메뉴 건너뛰기




Volumn 14, Issue 3, 1997, Pages 287-331

Targeted delivery of peptides, proteins, and genes by receptor-mediated endocytosis

Author keywords

Drug targeting; Gene; Polypeptide; Protein; Receptor mediated endocytosis

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; ASIALOGLYCOPROTEIN RECEPTOR; CELL SURFACE RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; FC RECEPTOR; GLYCOPROTEIN P; GROWTH HORMONE; INSULIN RECEPTOR; LOW DENSITY LIPOPROTEIN RECEPTOR; OX 26; PEPTIDE; PROTEIN; PSEUDOMONAS EXOTOXIN; RECEPTOR ANTIBODY; SECRETORY COMPONENT; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN RECEPTOR; TOXIN; TRANSFERRIN RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; VITAMIN RECEPTOR;

EID: 0030806214     PISSN: 07434863     EISSN: None     Source Type: Journal    
DOI: 10.1615/critrevtherdrugcarriersyst.v14.i3.30     Document Type: Review
Times cited : (37)

References (156)
  • 1
    • 0027741246 scopus 로고
    • Liver-directed gene delivery
    • Wu, G. Y. and Wu, C. H., Liver-directed gene delivery, Adv. Drug Delivery Rev., 12, 159, 1993.
    • (1993) Adv. Drug Delivery Rev. , vol.12 , pp. 159
    • Wu, G.Y.1    Wu, C.H.2
  • 2
    • 0026695276 scopus 로고
    • Recent developments in peptide drug delivery to the brain
    • Pardridge, W. M., Recent developments in peptide drug delivery to the brain, Pharmacol. Toxicol., 71, 3, 1992.
    • (1992) Pharmacol. Toxicol. , vol.71 , pp. 3
    • Pardridge, W.M.1
  • 4
    • 0026502766 scopus 로고
    • Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits
    • Wilson, J. M., Grossman, M., Wu, C. H., Chowdhury, N. R., Wu, G. Y., and Chowdhury, J. R., Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in low density lipoprotein receptor-deficient rabbits, J. Biol. Chem., 267, 963, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 963
    • Wilson, J.M.1    Grossman, M.2    Wu, C.H.3    Chowdhury, N.R.4    Wu, G.Y.5    Chowdhury, J.R.6
  • 5
    • 0028223310 scopus 로고
    • Gene transfer in vivo: Sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake
    • Perales, J. C., Ferkol, T., Beegen, H., Ratnoff, O. D., and Hanson, R. W., Gene transfer in vivo: Sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake, Proc. Natl. Acad. Sci. USA, 91, 4086, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 4086
    • Perales, J.C.1    Ferkol, T.2    Beegen, H.3    Ratnoff, O.D.4    Hanson, R.W.5
  • 6
    • 0028009151 scopus 로고
    • Phase I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: Complete response in a patient with Hodgkin's disease refractory to chemotherapy
    • Tepler, I., Schwartz, G., Parker, K., Charette, J., Kadin, M. E., Woodworth, T. G., and Schnipper, L. E., Phase I trial of an interleukin-2 fusion toxin (DAB486IL-2) in hematologic malignancies: Complete response in a patient with Hodgkin's disease refractory to chemotherapy, Cancer, 73, 1276, 1994.
    • (1994) Cancer , vol.73 , pp. 1276
    • Tepler, I.1    Schwartz, G.2    Parker, K.3    Charette, J.4    Kadin, M.E.5    Woodworth, T.G.6    Schnipper, L.E.7
  • 7
    • 0042048435 scopus 로고
    • Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of pseudomonas exotoxin
    • Batra, J. K., Jinno, Y., Chaudhary, V. K., Kondo, T., Willingham, M. C., Fitzgerald, D. J., and Pastan, I., Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of pseudomonas exotoxin, Proc. Natl. Acad. Sci. USA., 86, 8545, 1989.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 8545
    • Batra, J.K.1    Jinno, Y.2    Chaudhary, V.K.3    Kondo, T.4    Willingham, M.C.5    Fitzgerald, D.J.6    Pastan, I.7
  • 9
    • 0024323595 scopus 로고
    • Inhibition of human tumor growth in nude mice by a conjugate doxorubicin with monoclonal antibodies to epidermal growth factor receptor
    • Aboud-Pirak, E., Hurwitz, E., Bellot, F., Schlessinger J., and Sela M., Inhibition of human tumor growth in nude mice by a conjugate doxorubicin with monoclonal antibodies to epidermal growth factor receptor, Proc. Natl. Acad. Sci. USA, 86, 3778, 1989.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 3778
    • Aboud-Pirak, E.1    Hurwitz, E.2    Bellot, F.3    Schlessinger, J.4    Sela, M.5
  • 10
    • 0023811723 scopus 로고
    • Receptor-mediated gene delivery and expression in vivo
    • Wu, G. Y. and Wu, C. H., Receptor-mediated gene delivery and expression in vivo, J. Biol. Chem., 263, 14621, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 14621
    • Wu, G.Y.1    Wu, C.H.2
  • 11
    • 0014556033 scopus 로고
    • Deoxyribonucleic acid-polylysine complexes. Structure and nucleotide specificity
    • Shapiro, J. T., Leng, M., and Felsenfeld, G., Deoxyribonucleic acid-polylysine complexes. Structure and nucleotide specificity, Biochemistry, 8, 3219, 1969.
    • (1969) Biochemistry , vol.8 , pp. 3219
    • Shapiro, J.T.1    Leng, M.2    Felsenfeld, G.3
  • 12
    • 0028224965 scopus 로고
    • Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions
    • French, A. R., Sudlow, G. P., Wiley, H. S., and Lauffenburger, D. A., Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions, J. Biol. Chem., 269, 15749, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 15749
    • French, A.R.1    Sudlow, G.P.2    Wiley, H.S.3    Lauffenburger, D.A.4
  • 13
    • 0026200358 scopus 로고
    • Sorting of plasma membrane proteins in epithelial cells
    • Bomsel, M. and Mostov K., Sorting of plasma membrane proteins in epithelial cells, Curr. Opin. Cell Biol., 3, 647, 1991.
    • (1991) Curr. Opin. Cell Biol. , vol.3 , pp. 647
    • Bomsel, M.1    Mostov, K.2
  • 14
    • 0028079888 scopus 로고
    • An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes
    • Perales, J. C., Ferkol, T., Molas, M., and Hanson, R. W., An evaluation of receptor-mediated gene transfer using synthetic DNA-ligand complexes, Eur. J. Biochem., 226, 255, 1994.
    • (1994) Eur. J. Biochem. , vol.226 , pp. 255
    • Perales, J.C.1    Ferkol, T.2    Molas, M.3    Hanson, R.W.4
  • 15
    • 0025949812 scopus 로고
    • Adenovirus enhancement of transferrin-polylysine-mediated gene delivery
    • Curiel, D. T., Agarwal, S., Wagner, E., and Cotten, M., Adenovirus enhancement of transferrin-polylysine-mediated gene delivery, Proc. Natl. Acad. Sci. USA, 88, 8850, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8850
    • Curiel, D.T.1    Agarwal, S.2    Wagner, E.3    Cotten, M.4
  • 16
    • 0024390310 scopus 로고
    • 131I-labeled follicle-stimulating hormone in mouse sertoli cells and its relevance to other systems
    • 131I-labeled follicle-stimulating hormone in mouse sertoli cells and its relevance to other systems., J. Biol. Chem., 264, 13632, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13632
    • Shimizu, A.1    Kawashima, S.2
  • 17
    • 0027478333 scopus 로고
    • Binding, internalization, degradation, and mitogenic effect of epidermal growth factor in cultured rat hepatocytes
    • Kato, Y. and Sugiyama, Y., Binding, internalization, degradation, and mitogenic effect of epidermal growth factor in cultured rat hepatocytes, STP Pharm. Sci., 3, 75, 1993.
    • (1993) STP Pharm. Sci. , vol.3 , pp. 75
    • Kato, Y.1    Sugiyama, Y.2
  • 18
    • 0001232787 scopus 로고
    • In vitro models of hepatic uptake: Methods to determine kinetic parameters for receptor-mediated hepatic uptake
    • Taylor, M. D. and Amidon, G. L., Eds., American Chemical Society, Washington, D.C.
    • Sugiyama, Y. and Kato, Y., In vitro models of hepatic uptake: Methods to determine kinetic parameters for receptor-mediated hepatic uptake, in Peptide-Based Drug Design: Controlling Transport and Metabolism, Taylor, M. D. and Amidon, G. L., Eds., American Chemical Society, Washington, D.C., 1995, 525.
