Programming of defective rat pancreatic β-cell function in offspring from mothers fed a low-protein diet during gestation and the suckling periods

Clinical Science

Volumn 107, Issue 1, 2004, Pages 37-45

  Heywood, Wendy E ^a,b   Mian, Nasi ^a   Milla, Peter J ^a   Lindley, Keith J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Glucokinase; Irregular pulsatile insulin secretion; Low protein diet; Pancreatic cell function; Reaction kinetics

Indexed keywords

GLUCOKINASE; GLUCOSE; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BIRTH; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; INSULIN RELEASE; LYMPHOCYTE FUNCTION; MALE; MATERNAL NUTRITION; NEWBORN; NONHUMAN; NUTRITIONAL STATUS; PANCREAS; PERINATAL PERIOD; PREGNANCY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEFICIENCY; PROTEIN FUNCTION; PROTEIN INTAKE; PROTEIN RESTRICTION; RAT; SUCKLING; WEANING; WESTERN BLOTTING;

AGING; ANIMALS; DIET, PROTEIN-RESTRICTED; EMBRYONIC AND FETAL DEVELOPMENT; FEMALE; GLUCOKINASE; GLUCOSE INTOLERANCE; HEXOKINASE; INSULIN; ISLETS OF LANGERHANS; LACTATION; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL EXPOSURE DELAYED EFFECTS; PROTEIN DEFICIENCY; RATS; WEIGHT GAIN;

EID: 3142726182     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20030350     Document Type: Article

References (42)

