Short-term feeding of conjugated linoleic acid does not induce hepatic steatosis in C57BL/6J mice

Journal of Nutritional Science and Vitaminology

Volumn 51, Issue 6, 2005, Pages 440-444

  Wang, Yu Ming ^a   Nagao, Koji ^a   Ujino, Yoko ^a   Sakata, Kotaro ^a   Higa, Kouki ^a   Inoue, Nao ^a   Yanagita, Teruyoshi ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

C57BL 6J mice; Conjugated linoleic acid; Diacylglycerol acyltransferase; Hepatic steatosis

Indexed keywords

ADIPOCYTOKINE; DIACYLGLYCEROL ACYLTRANSFERASE; LINOLEIC ACID; LIPOPROTEIN; SAFFLOWER OIL; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; CONCENTRATION RESPONSE; CONJUGATION; CONTROLLED STUDY; DIETARY INTAKE; FATTY ACID DESATURATION; FATTY ACID OXIDATION; FATTY LIVER; FEEDING BEHAVIOR; HEPATOMEGALY; LIPID LIVER LEVEL; LIPID METABOLISM; LIPODYSTROPHY; LIVER METABOLISM; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; OBESITY;

ANIMALIA; CARTHAMUS TINCTORIUS;

EID: 31444437257     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.51.440     Document Type: Article

References (50)