    • (1995) Peptide-Based Drug Design: Controlling Transport and Metabolism , pp. 525
    • Sugiyama, Y.1    Kato, Y.2
  • 19
    • 0024996478 scopus 로고
    • Receptor-mediated disposition of polypeptides: Kinetic analysis of the transport of epidermal growth factor using in vitro, isolated perfused organs, and in vivo system
    • Sugiyama, Y., Kim, D. C., Sato, H., Yanai, S., Satoh, H., Iga, T., and Hanano, M., Receptor-mediated disposition of polypeptides: Kinetic analysis of the transport of epidermal growth factor using in vitro, isolated perfused organs, and in vivo system, J. Control Rel., 13, 157, 1990.
    • (1990) J. Control Rel. , vol.13 , pp. 157
    • Sugiyama, Y.1    Kim, D.C.2    Sato, H.3    Yanai, S.4    Satoh, H.5    Iga, T.6    Hanano, M.7
  • 20
    • 0342337058 scopus 로고
    • Receptor-mediated hepatic clearance of peptide hormones
    • Breimer, D. D., Crommelin, D. J. A., and Midha. K. K., Eds., Amsterdam Medical Press, Noordwijk
    • Sugiyama, Y., Sato, H., Yanai, S., Kim, D. C., Miyauchi, S., Sawada, Y., Iga, T., and Hanano, M., Receptor-mediated hepatic clearance of peptide hormones, in Topics in Pharmaceutical Sciences 1989, Breimer, D. D., Crommelin, D. J. A., and Midha. K. K., Eds., Amsterdam Medical Press, Noordwijk, 1989, 429.
    • (1989) Topics in Pharmaceutical Sciences 1989 , pp. 429
    • Sugiyama, Y.1    Sato, H.2    Yanai, S.3    Kim, D.C.4    Miyauchi, S.5    Sawada, Y.6    Iga, T.7    Hanano, M.8
  • 22
    • 0027403383 scopus 로고
    • Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats
    • Liu, K., Kato, Y., Yamazaki, M., Higuchi, O., Nakamura, T., and Sugiyama, Y., Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride-intoxicated rats, Hepatology, 17, 651, 1993.
    • (1993) Hepatology , vol.17 , pp. 651
    • Liu, K.1    Kato, Y.2    Yamazaki, M.3    Higuchi, O.4    Nakamura, T.5    Sugiyama, Y.6
  • 23
    • 0028867040 scopus 로고
    • Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats
    • Liu, K., Kato, Y., Terasaki, T., Nakamura, T., and Sugiyama, Y., Change in hepatic handling of hepatocyte growth factor during liver regeneration in rats, Am. J. Physiol., 269, G745, 1995.
    • (1995) Am. J. Physiol. , vol.269
    • Liu, K.1    Kato, Y.2    Terasaki, T.3    Nakamura, T.4    Sugiyama, Y.5
  • 24
    • 0028114416 scopus 로고
    • Non-linear pharmacokinetics of the recombinant granulocyte colony-stimulating factor nartograstim: Species differences among rats, monkeys, and humans
    • Kuwabara, T., Kato, Y., Kobayashi, S., Suzuki, H., and Sugiyama, Y., Non-linear pharmacokinetics of the recombinant granulocyte colony-stimulating factor nartograstim: Species differences among rats, monkeys, and humans, J. Pharmacol. Exp. Ther., 271, 1535, 1994.
    • (1994) J. Pharmacol. Exp. Ther. , vol.271 , pp. 1535
    • Kuwabara, T.1    Kato, Y.2    Kobayashi, S.3    Suzuki, H.4    Sugiyama, Y.5
  • 25
  • 26
    • 0029053166 scopus 로고
    • Saturable uptake of a recombinant human granulocyte colony-stimulating factor derivative, nartograstim, by the bone marrow and spleen of rats in vivo
    • Kuwabara, T., Uchimura, T., Takai, K., Kobayashi, H., Kobayashi, S., and Sugiyama, Y., Saturable uptake of a recombinant human granulocyte colony-stimulating factor derivative, nartograstim, by the bone marrow and spleen of rats in vivo, J. Pharmacol. Exp. Ther., 273, 1114, 1995.
    • (1995) J. Pharmacol. Exp. Ther. , vol.273 , pp. 1114
    • Kuwabara, T.1    Uchimura, T.2    Takai, K.3    Kobayashi, H.4    Kobayashi, S.5    Sugiyama, Y.6
  • 27
    • 0027263152 scopus 로고
    • A transforming growth factor-α-Pseudomonas exotoxin hybrid protein undergoes pH-dependent conformational changes conducive to membrane interaction
    • Sanyal, G., Marquis-Omer, D., Gress, J. O., Middaugh, C. R., A transforming growth factor-α-Pseudomonas exotoxin hybrid protein undergoes pH-dependent conformational changes conducive to membrane interaction, Biochemistry, 32, 3488, 1993.
    • (1993) Biochemistry , vol.32 , pp. 3488
    • Sanyal, G.1    Marquis-Omer, D.2    Gress, J.O.3    Middaugh, C.R.4
  • 28
    • 0027532624 scopus 로고
    • Heparin-binding transforming growth factor a-pseudomonas exotoxin A
    • Mesri, E. A., Kreitman, R. J., Fu, Y., Epstein, S. E., and Pastan, I., Heparin-binding transforming growth factor a-pseudomonas exotoxin A, J. Biol. Chem., 268, 4853, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4853
    • Mesri, E.A.1    Kreitman, R.J.2    Fu, Y.3    Epstein, S.E.4    Pastan, I.5
  • 29
    • 0006052482 scopus 로고
    • A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: In vitro and in vivo studies
    • Trouet, A., Masquelier, M., Baurain, R., and Campeneere, D. D., A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: In vitro and in vivo studies, Proc. Natl. Acad. Sci. USA, 79, 626, 1982.
    • (1982) Proc. Natl. Acad. Sci. USA , vol.79 , pp. 626
    • Trouet, A.1    Masquelier, M.2    Baurain, R.3    Campeneere, D.D.4
  • 30
    • 0025809808 scopus 로고
    • N-(2-hydroxypropyl) methacrylamide copolymers targetted to the hepatocyte galactose-receptor: Pharmacokinetics in DBA2 mice
    • Seymour, L. W., Ulbrich, K., Wedge, S. R., Hume, I. C., Strohalm, J., and Duncan, R., N-(2-hydroxypropyl) methacrylamide copolymers targetted to the hepatocyte galactose-receptor: pharmacokinetics in DBA2 mice, Br. J. Cancer, 63, 859, 1991.
    • (1991) Br. J. Cancer , vol.63 , pp. 859
    • Seymour, L.W.1    Ulbrich, K.2    Wedge, S.R.3    Hume, I.C.4    Strohalm, J.5    Duncan, R.6
  • 31
    • 0024343077 scopus 로고
    • Targeting genes: Delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo
    • Wu, C. H., Wilson, J. M., and Wu, G. Y., Targeting genes: Delivery and persistent expression of a foreign gene driven by mammalian regulatory elements in vivo, J. Biol. Chem., 264, 16985, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16985
    • Wu, C.H.1    Wilson, J.M.2    Wu, G.Y.3
  • 32
    • 0026315433 scopus 로고
    • Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats
    • Wu, G. Y., Wilson, J. M., Shalaby, F., Grossman, M., Shafritz, D. A., and Wu, C. H., Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats, J. Biol. Chem., 266, 14338, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 14338
    • Wu, G.Y.1    Wilson, J.M.2    Shalaby, F.3    Grossman, M.4    Shafritz, D.A.5    Wu, C.H.6
  • 33
    • 0026722109 scopus 로고
    • A novel mechanism for achieving transgene persistence in vivo after somatic gene transfer into hepatocytes
    • Wilson, J. M., Grossman, M., Cabrera, J. A., Wu, C. H., and Wu, G. Y., A novel mechanism for achieving transgene persistence in vivo after somatic gene transfer into hepatocytes, J. Biol. Chem., 267, 11483, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 11483
    • Wilson, J.M.1    Grossman, M.2    Cabrera, J.A.3    Wu, C.H.4    Wu, G.Y.5
  • 34
    • 0025891831 scopus 로고
    • Transferrin-polycation-DNA complexes: The effect of polycations on the structure of the complex and DNA delivery to cells
    • Wagner, E., Cotten, M., Foisner, R., and Birnstiel, M. L., Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells, Proc. Natl. Acad. Sci. USA, 88, 4255, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4255
    • Wagner, E.1    Cotten, M.2    Foisner, R.3    Birnstiel, M.L.4
  • 35
    • 0027325520 scopus 로고
    • Regulation of the phosphoenolpyruvate carboxykinase/human factor IX gene introduced into the livers of adult rats by receptor-mediated gene transfer
    • Ferkol, T., Lindberg, G. L., Chen, J., Perales, J. C., Crawford, D. R., Ratnoff, O. D., and Hanson, R. W., Regulation of the phosphoenolpyruvate carboxykinase/human factor IX gene introduced into the livers of adult rats by receptor-mediated gene transfer, FASEB J., 7, 1081, 1993.
