Temperature-sensitive hydrogels: Potential therapeutic applications

American Journal of Drug Delivery

Volumn 3, Issue 4, 2005, Pages 239-251

  Grassi, Gabriele ^a,b   Farra, Rossella ^a   Caliceti, Paolo ^c   Guarnieri, Gianfranco ^a   Salmaso, Stefano ^c   Carenza, Mario ^d   Grassi, Mario ^e  

^a UNIVERSITY HOSPITAL OF TRIESTE   (Italy)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY OF PADOVA   (Italy)

^d Istituto Per La Sintesi Organica E La Fotoreattività   (Italy)

^e UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID COPOLYMER; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CHITOSAN; CLOTRIMAZOLE; COPOLYMER; DICLOFENAC; DODECYL SULFATE SODIUM; DOXORUBICIN; INTERLEUKIN 2; LIDOCAINE; LIPOSOME; MACROGOL; N LAUROYLSARCOSINE; PACLITAXEL; POLOXAMER; POLY(N ISOPROPYLACRYLAMIDE); POLYACRYLAMIDE; POLYETHER; POLYMER; POLYOXYETHYLENE; POLYSACCHARIDE; POLYVINYL DERIVATIVE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UNINDEXED DRUG; UREASE; VANCOMYCIN;

ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL THERAPY; BIOTECHNOLOGY; CANCER; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONJUGATION; CONTROLLED DRUG RELEASE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG SAFETY; DRUG STABILITY; DRUG STRUCTURE; HUMAN; HYDROGEL; INFECTION; MACROMOLECULE; NECROSIS; NONHUMAN; PH; PHASE TRANSITION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN SECRETION; REGENERATIVE MEDICINE; REVIEW; SEXUALLY TRANSMITTED DISEASE; STEM CELL; TEMPERATURE SENSITIVITY; UNSPECIFIED SIDE EFFECT; UROGENITAL TRACT DISEASE; VAGINA DISEASE; VAGINA MUCOSA; VAGINAL ULCER; VAGINITIS;

EID: 31544463276     PISSN: 11759038     EISSN: 11759038     Source Type: Journal    
DOI: 10.2165/00137696-200503040-00004     Document Type: Review

References (100)