1. Hales, C. N., Barker, D. J., Clark, P. M. et al. (1991) Fetal and infant growth and impaired glucose tolerance at age 64. Br. Med. J. 303, 1019-1022
2. Phillips, D. I. (1996) Insulin resistance as a programmed response to fetal undernutrition. Diabetologia 39, 1119-1122
3. Lithell, H. O., McKeigue, P. M., Berglund, L., Mohsen, R., Lithell, U. B. and Leon, D. A. (1996) Relation of size at birth to non-insulin dependent diabetes and insulin concentrations in men aged 50-60 years. Br. Med. J. 312, 406-410
4. McCance, D. R., Pettitt, D. J., Hanson, R. L., Jacobsson, L. T., Knowler, W. C. and Bennett, P. H. (1994) Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? Br. Med. J. 308, 942-945
5. Phillips, D. I., Barker, D. J., Hales, C. N., Hirst, S. and Osmond, C. (1994) Thinness at birth and insulin resistance in adult life. Diabetologia 37, 150-154
6. Phipps, K., Barker, D. J., Hales, C. N., Fall, C. H., Osmond, C. and Clark, P. M. (1993) Fetal growth and impaired glucose tolerance in men and women. Diabetologia 36, 225-228
7. Hales, C. N. and Barker, D. J. (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595-601
8. Lucas, A. (1991) Programming by early nutrition in man. The Childhood Environment and Adult Disease. (Bock, G. R. and Whelan, J., eds.), pp. 38-35, Wiley, Chichester
9. Langley-Evans, S. C. (2001) Fetal programming of cardiovascular function through exposure to maternal undernutrition. Proc. Nutr. Soc. 60, 505-513
10. Snoeck, A., Remacle, C., Reusens, B. and Hoet, J. J. (1990) Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biol. Neonate 57, 107-118
11. Dahri, S., Snoeck, A., Reusens-Billen, B., Remacle, C. and Hoet, J. J. (1991) Islet function in offspring of mothers on low-protein diet during gestation. Diabetes 40 (Suppl. 2), 115-120
12. Wilson, M. R. and Hughes, S. J. (1997) The effect of maternal protein deficiency during pregnancy and lactation on glucose tolerance and pancreatic islet function in adult rat offspring. J. Endocrinol. 154, 177-185
13. Berney, D. M., Desai, M., Palmer, D. J. et al. (1997) The effects of maternal protein deprivation on the fetal rat pancreas: major structural changes and their recuperation. J. Pathol. 183, 109-115
14. Petrik, J., Reusens, B., Arany, E. et al. (1999) A low protein diet alters the balance of islet cell replication and apoptosis in the fetal and neonatal rat and is associated with a reduced pancreatic expression of insulin-like growth factor-II. Endocrinology 140, 4861-4873
15. Petry, C. J., Ozanne, S. E. and Hales, C. N. (2001) Programming of intermediary metabolism. Mol. Cell. Endocrinol. 185, 81-91
16. Tal, M., Liang, Y., Najafi, H., Lodish, H. F. and Matschinsky, F. M. (1992) Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets. J. Biol. Chem. 267, 17241-17247
17. Matschinsky, F., Liang, Y., Kesavan, P. et al. (1993) Glucokinase as pancreatic β cell glucose sensor and diabetes gene. J. Clin. Invest. 92, 2092-2098
18. Matschinsky, F. M., Glaser, B. and Magnuson, M. A. (1998) Pancreatic β-cell glucokinase: closing the gap between theoretical concepts and experimental realities. Diabetes 47, 307-315
19. Desai, M., Byrne, C. D., Meeran, K., Martenz, N. D., Bloom, S. R. and Hales, C. N. (1997) Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. Am. J. Physiol. 273, G899-G904
20. Desai, M., Byrne, C. D., Zhang, J., Petry, C. J., Lucas, A. and Hales, C. N. (1997) Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet. Am. J. Physiol. 272, G1083-G1090
21. Velho, G., Froguel, P., Clement, K. et al. (1992) Primary pancreatic β-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet 340, 444-448
22. Burke, C. V., Buettger, C. W., Davis, E. A., McClane, S. J., Matschinsky, F. M. and Raper, S. E. (1999) Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase- linked hyperinsulinaemia (GK-HI). Biochem. J. 342, 345-352
23. Langley, S. C. and Jackson, A. A. (1994) Increase in sytosolic blood pressure in adult rats induced by exposure to maternal low protein diet. Clin. Sci. 86, 217-222
24. Lacey, P. and Kostianovsky, M. (1967) Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16, 35
25. Gotoh, M., Maki, T., Satomi, S. et al. (1987) Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation 43, 725-730
26. Tu, J. and Tuch, B. E. (1996) Glucose regulates the maximal velocities of glucokinase and glucose utilization in the immature fetal rat pancreatic islets. Diabetes 45, 1068-1075
27. Holmes, M. A., Clayton, H. A., Chadwick, D. R., Bell, P. R., London, N. J. and James, R. F. (1995) Functional studies of rat, porcine, and human pancreatic islets cultured in ten commercially available media. Transplantation 60, 854-860
28. Trus, M. D., Zawalich, W. S., Burch, P. T., Berner, D. K., Weill, V. A. and Matschinsky, F. M. (1981) Regulation of glucose metabolism in pancreatic islets. Diabetes 30, 911-922
29. Chen, C., Hosokawa, H., Bumbalo, L. M. and Leahy, J. L. (1994) Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic β cell. Study using cultured rat islets. J. Clin. Invest. 94, 1616-1620
30. Sugden, M. C. and Holness, M. J. (2002) Gender-specific programming of insulin secretion and action. J. Endocrinol. 175, 757-767
31. Iynedjian, P. B. (1993) Mammalian glucokinase and its gene. Biochem. J. 293, 1-13
32. Leibiger, B., Leibiger, I. B., Moede, T. et al. (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic β cells. Mol. Cell 7, 559-570
33. Wang, H., Gauthier, B. R., Hagenfeldt, K. A., Iezzi, M. and Wollheim, C. B. (2002) Foxa2 (HNF3 β) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. J. Biol. Chem. 277, 17564-17570
34. Kim, H. I., Cha, J. Y., Kim, S. Y. et al. (2002) Peroxisomal proliferator-activated receptor-γ upregulates glucokinase gene expression in β-cells. Diabetes 51, 676-685
35. Vandercammen, A. and Van Schaftingen, E. (1990) The mechanism by which rat liver glucokinase is inhibited by the regulatory protein. Eur. J. Biochem. 191, 483-489
36. Malaisse, W. J., Malaisse-Lagae, F., Davies, D. R., Vandercammen, A. and Van Schaftingen, E. (1990) Regulation of glucokinase by a fructose-1-phosphate- sensitive protein in pancreatic islets. Eur. J. Biochem. 190, 539-545
37. Munoz-Alonso, M. J., Guillemain, G., Kassis, N., Girard, J., Burnol, A. F. and Leturque, A. (2000) A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate. J. Biol. Chem. 275, 32406-32412
38. Shiraishi, A., Yamada, Y., Tsuura, Y. et al. (2001) A novel glucokinase regulator in pancreatic β cells: precursor of propionyl-CoA carboxylase β subunit interacts with glucokinase and augments its activity. J. Biol. Chem. 276, 2325-2328
39. Baltrusch, S., Lenzen, S., Okar, D. A., Lange, A. J. and Tiedge, M. (2001) Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase as a novel interaction partner. J. Biol. Chem. 276, 43915-43923
40. Rizzo, M. A., Magnuson, M. A., Drain, P. F. and Piston, D. W. (2002) A functional link between glucokinase binding to insulin granules and conformational alterations in response to glucose and insulin. J. Biol. Chem. 277, 34168-34175
41. Rizzo, M. A. and Piston, D. W. (2003) Regulation of β cell glucokinase by S-nitrosylation and association with nitric oxide synthase. J. Cell Biol. 161, 243-248
42. Davis, E. A., Cuesta-Munoz, A., Raoul, M. et al. (1999) Mutants of glucokinase cause hypoglycaemia and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis. Diabetologia 42, 1175-1186