Heterogeneous oxygen extraction in the visual cortex during activation in mild hypoxic hypoxia revealed by quantitative functional magnetic resonance imaging

Journal of Cerebral Blood Flow and Metabolism

Volumn 26, Issue 2, 2006, Pages 263-273

  Tuunanen, Pasi I ^a,b   Murray, Ian J ^a   Parry, Neil R A ^c   Kauppinen, Risto A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c MANCHESTER ROYAL EYE HOSPITAL   (United Kingdom)

Author keywords

BOLD; Cerebral blood flow; fMRI; Hypoxia; Oxygen extraction; Visual cortex

Indexed keywords

ADULT; ARTICLE; BLOOD OXYGEN TENSION; BLOOD OXYGENATION; BLOOD VOLUME; BRAIN BLOOD FLOW; BRAIN METABOLISM; EVOKED VISUAL RESPONSE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEMODYNAMICS; HUMAN; HYPOXIA; MALE; NORMAL HUMAN; OXYGEN BLOOD LEVEL; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PULSE OXIMETRY; QUANTITATIVE ANALYSIS; VISUAL CORTEX;

ADULT; EVOKED POTENTIALS, VISUAL; FEMALE; HUMANS; HYPOXIA, BRAIN; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OXYGEN; OXYGEN CONSUMPTION; REFERENCE VALUES; VISUAL CORTEX;

EID: 31444447592     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600186     Document Type: Article

References (45)

