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Volumn 70, Issue 5, 2004, Pages 339-350

Protein C and coagulation in sepsis;La proteina C e la coagulazione nella sepsi

Author keywords

Inflammation; Protein C; Sepsis

Indexed keywords

ACTIVATED PROTEIN C; ACUTE PHASE PROTEIN; ANTIBIOTIC AGENT; ANTIINFLAMMATORY AGENT; ANTITHROMBIN; CYTOKINE; DROTRECOGIN; HEPARIN; PROCOAGULANT; PROTEIN C; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; THROMBIN; THROMBOPLASTIN; TUMOR NECROSIS FACTOR ANTIBODY;

EID: 3142715350     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (7)

References (57)
  • 2
    • 0029401567 scopus 로고
    • The Italian Sepsis Study: Preliminary results on the incidence and evolution of SIRS, severe sepsis and septic shock
    • Salvo I, de Cian W, Musico M, Langer M, Piadena R, Wolfler A,et al.. The Italian Sepsis Study: preliminary results on the incidence and evolution of SIRS, severe sepsis and septic shock. Intensive Care Med 1995;21:S244-S249.
    • (1995) Intensive Care Med. , vol.21
    • Salvo, I.1    de Cian, W.2    Musico, M.3    Langer, M.4    Piadena, R.5    Wolfler, A.6
  • 3
    • 3142693440 scopus 로고    scopus 로고
    • Personal communication
    • Fumagalli R. Personal communication.
    • Fumagalli, R.1
  • 4
  • 5
    • 0032433470 scopus 로고    scopus 로고
    • Has the mortality of septic shock changed with time ?
    • Friedman G, Silva E, Vincent JL. Has the mortality of septic shock changed with time ? Crit Care Med 1998;26:2078-86.
    • (1998) Crit. Care Med. , vol.26 , pp. 2078-2086
    • Friedman, G.1    Silva, E.2    Vincent, J.L.3
  • 6
    • 0025162844 scopus 로고
    • Structural design and molecular evaluation of a cytokine receptor family
    • Buzan J. Structural design and molecular evaluation of a cytokine receptor family. Proc Natl Acad Sci USA 1990;87:6934-8.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 6934-6938
    • Buzan, J.1
  • 7
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003;101:3765-77.
    • (2003) Blood , vol.101 , pp. 3765-3777
    • Aird, W.C.1
  • 8
    • 0033586986 scopus 로고    scopus 로고
    • Vascular-bed specific hemostasis and hypercoagulable states
    • Rosenberg RD. Vascular-bed specific hemostasis and hypercoagulable states. N Engl J Med 1999;340:1555-64.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1555-1564
    • Rosenberg, R.D.1
  • 9
    • 0021924404 scopus 로고
    • A radioimmunoassay for protein C
    • Ikeda K, Stenflo J. A radioimmunoassay for protein C. Thromb Res 1985;39:297-306.
    • (1985) Thromb. Res. , vol.39 , pp. 297-306
    • Ikeda, K.1    Stenflo, J.2
  • 10
    • 0033815369 scopus 로고    scopus 로고
    • The protein C pathway
    • Esmon CT. The protein C pathway. Crit Care Med 2000;28:S44-S48.
    • (2000) Crit. Care Med. , vol.28
    • Esmon, C.T.1
  • 11
    • 0034758304 scopus 로고    scopus 로고
    • Protein C inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of TAFI activation
    • Mosnier LO, Meijers JC, Bouma BN. Protein C inhibitor regulates the thrombin-thrombomodulin complex in the up- and down regulation of TAFI activation. Thromb Haemost 2001;86:1057-64.
    • (2001) Thromb. Haemost. , vol.86 , pp. 1057-1064
    • Mosnier, L.O.1    Meijers, J.C.2    Bouma, B.N.3
  • 12
    • 0026065417 scopus 로고
    • Endotoxin and cytokine profile in plasma of baboons challenged with lethal and sublethal Escherichia Coli
    • Creasey AA, Stevens P, Kenney J, Allison AC, Warren K, Catlett R, et al.. Endotoxin and cytokine profile in plasma of baboons challenged with lethal and sublethal Escherichia Coli. Circ Shock 1991;33:84-91.
    • (1991) Circ. Shock , vol.33 , pp. 84-91
    • Creasey, A.A.1    Stevens, P.2    Kenney, J.3    Allison, A.C.4    Warren, K.5    Catlett, R.6
  • 13
    • 0025738726 scopus 로고
    • Baboon model of Escherichia Coli sepsis: Description of its four stages and the role of tumor necrosis factor, tissue factors, and the protein C system in septic shock
    • Taylor FB Jr, Chang AC, Esmon CT, Hinshaw LB. Baboon model of Escherichia Coli sepsis: description of its four stages and the role of tumor necrosis factor, tissue factors, and the protein C system in septic shock. Curr Stud Hematol Blood Trasfus 1991;58:8-14.
