. Al-Hussaini, L.E. Connolly Endometrial stromal neoplasms are immunoreactive with WT-1 antibody Int J Gynecol Pathol 2 2004 241 247
75. R. Bhargava, J. Shia, A.J. Hummer Distinction of endometrial stromal sarcomas from 'hemangiopericytomatous' tumors using a panel of immunohistochemical stains Mod Pathol 18 2005 40 47
76. A. Yilmaz, D.S. Rush, R.A. Soslow Endometrial stromal sarcomas with unusual histologic features a report of 24 primary and metastatic tumors emphasizing fibroblastic and smooth muscle differentiation Am J Surg Pathol 26 2002 1142 1150
77. W.G. McCluggage, E. Oliva, C.S. Herrington CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma Histopathology 43 2003 144 150
78. W.G. McCluggage Uterine tumors resembling uterine sex cord tumors immunohistochemical evidence for true sex-cord differentiation Histopathology 34 1999 374 375
79. L. Cheng, A. Thomas, L.M. Roth OCT4 a novel biomarker for dysgerminoma of the ovary Am J Surg Pathol 28 2004 1341 1346
80. E. Oliva, J.A. Ferry, R.H. Young Granulocytic sarcoma of the female genital tract a clinicopathologic study of 11 cases Am J Surg Pathol 21 1997 1156 1165
81. M. Shimizu, T. Toki, Y. Takagi Immunohistochemical detection of the Wilms' tumor gene (WT1) in epithelial ovarian tumors Int J Gynecol Pathol 19 2000 158 163
82. M. Al-Hussaini, A. Stockman, H. Foster WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma Histopathology 44 2004 109 115
83. A. Hashi, T. Yuminamochi, S. Murata Wilms tumor gene immunoreactivity in primary serous carcinomas of the fallopian tube, ovary, endometrium, and peritoneum Int J Gynecol Pathol 22 2003 374 377
84. N.S. Goldstein, A. Uzieblo WT1 Immunoreactivity in uterine papillary serous carcinomas is different from ovarian serous carcinomas Am J Clin Pathol 17 2002 541 545
85. W.G. McCluggage WT1 is of value in ascertaining the site of origin of serous carcinomas within the female genital tract Int J Gynecol Pathol 3 2004 97 99
86. P.M. Baker, P.B. Clement, R.H. Young Malignant peritoneal mesothelioma in women. A study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis Am J Clin Pathol 123 2005 724 737
87. R.L. Attanoos, R. Webb, S.D. Dojcinov Value of mesothelial and epithelial antibodies in distinguishing diffuse peritoneal mesothelioma in females from serous papillary adenocarcinoma of the ovary and peritoneum Histopathology 40 2002 237 244
88. R.L. Attanoos, A. Griffin, A. Gibbs The use of immunohistochemistry in distinguishing reactive from neoplastic mesothelium. A novel use for desmin and comparative evaluation with epithelial membrane antigen, p53, platelet-derived growth factor-receptor, P-glycoprotein and bcl-2 Histopathology 43 2003 231 238
89. M.R. Nucci, T. Krausz, B. Lifschitz-Mercer Angiosarcoma of the ovary clinicopathologic and immunohistochemical analysis of four cases with a broad morphologic spectrum Am J Surg Pathol 22 1998 620 630
90. T.A. Zirker, E.G. Silva, M. Morris Immunohistochemical differentiation of clear-cell carcinoma of the female genital tract and endodermal sinus tumor with the use of alpha-fetoprotein and leu-M1 Am J Clin Pathol 91 1989 511 514
91. W.G. McCluggage Ovarian neoplasms composed of small round cells a review Adv Anat Pathol 11 2004 288 296
92. P. Aguirre, A.D. Thor, R.E. Scully Ovarian small cell carcinoma Histogenetic considerations based on immunohistochemical and other findings Am J Clin Pathol 92 1989 140 149
93. A.G. Neto, M.T. Deavers, E.G. Silva Immunohistochemical profile of ovarian small cell carcinoma, hypercalcemic type Mod Pathol 16 2003 919
