Adrenomedullin, a vasodilator peptide implicated in hemodynamic alterations of liver cirrhosis: Relationship to nitric oxide

Digestive Diseases and Sciences

Volumn 44, Issue 2, 1999, Pages 372-376

  Genesca, Joan ^a,b,c   Gonzalez, Antonio ^a,b   Catalan, Roberto ^a,b   Segura, Rosa ^a,b   Martinez, Moises ^a,b   Esteban, Rafael ^a,b   Groszmann, Roberto J ^a,b   Guardia, Jaime ^a,b  

^a HUVH   (Spain)

^b YALE UNIVERSITY   (United States)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Adrenomedullin; Hyperdynamic circulation; Liver cirrhosis; Nitric oxide; Portal hypertension

Indexed keywords

ADRENOMEDULLIN;

ADULT; ARTICLE; ASCITES; BLOOD LEVEL; CONTROLLED STUDY; FEMALE; HUMAN; LIVER BLOOD FLOW; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PORTAL HYPERTENSION; PRIORITY JOURNAL; VASODILATATION;

EID: 0032941335     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026618904493     Document Type: Article

References (22)

1. 1. Groszmann RJ: Hyperdynamic circulation of liver disease 40 years later: Pathophysiology and clinical consequences. Hepatology 20:1359-1363, 1994
2. 2. Guarner C, Soriano G, Tomas A, Balbuena O, Novella MT, Balanzó J, Vilardell F, Mourelle M, Moncada S: Increased serum nitrite and nitrate levels in patients with cirrhosis: Relationship to endotoxemia. Hepatology 18:1139-1143, 1993
3. 3. Lopez-Talavera JC, Levitzki A, Martinez M, Gazit A, Esteban R, Guardia J: Tyrosine kinase inhibition ameliorates the hyperdynamic state and decreases nitric oxide production in cirrhotic rats with portal hypertension and ascites. J Clin Invest 100:664-670, 1997
4. 4. Forrest EH, Jones AL, Dillon JF, Walker J, Hayes PC: Defect of nitric oxide synthase inhibition on portal pressure and azygos blood flow in patients with cirrhosis. J Hepatol 23:254-258, 1995
5. 5. Pizcueta P, Piqué JM, Fernández M, Bosch J, Rodés J, Whittle JR, Moncada S: Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition. Gastroenterology 103:1909-1915, 1992
6. 6. Kitamura K, Kamgawa K, Kawamoto M, Ighiki Y, Nakamura S, Matsuo H, Eto T: Adrenomedullin: A novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553-560, 1993
7. 7. Sakata J, Shimokubo T, Kitamura S, Nakamura S, Kangawa K, Matsuo H, Eto T: Molecular cloning and biological activities of rat adrenomedullin, a hypotensive peptide. Biochem Biophys Res Commun 195:921-927, 1993
8. 8. Majid DSA, Kadowitz PJ, Coy DH, Navar LG: Renal responses to intra-arterial administration of adrenomedullin in dogs. Am J Physiol (Renal Fluid & Electrolyte Physiol) 39:F200-F205, 1996
9. 9. Sugo S, Ninamino N, Kangawa K, Miyamoto K, Kitamura K, Sakata J, Eto T, Matsuo H: Endothelial cells actively synthesize and secrete adrenomedullin. Biochem Biophys Res Commun 201:1160-1166, 1994
10. 10. Sugo S, Minamino N, Shoji H, Kangawa K, Kitamura K, Eto T, Matsuo H: Interleukin-1, tumor necrosis factor and lipopolysaccharide additively stimulate production of adrenomedullin in vascular smooth muscle cells. Biochem Biophys Res Commun 207:25-32, 1995
11. 11. Nakamura M, Yoshida H, Makita S, Arakawa N, Niinuma H, Hiramori K: Potent and long-lasting vasodilatory effects of adrenomedullin in humans - comparisons between normal subjects and patients with chronic heart failure. Circulation 95:1214-1221, 1997
12. 12. Ishimitsu T, Nishikimi T, Saito Y, Kitamura K, Eto T, Kangawa K, Matsuo H, Omae T, Matsuoka H: Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure. J Clin Invest 94:2158-2161, 1994
13. 13. Hirata Y, Mikata C, Sato K, Nagura T, Tsunoda Y, Amaha K, Marumo F: Increased circulating adrenomedullin, a novel vasodilatory peptide, in sepsis. J Clin Endocrinol Metab 81:1449-1453, 1996
14. 14. Jougasaki M, Rodeheffer RJ, Redfield MM, Yamamoto K, Wei CM, McKinley LJ, Burnett JC: Cardiac secretion of adrenomedullin in human heart failure. J Clin Invest 97:2370-2376, 1996
15. 15. Fahrega E, Casafont F, Crespo J, de la Peña J, San Miguel G, de las Heras G, Garcia-Unzueta MT, Amado JA, Pons-Romero F: Plasma adrenomedullin levels in patients with hepatic cirrhosis. Am J Gastroenterol 92:1901-1904, 1997
16. 16. Guevara M, Gines P, Jimenez W, Sort P, Fernandez-Esparrach G, Escorsell A, Bataller R, Bosch J, Arroyo V, Rivera F, Rodes J: Increased adrenomedullin levels in cirrhosis: relationship with hemodynamic abnormalities and vasoconstrictor systems. Gastroenterology 114:336-343, 1998
17. 17. Pugh RNH, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R: Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 60:646-649, 1973
18. 18. Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE: Oxidation of nitric oxide in aqueous solution to nitrate but not nitrite: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA 90:8103-8107, 1993
19. 19. Mackenzie IMJ, Ekangaki A, Young D, Garrad CS: Effect of renal function on serum nitrogen oxide concentrations. Clin Chem 42:440-444, 1996
20. 20. Ikeda U, Kanbe T, Shimada K: Adrenomedullin increases inducible nitric oxide synthase in rat vascular smooth muscle cells stimulated with interleukin-1. Hypertension 27:1240-1244, 1996
21. 21. Khorutz A, Stahnke L, McClein CJ, Logan G, Allen JI: Circulating tumor necrosis factor, interleukin-1, and interleukin-6 concentrations in chronic alcoholic patients, Hepatology 13:267-276, 1991
22. 22. Chun TH, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Doi K, Inoue M, Masatsugu K, Korenaga R, Ando J, Nakao K: Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension 29:1296-1302, 1997