    • (1993) FASEB J. , vol.7 , pp. 1081
    • Ferkol, T.1    Lindberg, G.L.2    Chen, J.3    Perales, J.C.4    Crawford, D.R.5    Ratnoff, O.D.6    Hanson, R.W.7
  • 36
    • 0027954666 scopus 로고
    • A novel gene delivery system using EGF receptor-mediated endocytosis
    • Chen, J., Gamou, S., Takayanagi, A., and Shimizu, N., A novel gene delivery system using EGF receptor-mediated endocytosis, FEBS Lett., 338, 167, 1994.
    • (1994) FEBS Lett. , vol.338 , pp. 167
    • Chen, J.1    Gamou, S.2    Takayanagi, A.3    Shimizu, N.4
  • 37
    • 0028954476 scopus 로고
    • Malarial circumsporozoite protein is a novel gene delivery vehicle to primary hepatocyte cultures and cultured cells
    • Ding, Z. M., Cristiano, R. J., Roth, J. A., Takacs, B., and Kuo, M. T., Malarial circumsporozoite protein is a novel gene delivery vehicle to primary hepatocyte cultures and cultured cells, J. Biol. Chem., 270, 3667, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3667
    • Ding, Z.M.1    Cristiano, R.J.2    Roth, J.A.3    Takacs, B.4    Kuo, M.T.5
  • 38
    • 0026480374 scopus 로고
    • Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor
    • Yoshikawa, T. and Pardridge, W. M., Biotin delivery to brain with a covalent conjugate of avidin and a monoclonal antibody to the transferrin receptor, J. Pharmacol. Exp. Ther., 263, 897, 1992.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 897
    • Yoshikawa, T.1    Pardridge, W.M.2
  • 39
    • 0028354593 scopus 로고
    • Synthesis and bioactivity of monobiotinylated DALDA: A mu-specific opioid peptide designed for targeted brain delivery
    • Bickel, U., Yamada, S., and Pardridge, W. M., Synthesis and bioactivity of monobiotinylated DALDA: a mu-specific opioid peptide designed for targeted brain delivery, J. Pharmacol Exp. Ther., 268, 791, 1994.
    • (1994) J. Pharmacol Exp. Ther. , vol.268 , pp. 791
    • Bickel, U.1    Yamada, S.2    Pardridge, W.M.3
  • 40
    • 0028211211 scopus 로고
    • Use of neutral avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate
    • Kang, Y. S. and Pardridge, W. M., Use of neutral avidin improves pharmacokinetics and brain delivery of biotin bound to an avidin-monoclonal antibody conjugate, J. Pharmacol. Exp. Ther., 269, 344, 1994.
    • (1994) J. Pharmacol. Exp. Ther. , vol.269 , pp. 344
    • Kang, Y.S.1    Pardridge, W.M.2
  • 42
    • 0028222291 scopus 로고
    • Long-circulating (sterically stabilized) liposomes for targeted drug delivery
    • Allen, T. M., Long-circulating (sterically stabilized) liposomes for targeted drug delivery, TiPS, 15, 215, 1994.
    • (1994) TiPS , vol.15 , pp. 215
    • Allen, T.M.1
  • 43
    • 0026601597 scopus 로고
    • In vivo targeting of OV-TL 3 immunoliposomes to ascitic ovarian carcinoma cells (OVCAR-3) in athymic nude mice
    • Nassander, U. K., Steerenberg, P. A., Poppe, H., Storm, G., Poels, L. G., De-Jong, W. H., and Crommelin, D., J., In vivo targeting of OV-TL 3 immunoliposomes to ascitic ovarian carcinoma cells (OVCAR-3) in athymic nude mice, Cancer Res., 52, 646, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 646
    • Nassander, U.K.1    Steerenberg, P.A.2    Poppe, H.3    Storm, G.4    Poels, L.G.5    De-Jong, W.H.6    Crommelin, D.J.7
  • 44
    • 0028953974 scopus 로고
    • Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies
    • Maruyama, K., Takizawa, T., Yuda, T., Kennel, S. J., Huang, L., and Iwatsuru, M., Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies, Biochim. Biophy. Acta, 1234, 74, 1995.
    • (1995) Biochim. Biophy. Acta , vol.1234 , pp. 74
    • Maruyama, K.1    Takizawa, T.2    Yuda, T.3    Kennel, S.J.4    Huang, L.5    Iwatsuru, M.6
  • 45
    • 0026742081 scopus 로고
    • Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium
    • Torchilin, V. P., Klibanov, A. L., Huang, L., O'Donnell, S., Nossiff, N. D., and Khaw, B. A., Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium, FASEB J., 6, 2716, 1992.
    • (1992) FASEB J. , vol.6 , pp. 2716
    • Torchilin, V.P.1    Klibanov, A.L.2    Huang, L.3    O'Donnell, S.4    Nossiff, N.D.5    Khaw, B.A.6
  • 46
    • 0017260732 scopus 로고
    • Chemical and physical properties of an hepatic membrane protein that specifically binds asialoglycoproteins
    • Kawasaki, T. and Ashwell, G., Chemical and physical properties of an hepatic membrane protein that specifically binds asialoglycoproteins, J. Biol. Chem., 251, 1296, 1976.
    • (1976) J. Biol. Chem. , vol.251 , pp. 1296
    • Kawasaki, T.1    Ashwell, G.2
  • 47
    • 0017137316 scopus 로고
    • Carbohydrate structure of glycopeptides isolated from an hepatic membrane-binding protein specific for asialoglycoproteins
    • Kawasaki, T. and Ashwell, G., Carbohydrate structure of glycopeptides isolated from an hepatic membrane-binding protein specific for asialoglycoproteins, J. Biol. Chem., 251, 5292, 1976.
    • (1976) J. Biol. Chem. , vol.251 , pp. 5292
    • Kawasaki, T.1    Ashwell, G.2
  • 48
    • 0026980122 scopus 로고
    • Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives
    • Fujita, T., Nishikawa, M., Tamaki, C., Takakura, Y., Hashida, M., and Sezaki, H., Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives, J. Pharmacol. Exp. Ther., 263, 971, 1992.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 971
    • Fujita, T.1    Nishikawa, M.2    Tamaki, C.3    Takakura, Y.4    Hashida, M.5    Sezaki, H.6
  • 49
    • 0019992236 scopus 로고
    • Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line
    • Schwartz, A. L., Fridovich, S. E., and Lodish, H. F., Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line, J. Biol. Chem., 257, 4230, 1982.
    • (1982) J. Biol. Chem. , vol.257 , pp. 4230
    • Schwartz, A.L.1    Fridovich, S.E.2    Lodish, H.F.3
  • 51
    • 0028365876 scopus 로고
    • In vivo targeting function of N-linked oligosaccharides with terminating galactose and N-acetylgalactosamine residues
    • Chiu, M. H., Tamura, T., Wadhwa, M. S., and Rice K. G., In vivo targeting function of N-linked oligosaccharides with terminating galactose and N-acetylgalactosamine residues, J. Biol. Chem. 269, 16195, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16195
    • Chiu, M.H.1    Tamura, T.2    Wadhwa, M.S.3    Rice, K.G.4
  • 52
    • 0019417537 scopus 로고
    • Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats
    • Sawamura, T., Kawasato, S., Shiozaki, Y., Sameshima, Y., Nakada, H., and Tashiro, Y., Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats, Gastroenterology, 81, 527, 1981.
    • (1981) Gastroenterology , vol.81 , pp. 527
    • Sawamura, T.1    Kawasato, S.2    Shiozaki, Y.3    Sameshima, Y.4    Nakada, H.5    Tashiro, Y.6
  • 53
    • 0026540432 scopus 로고
    • Abnormal surface distribution of the human asialoglycoprotein receptorin cirrhosis
    • Burgess, J. B., Baenziger, J. U., and Browin, W. R., Abnormal surface distribution of the human asialoglycoprotein receptorin cirrhosis, Hepatology, 15, 702, 1992.
