SLI1 (YGR212W) is a major gene conferring resistance to the sphingolipid biosynthesis inhibitor ISP-1, and encodes an ISP-1 N-acetyltransferase in yeast

Biochemical Journal

Volumn 381, Issue 1, 2004, Pages 321-328

  Momoi, Michiko ^a,b   Tanoue, Daisuke ^a,b   Sun, Yidi ^a   Takematsu, Hiromu ^a   Suzuki, Yusuke ^b   Suzuki, Minoru ^b   Suzuki, Akemi ^b   Fujita, Tetsuro ^c   Kozutsumi, Yasunori ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b Japan Science and Technology Agency   (Japan)

^c RESEARCH INSTITUTE FOR PRODUCTION DEVELOPMENT   (Japan)

Author keywords

Condensation domain; Drug resistance gene; ISP 1; Myriocin; N acetyltransferase; Serine palmitoyltransferase

Indexed keywords

ALCOHOLS; BIOSYNTHESIS; CLONING; ENZYME INHIBITION; ENZYMES; GENES; LIPIDS; YEAST;

BIOLOGICAL FUNCTIONS; SPHINGOLIPIDS;

BIOCHEMISTRY;

ACYLTRANSFERASE; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID; THERMOZYMOCIDIN;

ARTICLE; BIOSYNTHESIS; FUNGAL STRAIN; FUNGUS GROWTH; GENETIC TRANSFECTION; IC 50; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; YEAST;

ACETYLATION; ACETYLTRANSFERASES; ANTIBIOTICS, ANTIFUNGAL; ARYLAMINE N-ACETYLTRANSFERASE; DRUG RESISTANCE, FUNGAL; ENZYME INHIBITORS; FATTY ACIDS, MONOUNSATURATED; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; OPEN READING FRAMES; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPHINGOLIPIDS;

FUNGI; MAMMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 3142740773     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20040108     Document Type: Article

References (45)