1. Ratner BD, Hoffan AS, Schoen FJ, editors. Biomaterials science: an introduction to materials in medicine. 1996
2. Lapasin R, Pricl S. Rheology of industrial polysaccharides: theory and applications. Glasgow: Balckie Academic & Professional/Chapman & Hall, 1995
3. Barbucci R, Busi E, Magnani A, et al. La chimica & l'industria. Biomaterials 1994; 76: 17-23
4. Kudela V. Hydrogels. In: Mark HF and Kroschwitz JI, editors. Encyclopedia of polymer science and technology. 2nd ed. New York: John Wiley & Sons publisher, 1987: 783-807
5. Peppas NA, Mikos AG. Preparation methods and structure of hydrogels. In: Peppas NA, editor. Hydrogels in medicine and pharmacy. Volume I: Fundamentals. Boca Raton (FL): CRC Press 1986: 1-25
6. Wichterle O, Lim D. Hydrophilic gels for biological use. Nature 1960; 185: 117-8
7. Jen AC, Conley Wake M, Mikos AG. Hydrogels for cell immobilization. Biotechnol Bioeng 1996; 50: 357-64
8. Lee KY, Mooney DJ. Hydrogels for tissue engineering. Chem Rev 2001; 101 (7): 1869-79
9. Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev 2002; 54 (1): 3-12
10. Kaetsu I. Immobilization of biofunctional substances. Radiation Physics and Chemistry 1981; 18: 343-56
11. Carenza M. Recent achievements in the use of radiation polymerization and grafting for biomedical applications. Radiation Physics and Chemistry 1992; 39: 485-93
12. Ulanski P, Janik I, Kadlubowski S, et al. Polymeric biomaterials synthesized by radiation techniques: current studies at IARC, Poland. Polym Adv Technol 2002; 13: 951-9
13. Badiger MV, Lele AK, Kulkarni MG, et al. Swelling and phase transitions in deforming polymeric gels. Ind Eng Chem Res 1994; (33): 2416-33
14. Osada Y, Ross-Murphy SB. Intelligent gels. Sci Am 1993; 268: 82-7
15. Peppas NA. Other biomedical applications of hydrogels. In: Peppas NA, editor. Boca Raton (FL): CRC Press, 1987
16. Mantovani F, Grassi M, Colombo I, et al. A combination of vapor sorption and dynamic laser light scattering methods for the determination of the Flory parameter χ and the crosslink density of a powdered polymeric gel. Fluid Phase Equilibria 2000; (167): 63-81
17. Liu X, Tong Z, Hu O. Swelling equilibria of hydrogels with sulfonate groups in water and in aqueous salt solutions. Macromolecules 1995; (28): 3813-7
18. Baker JP, Hong LH, Blanc HW, et al. Effect of initial total monomer concentration on the swelling behavior of cationic acrylamide-based hydrogels. Macromolecules 1994; 27 (6): 1446-54
19. Tanaka T. Phase transition of gels. Harland RS, Prud'homme RK, editors. Polyelectrolyte Gels, ACS Symp. Ser. 480. Washington, DC: American Chemical Society, 1992
20. Okano T, Bae TH, Jacobs H, et al. Thermally on-off switching polymers for drug permeation and release. J Control Release 1990; (11): 255-65
21. Jeong B, Kim SW, Bae YH. Thermosensitive sol-gel reversible hydrogels. Adv Drug Deliv Rev 2002; 54 (1): 37-51
22. Zhang XZ, Wu DQ, Chu CC. Synthesis, characterization and controlled drug release of thermosensitive IPN-PNIPAAm hydrogels. Biomaterials 2004; 25 (17): 3793-805
23. Kondo A, Fukuda AH. Preparation of thermo-sensitive magnetic hydrogel microspheres and application to enzyme immobilization. J Ferment Bioeng 1997; 84 (4): 337-41
24. Zhang XZ, Zhuo RX. Novel synthesis of temperature-sensitive poly (N- isopropylacrylamide) hydrogel with fast deswelling rate. European Polymer Journal 2000; (36): 643-5
25. Zhang XZ, Zhuo RX. Synthesis and properties of thermosensitive poly (N-isopropylacrylamide -co-methyl methacrylate) hydrogel with rapid response. Materials Letters 2002; (52): 5-9
26. Zhang XZ, Zhang JT, Zhuo RX, et al. Synthesis and properties of thermosensitive, crown ether incorporated poly (N-isopropylacrylamide) hydrogel. Polymer 2002; (43): 4823-7
27. Maolin Z, Ning L, Jun L, et al. Radiation preparation of PVA-g-NIPAAm in a homogeneous system and its application in controlled release. Radiation Physics and Chemistry 2000; (57): 481-4