    • (1991) Curr. Stud. Hematol. Blood Trasfus. , vol.58 , pp. 8-14
    • Taylor Jr., F.B.1    Chang, A.C.2    Esmon, C.T.3    Hinshaw, L.B.4
  • 14
    • 0025807728 scopus 로고
    • DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia Coli without preventing shock or organ damage
    • Taylor FB Jr, Chang AC, Peer GT, Mather T, Blick KE, Catlett R et al. DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia Coli without preventing shock or organ damage. Blood 1991;78:364-8.
    • (1991) Blood , vol.78 , pp. 364-368
    • Taylor Jr., F.B.1    Chang, A.C.2    Peer, G.T.3    Mather, T.4    Blick, K.E.5    Catlett, R.6
  • 15
    • 2642638788 scopus 로고    scopus 로고
    • Active site inhibited factor VIIa (DEGR VIIa) attenuates the coagulant and dinterelukin-6 and -8, but not tumor necrosis factor, responses of the baboon to LD 100 Escherichia coli
    • Taylor FB Jr, Chang AC, Peer G, Li A, Ezhan M, Hedner U. Active site inhibited factor VIIa (DEGR VIIa) attenuates the coagulant and dinterelukin-6 and -8, but not tumor necrosis factor, responses of the baboon to LD 100 Escherichia coli. Blood 1998;91:1609-15.
    • (1998) Blood , vol.91 , pp. 1609-1615
    • Taylor Jr., F.B.1    Chang, A.C.2    Peer, G.3    Li, A.4    Ezhan, M.5    Hedner, U.6
  • 18
    • 0029156005 scopus 로고
    • Role of free protein S and C4b binding protein in regulating the coagulant response to Escherichia coli
    • Taylor FB Jr, Dahlback B, Chang AC, Lockhart MS, Hatanaka K, Peer G et al. Role of free protein S and C4b binding protein in regulating the coagulant response to Escherichia coli. Blood 1995;86:2642-52.
    • (1995) Blood , vol.86 , pp. 2642-2652
    • Taylor Jr., F.B.1    Dahlback, B.2    Chang, A.C.3    Lockhart, M.S.4    Hatanaka, K.5    Peer, G.6
  • 22
    • 0033810792 scopus 로고    scopus 로고
    • Protein C levels as a prognostic indicator of outcome in sepsis and related diseases
    • Fisher CJ Jr, Yan SB. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit Care Med 2000;28:S49-S56.
    • (2000) Crit. Care Med. , vol.28
    • Fisher Jr., C.J.1    Yan, S.B.2
  • 23
    • 0031975435 scopus 로고    scopus 로고
    • The haematologic manifestations of sepsis
    • Mammen EF. The haematologic manifestations of sepsis. J Antimicrob Chemother 1998;41:17-24.
    • (1998) J. Antimicrob. Chemother. , vol.41 , pp. 17-24
    • Mammen, E.F.1
  • 24
    • 0025241217 scopus 로고
    • Plasma thrombomodulin in health and diseases
    • Takano S, Kimura S, Ohdama S, Aoki N. Plasma thrombomodulin in health and diseases. Blood 1990;76:2024-9.
    • (1990) Blood , vol.76 , pp. 2024-2049
    • Takano, S.1    Kimura, S.2    Ohdama, S.3    Aoki, N.4
  • 25
    • 0031973176 scopus 로고    scopus 로고
    • Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvment of different pathological processes
    • Kurosawa S, Stearns-Kurosawa DJ, Carson CW, D'Angelo A, Della Valle P, Esmon CT. Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: lack of correlation with thrombomodulin suggests involvment of different pathological processes. Blood 1998;91:725-7.
    • (1998) Blood , vol.91 , pp. 725-727
    • Kurosawa, S.1    Stearns-Kurosawa, D.J.2    Carson, C.W.3    D'Angelo, A.4    Della Valle, P.5    Esmon, C.T.6
  • 27
    • 0033880884 scopus 로고    scopus 로고
    • Activated protein C inhibits lipopolysaccharide-induced nuclear translocation on nuclear factor kB (NF-kB) and tumor necrosis factor a (TNFa) production in the THP-1 monocytic cell line
    • White B, Schmidt M, Murphy C, Livingstone W, O'Toole D, Lawler M et al. Activated protein C inhibits lipopolysaccharide-induced nuclear translocation on nuclear factor kB (NF-kB) and tumor necrosis factor a (TNFa) production in the THP-1 monocytic cell line. Br J Haematol 2000;110:130-4.
