Saccharomyces kluyveri FAD3 encodes an ω3 fatty acid desaturase

Microbiology

Volumn 150, Issue 6, 2004, Pages 1983-1990

  Oura, Takahiro ^a   Kajiwara, Susumu ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; FUNGAL ENZYME; LINOLEIC ACID; POLYUNSATURATED FATTY ACID;

AMINO ACID ANALYSIS; ARTICLE; CATALYSIS; CONTROLLED STUDY; CULTURE MEDIUM; FATTY ACID SYNTHESIS; GENE DISRUPTION; GENE SEQUENCE; GENETIC TRANSCRIPTION; LOW TEMPERATURE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SACCHAROMYCES; SACCHAROMYCES KLUYVERI;

ANIMALIA; EUKARYOTA; FUNGI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES KLUYVERI;

EID: 3142740934     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.27049-0     Document Type: Article

References (39)

1. Anamnart, S., Tomita, T., Fukui, F., Fujimori, K., Harashima, S., Yamada, Y. & Oshima, Y. (1997). The P-OLE1 gene of Pichia angusta encodes a Δ9-fatty acid desaturase and complements the ole1 mutation of Saccharomyces cerevisiae. Gene 184, 299-306.
2. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (1992). Current Protocols in Molecular Biology New York: Green Publishing Associates & Wiley-interscience.
3. Browse, J. & Somerville, C. (1991). Glycerolipid synthesis: biochemistry and regulation. Annu Rev Plant Physiol Plant Mol Biol 42, 467-506.
4. 16:3 leaf lipids. Plant Physiol 81, 859-864.
5. Browse, J., Kunst, L., Anderson, S., Hugly, S. & Somerville, C. R. (1989). A mutant of Arabidopsis deficient in the chloroplast 16:1/18:1 desaturase. Plant Physiol 90, 522-529.
6. Browse, J., McConn, M., James, D., Jr & Miquel, M. (1993). Mutants of Arabidopsis deficient in the synthesis of alpha-linolenate. Biochemical and genetic characterization of the endoplasmic reticulum linoleoyl desaturase. J Biol Chem 268, 16345-16351.
7. Burke, D., Dawson, D. & Stearns, T. (2000). Methods in Yeast Genetics: a Cold Spring Harbor Laboratory Manual, 2000 edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
8. Calvo, A. M., Gardner, H. W. & Keller, N. P. (2001). Genetic connection between fatty acid methabolism and sporulation in Aspergillus nidulans. J Biol Chem 276, 25766-25774.
9. Fay, L. & Richli, U. (1991). Location of double bonds in poly-unsaturated fatty acids by gas chromatography-mass spectrometry after 4,4-dimethyloxazoline derivatization. J Chromatogr 541, 89-98.
10. Jones, J. S. & Prakash, L. (1990). Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast 6, 363-369.
11. Kajiwara, S. (2002). Molecular cloning and characterization of the Δ9 fatty acid desaturase gene and its promoter region from Saccharomyces kluyveri. FEMS Yeast Res 2, 333-339.
12. Kajiwara, S., Shirai, A., Fujii, T., Toguri, T., Nakamura, K. & Ohtaguchi, K. (1996). Polyunsaturated fatty acid biosynthesis in Saccharomyces cerevisiae: expression of ethanol tolerance and the FAD2 gene from Arabidopsis thaliana. Appl Environ Microbiol 62, 4309-4313.
13. Kajiwara, S., Aritomi, T., Suga, K., Ohtaguchi, K. & Kobayashi, O. (2000a). Overexpression of the OLE1 gene enhances ethanol fermentation by Saccharomyces cerevisiae. Appl Microbiol Biotechnol 53, 568-574.
14. Kajiwara, S., Suga, K., Sone, H. & Nakamura, S. (2000b). Improved ethanol tolerance of Saccharomyces cerevisiae strains by increases in fatty acyl unsaturation via methabolic engineering. Biotechnol Lett 22, 1839-1843.
15. Kinsella, J. E., Lokesh, B., Broughton, S. & Whelan, J. (1990). Dietary polyunsaturated fatty acids and eicosanoids: potential effects on the modulation of inflammatory and immune cells: an overview. Nutrition 6, 24-44.
16. Laoteng, K., Anjard, C., Rachadawong, S., Tanticharoen, M., Maresca, B. & Cheevadhanarak, S. (1999). Mucor rouxii Δ 9-desaturase gene is transcriptionally regulated during cell growth and by low temperature. Mol Cell Biol Res Commun 1, 36-43.
17. Los, D. A. & Murata, N. (1998). Structure and expression of fatty acid desaturase. Biochim Biophys Acta 1394, 3-15.
18. McConn, M., Hugly, S., Somerville, C. & Browse, J. (1994). A mutation at the fad8 locus of Ambidopsis identifies a second chloroplast ω-3 desaturase. Plant Physiol 106, 1609-1614.