    • (1992) Hepatology , vol.15 , pp. 702
    • Burgess, J.B.1    Baenziger, J.U.2    Browin, W.R.3
  • 55
    • 0018583389 scopus 로고
    • Demonstration of a high affinity folate binder in human cell membranes and its characterization in cultured human KB cells
    • McHugh, M. and Cheng, Y., Demonstration of a high affinity folate binder in human cell membranes and its characterization in cultured human KB cells, J. Biol. Chem., 254, 11312, 1979.
    • (1979) J. Biol. Chem. , vol.254 , pp. 11312
    • McHugh, M.1    Cheng, Y.2
  • 58
    • 0026496180 scopus 로고
    • Cytotoxicity of momordin-folate conjugates in cultured human cells
    • Leamon, C. P. and Low, P. S., Cytotoxicity of momordin-folate conjugates in cultured human cells, J. Biol. Chem., 267, 24966, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 24966
    • Leamon, C.P.1    Low, P.S.2
  • 59
    • 0025951931 scopus 로고
    • Delivery of macromolecules into living cells: A method that exploits folate receptor endocytosis
    • Leamon, C. P. and Low, P. S., Delivery of macromolecules into living cells: A method that exploits folate receptor endocytosis, Proc. Natl. Acad. Sci. USA, 88, 5572, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5572
    • Leamon, C.P.1    Low, P.S.2
  • 60
    • 0028001056 scopus 로고
    • Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis
    • Lee, R. J. and Low, P. S., Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis. J. Biol. Chem., 269, 3198, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 3198
    • Lee, R.J.1    Low, P.S.2
  • 61
    • 0028924955 scopus 로고
    • Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol
    • Wang, S., Lee, R. J., Cauchon, G., Gorenstein, D. G., and Low, P. S., Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth factor receptor into cultured KB cells with liposomes conjugated to folate via polyethylene glycol, Proc. Natl. Acad. Sci. U S A, 92, 3318, 1995.
    • (1995) Proc. Natl. Acad. Sci. U S A , vol.92 , pp. 3318
    • Wang, S.1    Lee, R.J.2    Cauchon, G.3    Gorenstein, D.G.4    Low, P.S.5
  • 62
    • 0028794831 scopus 로고
    • Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro
    • Lee, R. J. and Low, P. S., Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro, Biochim. Biophys. Acta., 1233, 134, 1995.
    • (1995) Biochim. Biophys. Acta , vol.1233 , pp. 134
    • Lee, R.J.1    Low, P.S.2
  • 63
    • 0026545612 scopus 로고
    • Potocytosis: Sequestration and transport of small molecules by caveolæ
    • Anderson, R. G. W., Kamen, B. A., Rothberg, K. G., and Lacey, S. W., Potocytosis: Sequestration and transport of small molecules by caveolæ, Science, 255, 410, 1992.
    • (1992) Science , vol.255 , pp. 410
    • Anderson, R.G.W.1    Kamen, B.A.2    Rothberg, K.G.3    Lacey, S.W.4
  • 64
    • 0028000605 scopus 로고
    • Sequestration of GPI-anchored proteins in caveolæ triggered by cross-linking
    • Mayor, S., Rothberg, K. G., and Maxfield, F. R., Sequestration of GPI-anchored proteins in caveolæ triggered by cross-linking, Science , 264, 1948, 1994.
    • (1994) Science , vol.264 , pp. 1948
    • Mayor, S.1    Rothberg, K.G.2    Maxfield, F.R.3
  • 65
    • 0027443234 scopus 로고
    • Caveolæ: Where incoming and outgoing messengers meet
    • Anderson, R. G. W., Caveolæ: Where incoming and outgoing messengers meet, Proc. Natl. Acad. Sci. USA, 90, 10909, 1993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10909
    • Anderson, R.G.W.1
  • 67
    • 0023683407 scopus 로고
    • Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles
    • Kamen, B. A., Wang, M., Streckfuss, A. J., Peryea, X., and Anderson, R. G. W., Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles, J. Biol. Chem., 263, 13602, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 13602
    • Kamen, B.A.1    Wang, M.2    Streckfuss, A.J.3    Peryea, X.4    Anderson, R.G.W.5
  • 68
    • 0028986856 scopus 로고
    • Distinguishing between folate receptor-α-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells
    • Spinella, M. J., Brigle, K. E., Sierra, E. E., and Goldman, I. D., Distinguishing between folate receptor-α-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells, J. Biol. Chem., 270, 7842, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7842
    • Spinella, M.J.1    Brigle, K.E.2    Sierra, E.E.3    Goldman, I.D.4
  • 69
    • 0024371381 scopus 로고
    • Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas
    • Ozawa, S., Ueda, M., Ando, N., Shimizu, N., and Abe, O., Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas, Cancer, 63, 2169, 1989.
    • (1989) Cancer , vol.63 , pp. 2169
    • Ozawa, S.1    Ueda, M.2    Ando, N.3    Shimizu, N.4    Abe, O.5
  • 73
    • 0023227218 scopus 로고
    • Human blood-brain barrier transferrin receptor
    • Pardridge, W. M., Eisenberg, J., and Yang, J., Human blood-brain barrier transferrin receptor, Metabolism, 36, 892, 1987.
    • (1987) Metabolism , vol.36 , pp. 892
    • Pardridge, W.M.1    Eisenberg, J.2    Yang, J.3
  • 74
    • 0025836586 scopus 로고
    • Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo
    • Pardridge, W. M., Buciak, J. L., and Friden, P. M., Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo, J. Pharmacol. Exp. Ther., 259, 66, 1991.
    • (1991) J. Pharmacol. Exp. Ther. , vol.259 , pp. 66
    • Pardridge, W.M.1    Buciak, J.L.2    Friden, P.M.3
  • 78
    • 0027281928 scopus 로고
    • Low-density lipoprotein for cytotoxic drug targeting: Improved activity of elliptinium derivative against B16 melanoma in mice
    • Samadi-Baboli, M., Favre, G., Canal, P., and Soula, G., Low-density lipoprotein for cytotoxic drug targeting: Improved activity of elliptinium derivative against B16 melanoma in mice, Br. J. Cancer, 68, 319, 1993.
    • (1993) Br. J. Cancer , vol.68 , pp. 319
    • Samadi-Baboli, M.1    Favre, G.2    Canal, P.3    Soula, G.4
  • 80
    • 0023951327 scopus 로고
    • Recent advances in blood-brain barrier transport
    • Pardridge, W. M., Recent advances in blood-brain barrier transport, Ann. Rev. Pharmacol. Toxicol., 28, 25, 1988.
    • (1988) Ann. Rev. Pharmacol. Toxicol. , vol.28 , pp. 25
    • Pardridge, W.M.1
  • 81
    • 0028062850 scopus 로고
    • Insulin fragments as a carrier for peptide delivery across the blood-brain barrier
    • Fukuta, M., Okada, H., Iinuma, S., Yanai, S., and Toguchi, H., Insulin fragments as a carrier for peptide delivery across the blood-brain barrier, Pharm. Res., 11, 1681, 1994.
    • (1994) Pharm. Res. , vol.11 , pp. 1681
    • Fukuta, M.1    Okada, H.2    Iinuma, S.3    Yanai, S.4    Toguchi, H.5
  • 82
    • 0027365343 scopus 로고
    • Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor
    • Ferkol, T., Kaetzel, C. S., and Davis, P. B., Gene transfer into respiratory epithelial cells by targeting the polymeric immunoglobulin receptor, J. Clin. Invest., 92, 2394, 1993.
    • (1993) J. Clin. Invest. , vol.92 , pp. 2394
    • Ferkol, T.1    Kaetzel, C.S.2    Davis, P.B.3
  • 83
    • 0028052170 scopus 로고
    • Targeted gene delivery to alveolar macrophages via Fc receptor-mediated endocytosis
    • Rojanasakul, Y., Wang, L. Y., Malanga, C. J., Ma, J. K., and Liaw, J., Targeted gene delivery to alveolar macrophages via Fc receptor-mediated endocytosis, Pharm. Res., 11, 1731, 1994.
    • (1994) Pharm. Res. , vol.11 , pp. 1731
    • Rojanasakul, Y.1    Wang, L.Y.2    Malanga, C.J.3    Ma, J.K.4    Liaw, J.5
  • 84
    • 0028799484 scopus 로고
    • Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor
    • Ferkol, T., Perales, J. C., Eckman, E., Kaetzel, C. S., Hanson, R. W., and Davis, P. B., Gene transfer into the airway epithelium of animals by targeting the polymeric immunoglobulin receptor, J. Clin. Invest., 95, 493, 1995.