    • (2000) Br. J. Haematol. , vol.110 , pp. 130-134
    • White, B.1    Schmidt, M.2    Murphy, C.3    Livingstone, W.4    O'Toole, D.5    Lawler, M.6
  • 28
    • 0027998013 scopus 로고
    • Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma or phorbol esther
    • Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma or phorbol esther. J Immunol 1994;153:3664-72.
    • (1994) J. Immunol. , vol.153 , pp. 3664-3672
    • Grey, S.T.1    Tsuchida, A.2    Hau, H.3    Orthner, C.L.4    Salem, H.H.5    Hancock, W.W.6
  • 29
    • 0029626658 scopus 로고
    • Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signalling and monocyte-dependent proliferative responses
    • Hancock WW, Grey ST, Hau L, Akalin E, Orthner C, Sayegh MH et al. Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signalling and monocyte-dependent proliferative responses. Transplantation 1995;60:1525-32.
    • (1995) Transplantation , vol.60 , pp. 1525-1532
    • Hancock, W.W.1    Grey, S.T.2    Hau, L.3    Akalin, E.4    Orthner, C.5    Sayegh, M.H.6
  • 30
    • 0029873131 scopus 로고    scopus 로고
    • A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes
    • Grey ST, Hancock WW. A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996;156:2256-63.
    • (1996) J. Immunol. , vol.156 , pp. 2256-2263
    • Grey, S.T.1    Hancock, W.W.2
  • 31
    • 0034698261 scopus 로고    scopus 로고
    • Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner
    • Shu F, Kobayashi H, Fukudome K, Tsuneyoshi N, Kimoto M, Terao T. Activated protein C suppresses tissue factor expression on U937 cells in the endothelial protein C receptor-dependent manner. FEBS Lett 2000;477:208-12.
    • (2000) FEBS Lett. , vol.477 , pp. 208-212
    • Shu, F.1    Kobayashi, H.2    Fukudome, K.3    Tsuneyoshi, N.4    Kimoto, M.5    Terao, T.6
  • 32
    • 0028299926 scopus 로고
    • Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide
    • Grinnell BW, Hermann RB, Yan SB. Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology 1994;2: 221-5.
    • (1994) Glycobiology , vol.2 , pp. 221-225
    • Grinnell, B.W.1    Hermann, R.B.2    Yan, S.B.3
  • 33
    • 0033866550 scopus 로고    scopus 로고
    • Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation
    • Hirose K, Okajima K, Taoka Y, Uchiba M, Tagami H, Nakano KY et al. Activated protein C reduces the ischemia/reperfusion-induced spinal cord injury in rats by inhibiting neutrophil activation. Ann Surg 2000;232:272-80.
    • (2000) Ann. Surg. , vol.232 , pp. 272-280
    • Hirose, K.1    Okajima, K.2    Taoka, Y.3    Uchiba, M.4    Tagami, H.5    Nakano, K.Y.6
  • 35
    • 0035826096 scopus 로고    scopus 로고
    • Efficacy and safety of recombinant human activated protein C for severe sepsis
    • for the Recombinant Human Acitvated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group
    • Bernard GR, Vincent JL, Laterre P-F, La Rosa SP et al. for the Recombinant Human Acitvated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001;344:699-709.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 699-709
    • Bernard, G.R.1    Vincent, J.L.2    Laterre, P.-F.3    La Rosa, S.P.4
  • 36
    • 0242563999 scopus 로고    scopus 로고
    • FDA Briefing Document: Drotrecogin alfa (activated) (Recombinant human activated protein C (rhAPC)) Xigris
    • Anti-infective Advisory Committee. Rockville, MD: Food and Drug Administration, September 12
    • Anti-infective Advisory Committee. FDA Briefing Document: Drotrecogin alfa (activated) (Recombinant human activated protein C (rhAPC)) Xigris. Rockville, MD: Food and Drug Administration, September 12, 2001.
    • (2001)
  • 37
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of Tifacogin (Recombinant tissue factor pathway inhihitor) in severe sepsis
    • for the Optimist Trial Study Group
    • Abraham E, Reinhart K, Opal S, Demeyer I et al. for the Optimist Trial Study Group. Efficacy and safety of Tifacogin (Recombinant tissue factor pathway inhihitor) in severe sepsis. JAMA 2003;290:238-47.