19. McDonough, V. M., Stukey, J. E. & Martin, C. E. (1992). Specificity of unsaturated fatty acid-regulated expression of Saccharomyces cerevisiae OLE1 gene. J Biol Chem 267, 5931-5936.
20. Meesapyodsuk, D., Reed, D. W., Savile, C. K., Buist, P. H., Schfäer, U. A., Ambrose, S. J. & Covello, P. S. (2000). Substrate specificity, regioselectivity and cryptoregiochemistry of plant and animal ω-3 fatty acid desaturases. Biochem Soc Trans 28, 632-635.
21. Miquel, M. & Browse, J. (1992). Arabidopsis mutants deficient in polyunsaturated fatty acid synthesis. Biochemical and genetic characterization of a plant oleoyl-phosphatidylcholine desaturase. J Biol Chem 267, 1502-1509.
22. Nakagawa, Y., Sakumoto, N., Kaneko, Y. & Harashima, S. (2002). Mga2p is a putative sensor for low temperature and oxygen to induce OLE1 transcription in Saccharomyces cerevisiae. Biochem Biophys Res Commun 291, 707-713.
23. Okuley, J., Lightner, J., Feidmann, K. A., Yadav, N., Lark, E. & Browse, J. (1994). Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid biosynthesis. Plant Cell 6, 147-158.
24. Passorn, S., Laoteng, K., Rachadawong, S., Tanticharoen, M. & Cheevadhanarak, S. (1999). Heterogous expression of Mucor rouxii Δ12-desaturase gene in Saccharomyces cerevisiae. Biochem Biophys Res Commun 263, 47-51.
25. Pereira, S. L., Huang, Y.-S., Bobik, E. G., Kinney, A. J., Stecca, K. L., Packer, J. C. & Mukerji, P. (2004). A novel omega3- (ω3-) fatty acid desaturase involved in the biosynthesis of eicosapentaenoic acid. Biochem J 378, 665-671.
26. Peyou-Ndi, M. M., Watts, J. L. & Browse, J. (2000). Identification and characterization of an animal Δ12 fatty acid desaturase gene by heterogous expression in Saccharomyces cerevisiae. Arch Biochem Biophys 376, 399-408.
27. Ratledge, C. & Evans, C. T. (1991). Lipids and their metabolism. In The Yeasts, 2nd edn, pp. 367-455. London: Academic Press.
28. Sakai, H. & Kajiwara, S. (2003). A stearoyl-CoA-specific Δ9 fatty acid desaturase from basidiomycete Lentinula edodes. Biosci Biotechnol Biochem 67, 2431-2437.
29. Sakamoto, T., Los, D. A., Higashi, S., Wada, H., Nishida, I., Ohmori, M. & Murata, N. (1994). Cloning of ω3 desaturase from cyanobacteria and its use in altering the degree of membrane lipid unsaturation. Plant Mol Biol 26, 249-263.
30. Sakuradani, E., Kobayashi, M., Ashikari, T. & Shimizu, S. (1999). Identification of Δ12 fatty acid desaturase from arachidonic acid-producing Mortierella fungus by heterologous expression in the yeast Saccharomyces cerevisiae and the fungus Aspergillus oryzae. Eur J Biochem 261, 812-820.
31. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
32. Spitzer, V. (1997). Structure analysis of fatty acids by gas chromatography-low resolution electron impact mass spectrometry of their 4,4-dimethyloxazoline derivatives - a review. Prog Lipid Res 35, 387-408.
33. Spychalla, J. P., Kinney, A. J. & Browse, J. (1997). Identification of an animal ω-3 fatty acid desaturase by heterogous expression in Arabidopsis. Proc Natl Acad Sci U S A 94, 1142-1147.
34. Tocher, D. R., Leaver, M. J. & Hodgson, P. A. (1998). Recent advances in the biochemistry and molecular biology of fatty acyl desaturases. Prog Lipid Res 37, 73-117.
35. Wada, H., Gombos, Z. & Murata, N. (1990). Enhancement of chilling tolerance of a cyanobacterium by genetic manipulation of fatty acid desaturation. Nature 347, 200-203.
36. Wallis, J. G. & Browse, J. (2002). Mutants of Arabidopsis reveal many roles for membrane lipids. Prog Lipid Res 41, 254-278.
37. Wallis, J. G., Watts, J. L. & Browse, J. (2002). Polyunsaturated fatty acid synthesis: what will they think of next? Trends Biochem Sci 27, 467-473.
38. Watanabe, K., Oura, T., Sakal, H. & Kajiwara, S. (2004). Yeast Δ12 fatty acid desaturase: gene cloning, expression and function. Biosci Biotechnol Biochem 68, 721-727.
39. Yadav, N. S., Wierzbicki, A., Aegerter, M. & 15 other authors (1993). Cloning of higher plant ω-3 fatty acid desaturases. Plant Physiol 103, 467-476.