    • (1995) J. Clin. Invest. , vol.95 , pp. 493
    • Ferkol, T.1    Perales, J.C.2    Eckman, E.3    Kaetzel, C.S.4    Hanson, R.W.5    Davis, P.B.6
  • 85
    • 0020021127 scopus 로고
    • Carbohydrate-specific receptors of the liver
    • Ashwell, G. and Harford, J., Carbohydrate-specific receptors of the liver, Ann. Rev. Biochem., 51, 531, 1982.
    • (1982) Ann. Rev. Biochem. , vol.51 , pp. 531
    • Ashwell, G.1    Harford, J.2
  • 86
    • 0023230938 scopus 로고
    • Uptake and processing of glycoproteins by rat hepatic mannose receptor
    • Taylor, M. E., Leaning, M. S., and Summerfield, J. A., Uptake and processing of glycoproteins by rat hepatic mannose receptor, Am. J. Physiol., 252, E690, 1987.
    • (1987) Am. J. Physiol. , vol.252
    • Taylor, M.E.1    Leaning, M.S.2    Summerfield, J.A.3
  • 87
    • 0027417057 scopus 로고
    • Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules
    • Franssen, E. J., Jansen, R. W., Vaalburg, M., and Meijer, D. K., Hepatic and intrahepatic targeting of an anti-inflammatory agent with human serum albumin and neoglycoproteins as carrier molecules, Biochem. Pharmacol., 45, 1215, 1993.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 1215
    • Franssen, E.J.1    Jansen, R.W.2    Vaalburg, M.3    Meijer, D.K.4
  • 88
    • 0027185699 scopus 로고
    • Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyldextran, and its application to drug targeting
    • Nishikawa, M., Kamijo, A., Fujita, T., Takakura, Y., Sezaki, H., and Hashida, M., Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyldextran, and its application to drug targeting, Pharm. Res., 10, 1253, 1993.
    • (1993) Pharm. Res. , vol.10 , pp. 1253
    • Nishikawa, M.1    Kamijo, A.2    Fujita, T.3    Takakura, Y.4    Sezaki, H.5    Hashida, M.6
  • 91
    • 0027768571 scopus 로고
    • Adenoviral vectors for gene transfer
    • Trapnell, B. C., Adenoviral vectors for gene transfer, Adv. Drug Deliv. Rev., 12, 185, 1993.
    • (1993) Adv. Drug Deliv. Rev. , vol.12 , pp. 185
    • Trapnell, B.C.1
  • 92
    • 0028618172 scopus 로고
    • Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers
    • Chiou, H. C., Tangco, M. V., Levine, S. M., Robertson, D., Kormis, K., Wu, C. H., and Wu, G. Y., Enhanced resistance to nuclease degradation of nucleic acids complexed to asialoglycoprotein-polylysine carriers, Nucleic Acids Res., 22, 5439, 1994.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5439
    • Chiou, H.C.1    Tangco, M.V.2    Levine, S.M.3    Robertson, D.4    Kormis, K.5    Wu, C.H.6    Wu, G.Y.7
  • 93
    • 0023212742 scopus 로고
    • Receptor-mediated in vitro gene transformation by a soluble DNa carrier system
    • Wu, G. Y. and Wu, H. W., Receptor-mediated in vitro gene transformation by a soluble DNA carrier system, J. Biol. Chem., 262, 4429, 1987.
    • (1987) J. Biol. Chem. , vol.262 , pp. 4429
    • Wu, G.Y.1    Wu, H.W.2
  • 95
    • 0027233696 scopus 로고
    • Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy
    • Chowdhury, N. R., Wu, C. H., Wu, G. Y., Yerneni, P. C., Bommineni, V. R., and Chowdhury, J. R., Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. Prolonged persistence in cytoplasmic vesicles after partial hepatectomy, J. Biol. Chem., 268, 11265, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11265
    • Chowdhury, N.R.1    Wu, C.H.2    Wu, G.Y.3    Yerneni, P.C.4    Bommineni, V.R.5    Chowdhury, J.R.6
  • 96
    • 0028244315 scopus 로고
    • Transport of oligonucleotides across natural and model membranes
    • Vlassov, V. V., Balakireva, L. A., and Yakubov, L. A., Transport of oligonucleotides across natural and model membranes, Biochim. Biophys. Acta., 1197, 95, 1994.
    • (1994) Biochim. Biophys. Acta , vol.1197 , pp. 95
    • Vlassov, V.V.1    Balakireva, L.A.2    Yakubov, L.A.3
  • 97
    • 0026651984 scopus 로고
    • Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides
    • Citro, G., Perrotti, D., Cucco, C., D'Agnano, I., Sacchi, A., Zupi, G., and Calabretta, B., Inhibition of leukemia cell proliferation by receptor-mediated uptake of c-myb antisense oligodeoxynucleotides, Proc. Natl. Acad. Sci. USA., 89, 7031, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7031
    • Citro, G.1    Perrotti, D.2    Cucco, C.3    D'Agnano, I.4    Sacchi, A.5    Zupi, G.6    Calabretta, B.7
  • 98
    • 0028564905 scopus 로고
    • Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit
    • Marcello, A., Loregian, A., Cross, A., Marsden, H., Hirst, T. R., and Palu, G., Specific inhibition of herpes virus replication by receptor-mediated entry of an antiviral peptide linked to Escherichia coli enterotoxin B subunit, Proc. Natl. Acad. Sci. USA., 91, 8994, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8994
    • Marcello, A.1    Loregian, A.2    Cross, A.3    Marsden, H.4    Hirst, T.R.5    Palu, G.6
  • 99
    • 0000758331 scopus 로고
    • Approaches to modulating liver transport of peptide drugs
    • Taylor, M. D. and Amidon, G. L., Eds., American Chemical Society, Washington, D.C.
    • Ruwart, M., Approaches to modulating liver transport of peptide drugs, in Peptide-Based Drug Design: Controlling Transport and Metabolism, Taylor, M. D. and Amidon, G. L., Eds., American Chemical Society, Washington, D.C., 1995, 249.
    • (1995) Peptide-Based Drug Design: Controlling Transport and Metabolism , pp. 249
    • Ruwart, M.1
  • 101
    • 0024433513 scopus 로고
    • Pseudomonas exotoxin: Chimeric toxins
    • Pastan, I. and FitzGerald, D., Pseudomonas exotoxin: Chimeric toxins, J. Biol. Chem., 264, 15157, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 15157
    • Pastan, I.1    Fitzgerald, D.2
  • 102
    • 0025243542 scopus 로고
    • Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol
    • Ogata, M., Chaudhary, V. K., Pastan, I., and FitzGerald, D. J., Processing of Pseudomonas exotoxin by a cellular protease results in the generation of a 37,000-Da toxin fragment that is translocated to the cytosol, J. Biol. Chem., 265, 20678, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 20678
    • Ogata, M.1    Chaudhary, V.K.2    Pastan, I.3    FitzGerald, D.J.4
  • 103
    • 0026621245 scopus 로고
    • ABC transporters: From microorganisms to man
    • Higgins, C. F., ABC transporters: from microorganisms to man, Ann. Rev. Cell Biol., 8, 67, 1992.
    • (1992) Ann. Rev. Cell Biol. , vol.8 , pp. 67
    • Higgins, C.F.1
  • 104
    • 0027102397 scopus 로고
    • Therapeutic effects of superoxide dismutase derivatives modified with mono- Or polysaccharides on hepatic injury induced by ischemia/reperfusion
    • Fujita, T., Furitsu, H., Nishikawa, M., Takakura, Y., Sezaki, H., and Hashida, M., Therapeutic effects of superoxide dismutase derivatives modified with mono-or polysaccharides on hepatic injury induced by ischemia/reperfusion, Biochem. Biophys. Res. Commun., 189, 191, 1992.