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3    Demeyer, I.4
  • 38
    • 0035904368 scopus 로고    scopus 로고
    • Caring for the critically ill patient. High-close antithrombin III in severe sepsis: A randomized controlled trial
    • for the Kybersept Trial Study Group
    • Warren BL, Eid A, Singer P, Pillay SS et al. for the Kybersept Trial Study Group. Caring for the critically ill patient. High-close antithrombin III in severe sepsis: a randomized controlled trial. JAMA 2001;286:1869-78.
    • (2001) JAMA , vol.286 , pp. 1869-1878
    • Warren, B.L.1    Eid, A.2    Singer, P.3    Pillay, S.S.4
  • 40
    • 0030034186 scopus 로고    scopus 로고
    • Activated protein C attenuates enodtozin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats
    • Murakami K, Okajima K, Uchiba M, Johno M, Nakagaki T, Okabe H et al. Activated protein C attenuates enodtozin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood 1996;87:642-7.
    • (1996) Blood , vol.87 , pp. 642-647
    • Murakami, K.1    Okajima, K.2    Uchiba, M.3    Johno, M.4    Nakagaki, T.5    Okabe, H.6
  • 41
    • 0026409651 scopus 로고
    • Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C cocnentrate
    • Dreyfus M, Magny JF, Brudey F, Schwarz HP, Planche C, Dehan M et al. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C cocnentrate. N Engl J Med 1991;325: 1565-8.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 1565-1568
    • Dreyfus, M.1    Magny, J.F.2    Brudey, F.3    Schwarz, H.P.4    Planche, C.5    Dehan, M.6
  • 42
    • 0029617466 scopus 로고
    • Replacement therapy with a monoclonal antibody purified purified protein C concentrate in newborns with severe congenital protein C deficiency
    • Dreyfus M, Masterson M, David M, Rivard GE, Muller FM, Kreuz W et al. Replacement therapy with a monoclonal antibody purified purified protein C concentrate in newborns with severe congenital protein C deficiency. Semin Thromb Hemost 1995;21:371-81.
    • (1995) Semin. Thromb. Hemost. , vol.21 , pp. 371-381
    • Dreyfus, M.1    Masterson, M.2    David, M.3    Rivard, G.E.4    Muller, F.M.5    Kreuz, W.6
  • 43
    • 0030044808 scopus 로고    scopus 로고
    • Purpura fulminans in severe congenital protein C deficiency: Monitoring of treatment with protein C concentrate
    • Muller FM, Ehrenthal W, Hafner G, Schranz D. Purpura fulminans in severe congenital protein C deficiency: monitoring of treatment with protein C concentrate. Eur J Pediatr 1996;155:20-5.
    • (1996) Eur. J. Pediatr. , vol.155 , pp. 20-25
    • Muller, F.M.1    Ehrenthal, W.2    Hafner, G.3    Schranz, D.4
  • 45
    • 0027397621 scopus 로고
    • Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: Treatment with protein C concentrate
    • Gerson WT, Dickerman JD, Bovill EG, Golden E. Severe acquired protein C deficiency in purpura fulminans associated with disseminated intravascular coagulation: treatment with protein C concentrate. Pediatrics 1993;91:418-22.
    • (1993) Pediatrics , vol.91 , pp. 418-422
    • Gerson, W.T.1    Dickerman, J.D.2    Bovill, E.G.3    Golden, E.4
  • 46
    • 0028855106 scopus 로고
    • Coagulation activation and tissue necrosis in meningococcal septic shock: Severely reduced protein C levels predict a high mortality
    • Fijnvandraat K, Derkx B, Peters M, Bijlmer R, Sturk A, Prins MH et al. Coagulation activation and tissue necrosis in meningococcal septic shock: severely reduced protein C levels predict a high mortality. Thromb Haemost 1995;73:15-20.
    • (1995) Thromb. Haemost. , vol.73 , pp. 15-20
    • Fijnvandraat, K.1    Derkx, B.2    Peters, M.3    Bijlmer, R.4    Sturk, A.5    Prins, M.H.6
  • 47
    • 0022549729 scopus 로고
    • Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states
    • Viganò D'Angelo S, Comp PC, Esmon CT, D'Angelo A. Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states. J Clin Invest 1986;77:416-25.
    • (1986) J. Clin. Invest. , vol.77 , pp. 416-425
    • Viganò D'Angelo, S.1    Comp, P.C.2    Esmon, C.T.3    D'Angelo, A.4
  • 48
    • 0028958909 scopus 로고
    • Treatment of purpura fulminans in meningococcemia with protein C concentrate
    • Rivard GE, David M, Farrell C, Schwarz HP. Treatment of purpura fulminans in meningococcemia with protein C concentrate. J Pediatr 1995;126:646-52.
