Cetirizine treatment of rhinitis in children with pollen allergy: Evidence of its antiallergic activity

Clinical and Experimental Allergy

Volumn 27, Issue 10, 1997, Pages 1160-1166

  Ciprandi, G ^a   Tosca, M ^a   Ricca, V ^b   Passalacqua, G ^a   Riccio, A M ^a   Bagnasco, M ^a   Canonica, G W ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b Ospedale Koelliker   (Italy)

Author keywords

Adhesion molecules; Allergic rhinitis; Antiallergic activity; Cetirizine; Children; Inflammation; Mediators; Symptoms

Indexed keywords

CETIRIZINE; INTERCELLULAR ADHESION MOLECULE 1; PLACEBO;

ADOLESCENT; ALLERGIC RHINITIS; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL EXAMINATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG EFFICACY; DRUG SCREENING; FEMALE; HUMAN; INFLAMMATORY INFILTRATE; MALE; POLLEN ALLERGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ANTI-ALLERGIC AGENTS; BLOOD PROTEINS; CETIRIZINE; CHILD; DOUBLE-BLIND METHOD; EOSINOPHIL GRANULE PROTEINS; EPITHELIAL CELLS; FEMALE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTE COUNT; MALE; NASAL LAVAGE FLUID; NASAL MUCOSA; RHINITIS, ALLERGIC, SEASONAL; RIBONUCLEASES; SEASONS;

EID: 0030819484     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.1997.tb01153.x     Document Type: Article

References (20)

1. Djukanovic R, Roche WR, Wilson R et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142: 434-57.
2. Calderon E, Lockey RF. A possible role for adhesion molecules in asthma. J Allergy Clin Immunol 1992; 90: 852-65.
3. Ciprandi G, Buscaglia S, Pesce GP et al. Allergic subjects express Intercellular Adhesion Molecule 1 (ICAM-1 or CD54) on epithelial cells of conjunctiva after allergen challenge. J Allergy Clin Immunol 1993; 91:783-92.
4. Ciprandi G, Pronzato C, Ricca V et al. Allergen-specific challenge induces Intercellular Adhesion Molecule-1 (ICAM-1/CD54) on nasal epithelial cells in allergic subjects. Relationship with early and late inflammatory phenomena. Am J Resp Crit Care Med 1994; 150:1653-9.
5. Hansel TH, Walker C. The migration of eosinophils into the sputum of asthmatics: the role of adhesion molecules. Clin Exp Allergy 1992; 22:345-56.
6. Spencer CM, Faulds D, Peters D. Cetirizine: a reappraisal of its pharmacological properties and therapeutic use in selected allergic disorders. Drugs 1993; 46:1055-80.
7. Ciprandi G, Buscaglia S, Pesce GP et al. Cetirizine reduces ICAM-1 (or CD54) expression both in early and late phase events following allergen-specific conjunctival challenge. J Allergy Clin Immunol 1995; 95:612-21.
8. Fasce L, Ciprandi G, Pronzato C et al. Cetirizine reduces ICAM-1 on epithelial cells during nasal minimal persistent inflammation in asymptomatic children with mite allergic asthma. Int Arch Allergy Immunol 1996; 109:272-6.
9. Ciprandi G, Pronzato C, Ricca V et al. Terfenadine exerts antiallergic activity reducing ICAM-1 expression on nasal epithelial cells in patients with pollen allergy. Clin Exp Allergy 1995; 25:871-8.
10. Cordell JL, Falini B, Erber WN et al. Immunoenzymatic labelling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAAP complexes). J Histochem Cytochem 1984; 32:219-45.
11. Passalacqua G, Bousquet J, Bachert C et al. The clinical safety of H1 receptor antagonists. EAACI Position paper. Allergy 1996; 51:555-60.
12. Bochner BS, Ebisawa M, Knol EF et al. Mechanisms of eosinophil accumulation during allergic inflammation. In: Respiratory Allergy - Advances in Clinical Immunology and Pulmonary Medicine. Elsevier, Amsterdam 1993; 3-9.
13. Walsh GM. The anti-inflammatory effects of cetirizine. Clin Exp Allergy 1994; 24:81-5.
14. Sehmi R, Walsh GM, Hartnell A et al. Modulation of human eosinophil chemotaxis and adhesion by anti-allergic drugs in vitro. Pediatric Allergy Immunol 1993; 4(suppl 4): 13-8.
15. Fadel R, Herpin-Richard N, Rihoux JP, Henocq E. Inhibitory effect of cetirizine 2 HC1 on eosinophil migration in vivo. Clin Allergy 1987; 17:373-9.
16. Redier H, Chanez P, De Vos C et al. Inhibitory effect of cetirizine on the bronchial eosinophil recruitment induced by allergen inhalation challenge in allergic patients with asthma. J Allergy Clin Immunol 1992; 90:215-24.
17. Caproni M, Palleschi GM, Falcos D, Papi C, Lotti T. Pharmacologic modulation by cetirizine of some adhesion molecules expression in psoriatic skin lesions. Int J Dermatol 1995; 34:510-3.
18. Vignola AM, Crampette L, Mondain M et al. Inhibitory activity of loratadine and descarboethoxyloratadine on expression of ICAM-1 and HLA-DR by nasal epithelial cells. Allergy 1995; 50:200-3.
19. Altman LC, Ayars GH, Baker C, Luchtel DL. Cytokines and eosiniphil-derived cationic proteins upregulate Intercellular Adhesion Molecules-1 on human nasal epithelial cells. J Allergy Clin Immunol 1993; 92:527-36.
20. Canonica GW, Ciprandi G, Pesce GP, Buscaglia S, Paolieri F, Bagnasco M. ICAM-1 on epithelial cells in allergic subjects: a hallmark of allergic inflammation. Int Arch Allergy Immunol 1995; 107:99-102.