94. W.G. McCluggage, E. Oliva, L.E. Connolly An immunohistochemical analysis of ovarian small cell carcinoma of hypercalcemic type Int J Gynecol Pathol 23 2004 330 336
95. J.H. Eichhorn, R.H. Young, R.E. Scully Primary ovarian small cell carcinoma of pulmonary type. A clinicopathologic, immunohistologic and flow cytometric analysis of 11 cases Am J Surg Pathol 16 1992 926 938
96. A.L. Folpe, C.E. Hill, D.M. Parham Immunohistochemical detection of FLI-1 protein expression a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor Am J Surg Pathol 24 2000 1657 1662
97. R.H. Young, R.E. Scully Oxyphilic tumors of the female and male genital tracts Semin Diagn Pathol 16 1999 146 161
98. M.B. Pitman, S. Triratanachat, R.H. Young Hepatocyte paraffin 1 antibody does not distinguish primary ovarian tumors with hepatoid differentiation from metastatic hepatocellular carcinoma Int J Gynecol Pathol 23 2004 58 64
99. M.F. Lerwill, R. Sung, E. Oliva Smooth muscle tumors of the ovary a clinicopathologic study of 54 cases emphasizing prognostic criteria, histologic variants and differential diagnosis Am J Surg Pathol 28 2004 1436 1451
100. McCluggage WG, Young RH: Paraganglioma of the ovary: Report of three cases of a rare ovarian neoplasm, including two exhibiting inhibin positivity. Am J Surg Pathol, in press
101. E.J. Schwartz, T.A. Longacre Adenomatoid tumors of the female and male genital tracts express WT1 Int J Gynecol Pathol 23 2004 123 128
102. R.I. Cameron, P. Ashe, D.M. O'Rourke A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma Int J Gynecol Pathol 22 2003 272 276
103. R.H. Young, W.R. Hart Metastatic intestinal carcinomas simulating primary ovarian clear cell carcinoma and secretory endometrioid carcinoma a clinicopathologic and immunohistochemical study of five cases Am J Surg Pathol 22 1998 805 815
104. C. Tornos, E.G. Silva, N.G. Ordonez Endometrioid carcinoma of the ovary with a prominent spindle-cell component, a source of diagnostic confusion. A report of 14 cases Am J Surg Pathol 19 1995 1343 1353
105. J.S. Irving, M. Lerwill, R.H. Young Gastrointestinal stromal tumors metastatic to the ovary a report of five cases Am J Surg Pathol 29 2005 920 926
106. Y. Kuwashima, T. Uehara, K. Kishi Immunohistochemical characterization of undifferentiated carcinomas of the ovary J Cancer Res Clin Oncol 120 1994 672 677
107. J.A. Ferry, R.H. Young Malignant lymphoma of the genitourinary tract Curr Diagn Pathol 4 1997 145 169
108. W.M. Szyfelbein, R.H. Young, R.E. Scully Cystic struma ovarii: a frequently unrecognized tumor. A report of 20 cases Am J Surg Pathol 18 1994 785 788
109. K. Braaten, R.H. Young Ovarian serous cystadenoma with associated genital rhabdomyoma Hum Pathol 36 2005 1240 1241
110. A.G.J.M. Hanselaar, G.P. Vooijs, B. Mayall Epithelial markers to detect occult microinvasion in serous ovarian tumors Int J Gynecol Pathol 12 1993 20 27
111. X. Matias-Guiu, I. Aranda, J. Prat Immunohistochemical study of sarcoma-like mural nodules in a mucinous cystadenocarcinoma of the ovary Virchows Archiv A Pathol Anat 419 1991 89 92
112. P.G. Chu, L.M. Weiss Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast and colon Am J Clin Pathol 121 2004 884 892
113. R. Vang, S. Bague, F.A. Tavassoli Signet-ring stromal tumor of the ovary clinicopathologic analysis and comparison with Krukenberg tumor Int J Gynecol Pathol 23 2003 45-45
114. P. Aguirre, R.E. Scully, R.A. DeLellis Ovarian heterologous Sertoli-Leydig cell tumors with gastrointestinal-type epithelium. An immunohistochemical analysis Arch Pathol Lab Med 110 1986 528 533
115. E. Oliva, E. Andrada, E. Pezzica Ovarian carcinomas with choriocarcinomatous differentiation Cancer 72 1993 2441 2446