Adrenomedullin contributes to vascular hyporeactivity in cirrhotic rats with ascites via a release of nitric oxide

Scandinavian Journal of Gastroenterology

Volumn 39, Issue 7, 2004, Pages 686-693

  Kojima, H ^a   Sakurai, S ^b   Uemura, M ^b   Satoh, H ^b   Nakashima, T ^b   Minamino, N ^b   Kangawa, K ^b   Matsuo, H ^b   Fukui, H ^b  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b NONE

Author keywords

Adrenomedullin; Liver cirrhosis; Nitric oxide; Vascular hyporeactivity

Indexed keywords

ADRENOMEDULLIN; N(G) NITROARGININE METHYL ESTER; NEUTRALIZING ANTIBODY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PEPTIDE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIAL PRESSURE; ARTICLE; ASCITES; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; KIDNEY; LIVER; LIVER CIRRHOSIS; LUNG; MALE; NONHUMAN; PATHOPHYSIOLOGY; PORTAL VEIN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION; VASODILATATION;

ADRENERGIC ALPHA-AGONISTS; ADRENOMEDULLIN; ANIMALS; AORTA, THORACIC; ASCITES; KIDNEY; LIVER; LIVER CIRRHOSIS; LUNG; MALE; NITRIC OXIDE; PEPTIDES; PHENYLEPHRINE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VASODILATION;

EID: 3142713939     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520410005306     Document Type: Article

References (35)