    • (1992) Biochem. Biophys. Res. Commun. , vol.189 , pp. 191
    • Fujita, T.1    Furitsu, H.2    Nishikawa, M.3    Takakura, Y.4    Sezaki, H.5    Hashida, M.6
  • 105
    • 0028297535 scopus 로고
    • Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism
    • Takakura, Y., Masuda, S., Tokuda, H., Nishikawa, M., and Hashida M., Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism, Biochem. Pharmacol., 47, 853-8, 1994.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 853-858
    • Takakura, Y.1    Masuda, S.2    Tokuda, H.3    Nishikawa, M.4    Hashida, M.5
  • 106
    • 0028102430 scopus 로고
    • Novel delivery of antioxidant enzyme catalase to alveolar macrophages by Fc receptor-mediated endocytosis
    • Harrison, J., Shi, X., Wang, L., Ma, J. K., and Rojanasakul, Y., Novel delivery of antioxidant enzyme catalase to alveolar macrophages by Fc receptor-mediated endocytosis, Pharm. Res., 11, 1110, 1994.
    • (1994) Pharm. Res. , vol.11 , pp. 1110
    • Harrison, J.1    Shi, X.2    Wang, L.3    Ma, J.K.4    Rojanasakul, Y.5
  • 107
    • 0012452835 scopus 로고
    • Receptor-mediated transcytosis of peptides through the blood-brain barrier
    • Pardridge, W. M., Ed., Raven Press, New York
    • Pardridge, W. M., Receptor-mediated transcytosis of peptides through the blood-brain barrier, in Peptide Drug Delivery to the Brain, Pardridge, W. M., Ed., Raven Press, New York, 1991, 160.
    • (1991) Peptide Drug Delivery to the Brain , pp. 160
    • Pardridge, W.M.1
  • 108
    • 0029153418 scopus 로고
    • Targeting of drugs to the liver
    • Meijer, D. K. F. and Molema, G., Targeting of drugs to the liver, Semin. Liver Dis., 15, 202, 1995.
    • (1995) Semin. Liver Dis. , vol.15 , pp. 202
    • Meijer, D.K.F.1    Molema, G.2
  • 109
    • 0026081301 scopus 로고
    • Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions
    • Jackle, S., Runquist, E. A., Miranda-Brady, S., and Havel, R. J., Trafficking of the epidermal growth factor receptor and transferrin in three hepatocytic endosomal fractions, J. Biol. Chem., 266, 1396, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 1396
    • Jackle, S.1    Runquist, E.A.2    Miranda-Brady, S.3    Havel, R.J.4
  • 110
    • 0021234231 scopus 로고
    • Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: Ligand and receptor dynamics
    • Dunn, W. A. and Hubbard, A. L., Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: Ligand and receptor dynamics, J. Cell. Biol., 98, 2148, 1984.
    • (1984) J. Cell. Biol. , vol.98 , pp. 2148
    • Dunn, W.A.1    Hubbard, A.L.2
  • 111
    • 0024324406 scopus 로고
    • An analysis of the relationship between the cellular distribution and the rate of turnover for the separate classes of unoccupied, noncovalently occupied, and covalently occupied insulin receptor
    • Reed, D. K., Newton, C., Fraga, M., Glastad, K., Bagheri, A., Harris, S., and Reed, B. C., An analysis of the relationship between the cellular distribution and the rate of turnover for the separate classes of unoccupied, noncovalently occupied, and covalently occupied insulin receptor, J. Biol Chem., 264, 12673, 1989.
    • (1989) J. Biol Chem. , vol.264 , pp. 12673
    • Reed, D.K.1    Newton, C.2    Fraga, M.3    Glastad, K.4    Bagheri, A.5    Harris, S.6    Reed, B.C.7
  • 112
    • 0021075885 scopus 로고
    • Recycling of the asialoglycoprotein receptor in isolated rat hepatocytes
    • Oka, J. A. and Weigel, P. H., Recycling of the asialoglycoprotein receptor in isolated rat hepatocytes, J. Biol. Chem., 258, 10253, 1983.
    • (1983) J. Biol. Chem. , vol.258 , pp. 10253
    • Oka, J.A.1    Weigel, P.H.2
  • 113
    • 0027325994 scopus 로고
    • Cell density-dependent regulation of hepatocyte growth factor receptor on adult rat hepatocytes in primary culture
    • Mizuno, K., Higuchi, O., Tajima, H., Yonemasu, T., and Nakamura, T., Cell density-dependent regulation of hepatocyte growth factor receptor on adult rat hepatocytes in primary culture, J. Biochem., 114, 96, 1993.
    • (1993) J. Biochem. , vol.114 , pp. 96
    • Mizuno, K.1    Higuchi, O.2    Tajima, H.3    Yonemasu, T.4    Nakamura, T.5
  • 114
    • 0025756553 scopus 로고
    • Kinetic analysis of receptor-mediated endocytosis of epidermal growth factor by isolated rat hepatocytes
    • Yanai, S., Sugiyama, Y., Kim, D. C., Iga, T., Fuwa, T., and Hanano, M., Kinetic analysis of receptor-mediated endocytosis of epidermal growth factor by isolated rat hepatocytes, Am. J. Physiol., 260, C457, 1991.
    • (1991) Am. J. Physiol. , vol.260
    • Yanai, S.1    Sugiyama, Y.2    Kim, D.C.3    Iga, T.4    Fuwa, T.5    Hanano, M.6
  • 115
    • 0024521276 scopus 로고
    • Insulin receptor recycling in vascular endothelial cells
    • Bottaro, D. P., Bonner-Weir, S., and King, G. L., Insulin receptor recycling in vascular endothelial cells, J. Biol. Chem., 264, 5916, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 5916
    • Bottaro, D.P.1    Bonner-Weir, S.2    King, G.L.3
  • 116
    • 0021333875 scopus 로고
    • Relationship between epidermal growth factor receptor occupancy and mitogenic response
    • Knauer, D. J., Wiley, H. S., and Cunningham, D. D., Relationship between epidermal growth factor receptor occupancy and mitogenic response, J. Biol. Chem., 259, 5623, 1984.
    • (1984) J. Biol. Chem. , vol.259 , pp. 5623
    • Knauer, D.J.1    Wiley, H.S.2    Cunningham, D.D.3
  • 117
    • 0019404817 scopus 로고
    • A steady-state model for analyzing the cellular binding, internalization, and degradation ofpolypeptide ligands
    • Wiley, H. S. and Cunningham, D. D., A steady-state model for analyzing the cellular binding, internalization, and degradation ofpolypeptide ligands, Cell, 25, 433, 1981.
    • (1981) Cell , vol.25 , pp. 433
    • Wiley, H.S.1    Cunningham, D.D.2
  • 118
    • 0024364294 scopus 로고
    • Binding, internalization, and intracellular processing of proteins interacting with recycling receptors
    • Bajzer, Z., Myers, A. C., and Vuk-Pavlovic, S., Binding, internalization, and intracellular processing of proteins interacting with recycling receptors, J. Biol. Chem., 264, 13623, 1989.
    • (1989) J. Biol. Chem. , vol.264 , pp. 13623
    • Bajzer, Z.1    Myers, A.C.2    Vuk-Pavlovic, S.3
  • 119
    • 0029934710 scopus 로고    scopus 로고
    • Kinetic analysis of receptor-mediated endocytosis (RME) of proteins and peptides: Use of RME as a drug delivery system
    • Kato, Y., Seita, T., Kuwabara, T., and Sugiyama, Y., Kinetic analysis of receptor-mediated endocytosis (RME) of proteins and peptides: Use of RME as a drug delivery system, J. Controll. Rel., 39, 191, 1996.
    • (1996) J. Controll. Rel. , vol.39 , pp. 191
    • Kato, Y.1    Seita, T.2    Kuwabara, T.3    Sugiyama, Y.4
  • 121
    • 0025313130 scopus 로고
    • Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels
    • Cotten, M., Langle-Rouault, F., Kirlappos, H., Wagner, E., Mechtler, K., Zenke, M., Beug, H., and Birnstiel, M. L., Transferrin-polycation-mediated introduction of DNA into human leukemic cells: Stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels, Proc. Natl. Acad. Sci. USA, 87, 4033, 1990.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 4033
    • Cotten, M.1    Langle-Rouault, F.2    Kirlappos, H.3    Wagner, E.4    Mechtler, K.5    Zenke, M.6    Beug, H.7    Birnstiel, M.L.8
  • 122
    • 0026687453 scopus 로고
    • Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes
    • Wagner, E., Zatloukal, K., Cotten, M., Kirlappos, H., Mechtler, K., Curiel, D. T., and Birnstiel, M. L., Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes, Proc. Natl. Acad. Sci. USA, 89, 6099, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6099
    • Wagner, E.1    Zatloukal, K.2    Cotten, M.3    Kirlappos, H.4    Mechtler, K.5    Curiel, D.T.6    Birnstiel, M.L.7
  • 123
    • 0026755818 scopus 로고
    • High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles
    • Cotten, M., Wagner, E., Zatloukal, K., Phillips, S., Curiel, D. T., and Birnstiel, M. L., High-efficiency receptor-mediated delivery of small and large (48 kilobase) gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles, Proc. Natl. Acad. Sci. USA, 89, 6094, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 6094
    • Cotten, M.1    Wagner, E.2    Zatloukal, K.3    Phillips, S.4    Curiel, D.T.5    Birnstiel, M.L.6
  • 124
    • 0019308195 scopus 로고
    • Nuclear accumulation of epidermal growth factor in cultured rat pituitary cells
    • Johnson, L. K., Vlodavsky, I., Baxter, J. D., and Gospodarowicz, D., Nuclear accumulation of epidermal growth factor in cultured rat pituitary cells, Nature, 287, 340, 1980.