    • (1995) J. Pediatr. , vol.126 , pp. 646-652
    • Rivard, G.E.1    David, M.2    Farrell, C.3    Schwarz, H.P.4
  • 50
    • 0031590612 scopus 로고    scopus 로고
    • Use of protein C concentrate, heparin and haemodiafiltration in meningococcus-induced purpura fulminans
    • Smith OP, White B, Vaughan D, Rafferty M, Claffey L, Lyons B et al. Use of protein C concentrate, heparin and haemodiafiltration in meningococcus-induced purpura fulminans. Lancet 1997;350:1590-3.
    • (1997) Lancet , vol.350 , pp. 1590-1593
    • Smith, O.P.1    White, B.2    Vaughan, D.3    Rafferty, M.4    Claffey, L.5    Lyons, B.6
  • 51
    • 0034548822 scopus 로고    scopus 로고
    • An open-label study of the role adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia
    • White B, Livingstone W, Murphy C, Hodgson A, Rafferty M, Smith OP. An open-label study of the role adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. Blood. 2000;96:3719-24.
    • (2000) Blood , vol.96 , pp. 3719-3724
    • White, B.1    Livingstone, W.2    Murphy, C.3    Hodgson, A.4    Rafferty, M.5    Smith, O.P.6
  • 53
    • 0033427845 scopus 로고    scopus 로고
    • Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans
    • Ettinghausen CE, Veldman A, Beeg T, Schneider W, Jager G, Kreuz W. Replacement therapy with protein C concentrate in infants and adolescents with meningococcal sepsis and purpura fulminans. Semin Thromb Hemost 1999;25:537-41.
    • (1999) Semin. Thromb. Hemost. , vol.25 , pp. 537-541
    • Ettinghausen, C.E.1    Veldman, A.2    Beeg, T.3    Schneider, W.4    Jager, G.5    Kreuz, W.6
  • 54
    • 0042347994 scopus 로고    scopus 로고
    • Low utilisation of unactivated protein C in a patients with meningococcal septic shock and disseminated intravascular coagulation
    • Lignell A, Siegbahn A, Stridsberg M, Pauksen K, Gedeborg R, Sjolin J. Low utilisation of unactivated protein C in a patients with meningococcal septic shock and disseminated intravascular coagulation. Acta Anesthesiol Scand 2003;47:897-900.
    • (2003) Acta Anesthesiol. Scand. , vol.47 , pp. 897-900
    • Lignell, A.1    Siegbahn, A.2    Stridsberg, M.3    Pauksen, K.4    Gedeborg, R.5    Sjolin, J.6
  • 55
    • 0038128677 scopus 로고    scopus 로고
    • Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: A randomized, double-blinded, placebo-controlled, dose-finding study
    • de Kleijn ED, de Groot R, Hack CE, Mulder PG, Engl W, Moritz B et al. Activation of protein C following infusion of protein C concentrate in children with severe meningococcal sepsis and purpura fulminans: a randomized, double-blinded, placebo-controlled, dose-finding study. Crit Care Med 2003;31:1839-47.
    • (2003) Crit. Care Med. , vol.31 , pp. 1839-1847
    • de Kleijn, E.D.1    de Groot, R.2    Hack, C.E.3    Mulder, P.G.4    Engl, W.5    Moritz, B.6
  • 56
    • 0042167223 scopus 로고    scopus 로고
    • Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: A pharmacokinetics study
    • Fourrier F, Leclerc F, Aidan K, Sadik A, Jourdain M, Tournoys A et al. Combined antithrombin and protein C supplementation in meningococcal purpura fulminans: a pharmacokinetics study. Intensive Care Med 2003;29:1081-7.
    • (2003) Intensive. Care Med. , vol.29 , pp. 1081-1087
    • Fourrier, F.1    Leclerc, F.2    Aidan, K.3    Sadik, A.4    Jourdain, M.5    Tournoys, A.6
  • 57
    • 0142245617 scopus 로고    scopus 로고
    • Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia
    • Kerlin BA, Yan SB, Isermann BH, Brandt JT, Sood R, Basson BR et al. Survival advantage associated with heterozygous factor V Leiden mutation in patients with severe sepsis and in mouse endotoxemia. Blood 2003;102:3085-92.
    • (2003) Blood , vol.102 , pp. 3085-3092
    • Kerlin, B.A.1    Yan, S.B.2    Isermann, B.H.3    Brandt, J.T.4    Sood, R.5    Basson, B.R.6


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