1. Schrier RW, Arroyo V, Bernardi M, Epstein M, Henriksen JH, Rodes J. Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis. Hepatology 1988;8:1151-7.
2. Claria J, Jimenez W, Ros J, Asbert M, Castro A, Arroyo V, et al. Pathogenesis of arterial hypotension in cirrhotic rats with ascites: role of endogenous nitric oxide. Hepatology 1992;15:343-9.
3. Niederberger M, Martin PY, Gines P, Morris K, Tsai P, Xu DL, et al. Normalization of nitric oxide production corrects arterial vasodilation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 1995;109:1624-30.
4. Henriksen JH, Moller S, Schifter S, Bendtsen F. Increased arterial compliance in decompensated cirrhosis. J Hepatol 1999; 31:712-8.
5. Henriksen JH, Moller S, Schifter S, Abrahamsen J, Becker U. High arterial compliance in cirrhosis is related to low adrenaline and elevated circulating calcitonin gene related peptide but not to activated vasoconstrictor systems. Gut 2001;49:112-8.
6. Arroyo V, Colmenero J. Ascites and hepatorenal syndrome in cirrhosis: pathophysiological basis of therapy and current management. J Hepatol 2003;38:S69-S89.
7. Bosch J, Abraldes JG, Groszmann R. Current management of portal hypertension. J Hepatol 2003;38:S54-S68.
8. Hadoke PW, Hayes PC. In vitro evidence for vascular hyporesponsiveness in clinical and experimental cirrhosis. Pharmacol Ther 1997;75:51-68.
9. Sieber CC, Groszmann RJ. Nitric oxide mediates hyporeactivity to vasopressors in mesenteric vessels of portal hypertensive rats. Gastroenterology 1992;103:235-9.
10. Weigert AL, Martin PY, Niederberger M, Higa EM, McMurtry IF, Gines P, et al. Endothelium-dependent vascular hyporesponsiveness without detection of nitric oxide synthase induction in aortas of cirrhotic rats. Hepatology 1995;22:1856-62.
11. Thurston M, Laragh JH. Prior receptor occupancy as a determinant of the pressor activity of infused angiotensin II in the rat. Circ Res 1975;36:113-7.
12. Tazi KA, Moreau R, Heller J, Poirel O, Lebrec D. Changes in protein kinase C isoforms in association with vascular hyporeactivity in cirrhotic rat aortas. Gastroenterology 2000;119:201-10.
13. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993;192:553-60.
14. 2+ mobilization, in bovine aortic endothelial cells. J Biol Chem 1995;270: 4412-7.
15. Hirata Y, Hayakawa H, Suzuki Y, Suzuki E, Ikenouchi H, Kohmoto O, et al. Mechanisms of adrenomedullin-induced vasodilation in the rat kidney. Hypertension 1995;25:790-5.
16. Hayakawa H, Hirata Y, Kakoki M, Suzuki Y, Nishimatsu H, Nagata D, et al. Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat. Hypertension 1999;33:689-93.
17. Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, et al. Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem Biophys Res Commun 1995;207: 25-32.
18. Sugo S, Minamino N, Shoji H, Kangawa K, Matsuo H. Effects of vasoactive substances and cAMP related compounds on adrenomedullin production in cultured vascular smooth muscle cells. FEBS Lett 1995;369:311-4.
19. Chun TH, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, et al. Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension 1997;29:1296-302.
20. Fukui H, Brauner B, Bode JC, Bode C. Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. J Hepatol 1991;12:162-9.
21. Deviere J, Content J, Denys C, Vandenbussche P, Schandene L, Wybran J, et al. Excessive in vitro bacterial lipopolysaccharide-induced production of monokines in cirrhosis. Hepatology 1990; 11:628-34.
22. Kojima H, Tsujimoto T, Uemura M, Takaya A, Okamoto S, Ueda S, et al. Significance of increased plasma adrenomedullin concentration in patients with cirrhosis. J Hepatol 1998;28:840-6.
23. Guevara M, Gines P, Jimenez W, Sort P, Fernandez-Esparrach G, Escorsell A, et al. Increased adrenomedullin levels in cirrhosis: relationship with hemodynamic abnormalities and vasoconstrictor systems. Gastroenterology 1998;114:336-43.
24. Fernandez-Rodriguez CM, Prada IR, Prieto J, Montuenga LM, Elssasser T, Quiroga J, et al. Circulating adrenomedullin in cirrhosis: relationship to hyperdynamic circulation. J Hepatol 1998;29:250-6.
25. Genesca J, Gonzalez A, Catalan R, Segura R, Martinez M, Esteban R, et al. Adrenomedullin, a vasodilator peptide implicated in hemodynamic alterations of liver cirrhosis: relationship to nitric oxide. Dig Dis Sci 1999;44:372-6.
26. Tsuruda T, Kato J, Kitamura K, Kuwasako K, Imamura T, Koiwaya Y, et al. Adrenomedullin: a possible autocrine or paracrine inhibitor of hypertrophy of cardiomyocytes. Hypertension 1998;31:505-10.
27. Proctor E, Chatamra K. High yield micronodular cirrhosis in the rat. Gastroenterology 1982;83:1183-90.
28. Sakata J, Shimokubo T, Kitamura K, Nishizono M, Iehiki Y, Kangawa K, et al. Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma. FEBS Lett 1994; 352:105-8.
29. Munson PJ, Rodbard D. LIGAND: a versatile computer approach for characterization of ligand binding systems. Anal Biochem 1980;107:220-39.
30. Kojima H, Sakurai S, Kuriyama S, Yoshiji H, Imazu H, Uemura M, et al. Endothelin-1 plays a major role in portal hypertension of biliary cirrhotic rats through endothelin receptor subtype B together with subtype A in vivo. J Hepatol 2001;34:805-11.
31. Owada A, Nonoguchi H, Terada Y, Marumo F, Tomita K. Microlocalization and effects of adrenomedullin in nephron segments and in mesangial cells of the rat. Am J Physiol 1997; 272:F691-7.
32. Seyde WC, Longnecker DE. Anesthetic influences on regional hemodynamics in normal and hemorrhaged rats. Anesthesiology 1984;61:686-98.
33. Kitamura K, Kato J, Kawamoto M, Tanaka M, Chino N, Kangawa K, et al. The intermediate form of glycine-extended adrenomedullin is the major circulating molecular form in human plasma. Biochem Biophys Res Commun 1998;244:551-5.
34. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor- like receptor. Nature 1998; 393:333-9.
35. Dotsch J, Schoof E, Hanze J, Dittrich K, Opherk P, Dumke K, et al. Nitric oxide stimulates adrenomedullin secretion and gene expression in endothelial cells. Pharmacology 2002;64:135-9.