A single mutation causes a spectrum of cardiovascular defects: The potential role of genetic modifiers, epigenetic influences, and stochastic events in phenotypic variability

Journal of Molecular and Cellular Cardiology

Volumn 40, Issue 2, 2006, Pages 201-204

  Black, Brian L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

BALB c; C57BL 6; CHF1; Developmental noise; DiGeorge; Epigenetic; Genetic modifiers; Gridlock; Hesr2; Hey2; Hirschsprung; Holt Oram; Hrt2; Mouse; Outflow tract; Sox10; Stochastic; Tbx1; Tbx5; Ventricular septal defect; VSD

Indexed keywords

CARDIOVASCULAR HELIX LOOP HELIX FACTOR 1; ENDOTHELIN RECEPTOR; HOMEODOMAIN PROTEIN; REPRESSOR PROTEIN; T BOX TRANSCRIPTION FACTOR; T BOX TRANSCRIPTION FACTOR 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX10; TRANSCRIPTION FACTOR SOX8; UNCLASSIFIED DRUG;

CARDIOVASCULAR DISEASE; CHROMOSOME 22Q; CRANIOFACIAL MALFORMATION; DIGEORGE SYNDROME; DNA MODIFICATION; EDITORIAL; GENE IDENTIFICATION; GENE MUTATION; HEART ATRIUM SEPTUM DEFECT; HIRSCHSPRUNG DISEASE; HUMAN; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARDIOVASCULAR ABNORMALITIES; EPIGENESIS, GENETIC; GENE DELETION; HIRSCHSPRUNG DISEASE; MICE; MUTATION; PHENOTYPE; REPRESSOR PROTEINS; STOCHASTIC PROCESSES; VARIATION (GENETICS);

EID: 31444439046     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2005.10.008     Document Type: Editorial

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