    • (1980) Nature , vol.287 , pp. 340
    • Johnson, L.K.1    Vlodavsky, I.2    Baxter, J.D.3    Gospodarowicz, D.4
  • 125
    • 0026702021 scopus 로고
    • Dynamics of interleukin-6 internalization and degradation in rat hepatocytes
    • Nesbitt, J. E. and Fuller, G. M., Dynamics of interleukin-6 internalization and degradation in rat hepatocytes, J. Biol. Chem., 267, 5739, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5739
    • Nesbitt, J.E.1    Fuller, G.M.2
  • 126
    • 0024465916 scopus 로고
    • Monensin and chloroquine inhibit transfer to lysosomes of endocytosed macromolecules in cultured mouse peritoneal macrophages
    • Stenseth, K. and Thyberg, J., Monensin and chloroquine inhibit transfer to lysosomes of endocytosed macromolecules in cultured mouse peritoneal macrophages, Eur. J. Cell Biol., 49, 326, 1989.
    • (1989) Eur. J. Cell Biol. , vol.49 , pp. 326
    • Stenseth, K.1    Thyberg, J.2
  • 127
    • 0021026555 scopus 로고
    • The effect of chloroquine on the binding, intracellular distribution, and action of insulin on isolated mouse pancreatic acini
    • Iwamoto, Y., Roach, E., Bailey, A., Williams, J. A., and Goldfine, I. D., The effect of chloroquine on the binding, intracellular distribution, and action of insulin on isolated mouse pancreatic acini, Diabetes, 32, 1102, 1983.
    • (1983) Diabetes , vol.32 , pp. 1102
    • Iwamoto, Y.1    Roach, E.2    Bailey, A.3    Williams, J.A.4    Goldfine, I.D.5
  • 128
    • 0021672250 scopus 로고
    • Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor
    • Seth, P., FitzGerald, D., Ginsberg, H., Willingham, M., and Pastan I., Evidence that the penton base of adenovirus is involved in potentiation of toxicity of Pseudomonas exotoxin conjugated to epidermal growth factor, Mol. Cell Biol., 4, 1528, 1984.
    • (1984) Mol. Cell Biol. , vol.4 , pp. 1528
    • Seth, P.1    Fitzgerald, D.2    Ginsberg, H.3    Willingham, M.4    Pastan, I.5
  • 129
    • 0021170531 scopus 로고
    • Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate
    • Seth, P., FitzGerald, D., Willingham, M., and Pastan, I., Role of a low-pH environment in adenovirus enhancement of the toxicity of a Pseudomonas exotoxin-epidermal growth factor conjugate, J. Virol., 51, 650, 1984.
    • (1984) J. Virol. , vol.51 , pp. 650
    • Seth, P.1    Fitzgerald, D.2    Willingham, M.3    Pastan, I.4
  • 130
    • 0027133660 scopus 로고
    • Hepatic gene therapy: Efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNa complex
    • USA
    • Cristiano, R. J., Smith, L. C., Kay, M. A., Brinkley, B. R., and Woo, S. L., Hepatic gene therapy: Efficient gene delivery and expression in primary hepatocytes utilizing a conjugated adenovirus-DNA complex, Proc. Natl. Acad. Sci., USA, 90, 11548, 1993.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 11548
    • Cristiano, R.J.1    Smith, L.C.2    Kay, M.A.3    Brinkley, B.R.4    Woo, S.L.5
  • 131
    • 0027511871 scopus 로고
    • Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway
    • Michael, S. I., Huang, C. H., Romer, M. U., Wagner, E., Hu, P. C., and Curiel, D.T., Binding-incompetent adenovirus facilitates molecular conjugate-mediated gene transfer by the receptor-mediated endocytosis pathway, J. Biol. Chem., 268, 6866, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 6866
    • Michael, S.I.1    Huang, C.H.2    Romer, M.U.3    Wagner, E.4    Hu, P.C.5    Curiel, D.T.6
  • 133
    • 0028290674 scopus 로고
    • In vivo production of human factor VIII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery
    • Zatloukal, K., Cotten, M., Berger, M., Schmidt, W., Wagner, E., and Birnstiel, M. L., In vivo production of human factor VIII in mice after intrasplenic implantation of primary fibroblasts transfected by receptor-mediated, adenovirus-augmented gene delivery, Proc. Natl. Acad. Sci. USA, 91, 5148, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5148
    • Zatloukal, K.1    Cotten, M.2    Berger, M.3    Schmidt, W.4    Wagner, E.5    Birnstiel, M.L.6
  • 135
    • 0026655684 scopus 로고
    • Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle
    • Wagner, E., Plank, C., Zatloukal, K., Cotten, M., and Birnstiel, M. L., Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: Toward a synthetic virus-like gene-transfer vehicle, Proc. Natl. Acad. Sci. USA, 89, 7934, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7934
    • Wagner, E.1    Plank, C.2    Zatloukal, K.3    Cotten, M.4    Birnstiel, M.L.5
  • 136
    • 0023082135 scopus 로고
    • The structure and function of the hemagglutinin membrane lycoprotein of influenza virus
    • Wiley, D. C. and Skehel, J. J., The structure and function of the hemagglutinin membrane lycoprotein of influenza virus, Ann. Rev. Biochem., 56, 365, 1987.
    • (1987) Ann. Rev. Biochem. , vol.56 , pp. 365
    • Wiley, D.C.1    Skehel, J.J.2
  • 137
    • 0025742806 scopus 로고
    • Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40)
    • Pai, L. H., Gallo, M. G., FitzGerald, D. J., and Pastan, I., Antitumor activity of a transforming growth factor alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE40), Cancer Res., 51, 2808, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 2808
    • Pai, L.H.1    Gallo, M.G.2    FitzGerald, D.J.3    Pastan, I.4
  • 138
    • 0028179159 scopus 로고
    • Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice
    • Phillips, P. C., Levow, C., Catterall, M., Colvin, O. M., Pastan, I., and Brem, H., Transforming growth factor-alpha-Pseudomonas exotoxin fusion protein (TGF-alpha-PE38) treatment of subcutaneous and intracranial human glioma and medulloblastoma xenografts in athymic mice, Cancer Res., 54, 1008, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 1008
    • Phillips, P.C.1    Levow, C.2    Catterall, M.3    Colvin, O.M.4    Pastan, I.5    Brem, H.6
  • 139
    • 0023368762 scopus 로고
    • Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin
    • Chaudhary, V. K., FitzGerald, D. J., Adhya, S., and Pastan, I., Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin, Proc. Natl. Acad. Sci. USA., 84, 4538, 1987.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 4538
    • Chaudhary, V.K.1    FitzGerald, D.J.2    Adhya, S.3    Pastan, I.4
  • 140
    • 85047680796 scopus 로고
    • Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin
    • Fu, Y. M., Mesri, E. A., Yu, Z. X., Kreitman, R. J., Pastan, I., and Epstein, S. E., Cytotoxic effects of vascular smooth muscle cells of the chimeric toxin, heparin binding TGF alpha-Pseudomonas exotoxin, Cardiovasc. Res., 27, 1691, 1993.
    • (1993) Cardiovasc. Res. , vol.27 , pp. 1691
    • Fu, Y.M.1    Mesri, E.A.2    Yu, Z.X.3    Kreitman, R.J.4    Pastan, I.5    Epstein, S.E.6
  • 141
    • 0026716393 scopus 로고
    • Brefeldin a enhances receptor-mediated transcytosis of transferrin in filter-grown Madin-Darby canine kidney cells
    • Wan, J., Taub, M. E., Shah, D., and Shen, W., Brefeldin A enhances receptor-mediated transcytosis of transferrin in filter-grown Madin-Darby canine kidney cells, J. Biol. Chem., 267, 13446, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 13446
    • Wan, J.1    Taub, M.E.2    Shah, D.3    Shen, W.4
  • 142
    • 0025943380 scopus 로고
    • Brefeldin a causes a microtubule-mediated fusion of the trans-Golgi network and early eridosomes
    • Wood, S. A., Park, J. E., and Brown, W. J., Brefeldin A causes a microtubule-mediated fusion of the trans-Golgi network and early eridosomes, Cell, 67, 591, 1991.
