Cetirizine reduces cytokines and inflammatory cells in children with perennial allergic rhinitis

European Annals of Allergy and Clinical Immunology

Volumn 36, Issue 6, 2004, Pages 237-240

  Ciprandi, G ^a   Tosca, M A ^b   Milanese, M ^a   Ricca, V ^c  

^a UNIVERSITY OF GENOA   (Italy)

^b G GASLINI INSTITUTE   (Italy)

^c Ospedale Koelliker   (Italy)

Author keywords

Cetirizine; Children; Cytokines; Inflammatory cells; Perennial allergic rhinitis

Indexed keywords

CETIRIZINE; CYTOKINE; INTERLEUKIN 4; INTERLEUKIN 8;

ADOLESCENT; ALLERGIC RHINITIS; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; EOSINOPHIL; EVALUATION; FEMALE; HUMAN; INFLAMMATORY CELL; MALE; NEUTROPHIL; NOSE OBSTRUCTION; PERENNIAL RHINITIS; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SCORING SYSTEM;

ADOLESCENT; ANIMALS; CETIRIZINE; CHILD; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; FEMALE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HUMANS; INTERLEUKIN-4; INTERLEUKIN-8; MALE; NASAL LAVAGE FLUID; NASAL MUCOSA; NASAL OBSTRUCTION; NEUTROPHILS; POLLEN; PROSPECTIVE STUDIES; PYROGLYPHIDAE; RHINITIS, ALLERGIC, PERENNIAL; RHINITIS, ALLERGIC, SEASONAL; TREATMENT OUTCOME;

EID: 3142736391     PISSN: 03979148     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Howarth P.-H., Wilson S., Lau L. et al. - The nasal mast cell and rhinitis. Clin Exp Allergy 1991; 21(Suppl. 21):3-15.
2. Bradding P., Feather I.-H., Wilson S. et al. - Direct in vivo evidence for mast cell degranulation during allergen-induced reactions in man. J Immunol 1993;151:3853-65.
3. Ciprandi G., Buscaglia S., Pesce G.-P. et al. - Cetirizine reduces ICAM-1 (or CD54) expression both in early and late phase events following allergen-specific conjunctival challenge. J Allergy Clin Immunol 1995;95:612-21.
4. Ciprandi G., Tosca M.-A., Ricca V. et al. - Cetirizine treatment of rhinitis in children with pollen allergy: evidence of its antiallergic activity. Clin Exp Allergy 1997;27:1160-6.
5. Fasce L., Ciprandi G., Pronzato C. et al. - Cetirizine reduces ICAM-1 on epithelial cells during nasal minimal persistent inflammation in asymptomatic children with mite allergic asthma. Int Arch Allergy Immunol 1996;109:272-276.
6. Church M.-K. - H1-antihistamines and inflammation. Clin Exp Allergy 2001;31:1341-3.
7. Allergic Rhinitis and its Impact on Asthma (ARIA). - Allergy 2002;57:841-55.
8. Riccio A.-M., Tosca M.-A., Cosentino C. et al. - Cytokine pattern in allergic and non-allergic chronic rhinosinusitis in asthmatic children. Clin Exp Allergy 2002;32:422-6.
9. Al-Ghamdi K., Ghaffar O., Small P. et al. - IL4 and IL13 expression in chronic sinusitis: relationship with cellular infiltrate and the effect of topical corticosteroid treatment. J Otolaryngol 1997;26:160-6.
10. Baggiolini M., Dewald B., Moser B. - IL8 and related chemotactic cytokines - CXC and Cc chemokines. Adv Immunol 1994;55:97-179.
11. Demoly P., Crampette L., Mondain M. et al. - Myeloperoxidase and IL-8 levels in chronic sinusitis. Clin Exp Allergy 1997;27:672-5.
12. Jin H.-R., Okamoto Y., Matsuzaki Z. et al. - Cetirizine decreases IL4, IL5 and IFN gamma gene expressions in nasal-associated lymphoid tissue of sensitised mice. Am J Rhinol 2002;16:43-8.
13. Arnold R., Rihoux J.-P., Konig W. - Cetirizine counter-regulates IL8 release from human epithelial cells. Clin Exp Allergy 1999;29:1681-91.
14. Barnes P.-J., Karin M. - Nuclear factor-kB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066-71.