28. Hsiue GH, Hsu SH, Yang CC, et al. Preparation of controlled release ophthalmic drops, for glaucoma therapy using thermosensitive poly-N-isopropylacrylamide. Biomaterials 2002; 23 (2): 457-62
29. Marsano E, Bianchi E, Viscardi A. Stimuli responsive gels based on interpenetrating network of hydroxy propylcellulose and poly (N-isopropylacrylamide). Polymer 2004; (45): 157-63
30. Molinaro G, Leroux JC, Damas J, et al. Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials. Biomaterials 2002; 23 (13): 2717-22
31. Jeong B, Choi YK, Bae YH, et al. New biodegradable polymers for injectable drug delivery systems. J Control Release 1999; 62 (1-2): 109-14
32. Alexandridis P, Hatton TA. Poly (ethylene oxide)-poly- (propylene oxide)-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surfaces A: Physicochem Eng Aspects 1995; 96 (1-2): 1-46
33. Jeong B, Bae YH, Lee DS, et al. Biodegradable block copolymers as injectable drug-delivery systems. Nature 1997; 388: 860-2
34. Bekturov EV, Bimendina LA. Interpolymer complexes. Adv Pol Sci 1981; (41): 99-147
35. Sassi AP, Blanch HW, Prausnitz JM. Macromolecular separation and identification, polymer applications for biotechnology. Soane DS, editor. Chapter 8. Englewood Cliffs: Prentice-Hall, 1991
36. Flory PJ. Principles of polymer chemistry. Ithaca (NY): Cornell University, 1953
37. Hooper HH, Baker JP, Blanch HW, et al. Swelling equilibria for positively ionized polyacrylamide hydrogels. Macromolecules 1990; 23: 1096-104
38. Erman B, Flory PJ. Critical phenomena and transitions in swollen polymer networks and linear macromolecules. Macromolecules 1986; 19: 2342-53
39. Brannon-Peppas L, Peppas NA. Equilibrium swelling behaviour of pH-sensitive hydrogels. Chemical Engineering Science 1991; 46 (3): 715-22
40. Hasa M, Ilavsky M, Dusek K. Deformational, swelling and potentiometric behavior of ionized poly (methacrylic acid) gels. I. Theory. J Polymer Sci 1975; 13: 253-62
41. Colombo I, Fermeglia M, Grassi M, et al. Modeling phase transitions and sorption-desorption kinetics in thermo-sensitive gels for controlled drug delivery systems. Fluid Phase Equilibria 1996; 116: 148-61
42. Grassi M, Colombo I, Lapasin R. Drug release from an ensemble of swellable crosslinked polymer particles. J Control Release 2000; 68 (1): 97-113
43. Grassi M, Lapasin R, Pricl S. Modeling of drug release from a swellable matrix. Chemical Engineering Communications 1998; 169: 79-109
44. Crank J. The mathematics of diffusion. 2nd ed. Oxford: Clarendon Press, 1975
45. Camera-Roda G, Sarti GC. Mass transport with relaxation in polymers. AIChE J 1990; 36 (6): 851-60
46. Miyazaki S, Takeuchi S, Yokouchi C, et al. Pluronic F-127 gels as a vehicle for topical administration of anticancer agents. Chem Pharm Bull (Tokyo) 1984; 32 (10): 4205-8
47. Chi SC, Jun HW. Release rates of ketoprofen from poloxamer gels in a membraneless diffusion cell. J Pharm Sci 1991; 80 (3): 280-3
48. Miyazaki S, Tobiyama T, Takada M, et al. Percutaneous absorption of indomethacin from pluronic F127 gels in rats. J Pharm Pharmacol 1995; 47 (6): 455-7
49. Esposito E, Carrotta V, Scabbia A, et al. Comparative analysis of tetracycline-containing dental gels: poloxamer- and monoglyceride-based formulations. Int J Pharm 1996; 142: 9-23
50. Pec EA, Wout ZG, Johnston TP. Biological activity of urease formulated in poloxamer 407 after intraperitoneal injection in the rat. J Pharm Sci 1992; 81 (7): 626-30
51. Johnston TP, Punjabi MA, Froelich CJ. Sustained delivery of interleukin-2 from a poloxamer 407 gel matrix following intraperitoneal injection in mice. Pharm Res 1992; 9 (3): 425-34
52. Paavola A, Yliruusi J, Kajimoto Y, et al. Controlled release of lidocaine from injectable gels and efficacy in rat sciatic nerve block. Pharm Res 1995; 12 (12): 1997-2002
53. Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284 (5411): 143-7
