Monoclonal antibody mediated intracellular targeting of tallysomycin S 10b

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 16, 2004, Pages 4323-4327

  Walker, Michael A ^a   King, H Dalton ^a   Dalterio, Richard A ^a   Trail, Pamela ^a   Firestone, Raymond ^a   Dubowchik, Gene M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Antibody; Antitumor; BR96; Cathepsin B; Immunoconjugate; Lysosome; Prodrug

Indexed keywords

BLEOMYCIN; CATHEPSIN B; MONOCLONAL ANTIBODY; TALLYSOMYCIN;

ANTIGEN BINDING; ARTICLE; CYTOTOXICITY; DRUG POTENCY; DRUG RELEASE; DRUG STRUCTURE; HUMAN; HUMAN CELL; LYSOSOME; SIGNAL TRANSDUCTION;

ANTIBODIES, MONOCLONAL; BLEOMYCIN; CHROMATOGRAPHY, ION EXCHANGE;

EID: 3142682236     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.05.089     Document Type: Article

References (27)

1. Dubowchik G.M., Walker M.A. Pharmacol. Ther. 83:1999;67
2. Hellström I., Garrigues H.J., Garrigues U., Hellström K.E. Cancer Res. 50:1990;2183
3. Trail P.A., Willner D., Lasch S.J., Henderson A.J., Hofsted S., Casazza A.M., Firestone R.A., Hellström I., Hellström K.E. Science. 261:1993;212
4. Sjögren H.O., Isaksson M., Willner D., Hellström I., Hellström K.E., Trail P.A. Cancer Res. 57:1997;4530
5. Reviews of intracellular delivery of mAbs: Kato Y., Sugiyama Y. Crit. Rev. Ther. Drug. 14:1997;287
6. Chen B.-X., Erlanger B.F. Immunol. Lett. 84:2002;63
7. Garrigues J., Garrigues U., Hellström I., Hellström K.E. Am. J. Pathol. 142:1993;607
8. Dubowchik G.M., Firestone R.A. Bioorg. Med. Chem. Lett. 8:1998;3341
9. Carl P.L., Chakravarty P.K., Katzenellbogen J.A. J. Med. Chem. 24:1981;479
10. Sinh A.A., Jamuar M.P., Wilson M.J., Rozhin J., Sloane B.F. Prostate. 49:2001;172
11. Hashimoto Y., Kakegawa H., Narita Y., Hachiya Y., Hayakawa T., Kos J., Turk V., Katunuma N. Biochem. Biophys. Res. Commun. 283:2001;334
12. (a) Dubowchik, G. M.; Firestone, R. A; Willner, D; Hofstead, S. J.; Trail, P. A.; Lasch, S. J.; Henderson, A. J.; Jure, M.; Mosure, K. W.; Knipe, J. O. Peptides 1996, Proceedings of the European Peptide Symposium, 24th, Edinburgh, Sept. 8-13, 1996, pp 347-348
13. Dubowchik G.M., Firestone R.A., Padilla L., Willner D., Hofstead S.J., Mosure K., Knipe J.O., Lasch S.J., Trail P.A. Bioconjugate Chem. 13:2002;855
14. Walker M.A., Dubowchik G.M., Hofstead S.J., Trail P.A., Firestone R.A. Bioorg. Med. Chem. Lett. 12:2002;217-219
15. Stubbe J., Kozarich J.W. Chem. Rev. 87:1987;1107
16. Schurig J.E., Rose W.C., Hirth R.S., Schein A., Huftalen J.B., Florezyk A.P., Bradner W.T. Cancer Chemother. Pharmacol. 13:1984;164
17. Nicaise C., Ajani J., Goudeau P., Rozencweig M., Levin B., Krakoff Cancer Chemother. Pharmacol. 26:1990;221
18. Nicaise C., Hong W.K., Dimery W., Usakewicz J., Rozencweig M., Krakoff I. Invest. New Drug. 8:1990;325
19. Bleomycin immunoconjugates have previously been reported. Manabe Y., Tsubota T., Haruta Y., Okazaki M., Haisa S., Nakamura K., Kimura I. Biochem. Biophys. Res. Commun. 115:1983;1009
20. Peng Z., Zhen Y.S. Yaoxue Xuebao. 26:1991;331
21. Deng Y.C., Zhen Y.S., Zheng S., Jiang M. Yaoxue Xuebao. 28:1993;410
22. Wang W.G., Wang S.H., Xue Y.C., Zhen Y.S. Yaoxue Xuebao. 30:1995;583
23. Poddevin B., Orlowski S., Belehradek J. Jr., Mir L.M. Biochem. Pharmacol. 42:1991;67
24. Mistry J.S., Jani J.P., Morris G., Mujumdar R.B., Reynolds I.J., Sebti S.M., Lazo J.S. Cancer Res. 52:1992;709
25. Bio-Rad Laboratories, Hercules CA
26. Voznesenskii A.I., Galanova Y.V., Shkrob A.M., Mathanov I.E., Archakov A.I. Arch. Biochem. Biophys. 283:1990;519
27. Pron G., Belehedrak J. Jr., Mir L.M. Biochem. Biophys. Res. Commun. 194:1993;333