1. Fishbein, J. D., Dobrowsky, R. T., Bielawska, A., Garrett, S. and Hannun, Y. A. (1993) Ceramide-mediated growth inhibition and CAPP are conserved in Saccharomyces cerevisiae. J. Biol. Chem. 268, 9255-9261
2. Nickels, J. T. and Broach, J. R. (1996) A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev. 10, 382-394
3. Jenkins, G. M., Richards, A., Wahl, T., Mao, C., Obeid, L. and Hannun, Y. (1997) Involvement of yeast sphingolipids in the heat stress response of Saccharomyces cerevisiae. J. Biol. Chem. 272, 32566-32572
4. Dickson, R. C., Nagiec, E. E., Skrzypek, M., Tillman, P., Wells, G. B. and Lester, R. L. (1997) Sphingolipids are potential heat stress signals in Saccharomyces. J. Biol. Chem. 272, 30196-30200
5. Chung, N., Jenkins, G., Hannun, Y. A., Heitman, J. and Obeid, L. M. (2000) Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J. Biol. Chem. 275, 17229-17232
6. Skrzypek, M. S., Nagiec, M. M., Lester, R. L. and Dickson, R. C. (1998) Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae. J. Biol. Chem. 273, 2829-2834
7. Chung, N., Mao, C., Heitman, J., Hannun, Y. A. and Obeid, L. M. (2001) Phytosphingosine as a specific inhibitor of growth and nutrient import in Saccharomyces cerevisiae. J. Biol. Chem. 276, 35614-35621
8. Sutterlin, C., Doering, T. L., Schimmoller, F., Schroder, S. and Riezman, H. (1997) Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast. J. Cell Sci. 110, 2703-2714
9. Zanolari, B., Friant, S., Funato, K., Sutterlin, C., Stevenson, B. J. and Riezman, H. (2000) Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J. 19, 2824-2833
10. Horvath, A., Sutterlin, C., Manning-Krieg, U., Movva, N. R. and Riezman, H. (1994) Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast. EMBO J. 13, 3687-3695
11. Buede, R., Rinker-Schaffer, C., Pinto, W. J., Lester, R. L. and Dickson, R. C. (1991) Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids. J. Bacteriol. 173, 4325-4332
12. Nagiec, M. M., Baltisberger, J. A., Wells, G. B., Lesler, R. L. and Dickson, R. C. (1994) The LCB2 gene of Saccharomyces and the related LCB1 gene encode subunits of serine palmitoyltransferase, the initial enzyme in sphingolipid synthesis. Proc. Natl. Acad. Sci. U.S.A. 91, 7899-7902
13. Nagiec, M. M., Skrzypek, M., Nagiec, E. E., Lester, R. L. and Dickson, R. C. (1998) The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J. Biol. Chem. 273, 19437-19442
14. Mao, C., Wadleigh, M., Jenkins, G. M., Hannun, Y. A. and Obeid, L. M. (1997) Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J. Biol. Chem. 272, 28690-28694
15. Qie, L., Nagiec, M. M., Baltisberger, J. A., Lester, R. L. and Dickson, R. C. (1997) Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. J. Biol. Chem. 272, 16110-16117
16. Mandala, S. M., Thornton, R., Tu, Z., Kurtz, M. B., Nickels, J., Broach, J., Menzeleev, R. and Spiegel, S. (1998) Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl. Acad. Sci. U.S.A. 95, 150-155
17. Schorling, S., Vallee, B., Barz, W. P., Riezman, H. and Oesterhelt, D. (2001) Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol. Biol. Cell 12, 3417-3427
18. Kluepfel, D., Bagli, J., Baker, H., Charest, M. P. and Kudelski, A. (1972) Myriocin, a new antifungal antibiotic from Myriococcum albomyces. J. Antibiot. 25, 109-115
19. Craveri, R., Manachini, P. L. and Aragozzini, F. (1972) Thermozymocidin new antifungal antibiotic from a thermophilic eumycete. Experientia 28, 867-868
20. Fujita, T., Inoue, K., Yamamoto, S., Ikumoto, T., Sasaki, S., Toyama, R., Chiba, K., Hoshino, Y. and Okumoto, T. (1994) Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. J. Antibiot. 47, 208-215
21. Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T. and Kawasaki, T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211, 396-403
22. Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M. and Hoshino, Y. (1998) FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. J. Immunol. 160, 5037-5044
23. Kahan, B. D. and Koch, S. M. (2001) Current immunosuppressant regimens: considerations for critical care. Curr. Opin. Crit. Care 7, 242-250
24. Mandala, S., Hajdu, R., Bergstrom, J., Quackenbush, E., Xie, J., Milligan, J., Thornton, R., Shei, G. J., Card, D., Keohane, C. et al. (2002) Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346-349
25. Brinkmann, V., Davis, M. D., Heise, C. E., Albert, R., Cottens, S., Hof, R., Bruns, C., Prieschl, E., Baumruker, T., Hiestand, P. et al. (2002) The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277, 21453-21457
26. Webster, M. K., Goya, L., Ge, Y., Maiyar, A. C. and Firestone, G. L. (1993) Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol. Cell. Biol. 13, 2031-2040
27. Kobayashi, T. and Cohen, P. (1999) Activation of serum- and glucocorticoid-regulated protein kinase by agonists that activate phosphatidylinositide 3-kinase is mediated by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and PDK2. Biochem. J. 339, 319-328
28. Sun, Y., Taniguchi, R., Tanoue, D., Yamaji, T., Takematsu, H., Mori, K., Fujita, T., Kawasaki, T. and Kozutsumi, Y. (2000) Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid- mediated signaling pathway of yeast. Mol. Cell. Biol. 20, 4411-4419
29. Friant, S., Lombardi, R., Schmelzle, T., Hall, M. N. and Riezman, H. (2001) Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J. 20, 6783-6792
30. Fujita, T., Inoue, K., Yamamoto, S., Ikumoto, T., Sasaki, S., Toyama, R., Yoneta, M., Chiba, K., Hoshino, Y. and Okumoto, T. (1994) Fungal metabolites. Part 12. Potent immunosuppressant, 14-deoxomyriocin,(2S,3R,4R)-(E)-2-amino-3,4- dihydroxy-2-hydroxymethyleicos-6-enoic acid and structure - activity relationships of myriocin derivatives. J. Antibiot. 47, 216-224
31. Roelants, F. M., Torrance, P. D., Bezman, M. and Thorner, J. (2002) Pkh1 and pkh2 differentially phosphorylate and activate ypk1 and ykr2 and define protein kinase modules required for mainfenance of cell wall integrity. Mol. Biol. Cell 13, 3005-3028
32. Hanson, B. A. and Lester, R. L. (1980) The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa. J. Lipid Res. 21, 309-315
33. Kohno, K., Normington, K., Sambrook, J., Gething, M. J. and Mori, K. (1993) The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum. Mol. Cell. Biol. 13, 877-890
34. Malcorps, P. and Dufour, J. P. (1992) Short-chain and medium-chain aliphatic-ester synthesis in Saccharomyces cerevisiae. Eur. J. Biochem. 210, 1015-1022
35. Fujii, T., Nagasawa, N., Iwamatsu, A., Bogaki, T., Tamai, Y. and Hamachi, M. (1994) Molecular cloning, sequence analysis, and expression of the yeast alcohol acetyltransferase gene. Appl. Environ. Microbiol. 60, 2786-2792
36. Yoshimoto, H., Fujiwara, D., Momma, T., Tanaka, K., Sone, H., Nagasawa, N. and Tamai, Y. (1999) Isolation and characterization of the ATF2 gene encoding alcohol acetyltransferase II in the bottom fermenting yeast Saccharomyces pastorianus. Yeast 15, 409-417
37. Casamayor, A., Torrance, P. D., Kobayashi, T., Thorner, J. and Alessi, D. R. (1999) Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr. Biol. 9, 186-197
38. Chen, P., Lee, K. S. and Levin, D. E. (1993) A pair of putative protein kinase genes (YPK1 and YPK2) is required for cell growth in Saccharomyces cerevisiae. Mol. Gen. Genet. 236, 443-447
39. Marahiel, M. A., Stachelhaus, T. and Mootz, H. D. (1997) Modular peptide synthetases involved in nonribosomal peptide synthesis. Chem. Rev. 97, 2651-2674
40. Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T. and Merrill, Jr, A. H. (1991) Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266, 14486-14490
41. Nagiec, M. M., Nagiec, E. E., Baltisberger, J. A., Wells, G. B., Lester, R. L. and Dickson, R. C. (1997) Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J. Biol. Chem. 272, 9809-9817
42. Rose, M. D., Misra, L. M. and Vogel, J. P. (1989) KAR2, a karyogamy gene, is the yeast homolog of the mammalian BiP/GRP78 gene. Cell 57, 1211-1221
43. Furuya, S., Mitoma, J., Makino, A. and Hirabayashi, Y. (1998) Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells. J. Neurochem. 71, 366-377
44. Hanada, K., Hara, T. and Nishijima, M. (2000) Purification of the serine palmitoyltransferase complex responsible for sphingoid base synthesis by using affinity peptide chromatography techniques. J. Biol. Chem. 275, 8409-8415
45. Hanada, K., Nishijima, M., Fujita, T. and Kobayashi, S. (2000) Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant. Biochem. Pharmacol. 59, 1211-1216