54. Wagers AJ, Weissman IL. Plasticity of adult stem cells. Cell 2004; 116 (5): 639-48
55. Kleinman HK, McGarvey ML, Liotta LA, et al. Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. Biochemistry 1982; 21 (24): 6188-93
56. Prusiner SB. Biology and genetics of prion diseases. Annu Rev Microbiol 1994; 48: 655-86
57. Hishikawa K, Miura S, Marumo T, et al. Gene expression profile of human mesenchymal stem cells during osteogenesis in three-dimensional thermoreversible gelation polymer. Biochem Biophys Res Commun 2004; 317 (4): 1103-7
58. Au A, Polotsky A, Krzyminski K, et al. Evaluation of thermoreversible polymers containing fibroblast growth factor 9 (FGF-9) for chondrocyte culture. J Biomed Mater Res 2004; 69A (2): 367-72
59. Au A, Ha J, Polotsky A, et al. Thermally reversible polymer gel for chondrocyte culture. J Biomed Mater Res 2003; 67A (4): 1310-9
60. Lee PY, Li Z, Huang L. Thermosensitive hydrogel as a Tgf-beta1 gene delivery vehicle enhances diabetic wound healing. Pharm Res 2003; 20 (12): 1995-2000
61. Li Z, Ning W, Wang J, et al. Controlled gene delivery system based on thermosensitive biodegradable hydrogel. Pharm Res 2003; 20 (6): 884-8
62. Lanning DA, Diegelmann RF, Yager DR, et al. Myofibroblast induction with transforming growth factor-beta1 and -beta3 in cutaneous fetal excisional wounds. J Pediatr Surg 2000; 35 (2): 183-7
63. Sidhu GS, Mani H, Gaddipati JP, et al. Curcumin enhances wound healing in streptozotocin induced diabetic rats and genetically diabetic mice. Wound Repair Regen 1999; 7 (5): 362-74
64. Beynon T, Laverty D, Baxter A, et al. Lutrol gel: a potential role in wounds? J Pain Symptom Manage 2003; 26 (2): 776-80
65. Veyries ML, Couarraze G, Geiger S, et al. Controlled release of vancomycin from poloxamer 407 gels. Int J Pharm 1999; 192 (2): 183-93
66. Wang J. Bacterial vaginosis. Prim Care Update Ob Gyns 2000; 7 (5): 181-5
67. Chang JY, Oh Y-K, Soo Kong H, et al. Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. J Control Release 2002; 82 (1): 39-50
68. Roy S, Gourde P, Piret J, et al. Thermoreversible gel formulations containing sodium lauryl sulfate or n-Lauroylsarcosine as potential topical microbicides against sexually transmitted diseases. Antimicrob Agents Chemother 2001; 45 (6): 1671-81
69. Piret J, Lamontagne J, Bestman-Smith J, et al. In vitro and in vivo evaluations of sodium lauryl sulfate and dextran sulfate as microbicides against herpes simplex and human immunodeficiency viruses. J Clin Microbiol 2000; 38 (1): 110-9
70. Piret J, Gagne N, Perron S, et al. Thermoreversible gel as a candidate barrier to prevent the transmission of HIV-1 and herpes simplex virus type 2. Sex Transm Dis 2001; 28 (8): 484-91
71. Wang BC, Li D, Budzilovich G, et al. Antinociception without motor blockade after subarachnoid administration of S- (+)-ibuprofen in rats. Life Sci 1994; 54 (11): 715-20
72. Paavola A, Kilpelainen I, Yliruusi J, et al. Controlled release injectable liposomal gel of ibuprofen for epidural analgesia. Int J Pharm 2000; 199 (1): 85-93
73. Paavola A, Tarkkila P, Xu M, et al. Controlled release gel of ibuprofen and lidocaine in epidural use: analgesia and systemic absorption in pigs. Pharm Res 1998; 15 (3): 482-7
74. Boogaerts J, Declercq A, Lafont N, et al. Toxicity of bupivicaine encapsulated into liposomes and injected intravenously: comparison with plain solutions. Anesth Analg 1993; 76 (3): 553-5
75. Mashimo T, Uchida I, Pak M, et al. Prolongation of canine epidural anesthesia by liposome encapsulation of lidocaine. Anesth Analg 1992; 74 (6): 827-34
76. Park YJ, Yong CS, Kim HM, et al. Effect of sodium chloride on the release, absorption and safety of diclofenac sodium delivered by poloxamer gel. Int J Pharm 2003; 263 (1-2): 105-11
77. Yong CS, Choi YK, Kim YI, et al. Physicochemical characterization and in vivo evaluation of thermosensitive diclofenac liquid suppository. Arch Pharm Res 2003; 26 (2): 162-7