    • (1991) Cell , vol.67 , pp. 591
    • Wood, S.A.1    Park, J.E.2    Brown, W.J.3
  • 143
    • 0025940101 scopus 로고    scopus 로고
    • Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic
    • Lippincott-Schwartz, J., Yuan, L., Tipper, C., Amherdt, M., Orci, L., and Klausner, R. D., Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic, Cell, 67, 601.
    • Cell , vol.67 , pp. 601
    • Lippincott-Schwartz, J.1    Yuan, L.2    Tipper, C.3    Amherdt, M.4    Orci, L.5    Klausner, R.D.6
  • 144
    • 0026000526 scopus 로고
    • Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL
    • Seetharam, S., Chaudhary, V. K., FitzGerald, D., and Pastan, I., Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL, J. Biol. Chem., 266, 17376, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 17376
    • Seetharam, S.1    Chaudhary, V.K.2    FitzGerald, D.3    Pastan, I.4
  • 145
    • 0023945518 scopus 로고
    • Acute down-regulation of the somatogenic receptors in rat liver by a single injection of growth hormone
    • Maiter, D., Underwood, L. E., Macs, M., and Ketelslegers, J. M., Acute down-regulation of the somatogenic receptors in rat liver by a single injection of growth hormone, Endocrinology, 122, 1291, 1988.
    • (1988) Endocrinology , vol.122 , pp. 1291
    • Maiter, D.1    Underwood, L.E.2    Macs, M.3    Ketelslegers, J.M.4
  • 146
    • 0023719424 scopus 로고
    • Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-c/ Insulin-like growth factor I and liver GH receptors in hypophysectomized rats
    • Maiter, D., Underwood, L. E., Macs, M., Davenport, M. L., and Ketelslegers, J. M., Different effects of intermittent and continuous growth hormone (GH) administration on serum somatomedin-c/ Insulin-like growth factor I and liver GH receptors in hypophysectomized rats, Endocrinology, 123, 1053, 1988.
    • (1988) Endocrinology , vol.123 , pp. 1053
    • Maiter, D.1    Underwood, L.E.2    Macs, M.3    Davenport, M.L.4    Ketelslegers, J.M.5
  • 147
    • 0025361244 scopus 로고
    • Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo
    • Yanai, S., Sugiyama, Y., Iga, T., Fuwa, T., and Hanano, M., Kinetic analysis of the downregulation of epidermal growth factor receptors in rats in vivo, Am. J. Physiol., 258, C593, 1990.
    • (1990) Am. J. Physiol. , vol.258
    • Yanai, S.1    Sugiyama, Y.2    Iga, T.3    Fuwa, T.4    Hanano, M.5
  • 148
    • 0023798828 scopus 로고
    • Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method
    • Sato, H., Sugiyama, Y., Sawada, Y., Iga, T., Sakamoto, S., Fuwa, T., and Hanano, M., Dynamic determination of kinetic parameters for the interaction between polypeptide hormones and cell-surface receptors in the perfused rat liver by the multiple-indicator dilution method, Proc. Natl. Acad. Sci. USA, 85, 8355, 1988.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 8355
    • Sato, H.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Sakamoto, S.5    Fuwa, T.6    Hanano, M.7
  • 149
    • 0025313718 scopus 로고
    • Internalization of EGF in perfused rat liver is independent of the degree of receptor occupancy
    • Sato, H., Sugiyama, Y., Sawada, Y., Iga, T., Fuwa, T., and Hanano, M., Internalization of EGF in perfused rat liver is independent of the degree of receptor occupancy, Am. J. Physiol., 258, G682, 1990.
    • (1990) Am. J. Physiol. , vol.258
    • Sato, H.1    Sugiyama, Y.2    Sawada, Y.3    Iga, T.4    Fuwa, T.5    Hanano, M.6
  • 150
    • 0026701924 scopus 로고
    • Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: Phenylarsine oxide-sensitive and -insensitive pathways
    • Kato, Y., Sato, H., Ichikawa, M., Suzuki, H., Sawada, Y., Hanano, M., Fuwa, T., and Sugiyama, Y., Existence of two pathways for the endocytosis of epidermal growth factor by rat liver: Phenylarsine oxide-sensitive and -insensitive pathways, Proc. Natl. Acad. Sci. USA, 89, 8507, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8507
    • Kato, Y.1    Sato, H.2    Ichikawa, M.3    Suzuki, H.4    Sawada, Y.5    Hanano, M.6    Fuwa, T.7    Sugiyama, Y.8
  • 151
    • 0343328820 scopus 로고
    • Modelization of tissue transfer of peptide: Hepatic transport of epidermal growth factor (EGF) and hepatocyte growth factor (HGF)
    • Tillement, J. P., Eckert, H., Albengres, E., Barre, J., Baumann, P., and Lemaire, M., Eds., Editions Fort et Clair, Paris
    • Sugiyama, Y., Liu, K., Nakamura, T., and Kato, Y., Modelization of tissue transfer of peptide: Hepatic transport of epidermal growth factor (EGF) and hepatocyte growth factor (HGF), in Proceedings of the International Symposium on Blood Binding and Drug Transfer, Tillement, J. P., Eckert, H., Albengres, E., Barre, J., Baumann, P., and Lemaire, M., Eds., Editions Fort et Clair, Paris, 1993, 179.
    • (1993) Proceedings of the International Symposium on Blood Binding and Drug Transfer , pp. 179
    • Sugiyama, Y.1    Liu, K.2    Nakamura, T.3    Kato, Y.4
  • 152
    • 0028315948 scopus 로고
    • Pharmacokinetic aspects of peptide delivery and targeting: Importance of receptor-mediated endocytosis
    • Sugiyama, Y. and Kato, Y., Pharmacokinetic aspects of peptide delivery and targeting: Importance of receptor-mediated endocytosis. Drug Devel. Indust.Pharm., 20, 591, 1994.
    • (1994) Drug Devel. Indust.Pharm. , vol.20 , pp. 591
    • Sugiyama, Y.1    Kato, Y.2
  • 153
    • 0027180158 scopus 로고
    • A receptor-mediated antigen delivery and incorporation system. Administration of alpha 2-macroglobulin-cytochrome c conjugate induced high concentrations of antibodies against cytochrome c in mice
    • Mitsuda, S., Nakagawa, T., Osada, T., and Ikai, A., A receptor-mediated antigen delivery and incorporation system. Administration of alpha 2-macroglobulin-cytochrome c conjugate induced high concentrations of antibodies against cytochrome c in mice, Biochem. Biophys. Res. Commun., 191, 1326, 1993.
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , pp. 1326
    • Mitsuda, S.1    Nakagawa, T.2    Osada, T.3    Ikai, A.4
  • 154
    • 0024355351 scopus 로고
    • Receptor-mediated drug delivery to macrophages in chemotherapy of leishmaniasis
    • Mukhopadhyay, A., Chaudhuri, G., Arora, S. K., Sehgal, S., and Basu, S. K., Receptor-mediated drug delivery to macrophages in chemotherapy of leishmaniasis, Science, 244, 705, 1989.
    • (1989) Science , vol.244 , pp. 705
    • Mukhopadhyay, A.1    Chaudhuri, G.2    Arora, S.K.3    Sehgal, S.4    Basu, S.K.5
  • 155
    • 0028416237 scopus 로고
    • Targeting of drugs to various blood cell types using (neo-)glycoproteins, antibodies, and other protein carriers
    • Molema, G. and Meijer, D. K. F., Targeting of drugs to various blood cell types using (neo-)glycoproteins, antibodies, and other protein carriers, Adv. Drug Delivery Rev., 14, 25, 1994.
    • (1994) Adv. Drug Delivery Rev. , vol.14 , pp. 25
    • Molema, G.1    Meijer, D.K.F.2
  • 156
    • 0029031794 scopus 로고
    • Vector-mediated peptide drug delivery to the brain
    • Pardridge, W. M., Vector-mediated peptide drug delivery to the brain, Adv. Drug Delivery Rev., 15, 109, 1995.
    • (1995) Adv. Drug Delivery Rev. , vol.15 , pp. 109
    • Pardridge, W.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.