Ovarian sex cord-stromal tumors: An immunohistochemical study including a comparison of calretinin and inhibin

Modern Pathology

Volumn 16, Issue 6, 2003, Pages 584-590

  Deavers, Michael T ^a   Malpica, Anais ^a   Liu, Jinsong ^a   Broaddus, Russell ^a   Silva, Elvio G ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Calretinin; CD10; EMA; Immunohistochemistry; Inhibin; Keratin; Ovary; Sex cord stromal tumor; WT1

Indexed keywords

CALRETININ; CYTOKERATIN; EPITHELIAL MEMBRANE ANTIGEN; INHIBIN; WT1 PROTEIN;

ANDROBLASTOMA; ARTICLE; CLINICAL ARTICLE; FEMALE; FIBROMA; GRANULOSA CELL; GRANULOSA CELL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX CORD TUMOR; THECOMA;

CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; INHIBINS; OVARIAN NEOPLASMS; SEX CORD-GONADAL STROMAL TUMORS; TUMOR MARKERS, BIOLOGICAL;

EID: 0038118422     PISSN: 08933952     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.MP.0000073133.79591.A1     Document Type: Article

References (28)

1. Scully RE, Young RH, Clement PB. Tumors of the ovary, maldeveloped gonads, fallopian tube, and broad ligament. Fascicle 23. 3rd series. Atlas of tumor pathology series. Washington, D.C.: Armed Forces Institute of Pathology; 1998.
2. Scully RE. Histological typing of ovarian tumors. 2nd ed. World Health Organization international histological classification of tumours series. Berlin: Springer; 1999.
3. Costa MJ, Ames PF, Walls J, Roth LM. Inhibin immunohistochemistry applied to ovarian neoplasms: a novel, effective, diagnostic tool. Hum Pathol 1997;28:1247-54.
4. Hildebrandt RH, Rouse RV, Longacre TA. Value of inhibin in the identification of granulosa cell tumors of the ovary. Hum Pathol 1997;28:1387-95.
5. Rishi M, Howard LH, Bratthauer GL, Tavassoli FA. Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumor of the ovary. Am J Surg Pathol 1997;21:583-9.
6. Stewart CJ, Jeffers MD, Kennedy A. Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histologic mimics. Histopathology 1997;31:67-74.
7. Kommoss F, Oliva E, Bhan AK, Young RH, Scully RE. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol 1998;11:656-64.
8. Doglioni C, Dei Tos AP, Laurino L, Iuzzolino P, Chiarelli C, Celio MR. Calretinin: a novel immunocytochemical marker for mesothelioma. Am J Surg Pathol 1996;20:1037-46.
9. McCluggage WG, Maxwell P. Immunohistochemical staining for calretinin is useful in the diagnosis of ovarian sex cord-stromal tumours. Histopathology 2001;38:403-8.
10. Cao QJ, Jones JG, Li M. Expression of calretinin in human ovary, testis, and ovarian sex cord-stromal tumors. Int J Gynecol Pathol 2001;20:346-52.
11. Movahedi-Lankarani S, Kurman RJ. Calretinin, a more sensitive but less specific marker than α-inhibin for ovarian sex cord-stromal neoplasms: an immunohistochemical study of 215 cases. Am J Surg Pathol 2002;26:1477-83.
12. Shimizu M, Toki T, Takagi Y, Konishi I, Fujii S. Immunohistochemical detection of the Wilms' tumor gene (WT1) in epithelial ovarian tumors. Int J Gynecol Pathol 2000;19:158-63.
13. Coppes MJ, Ye Y, Rackley R, Zhao XL, Liefers GJ, Casey G, et al. Analysis of WT1 in granulosa cell and other sex cord-stromal tumors. Cancer Res 1993;53:2712-4.
14. Ordonez NG. Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas. Am J Surg Pathol 1998;22:1203-14.
15. Pohl V, Van Rampelbergh J, Mellaert S, Parmentier M, Pochet R. Calretinin in rat ovary: an in situ hybridization and immunohistochemical study. Biochem Biophys Acta 1992;1160:87-94.
16. Bertschy S, Genton CY, Gotzos V. Selective immunocytochemical localization of calretinin in the human ovary. Histochem Cell Biol 1998;109:59-66.
17. Young RH, Prat J, Scully RE. Endometrioid stromal sarcomas of the ovary: a clinicopathologic analysis of 23 cases. Cancer 1984;53:1143-55.
18. Toki T, Shimizu M, Takagi Y, Ashida T, Konishi I. CD10 is a marker for normal and neoplastic endometrial stromal cells. Int J Gynecol Pathol 2002;21:41-7.
19. McCluggage WG, Maxwell P. Adenocarcinomas of various sites may exhibit immunoreactivity with anti-inhibin antibodies. Histopathology 1999;35:216-20.
20. Pelkey TJ, Frierson HF Jr, Mills SE, Stoler MH. The diagnostic utility of inhibin staining in ovarian neoplasms. Int J Gynecol Pathol 1998;17:97-105.
21. Devouassoux-Shisheboran M, Silver SA, Tavassoli FA. Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin. Hum Pathol 1999;30:856-63.
22. Benjamin E, Law S, Bobrow LG. Intermediate filaments cytokeratin and vimentin in ovarian sex cord-stromal tumours with correlative studies in adult and fetal ovaries. J Pathol 1987;152:253-63.
23. Costa MJ, De Rose PB, Roth LM, Brescia RJ, Zaloudek CJ, Cohen C. Immunohistochemical phenotype of ovarian granulosa cell tumors: absence of epithelial membrane antigen has diagnostic value. Hum Pathol 1994;25:60-6.
24. Gordon MD, Corless C, Renshaw AA, Beckstead J. CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis. Mod Pathol 1998;11:769-73.
25. Riopel MA, Perlman EJ, Seidman JD, Kurman RJ, Sherman ME. Inhibin and epithelial membrane antigen immunohistochemistry assist in the diagnosis of sex cord stromal tumors and provide clues to the histogenesis of hypercalcemic small cell carcinomas. Int J Gynecol Pathol 1998;17:46-53.
26. Guerrieri C, Franlund B, Malmstrom H, Boeryd B. Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. Int J Gynecol Pathol 1998;17:266-71.
27. Hsu SY, Kubo M, Chun S-Y, Haluska FG, Housman DE, Hsueh AJW. Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter. Mol Endocrinol 1995;9:1356-66.
28. Amin KM, Litzky LA, Symthe WR, Mooney AM, Morris JM, Mews DJ, et al. Wilms' tumor 1 susceptibility (WT1) gene products are selectively expressed in malignant mesothelioma. Am J Pathol 1995;146:344-56.