78. Yong CS, Choi JS, Quan QZ, et al. Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium. Int J Pharm 2001; 226 (1-2): 195-205
79. Grassi G, Dawson P, Guarnieri G, et al. Therapeutic potential of hammerhead ribozymes in the treatment of hyper-proliferative diseases. Curr Pharm Biotechnol 2004; 5 (4): 369-86
80. Ruel-Gariepy E, Shive M, Bichara A, et al. A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel. Eur J Pharm Biopharm 2004; 57 (1): 53-63
81. Bhargava B, Karthikeyan G, Abizaid AS, et al. New approaches to preventing restenosis. BMJ 2003; 327 (7409): 274-9
82. Kearney M, Pieczek A, Haley L, et al. Histopathology of in-stent restenosis in patients with peripheral artery disease. Circulation 1997; 95 (8): 1998-2002
83. Santiago FS, Lowe HC, Kavurma MM, et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nat Med 1999; 5 (11): 1264-9
84. Castier Y, Chemla E, Nierat J, et al. The activity of c-myb antisense oligonucleotide to prevent intimal hyperplasia is nonspecific. J Cardiovasc Surg (Torino) 1998; 39 (1): 1-7
85. Grassi G, Grassi M, Platz J, et al. Selection and characterization of active hammerhead ribozymes targeted against cyclin E and E2F1 full-length mRNA. Antisense Nucleic Acid Drug Dev 2001; 11 (5): 271-87
86. Cammas S, Suzuki K, Sone C, et al. Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers. J Control Release 1997; 48: 157-64
87. Caliceti P, Salmaso S, Lante A, et al. Controlled release of biomolecules from temperature-sensitive hydrogels prepared by radiation polymerization. J Control Release 2001; 75 (1-2): 173-81
88. Morishita M, Barichello JM, Takayama K, et al. Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin. Int J Pharm 2001; 212 (2): 289-93
89. Junginger HE, Hoogstraate JA, Verhoef JC. Recent advances in buccal drug delivery and absorption: in vitro and in vivo studies. J Control Release 1999; 62 (1-2): 149-59
90. Oh CK, Ritschel WA. Absorption characteristics of insulin through the buccal mucosa. Methods Find Exp Clin Pharmacol 1990; 12 (4): 275-9
91. Sieg JW, Robinson JR. Vehicle effects on ocular drug bioavailability. I: evaluation of fluorometholone. J Pharm Sci 1975; 64 (6): 931-6
92. Miyazaki S, Suzuki S, Kawasaki N, et al. In situ gelling xyloglucan formulations for sustained release ocular delivery of pilocarpine hydrochloride. Int J Pharm 2001; 229 (1-2): 29-36
93. Lin HR, Sung KC. Carbopol/pluronic phase change solutions for ophthalmic drug delivery. J Control Release 2000; 69 (3): 379-88
94. Haineault C, Gourde P, Perron S, et al. Thermoreversible gel formulation containing sodium lauryl sulfate as a potential contraceptive device. Biol Reprod 2003; 69 (2): 687-94
95. Tyagi P, Chancellor MB, Li Z, et al. Urodynamic and immunohistochemical evaluation of intravesical capsaicin delivery using thermosensitive hydrogel and liposomes. J Urol 2004; 171 (1): 483-9
96. Matsukata M, Aoki T, Sanui K, et al. Effect of molecular architecture of poly (N-isopropylacrylamide)-trypsin conjugates on their solution and enzymatic properties. Bioconjug Chem 1996; 7 (1): 96-101
97. Ding Z, Chen G, Hoffman AS. Synthesis and purification of thermally sensitive oligomer-enzyme conjugates of poly (N-isopropylacrylamide)-trypsin. Bioconjug Chem 1996; 7 (1): 121-6
98. Mustafaev M, Osada Y, Matsukata M, et al. New amphiphilic immunogens by poly (N-isopropylacrylamide)-modified bovine serum albumin. Polymer Gels and Networks 1996; 4 (4): 363-72
99. Dilgimen AS, Mustafaeva Z, Demchenko M, et al. Water-soluble covalent conjugates of bovine serum albumin with anionic poly (N-isopropyl-acrylamide) and their immunogenicity. Biomaterials 2001; 22 (17): 2383-92
100. Salmaso S, Pennadam S, Cunliffe D, et al. Physico-chemical and pharmacokinetic studies of avidin bioconjugates with thermosensitive polymers. 32nd Annual Meeting and Exposition of the Controlled Release Society; 2005 June 18-21; Miami (FL). Minneapolis (MN): Controlled Release Society, 2005: 347