Anti-cancer therapy: Diversion of polyamines in the gut

European Journal of Gastroenterology and Hepatology

Volumn 13, Issue 9, 2001, Pages 1041-1046

  Pryme, I F ^a   Bardocz, S ^a  

^a UNIVERSITY OF BERGEN   (Norway)

Author keywords

Hyperplasia; Lectin; Non Hodgkin lymphoma; Phytohaemagglutinin; Polyamines; Tumour growth

Indexed keywords

ANTINEOPLASTIC AGENT; LECTIN; PHYTOHEMAGGLUTININ;

ANTINEOPLASTIC ACTIVITY; ASCITES TUMOR; AUTORADIOGRAPHY; CANCER PATIENT; CANCER THERAPY; CELL PROLIFERATION; DIETARY INTAKE; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; NONHODGKIN LYMPHOMA; POLYAMINE METABOLISM; PRIORITY JOURNAL; REVIEW; TISSUE REGENERATION; TUMOR GROWTH;

ANIMALS; DIET; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; GASTROINTESTINAL NEOPLASMS; HUMANS; LYMPHOMA, NON-HODGKIN; MICE; POLYAMINES; PRIMARY PREVENTION; PROGNOSIS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY;

EID: 0034812925     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200109000-00007     Document Type: Review

References (46)

1. Polyamines
2. Recent advances in the biochemistry of polyamines in eukaryotes
3. Molecular and cellular functions of the polyamines
4. Molecular genetics of polyamine synthesis in eukaryotic cells
5. Polyamine transport in mammalian cells. An update
6. The induction of gut hyperplasia by phytohaemagglutinin in the diet and limitation of tumour growth
7. Determination of erythrocytic polyamines by reverse-phase liquid chromatography
8. Determination of erythrocyte polyamines by reversed-phase liquid chromatography
9. Elevated polyamine levels in erythrocytes of SLC:ICR mice inoculated with Ehrlich ascites carcinoma cells
10. Elevated polyamine content in erythrocytes of malignant lymphoma patients
11. Elevated contents of spermidine and spermine in the erythrocytes of cancer patients
12. Red blood cell polyamines as biological markers of supratentorial malignant gliomas
13. Induction of the polyamine-biosynthetic enzymes in mouse epidermis by tumor-promoting agents
14. Regulation of ornithine decarboxylase gene expression in mouse epidermis and epidermal tumours during two-stage tumorigenesis
15. High ornithine decarboxylase activity and polyamine levels in human colorectal neoplasia
16. Polyamine biosynthetic activity in normal and neoplastic human colorectal tissues
17. Evaluation of ornithine decarboxylase activity as a marker for tumor growth rate in malignant tumors
18. Activity of ornithine decarboxylase (ODC) and polyamine levels as biochemical markers of malignancy in human brain tumors
19. Degrees of malignancy in human primary central nervous system tumors: Ornithine decarboxylase levels as better indicators than adenosylmethionine decarboxylase levels
20. Labeled putrescine as a probe in brain tumors
21. Altered polyamine profiles in prostatic hyperplasia and in kidney tumors
22. Concentrations of polyamines in renal cell carcinoma
23. Regulation of cyclin B1 by estradiol and polyamines in MCF-7 breast cancer cells
24. Inhibition of basic amino acid decarboxylases involved in polyamine biosynthesis
25. Clinical aspects of inhibition of ornithine decarboxylase with emphasis on therapeutic trials of eflornithine (DFMO) in cancer and protozoan diseases
26. Inhibitors of polyamine biosynthesis: Cellular and in vivo effects on tumour proliferation
27. Polyamine inhibition in vivo and in organ growth and repair
28. Characterization of difluoromethylornithine-resistant mouse and human tumour cell lines
29. Polyamine transport in mammalian cells
30. The role of dietary polyamines
31. A diet containing the lectin phytohaemagglutinin (PHA) slows down the proliferation of Krebs II cell tumours in mice
32. Phytohaemagglutinin in the diet induces growth of the gut and modifies some organ weights in mice
33. Effect of phytohaemagglutinin on the growth of Krebs II tumour cells, body metabolism and internal organs of mice
34. Polyamine metabolism and uptake during Phaseolus vulgaris lectin, PHA-induced growth of the rat small intestine
35. Phaseolus vulgaris lectin induces growth and the uptake of polyamines by the rat small intestine in vivo
36. The initial growth rate of Krebs II ascites cell tumours in mice is slowed down by the inclusion of phytohaemagglutinin in the diet
37. Switching between control and phytohaemagglutinin-containing diets affects growth of Krebs II ascites cells and produces differences in the levels of putrescine, spermidine and spermine
38. The plant lectin PHA as a tool for reducing the progression of tumour growth
39. Limiting the availability of polyamines for a developing tumour: An alternative approach to reducing tumour growth
40. Phytohaemagglutinin-induced gut hyperplasia and the growth of a mouse lymphosarcoma tumour
41. The effect of switching between phytohaemagglutinin-containing and a control diet on the growth and lipid content of a Krebs II lymphosarcoma tumour
42. The growth of an established murine non-Hodgkin lymphoma tumour is limited by switching to a phytohaemagglutinin-containing diet
43. Intracellular levels of polyamines in Krebs II lymphosarcoma cells in mice fed phytohaemagglutinin-containing diets are coupled with altered tumour growth
44. Reduction in growth of a non-Hodgkin lymphoma tumour in mice fed a polyamine-poor phytohaemagglutinin-containing diet is reversed by addition of polyamines