1. Attwell D, Iadecola C (2002) The neural basis of functional brain imaging signals. Trends Neurosci 25:621-5
2. 2 changes - simulations using a deterministic diffusion model. Int J Imag Syst Technol 6:133-52
3. Berne RM, Winn HR, Rubio R (1981) The local regulation of cerebral blood flow. Prog Cardiovasc Dis 24:243-59
4. Buxton RB, Frank LR (1997) A model for the coupling between cerebral blood flow and oxygen metabolism during neural stimulation. J Cereb Blood Flow Metab 17:64-72
5. Cohen ER, Ugurbil K, Kim SG (2002) Effects of basal conditions on the magnitude and dynamics of the blood oxygenation level-dependent fMRI response. J Cereb Blood Flow Metab 22:1042-53
6. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC (1995) Improved assessment of significant activation in functional magnetic resonance imaging (fMRI) - use of a cluster-size threshold. Magn Reson Med 33:636-47
7. Fox PT, Raichle ME, Mintun MA, Dence C (1988) Nonoxidative glucose consumption during focal physiologic neural activity. Science 241:462-4
8. Friston KJ, Ashburner J, Frith CD, Poline JB, Heather JD, Frackowiak RSJ (1995) Spatial registration and normalization of images. Hum Brain Mapp 3:165-89
9. Friston KJ, Mechelli A, Turner R, Price CJ (2000) Nonlinear responses in fMRI - the Balloon model, Volterra kernels, and other hemodynamics. Neuroimage 12:466-77
10. 2 - increased precision and validation of principle. Magn Reson Med 46:282-91
11. Golay X, Stuber M, Pruessmann KP, Meier D, Boesiger P (1999) Transfer insensitive labeling technique (TILT) - application to multislice functional perfusion imaging. J Magn Reson Imag 9:454-61
12. 2 - a theoretical and experimental approach. J Cereb Blood Flow Metab 20:316-26
13. Haacke EM, Hopkins A, Lai S, Buckley P, Friedman L, Meltzer H, Hedera P, Friedland R, Klein S, Thompson D, Detterman D, Tkach J, Lewin JS (1994) 2D and 3D high resolution gradient echo functional imaging of the brain - venous contributions to signal in motor cortex studies. NMR Biomed 7:54-62
14. Hendrikse J, Lu H, van der Grond J, van Zijl PCM, Golay X (2003) Measurement of cerebral perfusion and arterial hemodynamics during visual stimulation using Turbo-TILT. Magn Reson Med 50:429-33
15. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB (1999) Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proc Natl Acad Sci USA 96:9403-8
16. Intaglietta M, Johnson PC, Winslow RM (1996) Microvascular and tissue oxygen distribution. Cardiovasc Res 32:632-43
17. Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17:825-41
18. Kashikura K, Kershaw J, Kashikura A, Matsuura T, Kanno I (2000) Hyperoxia-enhanced activation-induced hemodynamic response in human VI - an fMRI study. Neuroreport 11:903-6
19. Kashikura K, Kershaw J, Kashikura A, Zhang X, Matsuura T, Kanno I (2001) Hyperoxia modified activation-induced blood oxygenation level-dependent response of human visual cortex (V1) - an event-related functional magnetic resonance imaging study. Neurosci Lett 299:53-6
20. Kauppinen RA, Williams SR (1998) Acid-base disturbances monitored by NMR. In: pH and brain function (Kaila K, Ramson BR, eds), New York: John Wiley and Son, 605-20
21. Kemna LJ, Posse S, Tellmann L, Schmitz T, Herzog H (2001) Interdependence of regional and global cerebral blood flow during visual stimulation - an O-15-butanol positron emission tomography study. J Cereb Blood Flow Metab 21:664-70
22. Lindauer U, Gethmann J, Kuhl M, Kohl-Bareis M, Dirnagl U (2003) Neuronal activity induced changes of local cerebral microvascular blood oxygenation in the rat - effect of systemic hyperoxia or hypoxia. Brain Res 975:135-40
23. Lu H, Golay X, Pekar JJ, Van Zijl PC (2003) Functional magnetic resonance imaging based on changes in vascular space occupancy. Magn Reson Med 50:263-74
24. Lu H, Golay X, Pekar JJ, Van Zijl PC (2004) Sustained poststimulus elevation in cerebral oxygen utilization after vascular recovery. J Cereb Blood Flow Metab 24:764-70
25. Meadows GE, O'Driscoll DM, Simonds AK, Morrell MJ, Corfield DR (2004) Cerebral blood flow response to isocapnic hypoxia during slow-wave sleep and wakefulness. J Appl Physiol 97:1343-8
26. Mintun MA, Lundstrom BN, Snyder AZ, Vlassenko AG, Shulman GL, Raichle ME (2001) Blood flow and oxygen delivery to human brain during functional activity - theoretical modeling and experimental data. Proc Natl Acad Sci USA 98:6859-64
27. Mulligan SJ, MacVigar BA (2004) Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature 431:195-9
28. Ogawa S, Menon RS, Tank DW, Kim S-G, Merkle H, Ellerman JM, Ugurbil K (1993) Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging - a comparison of signal characteristics with a biophysical model. Biophys J 64:803-12
29. Oja JM, Gillen JS, Kauppinen RA, Kraut M, van Zijl PC (1999a) Determination of oxygen extraction ratios by magnetic resonance imaging. J Cereb Blood Flow Metab 19:1289-95
30. Oja JME, Gillen J, Kauppinen RA, Kraut M, van Zijl PCM (1999b) Venous blood effects in spin echo fMRI of human brain. Magn Reson Med 42:617-26
31. Posse S, Kemna LJ, Elghahwagi B, Wiese S, Kiselev VG (2001) Effect of graded hypo- and hypercapnia on fMRI contrast in visual cortex - quantification of T(*)(2) changes by multiecho EPI. Magn Reson Med 46:264-71
32. Powers WJ, Hirsch IB, Cryer PE (1996) Effect of stepped hypoglycemia on regional cerebral blood flow response to physiological brain activation. Am J Physiol 270: H554-9
33. Shimojyo S, Scheinberg P, Kogure K, Reinmuth OM (1968) The effects of graded hypoxia upon transient cerebral blood flow and oxygen consumption. Neurology 18: 127-33
34. Shimosegawa E, Kanno I, Hatazawa J, Fujita H, Iida H, Miura S, Murakami M, Inugami A, Ogawa T, Itoh H, Okudera T, Uemura K (1995) Photic stimulation study of changing the arterial partial pressure level of carbon dioxide. J Cereb Blood Flow Metab 15:111-4
35. Siesjö BK (1978) Brain Energy Metabolism. Chichester: John Wiley & Sons
36. 2* on oxygen saturation at 1.5 and 4.7 tesla. Magn Reson Med 49:47-60
37. Song AW, Wong EC, Tan SG, Hyde JS (1996) Diffusion weighted fMRI at 1.5 T. Magn Reson Med 35:155-8
38. Thompson JK, Peterson MR, Freeman RD (2004) High-resolution neurometabolic coupling revealed by focal activation of visual neurons. Nat Neurosci 7:919-92
39. Uludag K, Dubowitz DJ, Yoder EJ, Restom K, Liu TT, Buxton RB (2004) Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRI. Neuroimage 23:148-55
40. van Zijl PC, Eleff SM, Ulatowski JA, Oja JM, Ulug AM, Traystman RJ, Kauppinen RA (1998) Quantitative assessment of blood flow, blood volume and blood oxygenation effects in functional magnetic resonance imaging. Nat Med 4:159-67
41. Weckesser M, Posse S, Olthoff U, Kemna L, Dager S, Muller-Gartner HW (1999) Functional imaging of the visual cortex with bold-contrast MRI - hyperventilation decreases signal response. Magn Reson Med 41:213-6
42. Worsley KJ, Evans AC, Marrett S, Neelin P (1992) A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 12:900-18
43. Yablonskiy DA, Haacke EM (1994) Theory of NMR signal behavior in magnetically inhomogeneous tissues - the static dephasing regime. Magn Reson Med 32:749-63
44. Zheng Y, Martindale J, Johnston D, Jones M, Berwick J, Mayhew J (2002) A model of the hemodynamic response and oxygen delivery to brain. Neuroimage 16:617-37
45. Zonta M, Angulo MC, Gobbo S, Rosengarten B, Hossmann KA, Pozzan T, Carmignoto G (2003) Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat Neurosci 6:43-50