1. Ha YL, Grimm NK, Pariza MW. 1989. Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J Agric Food Chem 57: 75-81.
2. Chin SF, Liu W, Storkson JM, Ha YL, Pariza MW. 1992. Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens. J Food Comp Anal 5: 185-197.
3. Ip C, Scimeca JA, Thompson HJ. 1994. Conjugated linoleic acid, a powerful anticarcinogen from animal fat sources. Cancer 74: 1050-1054.
4. Lee KN, Kritchevsky D, Pariza MW. 1994. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108: 19-25.
5. Nagao K, Wang YM, Inoue N, Han SY, Buang Y, Noda T, Kouda N, Okamatsu H, Yanagita T. 2003. The 10trans, 12cis isomer of conjugated linoleic acid promotes energy metabolism in OLETF rats. Nutrition 19: 652-656.
6. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, Portocarrero CP, Peck LW, Nickel KP, Belury MA. 1998. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 244: 678-682.
7. Smedman A, Vessby B. 2001. Conjugated linoleic acid supplementation in human metabolic effects. Lipids 36: 773-781.
8. Nagao K, Inoue N, Wang YM, Buang Y, Hirata J, Nagao T, Shimada Y, Matsui T, Yanagita T. 2003. The 10trans, 12cis isomer of conjugated linoleic acid suppresses the development of hypertension in Otsuka Long-Evans Tokushima Fatty rats. Biochem Biophys Res Commun 306: 134-138.
9. Nagao K, Inoue, N, Wang YM, Yanagita T. 2003. Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats. Biochem Biophys Res Commun 310: 562-566.
10. Inoue N, Nagao K, Hirata J, Wang YM, Yanagita T. 2004. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Biochem Biophys Res Commun 323: 679-684.
11. Tsuboyama-Kasaoka N, Takahashi M, Tanemura K, Kim HJ, Tnage T, Okuyama H, Kasai M, Ikemoto S, Ezaki O. 2000. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes 49: 1534-1542.
12. Clement L, Pirier H, Niot I, Bocher V, Guerre-Millo M, Krief S, Staels B, Besnard P. 2002. Dietary trans-10, cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. J Lipid Res 43: 1400-1409.
13. Pariza MW. 2004. Perspective on the safety and effectiveness of conjugated linoleic acid. Am J Clin Nutr 79: S1132-S1136.
14. Berven G, Bye A, Hals O, Blankson H, Fagertun H, Thom E, Wadstein J, Gudmundsen O. 2000. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol 102: 455-462.
15. Kreider RB, Ferreira MP, Greenwood M, Wilson M, Almada AL. 2002. Effect of conjugated linoleic acid supplementation during resistance training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res 16: 325-334.
16. Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, Gudmundsen O. 2005. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135: 778-784.
17. Tsuboyama-Kasaoka N, Miyazaki H, Kasaoka S, Ezaki O. 2003. Increasing the amount of fat in a conjugated linoleic acid-supplemented diet reduces lipodystrophy in mice. J Nutr 133: 1793-1799.
18. Folch J, Lee M, Sloane-Stanley GH. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
19. Fletcher MJ. 1968. A colorimetric method for estimating serum triglyceride. Clin Chim Acta 22: 393-397.
20. Sperry WM, Webb M, 1950. A version of the Shoenheimer-Sperry method for cholesterol determination. J Biol Chem 187: 97-106.
21. Ikeda I, Cha JY, Yanagita T, Nakatani N, Oogami K, Imaizumi K, Yazawa K. 1998. Effects of dietary α-linoleic, eicosapentaenoic and docosahexaenoic acids on hepatic lipogenesis and β-oxidation in rats. Biosci Biotech Biochem 62: 675-680.
22. Usui S, Hara Y, Hosaki S, Okazaki M. 2002. A new online dual enzymatic method for simultaneous quantification of cholesterol and triglycerides in lipoproteins by HPLC. J Lipid Res 43: 805-814.
23. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
24. Markwell MAK, McGroarty EJ, Bieber LL, Tolbert NE. 1973. The subcellular distribution of carnitine acyltransferases in mammalian liver and kidney. J Biol Chem 248: 3433-3440.
25. Lazarow PB. 1981. Assay of peroxisomal β-oxidation of fatty acids. Methods Enzymol 72: 315-319.
26. Kelley DS, Nelson GJ, Hunt JE. 1986. Effect of prior nutritional status on the activity of lipogenic enzymes in primary monolayer cultures of rat hepatocytes. Biochem J 235: 87-90.
27. Coleman R, Bell M. 1976. Triacylglycerol synthesis in isolated fat cells. Studies on the microsomal diacylglycerol acyltransferase activity using ethanol-dispersed diacylglycerols. J Biol Chem 251: 4537-4543.
28. Kissebah AH, Krakower GR. 1994. Regional adiposity and morbidity. Physiol Rev 74: 761-811.
29. Must A, Spadano J, Coakley EH, Field AE, Colditz G, Detz WH. 1999. The disease burden associated with overweight and obesity. JAMA 282: 1523-1529.
30. Adler A. 2002. Obesity and target organ damage: diabetes. Int J Obes Relat Metab Disord 26: S11-S14.
31. Fiegal KM. Carroll MD, Ogden CL, Johnson CL. 2002. Prevalence and trends in obesity among U.S. adults 1999-2000. JAMA 288: 1723-1727.
32. Pi-Sunyer FX. 2002. The medical risks of obesity. Obes Surg 12: S6-S11.
33. Park Y, Albright KJ, Storkson JM, Liu W, Cook ME, Pariza MW. 1999. Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34: 243-248.
34. Delany JP, Blohm F, Truett AA, Scimeca JA, West DB. 1999. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 276: R1172-R1179.
35. Thom E, Wadstein J, Gudmundsen O. 2001. Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 29: 392-396.
36. Rahman SM, Wang YM, Yotsumoto H, Cha JY, Han SY, Inoue S, Yanagita T. 2001. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and β-oxidation of fatty acid in OLETF rats. Nutrition 17: 385-390.
37. Wang YM. Rahman SM, Nagao K, Arao K, Inoue N, Yanagita T. 2003. Comparison of the effects of triacylglycerol-CLA and free fatty acid-CLA on hepatic lipid metabolism in OLETF obese rats. J Oleo Sci 52: 121-128.
38. Wang YM. Rahman SM, Nagao K, Han SY, Buang Y. Cha JY, Yanagita T. 2003. Conjugated linoleic acid reduces hepatic microsomal triacylglycerol transfer protein activity and hepatic triacylglycerol mass in obese rats. J Oleo Sci 52: 129-134.
39. Rizvi F. Puri A, Bhatia G, Khanna AK, Wulff EM, Rastogi AK, Chander R. 2003. Antidyslipidemic action of fenofibrate in dyslipidemic-diabetic hamster model. Biochem Biophys Res Commun 305: 215-222.
40. Nagao K, Sakono M, Nakayama M, Hirakawa T, Imaizumi K. 1999. Effect of gemfibrozil on triacylglycerol synthesis and secretion by liver and lipoprotein lipase activity in adipose tissue of rats. Comp Biochem Physiol B Biochem Mol Biol 124: 289-294.
41. Nagao K, Yoshida S, Nakagiri H, Sakono M, Sato M, Imaizumi K. 1998. Gemfibrozil reduces non-high-density lipoprotein cholesterol in exogenously hypercholesterolemic (ExHC) rats fed a high-cholesterol diet. Comp Biochem Physiol B Biochem Mol Biol 120: 579-586.
42. Park Y, Storkson JM, Ntambi JM, Cook ME, Sih CJ, Pariza MW. 2000. Inhibition of hepatic stearoyl-CoA desaturase activity by irans-10,cis-12 conjugated linoleic acid and its derivatives. Biochem Biophys Acta 1486: 285-292.
43. Choi Y, Park Y. Pariza MW, Ntambi JM. 2001. Regulation of stearoyl-CoA desaturase activity by the trans-10, cis-12 isomer of conjugated linoleic acid in HepG2 cells. Biochem Biophys Res Commun 284: 689-693.
44. Lin X, Loor JJ, Herbein JH. 2004. Trans10,cis12-18:2 is a more potent inhibitor of de novo fatty acid synthesis and desaturation than cis9,trans11-18:2 in the mammary gland of lactating mice. J Nutr 134: 1362-1368.
45. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y. Funahashi T, Matsuzawa Y. 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257: 79-83.
46. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y. 2001. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50: 1126-1133.
47. Yu YH, Ginsberg HN. 2005. Adipocyte signaling and lipid homeostasis: sequelae of insulin-resistant adipose tissue. Circ Res 96: 1042-1052.
48. Shimomura I, Hammer RE, Ikemoto S, Brown MS, Goldstein JL. 1999. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401: 73-76.
49. Yamauchi T, Kamon J, Waki H, Terauchi Y. Kubota N, Kara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T. 2001. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-946.
50. Ohashi A, Matsushita Y, Shibata H, Kimura K, Miyashita K, Saito M. 2004. Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin. J Nutr Sci Vitaminol 50: 416-421.